Epoxide_hydrolase
Relationship
Comment
Epoxide hydrolases catalyze the conversion of epoxides to corresponding diols. The catalytic triad nucleophile is an invariable aspartate that opens the epoxide ring by nuclophile attack. The mammalian soluble EHs contain 2 evolutionarily distinct domains, the N-terminal domain is similar to bacterial haloacid dehalogenase (not related to alpha/beta-hydrolase fold), while the C-terminal domain is similar to soluble plant EH, microsomal EH, and bacterial haloalkane_dehalogenase (HLD). In InterPro IPR000639 groups Epoxide hydrolase and Haloalkane dehalogenase. IPR000639; Epoxide hydrolase contains some Carboxymethylbutenolide_lactonase (trembl Q9WWZ4) Carbon-carbon_bond_hydrolase (trembl Q98I15 Q9KH20 Q9K5C1 Q9KWQ6 Q9ZAY1 Q9ZNJ3 Q9RBF3 Q9RBT0) Monoglyceridelipase_lysophospholip (trembl Q97TG8). In ESTHER they are classified in the later sub family. (there are also epoxide hydrolases not related to a/b hydrolases ex: 1NWW limonene-1,2-epoxide hydrolase Arand et al. 2003) Zhu et al. (2003) identified compound heterozygosity for 2 mutations in the EPHX1 gene, which resulted in a significant decrease in EPHX1 promoter activity.Database
Interpro : IPR000639 Epoxide hydrolase-like , IPR016292 Epoxide hydrolase , IPR010497 Epoxide hydrolase, N-terminal
PIRSF : PIRSF001112 Epoxide_hydrolase
Pdoc : No Pdoc
Pfam : PF06441 EHN , PF00561 Abhydrolase_1
Prints : No Print
EC Number : 3.3.2.9 || 3.3.2.10
References (9)
| Title : Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice - Wu_2023_Neuron__ |
| Author(s) : Wu Y , Dong JH , Dai YF , Zhu MZ , Wang MY , Zhang Y , Pan YD , Yuan XR , Guo ZX , Wang CX , Li YQ , Zhu XH |
| Ref : Neuron , : , 2023 |
| Abstract : Wu_2023_Neuron__ |
| ESTHER : Wu_2023_Neuron__ |
| PubMedSearch : Wu_2023_Neuron__ |
| PubMedID: 37402372 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Evolution of tunnels in alpha\/beta-hydrolase fold proteins-What can we learn from studying epoxide hydrolases? - Bzowka_2022_PLoS.Comput.Biol_18_e1010119 |
| Author(s) : Bzowka M , Mitusinska K , Raczynska A , Skalski T , Samol A , Bagrowska W , Magdziarz T , Gora A |
| Ref : PLoS Comput Biol , 18 :e1010119 , 2022 |
| Abstract : Bzowka_2022_PLoS.Comput.Biol_18_e1010119 |
| ESTHER : Bzowka_2022_PLoS.Comput.Biol_18_e1010119 |
| PubMedSearch : Bzowka_2022_PLoS.Comput.Biol_18_e1010119 |
| PubMedID: 35580137 |
| Title : EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides - Decker_2012_J.Lipid.Res_53_2038 |
| Author(s) : Decker M , Adamska M , Cronin A , Di Giallonardo F , Burgener J , Marowsky A , Falck JR , Morisseau C , Hammock BD , Gruzdev A , Zeldin DC , Arand M |
| Ref : J Lipid Res , 53 :2038 , 2012 |
| Abstract : Decker_2012_J.Lipid.Res_53_2038 |
| ESTHER : Decker_2012_J.Lipid.Res_53_2038 |
| PubMedSearch : Decker_2012_J.Lipid.Res_53_2038 |
| PubMedID: 22798687 |
| Gene_locus related to this paper: human-EPHX3 , human-EPHX4 |
| Title : Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis - van Loo_2006_Appl.Environ.Microbiol_72_2905 |
