Family Report for: BCHE BCHE
Relationship
Comment
Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase. Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics.Various autosomal recessive mutations of the gene exist in human population
1 Risk(s) factors
1 Xenobiotic(s) sensitivity
Database
Sequences
Interpro
| PIRSF
| Pdoc
| PFam
| Prints
| Prosite
| EC at KEGG
| EC at EXPASY
|
References
2 more
Title: Old and new questions about cholinesterasesMassoulie J , Perrier N , Noureddine H , Liang D , Bon S Ref: Chemico-Biological Interactions, 175 :30, 2008 : PubMed Abstract ESTHER: Massoulie_2008_Chem.Biol.Interact_175_30 PubMedSearch: Massoulie 2008 Chem.Biol.Interact 175 30 PubMedID: 18541228 Abstract
Cholinesterases have been intensively studied for a long time, but still offer many fascinating and fundamental questions regarding their evolution, activity, biosynthesis, folding, post-translational modifications, association with structural proteins (ColQ, PRiMA and maybe others), export or degradation. They constitute an excellent model to study these processes, particularly because of the sensitivity and specificity of enzymic assays. In addition, a number of provocative ideas concerning their proposed non-conventional, or non-catalytic functions deserve to be further documented.
Title: Molecular and cellular biology of cholinesterasesMassoulie J , Pezzementi L , Bon S , Krejci E , Vallette FM Ref: Prog Neurobiol, 41 :31, 1993 : PubMed Abstract Title: Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.Lockridge O Ref: Pharmacol Ther, 47 :35, 1990 : PubMed Abstract ESTHER: Lockridge_1990_Pharmacol.Ther_47_35 PubMedSearch: Lockridge 1990 Pharmacol.Ther 47 35 PubMedID: 2195556 Gene_locus related to this paper: human-BCHE Inhibitor(s) related to this paper: 2-Chloroprocaine ,
17-desoxypancuronium ,
Aprophen ,
Chlorpromazine ,
Choline ,
Decamethonium ,
Dibucaine ,
Dibutyrate-pancuronium ,
Meperidine ,
Mivacurium ,
Neostigmine~Prostigmine ,
Pancuronium ,
Physostigmine~Eserine ,
Procaine ,
Ro-2-0683 ,
Succinylcholine~Suxamethonium ,
Tetracaine ,
Tetramethylammonium ,
Vecuronium ,
Win4510 ,
Win4510S ,
Win5303 Abstract
People with genetic variants of cholinesterase respond abnormally to succinylcholine, experiencing substantial prolongation of muscle paralysis with apnea rather than the usual 2-6 min. The structure of usual cholinesterase has been determined including the complete amino acid and nucleotide sequence. This has allowed identification of altered amino acids and nucleotides. The variant most frequently found in patients who respond abnormally to succinylcholine is atypical cholinesterase, which occurs in homozygous form in 1 out of 3500 Caucasians. Atypical cholinesterase has a single substitution at nucleotide 209 which changes aspartic acid 70 to glycine. This suggests that Asp 70 is part of the anionic site, and that the absence of this negatively charged amino acid explains the reduced affinity of atypical cholinesterase for positively charged substrates and inhibitors. The clinical consequence of reduced affinity for succinylcholine is that none of the succinylcholine is hydrolyzed in blood and a large overdose reaches the nerve-muscle junction where it causes prolonged muscle paralysis. Silent cholinesterase has a frame shift mutation at glycine 117 which prematurely terminates protein synthesis and yields no active enzyme. The K variant, named in honor of W. Kalow, has threonine in place of alanine 539. The K variant is associated with 33% lower activity. All variants arise from a single locus as there is only one gene for human cholinesterase (EC 3.1.1.8). Comparison of amino acid sequences of esterases and proteases shows that cholinesterase belongs to a new family of serine esterases which is different from the serine proteases.
2 less
Title: Old and new questions about cholinesterasesMassoulie J , Perrier N , Noureddine H , Liang D , Bon S Ref: Chemico-Biological Interactions, 175 :30, 2008 : PubMed Abstract ESTHER: Massoulie_2008_Chem.Biol.Interact_175_30 PubMedSearch: Massoulie 2008 Chem.Biol.Interact 175 30 PubMedID: 18541228 Abstract
Cholinesterases have been intensively studied for a long time, but still offer many fascinating and fundamental questions regarding their evolution, activity, biosynthesis, folding, post-translational modifications, association with structural proteins (ColQ, PRiMA and maybe others), export or degradation. They constitute an excellent model to study these processes, particularly because of the sensitivity and specificity of enzymic assays. In addition, a number of provocative ideas concerning their proposed non-conventional, or non-catalytic functions deserve to be further documented.
Title: The cholinesterases: from genes to proteinsTaylor P , Radic Z Ref: Annual Review of Pharmacology & Toxicology, 34 :281, 1994 : PubMed Abstract Title: Molecular and cellular biology of cholinesterasesMassoulie J , Pezzementi L , Bon S , Krejci E , Vallette FM Ref: Prog Neurobiol, 41 :31, 1993 : PubMed Abstract Title: Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.Lockridge O Ref: Pharmacol Ther, 47 :35, 1990 : PubMed Abstract ESTHER: Lockridge_1990_Pharmacol.Ther_47_35 PubMedSearch: Lockridge 1990 Pharmacol.Ther 47 35 PubMedID: 2195556 Gene_locus related to this paper: human-BCHE Inhibitor(s) related to this paper: 2-Chloroprocaine ,
17-desoxypancuronium ,
Aprophen ,
Chlorpromazine ,
Choline ,
Decamethonium ,
Dibucaine ,
Dibutyrate-pancuronium ,
Meperidine ,
Mivacurium ,
Neostigmine~Prostigmine ,
Pancuronium ,
Physostigmine~Eserine ,
Procaine ,
Ro-2-0683 ,
Succinylcholine~Suxamethonium ,
Tetracaine ,
Tetramethylammonium ,
Vecuronium ,
Win4510 ,
Win4510S ,
Win5303 Abstract
People with genetic variants of cholinesterase respond abnormally to succinylcholine, experiencing substantial prolongation of muscle paralysis with apnea rather than the usual 2-6 min. The structure of usual cholinesterase has been determined including the complete amino acid and nucleotide sequence. This has allowed identification of altered amino acids and nucleotides. The variant most frequently found in patients who respond abnormally to succinylcholine is atypical cholinesterase, which occurs in homozygous form in 1 out of 3500 Caucasians. Atypical cholinesterase has a single substitution at nucleotide 209 which changes aspartic acid 70 to glycine. This suggests that Asp 70 is part of the anionic site, and that the absence of this negatively charged amino acid explains the reduced affinity of atypical cholinesterase for positively charged substrates and inhibitors. The clinical consequence of reduced affinity for succinylcholine is that none of the succinylcholine is hydrolyzed in blood and a large overdose reaches the nerve-muscle junction where it causes prolonged muscle paralysis. Silent cholinesterase has a frame shift mutation at glycine 117 which prematurely terminates protein synthesis and yields no active enzyme. The K variant, named in honor of W. Kalow, has threonine in place of alanine 539. The K variant is associated with 33% lower activity. All variants arise from a single locus as there is only one gene for human cholinesterase (EC 3.1.1.8). Comparison of amino acid sequences of esterases and proteases shows that cholinesterase belongs to a new family of serine esterases which is different from the serine proteases.
