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Family Report for: Duf_726


Family Duf_726
Block X
A lipase like protein: yeast-yfd4 Mil1(Yfl034w) specifically binds Apm2, one of the adaptor protein of (AP) complexes responsible for binding clathrin, cargo-sorting motifs, accessory factors, and membrane lipids. The paper by Whitfield et al. is the first description of a function for a member of the Duf_726 family. The same protein had been shown to interact with the ribosomal phosphoprotein P0 Aruna et al.. yeast-yfd4 has a conserved catalytic triad. Male-sterile rice mutant oslddt1 (leaked and delayed degraded tapetum 1). oslddt1 plants show complete pollen abortion resulting from delayed degradation of the tapetum and blocked formation of Ubisch bodies and pollen walls. Wax and cutin contents in mature oslddt1 anthers are drastically reduced indicating that orysj-q10ss2 OsLDDT1 OsLDDT1 is involved in fatty acid synthesis and affects formation of the anther epidermis ( Sun et al. 2023)

IPR007941 (Protein of unknown function DUF726)
PF05277 (DUF726)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

1 more
    Title: OsLDDT1, encoding a transmembrane structural DUF726 family protein, is essential for tapetum degradation and pollen formation in rice
    Sun Z, Liu K, Chen C, Chen D, Peng Z, Zhou R, Liu L, He D, Duan W and Sun L <7 more author(s)>
    Ref: Plant Sci, :111596, 2023 : PubMed


    Title: The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting
    Whitfield ST, Burston HE, Bean BD, Raghuram N, Maldonado-Baez L, Davey M, Wendland B, Conibear E
    Ref: Mol Biology of the cell, 27:588, 2016 : PubMed


    Title: Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast
    Baxter SM, Rosenblum JS, Knutson S, Nelson MR, Montimurro JS, Di Gennaro JA, Speir JA, Burbaum JJ, Fetrow JS
    Ref: Mol Cell Proteomics, 3:209, 2004 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in Duf_726 family (139)

Fragments of genes in Duf_726 family (13)

No Substrate

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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