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Family Report for: Fungal-Bact_LIP


Block X
Secretory lipases. Fungal-Bact_LIP is a new family as described by Neugnot et al. and Hube et al. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue. CalA is highly unusual in that it accepts tertiary alcohols and shows a high selectivity for the N-acylation of beta-amino esters. It has also amidase activity. Bassegoda et al. defined the bacterial members of this family as Family X.2 of Bacterial lipases (Family 10.2 in the updated classification of Arpigny et Jaeger (1999) ). Castilla et al. Defined a new lipase family (Family XVII) (Family 17) with a novel thermophilic and halophilic esterase from Janibacter sp. R02 as the first member of this subfamily. Parapouli et al. analysed a new thermostable alkaliphilic lipase LipSm from Stenotrophomonas maltophilia. These authors created a new family XIX for homologues of this enzyme

IPR005152 (Lipase_secreted)
PF03583 (LIP)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

13 more
    Title: Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XIX)
    Parapouli M, Foukis A, Stergiou PY, Koukouritaki M, Magklaras P, Gkini OA, Papamichael EM, Afendra AS, Hatziloukas E
    Ref: J Biol Res (Thessalon), 25:4, 2018 : PubMed


    Title: A novel thermophilic and halophilic esterase from Janibacter sp. R02, the first member of a new lipase family (Family XVII)
    Castilla A, Panizza P, Rodriguez D, Bonino L, Diaz P, Irazoqui G, Rodriguez Giordano S
    Ref: Enzyme Microb Technol, 98:86, 2017 : PubMed


    Title: A glimpse into the specialization history of the lipases/acyltransferases family of CpLIP2
    Jan AH, Dubreucq E, Drone J, Subileau M
    Ref: Biochimica & Biophysica Acta, 1865:1105, 2017 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Fungal-Bact_LIP family (9)

Genes Proteins in Fungal-Bact_LIP family (412)

Fragments of genes in Fungal-Bact_LIP family (5)

Substrates of some enzymes in the Fungal-Bact_LIP family (10)

Inhibitors of some enzymes in the Fungal-Bact_LIP family (7)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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