BotH

Relationship

Family: BotH

Block: X

Parent Family: No family

Comment

The bottromycin epimerase BotH defines a group of atypical alpha/beta-hydrolase-fold enzymes. BotH is a peptide epimerase responsible for the post-translational epimerization of L-Asp to D-Asp during bottromycin biosynthesis. D-amino acids endow peptides with diverse, desirable properties, but the post-translational and site-specific epimerization of L-amino acids into their D-counterparts is rare and chemically challenging. The activity does not rely on a catalytic triad. No conservation of Ser (replaced by Phe) nor His or Asp. The residues Phe110 and Val41 seem important in hydrogen bonding to substrate

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in	Fasta
Nucleotide in	Fasta
Alignment with Multalin	Text only
Seed alignment with MAFFT	No colour
Alignment with MAFFT	No colour
Dendrogram	The dnd file

References (1)

Title : The bottromycin epimerase BotH defines a group of atypical alpha\/beta-hydrolase-fold enzymes - Sikandar_2020_Nat.Chem.Biol_16_1013

Author(s) : Sikandar A , Franz L , Adam S , Santos-Aberturas J , Horbal L , Luzhetskyy A , Truman AW , Kalinina OV , Koehnke J

Ref : Nat Chemical Biology , 16 :1013 , 2020

Abstract : Sikandar_2020_Nat.Chem.Biol_16_1013

ESTHER : Sikandar_2020_Nat.Chem.Biol_16_1013

PubMedSearch : Sikandar_2020_Nat.Chem.Biol_16_1013

PubMedID: 32601484

Gene_locus related to this paper: 9actn-k4mhv9

Structures (5)

Genes Proteins in BotH family (10)

No fragment of genes

Structures in BotH family (5)

Substrates in BotH family (4)

No Inhibitor