Title: Comparison of butyrylcholinesterase and acetylcholinesterase.Chatonnet A , Lockridge O Ref: Biochemical Journal, 260 :625, 1989 : PubMed Abstract
Other Papers
Structure scheme for
BCHE Structures in BCHE family
(92)
Structure Names Protein 1P0I (f )Crystal structure of human butyrylcholinesterase human-BCHE 1P0M (f )Crystal structure of human butyrylcholinesterase in complexe with a choline molecule human-BCHE 1P0P (f )Crystal structure of soman-aged human butyrylcholinesterase in complex with the substrate analog butyrylthiocholine human-BCHE 1P0Q (f )Crystal structure of soman-aged human butyrylcholinesterase human-BCHE 1XLU (f )X-Ray Structure Of Aged Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Bound To Butyrylcholinesterase human-BCHE 1XLV (f )Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate. human-BCHE 1XLW (f )Diethylphosphorylated Butyrylcholinesterase (Nonaged) Obtained By Reaction With Echothiophate human-BCHE 2J4C (f )Structure of human Butyrylcholinesterase in complex with 10mM HgCl2 human-BCHE 2PM8 (f )Crystal structure of recombinant full length human butyrylcholinesterase human-BCHE 2WID (f )Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA1 human-BCHE 2WIF (f )Aged form of human butyrylcholinesterase inhibited by tabun analogue TA1 human-BCHE 2WIG (f )Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA4 human-BCHE 2WIJ (f )Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA5 human-BCHE 2WIK (f )Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA6 human-BCHE 2WIL (f )Aged form of human butyrylcholinesterase inhibited by tabun analogue TA5 human-BCHE 2WSL (f )Aged form of human butyrylcholinesterase inhibited by tabun analogue TA4 human-BCHE 2XMB (f )G117H mutant of human butyrylcholinesterase in complex with sulfate human-BCHE 2XMC (f )G117H mutant of human butyrylcholinesterase in complex with fluoride anion human-BCHE 2XMD (f )G117H mutant of human butyrylcholinesterase in complex with echothiophate human-BCHE 2XMG (f )G117H mutant of human butyrylcholinesterase in complex with VX human-BCHE 2XQF (f )X-ray Structure of human butyrylcholinesterase inhibited by racemic VX human-BCHE 2XQG (f )X-ray Structure of human butyrylcholinesterase inhibited by racemic VR human-BCHE 2XQI (f )X-ray Structure of human butyrylcholinesterase inhibited by racemic CVX human-BCHE 2XQJ (f )X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(R) human-BCHE 2XQK (f )X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S) human-BCHE 2Y1K (f )Structure of Human Butyrylcholinesterase Inhibited by CBDP (12h soak) : Phosphoserine Adduct human-BCHE 3DJY (f )Nonaged Form of Human Butyrylcholinesterase Inhibited by Tabun human-BCHE 3DKK (f )Aged Form of Human Butyrylcholinesterase Inhibited by Tabun human-BCHE 3O9M (f )Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification human-BCHE 4AQD (f )Crystal structure of fully glycosylated human butyrylcholinesterase human-BCHE 4AXB (f )Crystal structure of soman-aged human butyrylcholinesterase in complex with 2-PAM human-BCHE 4B0O (f )Crystal structure of soman-aged human butyrylcholinesterase in complex with benzyl pyridinium-4-methyltrichloroacetimidate human-BCHE 4B0P (f )Crystal structure of soman-aged human butyrylcholinesterase in complex with methyl 2-(pentafluorobenzyloxyimino)pyridinium human-BCHE 4BBZ (f )Structure of human butyrylcholinesterase inhibited by CBDP (2-min soak): Cresyl-phosphoserine adduct human-BCHE 4BDS (f )Human butyrylcholinesterase in complex with tacrine human-BCHE 4TPK (f )Human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide human-BCHE 4XII (f )X-ray structure of human butyrylcholinesterase complex with 3-pyridin-4-yl-2,4-dihydro-indeno[1,2-.C.]pyrazole human-BCHE 5DYT (f )Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-methylnaphthalene-2-sulfonamide human-BCHE 5DYW (f )Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide human-BCHE 5DYY (f )Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)naphthalene-2-sulfonamide human-BCHE 5K5E (f )Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening (5JYW withdrawn) human-BCHE 5LKR (f )Human Butyrylcholinesterase complexed with N-Propargyliperidine 5LKR-6yc human-BCHE 5NN0 (f )Human butyrylcholinesterase in complex with inhibitor with picomolar activity human-BCHE 6EMI (f )Crystal structure of a variant of human butyrylcholinesterase expressed in bacteria human-BCHE 6EP4 (f )Human butyrylcholinesterase in complex with decamethonium human-BCHE 6EQP (f )Human butyrylcholinesterase in complex with ethopropazine human-BCHE 6EQQ (f )Human butyrylcholinesterase in complex with huprine 19 human-BCHE 6ESJ (f )Human butyrylcholinesterase in complex with propidium human-BCHE 6ESY (f )Human butyrylcholinesterase in complex with thioflavine T human-BCHE 6EUL (f )Butyrylcholinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue human-BCHE 6EYF (f )Butyrylcholinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue human-BCHE 6EZ2 (f )Human butyrylcholinesterase carbamylated. supersedes 6EUK human-BCHE 6F7Q (f )Human Butyrylcholinesterase complexed with N-Propargyliperidines human-BCHE 6I0B (f )Human butyrylcholinesterase in complex with the R enantiomer of a chlorotacrine-tryptophan multi-target inhibitor human-BCHE 6I0C (f )Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor human-BCHE 6I2T (f )model of full-length, fully-glycosylated human butyrylcholinesterase tetramer human-BCHE 6QAA (f )Human Butyrylcholinesterase in complex with (S)-2-(butylamino)-N-(2-cycloheptylethyl)-3-(1H-indol-3-yl)propanamide human-BCHE 6QAB (f )Human Butyrylcholinesterase in complex with (S)-N-(1-((2-cycloheptylethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-N,N-dimethylbutan-1-aminium human-BCHE 6QAC (f )Human Butyrylcholinesterase in complex with (S)-2-(butylamino)-N-(3-cycloheptylpropyl)-3-(1H-indol-3-yl)propanamide human-BCHE 6QAD (f )Human Butyrylcholinesterase in complex with ((S)-2-(butylamino)-N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-3-(1H-indol-3-yl)propanamide human-BCHE 6QAE (f )Human Butyrylcholinesterase in complex with (S)-N2-butyl-N1-(2-cycloheptylethyl)-3-(1H-indol-3-yl)-N1,N2-dimethylpropane-1,2-diamine human-BCHE 6R6V (f )Structure of recombinant human butyrylcholinesterase in complex with a fluorescent coumarin-based probe human-BCHE 6R6W (f )Structure of recombinant human butyrylcholinesterase in complex with a fluorescent NBD-based probe human-BCHE 6RUA (f )Structure of recombinant human butyrylcholinesterase in complex with a coumarin-based fluorescent probe linked to sulfonamide type inhibitor human-BCHE 6SAM (f )Structure of human butyrylcholinesterase in complex with 1-(2,3-dihydro-1H-inden2-yl)piperidin-3-yl N-phenyl carbamate human-BCHE 6T9P (f )Structure of human butyrylcholinesterase in complex with R enantiomer of oxime III, methylimidazole derivative of 2-hydroxyimino-N-(azidophenylpropyl)acetamide human-BCHE 6T9S (f )Structure of human butyrylcholinesterase in complex with S enantiomer of oxime III, methylimidazole derivative of 2-hydroxyimino-N-(azidophenylpropyl)acetamide human-BCHE 6XTA (f )Human Butyrylcholinesterase in complex with compound 18 human-BCHE 6ZWI (f )Human butyrylcholinesterase in complex with ((6-((2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamido)hexyl)triphenylphosphonium bromide) human-BCHE 7AIY (f )Crystal structure of human butyrylcholinesterase in complex with 2-{1-[4-(12-Amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}-N-[4-hydroxy-3-methoxybenzyl]acetamide compound 5i human-BCHE 7AMZ (f )Human butyrylcholinesterase in complexe with N-((2S,3R)-3-hydr oxy-4-(neopentylamino)-1-phenylbutan-2-yl)-2,2-diphenylacetamide (51) human-BCHE 7AWG (f )Crystal structure of human butyrylcholinesterase in complex with compound 27 (2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)(benzyl)amine human-BCHE 7AWH (f )Crystal structure of human butyrylcholinesterase in complex with compound 54 tert-butyl 3-(((2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)methyl)piperidine-1-carboxylate human-BCHE 7AWI (f )Crystal structure of human butyrylcholinesterase in complex with compound 70 tert-butyl 3-(((2-((1-benzyl-1H-indol-4-yl)oxy)ethyl)amino)methyl]piperidine-1-carboxylate human-BCHE 7BGC (f )human butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor human-BCHE 7BO3 (f )Human Butyrylcholinesterase in complex with N-(2-(1H-Indol-3-yl)ethyl)-2-cycloheptyl-N-methylethan-1-amine human-BCHE 7BO4 (f )Human Butyrylcholinesterase in complex with 3-(2-(butyl(2-cycloheptylethyl)amino)ethyl)-1H-indol-6-ol human-BCHE 7P86 (f )Crystal structure of human butyrylcholinesterase inibited by omethoate human-BCHE 7P89 (f )Crystal structure of human butyrylcholinesterase inibited by chlorpyrifos oxon human-BCHE 7Q1M (f )Crystal structure of human butyrylcholinesterase in complex with N-[(2S)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-2,2-diphenylacetamide human-BCHE 7Q1N (f )Crystal structure of human butyrylcholinesterase in complex with N-[(2R)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-2,2-diphenylacetamide human-BCHE 7Q1O (f )Crystal structure of human butyrylcholinesterase in complex with N-[(2S)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-3,3-diphenylpropanamide human-BCHE 7Q1P (f )Crystal structure of human butyrylcholinesterase in complex with N-[(2R)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-3,3-diphenylpropanamide human-BCHE 7QBQ (f )Human butyrylcholinesterase in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide human-BCHE 7QBR (f )Human butyrylcholinesterase in complex with (Z)-N-tert-butyl-1-(8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinolin-2-yl)methanimine oxide human-BCHE 7QHD (f )Human Butyrylcholinesterase in complex with (S)-1-(4-((2-(1H-indol-3-yl)ethyl)carbamoyl)benzyl)-N-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperidine-3-carboxamide, compound 39 human-BCHE 7QHE (f )Human Butyrylcholinesterase in complex with (S)-1-(4-((naphthalen-1-yl)carbamoyl)benzyl)-N-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperidine-3-carboxamide, compound 43 human-BCHE 7ZPB (f )Structure of hemiacetylated human butyrylcholinesterase upon reaction with 8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinoline-2-carbaldehyde human-BCHE 8AI7 (f )Human butyrylcholinesterase in complex with Cpd-6-8AI7 human-BCHE 8AM1 (f )Human butyrylcholinesterase in complex with zinc and N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium human-BCHE 8AM2 (f )Human butyrylcholinesterase in complex with 2,2'-(((1E,1'E)-(2-phenylpyrimidine-4,6-diyl)bis(methaneylylidene))bis(hydrazin-1-yl-2-ylidene))bis(N,N,N-trimethyl-2-oxoethan-1-aminium) human-BCHE 8CGO (f )Human butyrylcholinesterase in complex with compound 87 human-BCHE
Genes Proteins in BCHE family
(91) Fragments of genes in BCHE family
(193)
Fragment Names Species 9ceta-s9wtz7 Camelus ferus (Wild Bactrian camel) Cholinesterase Camelus ferus 9euth-a0a1j0n2y6 Scapanulus oweni (Gansu mole), Carboxylic ester hydrolase Scapanulus oweni 9euth-a0a1j0n312 Uropsilus sp. (Chinese shrew mole), Carboxylic ester hydrolase Uropsilus sp. 9euth-g3m626 Rhynchocyon petersi (black and rufous elephant shrew) Butyrylcholinesterase Rhynchocyon petersi 9euth-g3m657 Manis tricuspis (Tree pangolin) Butyrylcholinesterase Manis tricuspis 9euth-v6bq01 Euroscaptor parvidens (small-toothed mole). Butyrylcholinesterase Euroscaptor parvidens 9euth-v6bq07 Scaptochirus moschatus (short-faced mole). Butyrylcholinesterase Scaptochirus moschatus 9euth-v6bq45 Euroscaptor longirostris (long-nosed mole). Butyrylcholinesterase Euroscaptor longirostris 9euth-v6bq73 Parascaptor leucura (white-tailed mole). Butyrylcholinesterase Parascaptor leucura 9euth-v6bqa4 Euroscaptor longirostris (long-nosed mole). Butyrylcholinesterase Euroscaptor longirostris 9euth-v6bqa6 Parascaptor leucura (white-tailed mole). Butyrylcholinesterase Parascaptor leucura 9euth-v6bqd9 Euroscaptor longirostris (long-nosed mole). Butyrylcholinesterase Euroscaptor longirostris 9hyst-g3m687 Dasyprocta punctata (punctate agouti) Butyrylcholinesterase Dasyprocta punctata 9hyst-g3m688 Dinomys branickii (pacarana) Butyrylcholinesterase Dinomys branickii 9hyst-g3m697 Petromus typicus (dassie-rat) Butyrylcholinesterase Petromus typicus 9hyst-g3m699 Laonastes aenigmamus (Laotian rock rat) Butyrylcholinesterase Laonastes aenigmamus 9mamm-l7x890 Tachyglossus aculeatus (Australian echidna) BCHE Tachyglossus aculeatus 9saur-a0a2d4m6w2 Micrurus spixii (Amazon coral snake) Uncharacterized protein Micrurus spixii 9saur-g3ekj4 Podocnemis unifilis Butyrylcholinesterase Podocnemis unifilis 9saur-g3ekj7 Dibamus bourreti Butyrylcholinesterase Dibamus bourreti 9saur-g3ekk2 Hemidactylus bowringii Butyrylcholinesterase Hemidactylus bowringii 9tele-a0a0s7i9k3 Poeciliopsis prolifica (blackstripe livebearer). CHLE Poeciliopsis prolifica 9tele-a0a0s7ia58 Poeciliopsis prolifica (blackstripe livebearer). ACES Poeciliopsis prolifica 9tele-a0a0s7mad7 Poeciliopsis prolifica (blackstripe livebearer). Carboxylic ester hydrolase Poeciliopsis prolifica 9tele-a0a1a8ezw9 Nothobranchius korthausae. Butyrylcholinesterase Nothobranchius korthausae abrbe-g3m679 Abrocoma bennettii (Bennett's chinchilla rat) Butyrylcholinesterase Abrocoma bennettii acrpy-g3m613 Acrobates pygmaeus (Feathertail glider) Butyrylcholinesterase Acrobates pygmaeus aepru-g3m618 Aepyprymnus rufescens (Rufous rat-kangaroo) (Rufous bettong) Butyrylcholinesterase Aepyprymnus rufescens agota-g3m680 Agouti taczanowskii (Mountain paca) Butyrylcholinesterase Agouti taczanowskii ailfu-g3m644 Ailurus fulgens (Lesser panda) (Red panda) Butyrylcholinesterase Ailurus fulgens allsi-g3ekk3 Alligator sinensis (Chinese alligator) Butyrylcholinesterase Alligator sinensis ambho-g3m624 Amblysomus hottentotus (Hottentot golden mole) Butyrylcholinesterase Amblysomus hottentotus anapl-g3ekj5 Anas platyrhynchos (Domestic duck) (Anas boschas) Butyrylcholinesterase Anas platyrhynchos antam-g5cwf2 Antilocapra americana (Pronghorn) Butyrylcholinesterase Antilocapra americana arcfo-g3m651 Arctocephalus forsteri (New Zealand fur seal) Butyrylcholinesterase Arctocephalus forsteri artja-g3m663 Artibeus jamaicensis (Jamaican fruit-eating bat) Butyrylcholinesterase Artibeus jamaicensis balac-f2vr67 Balaenoptera acutorostrata (Common minke whale) (Balaena rostrata) Butyrylcholinesterase Balaenoptera acutorostrata balom-f2y4e0 Balaenoptera omurai (Omura's baleen whale) Butyrylcholinesterase