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Family Report for: Gliotactin


Family Gliotactin
Block C
Parent Family : Non-catalytic_C

Gliotactin, a transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. It is a marker of tricellular junctions, is necessary for septate junction development in Drosophila. Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila. The intracellular domain of gliotactin, is natively unfolded. Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia

IPR002018 (Carboxylesterase, type B)
PF00135 (COesterase)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

8 more
    Title: Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium
    Esmangart de Bournonville T, Le Borgne R
    Ref: Current Biology, 30:4245, 2020 : PubMed


    Title: The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila
    Wittek A, Hollmann M, Schleutker R, Luschnig S
    Ref: Current Biology, 30:4254, 2020 : PubMed


    Title: Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila
    Auld VJ, Fetter RD, Broadie K, Goodman CS
    Ref: Cell, 81:757, 1995 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in Gliotactin family (108)

Fragments of genes in Gliotactin family (32)

No Substrate

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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