| Author(s) : van Loo B , Kingma J , Arand M , Wubbolts MG , Janssen DB |
| Ref : Applied Environmental Microbiology , 72 :2905 , 2006 |
| Abstract : van Loo_2006_Appl.Environ.Microbiol_72_2905 |
| ESTHER : van Loo_2006_Appl.Environ.Microbiol_72_2905 |
| PubMedSearch : van Loo_2006_Appl.Environ.Microbiol_72_2905 |
| PubMedID: 16597997 |
| Gene_locus related to this paper: agrra-echA , bacsu-yfhM , corsp-cEH , deira-DR2549 , myctu-ephF , nosp7-b2j4w6 , nosp7-b2iv02 , psepu-PP4624 , rhopa-q6n645 , strco-2SCG4.13 , thefy-q47qj2 |
| Title : Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia - Zhu_2003_Biochim.Biophys.Acta_1638_208 |
| Author(s) : Zhu QS , Xing W , Qian B , von Dippe P , Shneider BL , Fox VL , Levy D |
| Ref : Biochimica & Biophysica Acta , 1638 :208 , 2003 |
| Abstract : Zhu_2003_Biochim.Biophys.Acta_1638_208 |
| ESTHER : Zhu_2003_Biochim.Biophys.Acta_1638_208 |
| PubMedSearch : Zhu_2003_Biochim.Biophys.Acta_1638_208 |
| PubMedID: 12878321 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Epoxide hydrolases: biochemistry and molecular biology - Fretland_2000_Chem.Biol.Interact_129_41 |
| Author(s) : Fretland AJ , Omiecinski CJ |
| Ref : Chemico-Biological Interactions , 129 :41 , 2000 |
| Abstract : Fretland_2000_Chem.Biol.Interact_129_41 |
| ESTHER : Fretland_2000_Chem.Biol.Interact_129_41 |
| PubMedSearch : Fretland_2000_Chem.Biol.Interact_129_41 |
| PubMedID: 11154734 |
| Title : Gene evolution of epoxide hydrolases and recommended nomenclature - Beetham_1995_DNA.Cell.Biol_14_61 |
| Author(s) : Beetham JK , Grant D , Arand M , Garbarino J , Kiyosue T , Pinot F , Oesch F , Belknap WR , Shinozaki K , Hammock BD |
| Ref : DNA & Cell Biology , 14 :61 , 1995 |
| Abstract : Beetham_1995_DNA.Cell.Biol_14_61 |
| ESTHER : Beetham_1995_DNA.Cell.Biol_14_61 |
| PubMedSearch : Beetham_1995_DNA.Cell.Biol_14_61 |
| PubMedID: 7832993 |
| Gene_locus related to this paper: mouse-hyes |
| Title : Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes - Lacourciere_1994_Chem.Res.Toxicol_7_121 |
| Author(s) : Lacourciere GM , Armstrong RN |
| Ref : Chemical Research in Toxicology , 7 :121 , 1994 |
| Abstract : Lacourciere_1994_Chem.Res.Toxicol_7_121 |
| ESTHER : Lacourciere_1994_Chem.Res.Toxicol_7_121 |
| PubMedSearch : Lacourciere_1994_Chem.Res.Toxicol_7_121 |
| PubMedID: 8199297 |
| Title : cDNA cloning and expression of a soluble epoxide hydrolase from human liver - Beetham_1993_Arch.Biochem.Biophys_305_197 |
| Author(s) : Beetham JK , Tian T , Hammock BD |
| Ref : Archives of Biochemistry & Biophysics , 305 :197 , 1993 |
| Abstract : Beetham_1993_Arch.Biochem.Biophys_305_197 |
| ESTHER : Beetham_1993_Arch.Biochem.Biophys_305_197 |
| PubMedSearch : Beetham_1993_Arch.Biochem.Biophys_305_197 |
| PubMedID: 8342951 |
| Gene_locus related to this paper: human-EPHX2 |
Structures (171)
Genes Proteins in Epoxide_hydrolase family (1166)
Fragments of genes in Epoxide_hydrolase family (81)
Structures in Epoxide_hydrolase family (171)Substrates in Epoxide_hydrolase family (41)
Inhibitors in Epoxide_hydrolase family (128)