Balaenoptera omurai bratr-g3m632 Bradypus tridactylus (Pale-throated three-toed sloth) Butyrylcholinesterase Bradypus tridactylus caefu-g3m609 Caenolestes fuliginosus (Shrew opossum) Butyrylcholinesterase Caenolestes fuliginosus calpd-g3m605 Caluromys philander (Bare-tailed woolly opossum) Butyrylcholinesterase Caluromys philander calsu-a0a226n3z5 Callipepla squamata (Scaled quail), Carboxylic ester hydrolase Callipepla squamata camba-f2vr70 Camelus bactrianus (Bactrian camel) Butyrylcholinesterase Camelus bactrianus capmr-g5cwe1 Caperea marginata (Pigmy right whale) (Balaena marginata) Butyrylcholinesterase Caperea marginata cappi-g3m682 Capromys pilorides (Desmarest's hutia) (Isodon pilorides) Butyrylcholinesterase Capromys pilorides carin-g3ekj9 Carettochelys insculpta (Pitted-shelled turtle) Butyrylcholinesterase Carettochelys insculpta cebal-g3m675 Cebus albifrons (White-fronted capuchin) Butyrylcholinesterase Cebus albifrons cerni-g3m636 Cervus nippon (Sika deer) Butyrylcholinesterase Cervus nippon cernu-g3m614 Cercartetus nanus (Eastern pygmy possum) Butyrylcholinesterase Cercartetus nanus cersi-f2vr71 Ceratotherium simum (White rhinoceros) (Square-lipped rhinoceros) Butyrylcholinesterase Ceratotherium simum cersi-g3m673 Ceratotherium simum (White rhinoceros) (Square-lipped rhinoceros) Butyrylcholinesterase Ceratotherium simum chemy-m7bvm4 Chelonia mydas (Green sea-turtle) (Chelonia agassizi) Cholinesterase Chelonia mydas chila-g3m684 Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Butyrylcholinesterase Chinchilla lanigera chras-g3m625 Chrysochloris asiatica (Cape golden mole) Butyrylcholinesterase Chrysochloris asiatica colvi-a0a226pr16 Colinus virginianus (Northern bobwhite) (Tetrao virginianus), Carboxylic ester hydrolase Colinus virginianus concr-a0a1j0n329 Condylura cristata (Star-nosed mole), Carboxylic ester hydrolase Condylura cristata craca-g3m692 Cratogeomys castanops (Yellow-faced pocket gopher) (Pappogeomys castanops) Butyrylcholinesterase Cratogeomys castanops crocr-g3m647 Crocuta crocuta (Spotted hyena) Butyrylcholinesterase Crocuta crocuta crosi-g3ekj8 Crocodylus siamensis (Siamese crocodile) Butyrylcholinesterase Crocodylus siamensis ctebo-g3m686 Ctenomys boliviensis (Bolivian tuco-tuco) Butyrylcholinesterase Ctenomys boliviensis ctegu-g3m685 Ctenodactylus gundi (Northern gundi) Butyrylcholinesterase Ctenodactylus gundi cycdi-g3m634 Cyclopes didactylus (Silky anteater) Butyrylcholinesterase Cyclopes didactylus dasal-g3m622 Dasyurus albopunctatus (Native cat) (New Guinean quoll) Butyrylcholinesterase Dasyurus albopunctatus dauma-g3m676 Daubentonia madagascariensis (Aye-aye) (Sciurus madagascariensis) Butyrylcholinesterase Daubentonia madagascariensis delca-f2y4d4 Delphinus capensis (Long-beaked common dolphin) Butyrylcholinesterase Delphinus capensis delle-g5cwe6 Delphinapterus leucas (Beluga whale) Butyrylcholinesterase Delphinapterus leucas didma-g3m604 Didelphis marsupialis virginiana (North American opossum) Butyrylcholinesterase Didelphis marsupialis virginiana droau-g3m607 Dromiciops australis (Monito del Monte) (Dromiciops gliroides) Butyrylcholinesterase Dromiciops australis dugdu-a0a0h4apx4 Dugong dugon (Dugong) (Trichechus dugon). Carboxylic ester hydrolase Dugong dugon dugdu-g3m629 Dugong dugon (Dugong) (Trichechus dugon) Butyrylcholinesterase Dugong dugon echka-g3m612 Echymipera kalubu (Kalubu echymipera) Butyrylcholinesterase Echymipera kalubu elada-f2y4e3 Elaphurus davidianus (Pere David's deer) Butyrylcholinesterase Elaphurus davidianus elema-g3m631 Elephas maximus (Indian elephant) Butyrylcholinesterase Elephas maximus eleru-l7x458 Elephantulus rufescens (East African long-eared elephant shrew) BCHE Elephantulus rufescens eredo-g3m691 Erethizon dorsatum (North American porcupine) Butyrylcholinesterase Erethizon dorsatum erico-g3m669 Erinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus) Butyrylcholinesterase Erinaceus concolor escgi-g5cwe3 Eschrichtius gibbosus (California gray whale) (Eschrichtius robustus) Butyrylcholinesterase Eschrichtius gibbosus eubas-g5cwe2 Eubalaena australis (Southern right whale) Butyrylcholinesterase Eubalaena australis eurmi-v6bq70 Euroscaptor mizura (Japanese mountain mole). Butyrylcholinesterase Euroscaptor mizura fosfo-g3m645 Fossa fossana (Malagasy civet) (Viverra fossa) Butyrylcholinesterase Fossa fossana funhe-a0a146mld5 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus funhe-a0a146uvp6 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus funhe-a0a146zig2 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus galpy-a0a1j0n2y7 Galemys pyrenaicus (Iberian desman) (Pyrenean desman), Carboxylic ester hydrolase Galemys pyrenaicus genge-g3m655 Genetta genetta (Small-spotted genet) Butyrylcholinesterase Genetta genetta glive-g3m606 Glironia venusta (Bushy-tailed opossum) Butyrylcholinesterase Glironia venusta gragr-f2y4d5 Grampus griseus (Risso's dolphin) (Delphinus griseus) Butyrylcholinesterase Grampus griseus gramu-g3m695 Graphiurus murinus (African pygmy dormouse) (African woodland dormouse) Butyrylcholinesterase Graphiurus murinus hetbr-g3m628 Heterohyrax brucei (Yellow-spotted hyrax) (Rock hyrax) Butyrylcholinesterase Heterohyrax brucei hipam-f2vr68 Hippopotamus amphibius (Hippopotamus) Butyrylcholinesterase Hippopotamus amphibius hipam-g3m638 Hippopotamus amphibius (Hippopotamus) Butyrylcholinesterase Hippopotamus amphibius hipco-g3m658 Hipposideros commersoni (Commerson's leaf-nosed bat) (Commerson's roundleaf bat) Butyrylcholinesterase Hipposideros commersoni hopgy-g3m690 Hoplomys gymnurus (Armored rat) (Echimys gymnurus) Butyrylcholinesterase Hoplomys gymnurus hydgi-a0a0h4avd5 Hydrodamalis gigas (Steller's sea cow). Carboxylic ester hydrolase Hydrodamalis gigas hydhy-g3m693 Hydrochoerus hydrochaeris (Capybara) (Carpincho) Butyrylcholinesterase Hydrochoerus hydrochaeris hypms-g3m619 Hypsiprymnodon moschatus (Musky rat kangaroo) Butyrylcholinesterase Hypsiprymnodon moschatus hysbr-g3m694 Hystrix brachyura (Malayan porcupine) Butyrylcholinesterase Hystrix brachyura inige-g5cwe5 Inia geoffrensis (Amazon dolphin) Butyrylcholinesterase Inia geoffrensis isoma-g3m611 Isoodon macrourus (Short-nosed bandicoot) (Northern brown bandicoot) Butyrylcholinesterase Isoodon macrourus ixori-a0a0k8rmw6 Ixodes ricinus (Common tick) Uncharacterized protein Ixodes ricinus jacja-g3m689 Jaculus jaculus (Lesser Egyptian jerboa) Butyrylcholinesterase Jaculus jaculus kogbr-g5cwe8 Kogia breviceps (Pygmy sperm whale) (Physeter breviceps) Butyrylcholinesterase Kogia breviceps kogsi-f2y4e1 Kogia sima (Dwarf sperm whale) (Physeter simus) Butyrylcholinesterase Kogia sima lamgl-g3m635 Lama glama (Llama) Butyrylcholinesterase Lama glama lipve-f2y4d3 Lipotes vexillifer (Yangtze river dolphin) Butyrylcholinesterase Lipotes vexillifer litct-a0a2g9rgc6 Aquarana Lithobates catesbeiana (American bullfrog) (Rana catesbeiana), Carboxylic ester hydrolase ; EC=3.1.1.