Dieckmann_Cyclase
Relationship
Comment
Off-loading Dieckmann cyclase, NcmC, that installs the tetramate head group in nocamycin, a hybrid polyketide/nonribosomalpeptide natural product. A conserved thioesterase-like scaffold has been adapted to perform a new chemical reaction: heterocyclization. The catalytic triad for the cyclization reaction consists of Cys89, Asp116, and His254 in 9pseu-NcmC. Dieckmann cyclase (TrdC, SlgL, LipX2, KirHI,and FacH) last step which generate actinomycete-derived tetramic acid and pyridone natural products in the biosynthetic pathways for Tirandamycin, Streptolydigin, alpha-Lipomycin, Kirromycin, and FactumycinDatabase
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (2)
| Title : Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation - Cogan_2020_ACS.Chem.Biol_15_2783 |
| Author(s) : Cogan DP , Ly J , Nair SK |
| Ref : ACS Chemical Biology , 15 :2783 , 2020 |
| Abstract : Cogan_2020_ACS.Chem.Biol_15_2783 |
| ESTHER : Cogan_2020_ACS.Chem.Biol_15_2783 |
| PubMedSearch : Cogan_2020_ACS.Chem.Biol_15_2783 |
| PubMedID: 33017142 |
| Gene_locus related to this paper: 9pseu-NcmC |
| Title : Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis - Gui_2015_Org.Lett_17_628 |
| Author(s) : Gui C , Li Q , Mo X , Qin X , Ma J , Ju J |
| Ref : Org Lett , 17 :628 , 2015 |
| Abstract : Gui_2015_Org.Lett_17_628 |
| ESTHER : Gui_2015_Org.Lett_17_628 |
| PubMedSearch : Gui_2015_Org.Lett_17_628 |
| PubMedID: 25621700 |
Structures (3)
Genes Proteins in Dieckmann_Cyclase family (89)
Fragments of genes in Dieckmann_Cyclase family (7)
Structures in Dieckmann_Cyclase family (3)Substrates in Dieckmann_Cyclase family (3)
Inhibitors in Dieckmann_Cyclase family (1)