Epoxide-hydrolase_like
Relationship
Comment
This family closely related to Abhydrolase_6 contains previously separated families (in Pfam they are partially included in Abhydrolase_6). In epoxide hydrolase, haloalkane dehalogenase, haloacetate_dehalogenase, the catalytic triad nucleophile is an invariable aspartate. Asp attacks a carbon of the epoxide moiety, opening the ring and forming an ester-linked substrate-enzyme intermediate complex. An activated water molecule, hydrolyzes the ester bond and releases diol as the product of catalysis. Two Tyr residues are located on the opposite side of the active site from the nucleophile. They hydrogen bond with the epoxide oxygen, positioning the substrate in the active site for nucleophilic attack. In Cif one of the Tyr is replaced by HisDatabase
Interpro : IPR000639 Epoxide hydrolase-like , IPR016292 Epoxide hydrolase , IPR010497 Epoxide hydrolase, N-terminal
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12697 Abhydrolase_6
Prints : No Print
EC Number : No EC Number
References (3)
| Title : alpha\/beta-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase - Pusch_2022_Metabolites_12_761 |
| Author(s) : Pusch LM , Riegler-Berket L , Oberer M , Zimmermann R , Taschler U |
| Ref : Metabolites , 12 : , 2022 |
| Abstract : Pusch_2022_Metabolites_12_761 |
| ESTHER : Pusch_2022_Metabolites_12_761 |
| PubMedSearch : Pusch_2022_Metabolites_12_761 |
| PubMedID: 36005632 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Epoxide hydrolases: structure, function, mechanism, and assay - Arand_2005_Methods.Enzymol_400_569 |
| Author(s) : Arand M , Cronin A , Adamska M , Oesch F |
| Ref : Methods Enzymol , 400 :569 , 2005 |
| Abstract : Arand_2005_Methods.Enzymol_400_569 |
| ESTHER : Arand_2005_Methods.Enzymol_400_569 |
| PubMedSearch : Arand_2005_Methods.Enzymol_400_569 |
| PubMedID: 16399371 |
| Title : The telltale structures of epoxide hydrolases - Arand_2003_Drug.Metab.Rev_35_365 |
| Author(s) : Arand M , Cronin A , Oesch F , Mowbray SL , Jones TA |
| Ref : Drug Metabolism Reviews , 35 :365 , 2003 |
| Abstract : Arand_2003_Drug.Metab.Rev_35_365 |
| ESTHER : Arand_2003_Drug.Metab.Rev_35_365 |
| PubMedSearch : Arand_2003_Drug.Metab.Rev_35_365 |
| PubMedID: 14705866 |
No structure scheme yet for this family
No Genes Proteins
No fragment of genes
No fragment of genesSubstrates in Epoxide-hydrolase_like family (1)
No Inhibitor