- Rana catesbeiana manle-BCHE Mandrillus leucophaeus (Drill) (Papio leucophaeus) Butyrylcholinesterase Mandrillus leucophaeus manpe-f2vr72 Manis pentadactyla (Chinese pangolin) Butyrylcholinesterase Manis pentadactyla manpe-g3m656 Manis pentadactyla (Chinese pangolin) Butyrylcholinesterase Manis pentadactyla megly-g3m659 Megaderma lyra (Greater false vampire bat) Butyrylcholinesterase Megaderma lyra megno-g3m642 Megaptera novaeangliae (Humpback whale) (Balaena novaeangliae) Butyrylcholinesterase Megaptera novaeangliae melme-g3m649 Meles meles (Eurasian badger) Butyrylcholinesterase Meles meles mepme-g3m648 Mephitis mephitis (Striped skunk) Butyrylcholinesterase Mephitis mephitis mesbi-g5cwe4 Mesoplodon bidens (Sowerby's beaked whale) Butyrylcholinesterase Mesoplodon bidens micsu-a0a2d4pet5 Micrurus surinamensis (Surinam coral snake), Carboxylic ester hydrolase ; EC=3.1.1.- Micrurus surinamensis mogim-v6bq43 Mogera imaizumii (Lesser Japanese mole). Butyrylcholinesterase Mogera imaizumii mogin-v6bq71 Mogera insularis (Formosan blind mole). Butyrylcholinesterase Mogera insularis mogwo-v6bq47 Mogera wogura (Japanese mole) (Mogera kobeae). Butyrylcholinesterase Mogera wogura mogwo-v6bqe0 Mogera wogura (Japanese mole) (Mogera kobeae). Butyrylcholinesterase Mogera wogura mosmo-g3m639 Moschus moschiferus (Siberian musk deer) (Moschus sibiricus) Butyrylcholinesterase Moschus moschiferus myoco-g3m683 Myocastor coypus (Coypu) (Nutria) Butyrylcholinesterase Myocastor coypus myrfa-g3m623 Myrmecobius fasciatus (Numbat) Butyrylcholinesterase Myrmecobius fasciatus myrtr-g3m633 Myrmecophaga tridactyla (Giant anteater) Butyrylcholinesterase Myrmecophaga tridactyla najat-g3ekk1 Naja atra (Chinese cobra) Butyrylcholinesterase Naja atra nanbi-g3m650 Nandinia binotata (African palm civet) Butyrylcholinesterase Nandinia binotata natst-g3m662 Natalus stramineus (Mexican funnel-eared bat) Butyrylcholinesterase Natalus stramineus neoph-f2y4d2 Neophocaena phocaenoides (Finless porpoise) (Delphinus phocaenoides) Butyrylcholinesterase Neophocaena phocaenoides neugi-a0a1j0n2x2 Neurotrichus gibbsii (American shrew mole), Carboxylic ester hydrolase ; EC=3.1.1.- Neurotrichus gibbsii notfu-a0a1a7z9q6 Nothobranchius furzeri (Turquoise killifish). Carboxylic ester hydrolase Nothobranchius furzeri notty-g3m608 Notoryctes typhlops (Southern marsupial mole) (Psammoryctes typhlops) Butyrylcholinesterase Notoryctes typhlops nycal-g3m665 Nyctimene albiventer (Common tube-nosed fruit bat) Butyrylcholinesterase Nyctimene albiventer nycco-g3m678 Nycticebus coucang (Slow loris) Butyrylcholinesterase Nycticebus coucang ochhy-g3m668 Ochotona hyperborea (Northern pika) Butyrylcholinesterase Ochotona hyperborea octgl-g3m696 Octodontomys gliroides (Mountain degu) Butyrylcholinesterase Octodontomys gliroides okajo-g3m637 Okapia johnstoni (Okapi) Butyrylcholinesterase Okapia johnstoni ophha-v8npz5 Ophiophagus hannah (King cobra) (Naja hannah); Micrurus corallinus (Brazilian coral snake). Cholinesterase Ophiophagus hannah oryaf-g3m627 Orycteropus afer (Aardvark) Butyrylcholinesterase Orycteropus afer ovook-u3t7b6 Ovophis okinavensis (Ryukyu Island pit viper) (Trimeresurus okinavensis) Acetylcholinesterase Ovophis okinavensis ovook-u3tdh9 Ovophis okinavensis (Ryukyu Island pit viper) (Trimeresurus okinavensis) Acetylcholinesterase Ovophis okinavensis parbe-a0a1j0n318 Parascalops breweri (Hairy-tailed mole), Carboxylic ester hydrolase Parascalops breweri pelni-g3ekj3 Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata) Butyrylcholinesterase Pelophylax nigromaculatus petbr-g3m615 Petaurus breviceps (Australian sugar glider) Butyrylcholinesterase Petaurus breviceps phaci-g3m617 Phascolarctos cinereus (Koala) Butyrylcholinesterase Phascolarctos cinereus phoph-g5cwe7 Phocoenoides phocoena (Harbor porpoise) Butyrylcholinesterase Phocoenoides phocoena phovi-g3m652 Phoca vitulina (Harbor seal) Butyrylcholinesterase Phoca vitulina phymc-g5cwe9 Physeter macrocephalus (Sperm whale) (Physeter catodon) Butyrylcholinesterase Physeter macrocephalus plagn-f2y4e2 Platanista gangetica (Ganges river dolphin) (Platanista gangetica subsp. gangetica) Butyrylcholinesterase Platanista gangetica plamn-g5cwf0 Platanista minor (Indus river dolphin) (Platanista gangetica subsp Butyrylcholinesterase Platanista minor ponbl-g5cwf1 Pontoporia blainvillei (Franciscana) (Delphinus blainvillei) Butyrylcholinesterase Pontoporia blainvillei prili-g3m643 Prionodon linsang (Banded linsang) (Tiger-civet) Butyrylcholinesterase Prionodon linsang proca-l7x976 Procavia capensis (Cape hyrax) (Rock dassie) BCHE Procavia capensis prolo-g3m653 Procyon lotor (Raccoon) Butyrylcholinesterase Procyon lotor prove-g3m677 Propithecus verreauxi (White sifaka) (Verreaux's sifaka) Butyrylcholinesterase Propithecus verreauxi psecu-g3m620 Pseudochirops cupreus (Coppery ringtail) Butyrylcholinesterase Pseudochirops cupreus ptegi-g3m664 Pteropus giganteus (Indian flying fox) Butyrylcholinesterase Pteropus giganteus ptepa-g3m661 Pteronotus parnellii (Parnell's mustached bat) Butyrylcholinesterase Pteronotus parnellii pytrg-a0a098ly81 Python regius (Ball python) (Boa regia). Carboxylic ester hydrolase Python regius ransi-g3ekk0 Ranodon sibiricus (Siberian salamander) Butyrylcholinesterase Ranodon sibiricus rhicr-g3m666 Rhinolophus creaghi (Creagh's horseshoe bat) Butyrylcholinesterase Rhinolophus creaghi rhyra-g3m610 Rhyncholestes raphanurus (Chilean shrew opossum) Butyrylcholinesterase Rhyncholestes raphanurus scafu-a0a1j0n326 Scaptonyx fusicaudus (Long-tailed mole), Carboxylic ester hydrolase Scaptonyx fusicaudus scato-a0a1j0n2y2 Scapanus townsendii (Townsend's mole, Coast mole, Eastern mole, Scapanus anthonyi), Carboxylic ester hydrolase Scapanus townsendii solpa-g3m670 Solenodon paradoxus (Hispaniolan solenodon) Butyrylcholinesterase Solenodon paradoxus sorar-g3m671 Sorex araneus (Eurasian common shrew) (European shrew) Butyrylcholinesterase Sorex araneus souch-f2y4d9 Sousa chinensis (Indo-pacific humpbacked dolphin) (Steno chinensis) Butyrylcholinesterase Sousa chinensis steat-f2y4d6 Stenella attenuata (Pantropical spotted dolphin) (Steno attenuatus) Butyrylcholinesterase Stenella attenuata steco-f2y4d8 Stenella coeruleoalba (Striped dolphin) (Delphinus coeruleoalbus) Butyrylcholinesterase Stenella coeruleoalba strca-g3ekj2 Struthio camelus (Ostrich) Butyrylcholinesterase Struthio camelus sursu-g3m646 Suricata suricatta (Meerkat) Butyrylcholinesterase Suricata suricatta tadbr-g3m660 Tadarida brasiliensis (Brazilian free-tailed bat) Butyrylcholinesterase Tadarida brasiliensis talal-g3m672 Talpa altaica (Siberian mole) Butyrylcholinesterase Talpa altaica talal-v6bqa7 Talpa altaica (Siberian mole). Butyrylcholinesterase Talpa altaica taleu-v6bqe2 Talpa europaea (European mole). Butyrylcholinesterase Talpa europaea tapin-g3m674 Tapirus indicus (Asiatic tapir) (Malayan tapir) Butyrylcholinesterase Tapirus indicus tarro-g3m621 Tarsipes rostratus (Honey possum) Butyrylcholinesterase Tarsipes rostratus tayta-g3m640 Tayassu tajacu (Collared peccary) (Pecari tajacu) Butyrylcholinesterase Tayassu tajacu tetng-h3c766 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein Tetraodon nigroviridis tetng-q4svx3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis tetng-q4svx5 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis thrsw-g3m698 Thryonomys swinderianus (Greater cane rat) (African grasscutter) Butyrylcholinesterase Thryonomys swinderianus thytr-g3m667 Thyroptera tricolor (Spix's disk-winged bat) Butyrylcholinesterase Thyroptera tricolor