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Family Report for: Cholinesterase-like


Block C
Parent Family : Cholinesterase

Analysis of the complete genome sequences of numerous representatives of the various metazoan phyla show that moderate amplification of cholinesterase genes is not uncommon in molluscs, echinoderms, hemichordates, prochordates or lepidosauria. Amplification of acetylcholinesterase genes is also a feature of parasitic nematodes or ticks. This family is now called Cholinesterase like. It also contains sequences very close to AChE but which are either incomplete or are missing W84 or one of the residue of the catalytic triad or are pseudogenes with deletions or errors of conceptual splicing Before this family was called Dictyostelium_crys as it contained only Dict proteins. These proteins have an active site serine and have probably an esterase activity but are in membrane-enclosed crystals and probably have non catalytic functions.

IPR000997 (Cholinesterase), IPR002018 (Carboxylesterase, type B)
PF00135 (COesterase)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

3 more
    Title: Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid
    Krejci E, Duval N, Chatonnet A, Vincens P, Massoulie J
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 88:6647, 1991 : PubMed


    Title: Membrane-enclosed crystals in Dictyostelium discoideum cells, consisting of developmentally regulated proteins with sequence similarities to known esterases
    Bomblies L, Biegelmann E, Doring V, Gerisch G, Krafft-Czepa H, Noegel AA, Schleicher M, Humbel BM
    Ref: Journal of Cell Biology, 110:669, 1990 : PubMed


    Title: Molecular analysis of a developmentally regulated gene required for Dictyostelium aggregation
    Rubino S, Mann SK, Hori RT, Pinko C, Firtel RA
    Ref: Developmental Biology, 131:27, 1989 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in Cholinesterase-like family (555)

Fragments of genes in Cholinesterase-like family (395)

Substrates of some enzymes in the Cholinesterase-like family (3)

Inhibitors of some enzymes in the Cholinesterase-like family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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