Cholinesterase-like
Relationship
Comment
Analysis of the complete genome sequences of numerous representatives of the various metazoan phyla show that moderate amplification of cholinesterase genes is not uncommon in molluscs, echinoderms, hemichordates, prochordates or lepidosauria. Amplification of acetylcholinesterase genes is also a feature of parasitic nematodes or ticks. This family is now called Cholinesterase like. It also contains sequences very close to AChE but which are either incomplete or are missing W84 or one of the residue of the catalytic triad or are pseudogenes with deletions or errors of conceptual splicing
Before this family was called Dictyostelium_crys as it contained only Dict proteins. These proteins have an active site serine and have probably an esterase activity but are in membrane-enclosed crystals and probably have non catalytic functions. Database
Interpro : IPR000997 Cholinesterase , IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : No Print
EC Number : No EC Number
References (6)
| Title : Molecular biology of tick acetylcholinesterases - Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320 |
| Author(s) : Temeyer KB |
| Ref : Front Biosci (Landmark Ed) , 23 :1320 , 2018 |
| Abstract : Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320 |
| ESTHER : Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320 |
| PubMedSearch : Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320 |
| PubMedID: 28930602 |
| Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3 |
| Title : Natural genomic amplification of cholinesterase genes in animals - Chatonnet_2017_J.Neurochem_142 Suppl 2_73 |
| Author(s) : Chatonnet A , Lenfant N , Marchot P , Selkirk ME |
| Ref : Journal of Neurochemistry , 142 Suppl 2 :73 , 2017 |
| Abstract : Chatonnet_2017_J.Neurochem_142 Suppl 2_73 |
| ESTHER : Chatonnet_2017_J.Neurochem_142 Suppl 2_73 |
| PubMedSearch : Chatonnet_2017_J.Neurochem_142 Suppl 2_73 |
| PubMedID: 28382676 |
| Title : Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions - Selkirk_2005_Chem.Biol.Interact_157-158_263 |
| Author(s) : Selkirk ME , Lazari O , Hussein AS , Matthews JB |
| Ref : Chemico-Biological Interactions , 157-158 :263 , 2005 |
| Abstract : Selkirk_2005_Chem.Biol.Interact_157-158_263 |
| ESTHER : Selkirk_2005_Chem.Biol.Interact_157-158_263 |
| PubMedSearch : Selkirk_2005_Chem.Biol.Interact_157-158_263 |
| PubMedID: 16243303 |
| Title : Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid - Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
| Author(s) : Krejci E , Duval N , Chatonnet A , Vincens P , Massoulie J |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 88 :6647 , 1991 |
| Abstract : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
| ESTHER : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
| PubMedSearch : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
| PubMedID: 1862088 |
| Title : Membrane-enclosed crystals in Dictyostelium discoideum cells, consisting of developmentally regulated proteins with sequence similarities to known esterases - Bomblies_1990_J.Cell.Biol_110_669 |
| Author(s) : Bomblies L , Biegelmann E , Doring V , Gerisch G , Krafft-Czepa H , Noegel AA , Schleicher M , Humbel BM |
| Ref : Journal of Cell Biology , 110 :669 , 1990 |
| Abstract : Bomblies_1990_J.Cell.Biol_110_669 |
| ESTHER : Bomblies_1990_J.Cell.Biol_110_669 |
| PubMedSearch : Bomblies_1990_J.Cell.Biol_110_669 |
| PubMedID: 2307702 |
| Gene_locus related to this paper: dicdi-crd2p , dicdi-crysp , dicdi-drgen |
| Title : Molecular analysis of a developmentally regulated gene required for Dictyostelium aggregation - Rubino_1989_Dev.Biol_131_27 |
| Author(s) : Rubino S , Mann SK , Hori RT , Pinko C , Firtel RA |
| Ref : Developmental Biology , 131 :27 , 1989 |
| Abstract : Rubino_1989_Dev.Biol_131_27 |
| ESTHER : Rubino_1989_Dev.Biol_131_27 |
| PubMedSearch : Rubino_1989_Dev.Biol_131_27 |
| PubMedID: 2909407 |
| Gene_locus related to this paper: dicdi-drgen |
No structure scheme yet for this family
Genes Proteins in Cholinesterase-like family (556)
Fragments of genes in Cholinesterase-like family (394)
No fragment of genesSubstrates in Cholinesterase-like family (4)
Inhibitors in Cholinesterase-like family (1)