trana-g3m641 Tragulus napu (Larger Malay chevrotain) (Greater mouse deer) Butyrylcholinesterase Tragulus napu trasc-g3ekj0 Trachemys scripta (Red-eared slider turtle) (Pseudemys scripta) Butyrylcholinesterase Trachemys scripta trima-g3m630 Trichechus manatus (Caribbean manatee) (West Indian manatee) Butyrylcholinesterase Trichechus manatus trivu-g3m616 Trichosurus vulpecula (Brush-tailed possum) Butyrylcholinesterase Trichosurus vulpecula tupch-l9kue3 Tupaia chinensis (Chinese tree shrew) Cholinesterase Tupaia chinensis turad-f2y4d7 Tursiops aduncus (Indo-pacific bottle-nosed dolphin) (Delphinus aduncus) Butyrylcholinesterase Tursiops aduncus typna-g3ekj6 Typhlonectes natans (Rubber eel) Butyrylcholinesterase Typhlonectes natans urota-a0a1j0n2z7 Urotrichus talpoides (Japanese shrew mole), Carboxylic ester hydrolase Urotrichus talpoides vomur-l7xbh5 Vombatus ursinus (Common wombat) BCHE Vombatus ursinus xenla-a0a1l8g4b7 Xenopus laevis (African clawed frog). Uncharacterized protein Xenopus laevis xenla-a0a1l8g407 Xenopus laevis (African clawed frog). Carboxylic ester hydrolase Xenopus laevis xipma-m4as84 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein Xiphophorus maculatus
Substrates of some enzymes in the BCHE family
(48)
Substrate Chemical_Nomenclature Protein 1-Naphtylacetate naphthalen-1-yl acetate burgl-EstC 1-Naphtylacetate naphthalen-1-yl acetate human-BCHE 1-Naphtylacetate naphthalen-1-yl acetate lacjo-q74hk5 1-Naphtylacetate naphthalen-1-yl acetate aspor-faec 1-Naphtylacetate naphthalen-1-yl acetate aspor-q2uf27 1-Naphtylacetate naphthalen-1-yl acetate pseae-PA3859 1-Naphtylacetate naphthalen-1-yl acetate aphgo-cxest 2,6-Dichlorophenolindophenyl-acetate [4-[(3,5-dichloro-4-oxocyclohexa-2,5-dien-1-ylidene)amino]phenyl] acetate human-ACHE 2,6-Dichlorophenolindophenyl-acetate [4-[(3,5-dichloro-4-oxocyclohexa-2,5-dien-1-ylidene)amino]phenyl] acetate human-BCHE 6-monoacetylmorphine (9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl) acetate Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium bunfa-ACHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium eleel-ACHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium chick-ACHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium human-ACHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium human-BCHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium mouse-ACHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium mouse-BCHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium ratno-ACHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium torca-ACHE Acetylcholine 2-(Acetyloxy)-N,N,N,-trimethylethanaminium torma-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium bunfa-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium eleel-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium chick-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium human-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium human-BCHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium mouse-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium mouse-BCHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium ratno-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium torca-ACHE Acetylthiocholine 2-acetylsulfanylethyl(trimethyl)azanium torma-ACHE AND-logic-probe-P2 human-BCHE Aspirin 2-acetyloxybenzoic acid human-BCHE ATMA (3-acetamidophenyl)-trimethylazanium Bambuterol [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate human-BCHE Benzoylcholine 2-benzoyloxyethyl(trimethyl)azanium human-BCHE Benzoylecgonine (1S,3S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid human-BCHE Benzoylecgonine (1S,3S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid rhosm-cocE Benzoylthiocholine 2-benzoylsulfanylethyl(trimethyl)azanium human-BCHE Butyrylcholine 2-butanoyloxyethyl(trimethyl)azanium human-BCHE Butyrylthiocholine 2-butanoylsulfanylethyl(trimethyl)azanium human-BCHE Butyrylthiocholine 2-butanoylsulfanylethyl(trimethyl)azanium mouse-BCHE Butyrylthiocholine 2-butanoylsulfanylethyl(trimethyl)azanium horse-BCHE Cocaine methyl (1S,3S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate human-BCHE Cocaine methyl (1S,3S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate human-CES1 CurDD 4,4'-((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene)diethyl disuccinate human-CES2 CurDD 4,4'-((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene)diethyl disuccinate human-CES1 CurDD 4,4'-((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene)diethyl disuccinate human-CMBL CurDD 4,4'-((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene)diethyl disuccinate human-BCHE Dipivefrin [2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate Heptanoylcholine 2-heptanoyloxyethyl(trimethyl)azanium Heroin [(4R,4aR,7S,7aR,12bS)-9-acetyloxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] acetate human-BCHE Heroin [(4R,4aR,7S,7aR,12bS)-9-acetyloxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] acetate human-CES1 Hexanoylcholine 2-hexanoyloxyethyl(trimethyl)azanium Idalopirdine-rivastigmine human-BCHE Indophenylacetate [4-[(4-oxocyclohexa-2,5-dien-1-ylidene)amino]phenyl] acetate Irinotecan 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) human-BCHE Irinotecan 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) human-CES1 Irinotecan 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) 9sphn-E93 Isobucaine [2-methyl-2-(2-methylpropylamino)propyl] benzoate human-BCHE Isosorbide-2-aspirinate-5-salicylate [(3S,3aR,6R,6aR)-6-(2-acetyloxybenzoyl)oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] 2-hydroxybenzoate human-BCHE Meperidine ethyl 1-methyl-4-phenylpiperidine-4-carboxylate human-BCHE Meperidine ethyl 1-methyl-4-phenylpiperidine-4-carboxylate human-CES1 Meprylcaine [2-methyl-2-(propylamino)propyl] benzoate human-BCHE Methyl-4-piperidinyl-N-benzoate (1-methylpiperidin-4-yl) benzoate human-BCHE Methyl-4-piperidinyl-N-butyrate (1-methylpiperidin-4-yl) butanoate human-BCHE Methylprednisolone-acetate [2-[(6S,10R,11S,13S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate human-BCHE Mivacurium bis[3-[(1S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] oct-4-enedioate dichloride human-BCHE Monocaprin 2,3-dihydroxypropyl decanoate pig-EST1 Monocaprin 2,3-dihydroxypropyl decanoate rhimi-lipas Monocaprin 2,3-dihydroxypropyl decanoate human-BCHE N-Methylindoxyl-acetate (1-methylindol-3-yl) acetate torca-ACHE N-Methylindoxyl-acetate (1-methylindol-3-yl) acetate human-BCHE O-Nitroacetanilide N-(2-nitrophenyl)acetamide human-ACHE O-Nitroacetanilide N-(2-nitrophenyl)acetamide human-BCHE O-Nitrophenylbutyrate (2-nitrophenyl) butanoate o-NTFNAC 2,2,2-Trifluoro-N-(2-nitrophenyl)acetamide human-ACHE o-NTFNAC 2,2,2-Trifluoro-N-(2-nitrophenyl)acetamide human-BCHE Octanoyl-ghrelin octanoyl ghrelin; [O-n-octanoyl-Ser3]-human ghrelin human-BCHE Octanoyl-ghrelin octanoyl ghrelin; [O-n-octanoyl-Ser3]-human ghrelin human-NOTUM Paranitrophenylacetate (4-nitrophenyl) acetate arath-AT5G62180 Paranitrophenylacetate (4-nitrophenyl) acetate 9psed-q0mrg5 Paranitrophenylacetate (4-nitrophenyl) acetate burgl-EstC Paranitrophenylacetate (4-nitrophenyl) acetate 9bace-b3cet1 Paranitrophenylacetate (4-nitrophenyl) acetate 9bace-b3c9d0.2 