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Family Report for: CIB-CCG1-interacting-factor-B


Block X
Parent Family : Abhydrolase_6

Alpha/beta hydrolase domain-containing protein 14B. The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription. TFIID interactor CCG1/TAF(II)250-interacting factor B (CIB) activates transcription and has hydrolase activity towards p-nitrophenyl butyrate (in vitro). Dorz1 (ABHD14A,ABHEA) was identified and characterized as one of the most significantly down-regulated genes in Zic1-deficient cerebellum (Zic1: zinc finger protein that controls vertebrate neural development) Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum has also been released. ABHD14B is able to transfer an acetyl group from a post-translationally acetylated-lysine to coenzyme A (CoA) and yield acetyl-CoA, while re-generating the free amine of protein lysine residues (Rajendran et al. 2020): lysine deacetylase

IPR026764 (Alpha/beta hydrolase domain containing protein 14B)
PF12695 (Abhydrolase_5)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

1 more
    Title: A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals
    Rajendran A, Soory A, Khandelwal N, Ratnaparkhi G, Kamat SS
    Ref: Journal of Biological Chemistry, 298:102128, 2022 : PubMed


    Title: Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme
    Rajendran A, Vaidya K, Mendoza J, Bridwell-Rabb J, Kamat SS
    Ref: Biochemistry, 59:183, 2020 : PubMed


    Title: The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB)
    Padmanabhan B, Kuzuhara T, Adachi N, Horikoshi M
    Ref: Journal of Biological Chemistry, 279:9615, 2004 : PubMed


Other Papers

No structure scheme yet for this family

Structures in CIB-CCG1-interacting-factor-B family (2)

Genes Proteins in CIB-CCG1-interacting-factor-B family (92)

Fragments of genes in CIB-CCG1-interacting-factor-B family (8)

Substrates of some enzymes in the CIB-CCG1-interacting-factor-B family (2)

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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AcePerl Lincoln Stein Home Page

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