Paranitrophenylacetate (4-nitrophenyl) acetate emeni-faec Paranitrophenylacetate (4-nitrophenyl) acetate 9acto-h1qtl0 Paranitrophenylacetate (4-nitrophenyl) acetate strco-SCO2123 Paranitrophenylacetate (4-nitrophenyl) acetate human-NOTUM Paranitrophenylacetate (4-nitrophenyl) acetate pseae-PA3859 Paranitrophenylacetate (4-nitrophenyl) acetate pyrbr-Q9Y7G8 Paranitrophenylacetate (4-nitrophenyl) acetate 9baci-EstD9 Paranitrophenylacetate (4-nitrophenyl) acetate 9rhiz-g9i933 Paranitrophenylacetate (4-nitrophenyl) acetate malgo-a8puy1 Paranitrophenylacetate (4-nitrophenyl) acetate human-CIB Paranitrophenylacetate (4-nitrophenyl) acetate 9actn-EstGS1 Paraoxon diethyl (4-nitrophenyl) phosphate 9bact-KP212148 Pentanoylcholine trimethyl(2-pentanoyloxyethyl)azanium human-BCHE Procaine 4-Aminobenzoic acid 2-(diethylamino) ethyl ester hydrochloride human-BCHE Propionylcholine trimethyl(2-propanoyloxyethyl)azanium human-BCHE Propionylthiocholine trimethyl(2-propanoylsulfanylethyl)azanium human-BCHE Succinylcholine~Suxamethonium trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium human-BCHE Succinyldithiocholine trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethylsulfanyl]butanoyl]sulfanylethyl]azanium human-BCHE Tetracaine 4-(Butylamino)benzoicacid 2-(dimethylamino)ehtyl ester human-BCHE Vinyl-acetate ethenyl acetate 9psed-q0mrg5 Vinyl-acetate ethenyl acetate bovin-balip Vinyl-acetate ethenyl acetate rabit-1cxes [I125]Methyl-4-piperidinyl-N-benzoate (1-methylpiperidin-4-yl) 4-iodobenzoate human-BCHE
Inhibitors of some enzymes in the BCHE family
(283)
Inhibitor Chemical_Nomenclature Protein 1,9-dimethyl-methylene-blue [7-(dimethylamino)-1,9-dimethylphenothiazin-3-ylidene]-dimethylazanium human-BCHE 2-Chloroprocaine 4-amino-2-chlorobenzoic acid 2-diethylaminoethyl ester hydrochlorid human-BCHE 2-trimethylsilyl-ethyl-N-butylcarbamate 2-trimethylsilylethyl N-butylcarbamate 3,3-Dimethylbutyl-N-butylcarbamate 3,3-dimethylbutyl N-butylcarbamate 3,5-dihydroxybenzamido-huprine-hybrid-11 N-[9-[(7-chloro-15-methyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-yl)amino]nonyl]-3,5-dihydroxybenzamide human-BCHE 3,5-dihydroxybenzamido-huprine-hybrid-11 N-[9-[(7-chloro-15-methyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-yl)amino]nonyl]-3,5-dihydroxybenzamide human-ACHE 3-chloro-7-hydroxy-4-methylcoumarin 3-chloro-7-Hydroxy-4-methylcoumarin 3F9 N-[[(3R)-1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl]methyl]-N-(2-methoxyethyl)naphthalene-2-carboxamide human-BCHE 4,4'-bipyridine 4,4'-bipyridine dihydrochloride 5-hydroxy-tryptamine 3-(2-aminoethyl) indol-5-ol 5-pyrid-3-yl-1,3,4-oxadiazole-5e 2-(4-Chlorophenyl)-5-(5-Phenylpyridin)-3-yl-1,3,4-oxadiazole human-ACHE 5-pyrid-3-yl-1,3,4-oxadiazole-5e 2-(4-Chlorophenyl)-5-(5-Phenylpyridin)-3-yl-1,3,4-oxadiazole human-BCHE 5DYT-5hb N-[[(3R)-1-benzylpiperidin-3-yl]methyl]-N-methylnaphthalene-2-sulfonamide human-BCHE 5DYW-5hf N-{[(3S)-1-benzylpiperidin-3-yl]methyl}-N- (2-methoxyethyl)naphthalene-2-sulfonamide human-BCHE 5DYW-5hf-C11 N-[(1-benzylpiperidin-3-yl)methyl]-N-(2-methoxyethyl)naphthalene-2-sulfonamide human-BCHE 5DYW-5hf-F human-BCHE 5DYY-5hh N-[[(3R)-1-benzylpiperidin-3-yl]methyl]naphthalene-2-sulfonamide human-BCHE 5LKR-6yc N-(2-methoxyethyl)-N-[[(3S)-1-prop-2-ynylpiperidin-3-yl]methyl]naphthalene-2-carboxamide human-BCHE 5NN0-cpd3 (+/-)-N-((1-(2,3-Dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide human-BCHE 6F7Q-cpd11 4.5.4.(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-8-hydroxyquinoline-2-carboxamide human-BCHE 6H6-Heptyl-Carbamate 3-(2-(2-(phenylamino)benzamido)ethyl)-1H-indol-5-yl heptylcarbamate human-BCHE 6o-5-HT3 3-methyl-2-(4-methylpiperazin-1-yl)-N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]quinoline-4-carboxamide human-BCHE 6o-5-HT3 3-methyl-2-(4-methylpiperazin-1-yl)-N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]quinoline-4-carboxamide human-ACHE 6QAA-HUN butyl-[(2S)-1-(2-cycloheptylethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]azanium human-BCHE 6QAB-HUQ butyl-[(2S)-1-(2-cycloheptylethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-dimethylazanium human-BCHE 6QAC-HUT (2S)-2-(butylamino)-N-(3-cycloheptylpropyl)-3-(1H-indol-3-yl)propanamide human-BCHE 6QAD-HUZ (2S)-2-(butylamino)-N-[2-[4-(dimethylamino)cyclohexyl]ethyl]-3-(1H-indol-3-yl)propanamide human-BCHE 6QAE-HUK butyl-[(2S)-1-[2-cycloheptylethyl(methyl)azaniumyl]-3-(1H-indol-3-yl)propan-2-yl]-methylazanium human-BCHE 6RUA-3a N-(2-(2-(2-(N-((1-Benzylpiperidin-3-yl)methyl)naphthalene-2-sulfonamido)ethoxy)ethoxy)ethyl)-7-(diethylamino)-2-oxo-2H-chromene-3-carboxamide human-BCHE 6RUA-3a [(4aR,6R,8aR)-6-[(R)-[2-[2-[2-[[(3R)-1-benzylpiperidin-3-yl]methyl-naphthalen-2-ylsulfonylamino]ethoxy]ethoxy]ethylamino]-hydroxymethyl]-7-oxo-1,3,4,4a,5,6,8,8a-octahydronaphthalen-2-ylidene]-diethylazanium human-BCHE 6SAM-cpd13 1-(2,3-dihydro-1H-inden2-yl)piperidin-3-yl N-phenyl carbamate human-BCHE 6SAM-cpd13 [(3S)-1-(2,3-dihydro-1H-inden-2-yl)piperidin-1-ium-3-yl] N-phenylcarbamate human-BCHE 6XTA-cpd18 (2S)-N-(2-(1-Benzylazepan-4-yl)ethyl)-2-(butylamino)-3-(1H-indol-3-yl)propanamide human-BCHE 6XTA-cpd18 (2S)-N-[2-[(4R)-1-benzylazepan-4-yl]ethyl]-2-(butylamino)-3-(1H-indol-3-yl)propanamide human-BCHE 6ZWE-Cpd3 (6-((2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamido)hexyl)triphenylphosphonium bromide human-BCHE 6ZWE-Cpd3 (6-((2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamido)hexyl)triphenylphosphonium bromide human-ACHE 6ZWE-Cpd3 (2~{E},4~{E})-5-(1,3-benzodioxol-5-yl)-~{N}-[6-(triphenyl-$l^{5}-phosphanyl)hexyl]penta-2,4-dienamide human-BCHE 6ZWE-Cpd3 (2~{E},4~{E})-5-(1,3-benzodioxol-5-yl)-~{N}-[6-(triphenyl-$l^{5}-phosphanyl)hexyl]penta-2,4-dienamide human-ACHE 8AM1-5a trimethyl-[2-oxo-2-[2-(pyridin-2-ylmethylidene)hydrazinyl]ethyl]azanium 8IS-7Q1M N-[(2S)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-2,2-diphenylacetamide human-BCHE 8IV-7Q1N N-[(2R)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-2,2-diphenylacetamide human-BCHE 8U2-7AIX7AY-compound5i 2-{1-[4-(12-Amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}-N-[4-hydroxy-3-methoxybenzyl]acetamide torca-ACHE 8U2-7AIX7AY-compound5i 2-{1-[4-(12-Amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}-N-[4-hydroxy-3-methoxybenzyl]acetamide human-BCHE 8UW-7Q1P N-[(2R)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-3,3-diphenylpropanamide human-BCHE 9CI-7Q1O N-[(2S)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-3,3-diphenylpropanamide human-BCHE 11a-quinoxaline N-(3-aminoquinoxalin-2-yl)-4-(piperidin-1-ylmethyl)benzamide 17-desoxypancuronium [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-hydroxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate 18-E100 1-(7-(4-chlorophenoxy)heptyl)homopiperidine 18-E100 1-[7-(4-chlorophenoxy)heptyl]azepane 40V N-[[(3R)-1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl]methyl]-8-hydroxy-N-(2-methoxyethyl)-5-nitroquinoline-7-carboxamide human-BCHE 123I-PIP phenyl N-(4-iodophenyl)carbamate human-BCHE 8012-9656 2-[2-(4-amino-1,2,5-oxadiazol-3-yl)benzimidazol-1-yl]-N-(2-methylquinolin-6-yl)acetamide human-BCHE A87-7BO4 3-[2-[butyl(2-cycloheptylethyl)amino]ethyl]-1~{H}-indol-6-ol human-BCHE ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-hslip ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-MGLL ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Abhd11 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Ces1d ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-ES10 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-lypla2 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate drome-CG18815 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-lypla1 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Ces1c ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Ces1f ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Ces1g ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-PPME1 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-apeh ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-abhd5 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-lypl1 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Ces2c ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Ces2a ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-Ces2e ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-aryla ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-BCHE ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-dpp2 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-dpp4 ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-C87498 Aflatoxin-M1 (3R,7R)-3-hydroxy-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione AI0-7QBQ 1-(8-oxidanylquinolin-2-yl)-N-(phenylmethyl)methanimine oxide AI6-7QBR N-tert-butyl-1-[8-[3-(4-prop-2-ynylpiperazin-1-yl)propoxy]quinolin-2-yl]methanimine oxide alpha-Chaconine (2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[[(1S,2S,7S,10R,11S,14S,15R,16S,17R,20S,23S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-4-en-7-yl]oxy]-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol Amantadine-M30D-hybrid5e Ambenonium N,N'-bis(2-chlorobenzyldiethylammoniummethyl)oxamide dichloride Oxalbis(iminomethylene)bis(o-chlorobenzyl)diethylammonium chloride Amiloride 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide Amitriptyline 3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride Anilofos N-(4-chlorophenyl)-2-dimethoxyphosphinothioylsulfanyl-N-propan-2-ylacetamide Aprophen 2-diethylaminoethyl 2,2-diphenylpropanoate ; alpha-Methyl-alpha-phenylbenzeeacetic acid 2-(diethylamino)ethyl ester human-BCHE Aromatic-tertiary-amine-17c N-(2-methylphenyl)-2-[2-methylpropyl(naphthalen-2-ylmethyl)amino]acetamide human-BCHE Aroylacrylic-acid-amide-Tacrine-10 4-(3,4-Dimethylphenyl)-4-oxo-N-phenyl-2-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl-amino]-butanamide human-BCHE Aroylacrylic-acid-amide-Tacrine-10 4-(3,4-Dimethylphenyl)-4-oxo-N-phenyl-2-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl-amino]-butanamide torca-ACHE Ass-IN-10 1-[(3-tert-butylphenyl)methylamino]-3-(3,3-diphenylpropylamino)propan-2-ol human-BCHE Atracurium 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate Bambuterol [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate Bensulide N-[2-di(propan-2-yloxy)phosphinothioylsulfanylethyl]benzenesulfonamide Benzimidazole-phenyl-azetidine-carboxylate-11d 4-((5-(Diethylcarbamoyl)-1-isopentyl-1H-benzo[d]imidazol-2-yl)methyl)phenyl azetidine-1-carboxylate human-BCHE Berberine 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene BIGI-3h BIMP 2-[methyl-[methyl(propan-2-yloxy)phosphoryl]oxyphosphoryl]oxypropane Bis-Thiazolidinone-Based-20 2-((4-oxo-5-((E)-2,3,4-trihydroxybenzylidene)thiazolidin-2-ylidene)hydrazono)-5-((E)-3,4,5-trihydroxybenzylidene)thiazolidin-4-one Bisnorcymserine [(3aR,8bS)-8b-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(4-propan-2-ylphenyl)carbamate torca-ACHE BPMP 3-[[3,3-dimethylbutan-2-yloxy(methyl)phosphoryl]oxy-methylphosphoryl]oxy-2,2-dimethylbutane Bromophenyl-tacrine6i Ethyl 5-amino-4-(3-bromophenyl)-2-phenyl-6,7,8,9-tetrahydro-4H-pyrano [2,3-b]quinoline-3-carboxylate BYYT-25 5,6-dimethoxy-2-[4-(pyrrolidin-1-ylmethyl)phenoxy]-2,3-dihydroinden-1-one C0I-7QHD (3~{S})-1-[[4-[2-(1~{H}-indol-3-yl)ethylcarbamoyl]phenyl]methyl]-~{N}-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidine-3-carboxamide human-BCHE C4I-7QHE (3~{S})-1-[[4-(naphthalen-1-ylcarbamoyl)phenyl]methyl]-~{N}-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidine-3-carboxamide human-BCHE Caffeic-acid-phenethyl-ester 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate human-BCHE Caffeic-acid-phenethyl-ester 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate human-ACHE Canadine 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene Carbachol 2-carbamoyloxyethyl(trimethyl)azanium;chloride Carltonine-A Carltonine-B CB2R-BCHE-20a 2-(4-Ethoxybenzyl)-N,1-diisopentyl-1H-benzo[d]imidazole-5-carboxamide CB2R-BCHE-x CBD-carbamate-C16 6-Hydroxy-50-methyl-4-pentyl-2'-(prop-1-en-2-yl)-10,20,30,40-tetrahydro-[1,10-biphenyl]-2-yl (4-chlorobenzyl) (methyl)carbamate human-BCHE CBDP 2-(2-methylphenoxy)-4H-1,3,2$l^{5}-benzodioxaphosphinine 2-oxide human-BCHE CBDP 2-(2-methylphenoxy)-4H-1,3,2$l^{5}-benzodioxaphosphinine 2-oxide mouse-ACHE CD-Bzl (1-benzyl-5-ethenyl-1-azoniabicyclo[2.2.2]octan-2-yl)-quinolin-4-ylmethanol CHEMBL440526 [3-[[methyl-[3-(2-oxochromen-7-yl)oxypropyl]amino]methyl]phenyl] N-heptylcarbamate CHEMBL3104293 [5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] diethyl phosphate CHEMBL4079247 [(1R,3R)-3-(4-methoxyanilino)cyclohexyl] N,N-dimethylcarbamate human-BCHE CHEMBL4293015 N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(1-methylindol-3-yl)acetamide" CHEMBL4442990 [4-[(4-fluorophenyl)methylamino]phenyl]-[2-(4-methoxyphenyl)-1-benzofuran-3-yl]methanone CHEMBL4454960 (13-methyl-5,6,8,13a-tetrahydroisoquinolino[1,2-b]quinazolin-10-yl) N-(6-morpholin-4-ylhexyl)carbamate human-BCHE CHEMBL4454960-PET human-BCHE Chinese-VX 2-[butoxy(methyl)phosphoryl]sulfanyl-N,N-diethylethanamine human-BCHE Chlorotacrine-tryptophan-hybrid (2~{S})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide torca-ACHE Chlorotacrine-tryptophan-hybrid (2~{S})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide human-BCHE Chlorproethazine 3-(2-chlorophenothiazin-10-yl)-N,N-diethylpropan-1-amine Chlorpromazine 8-chlorpromazine, 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine Choline [2-hydroxyethyl]trimethylammonium mouse-ACHE Choline [2-hydroxyethyl]trimethylammonium human-BCHE Cinchonidine R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol Cinchonine (5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-quinolin-4-ylmethanol Cisatracurium 5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl Cocaine 2beta-carbomethoxy-3beta-benzoyloxytropane hydrochloride human-BCHE Compound87 N-{[2-(benzyloxy)-3-methoxyphenyl]methyl}-N-[3-(2-fluorophenyl)propyl]cyclobutanamine Contilisant N-Methyl-N-((1-methyl-5-(3-(piperidin-1-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine Coumarin-Pyridine-3f 1-(3-(4-(6-Nitro-2-oxo-2H-chromen-3-yl)phenoxy) propyl)pyridinium Bromide human-ACHE Coumarin-Pyridine-3f 1-(3-(4-(6-Nitro-2-oxo-2H-chromen-3-yl)phenoxy) propyl)pyridinium Bromide human-BCHE Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate N-[4-[[ethoxy-(4-methyl-2-oxochromen-7-yl)oxy-oxidophosphaniumyl]methyl]phenyl]-2,2,2-trifluoroacetamide Cpd-6-8AI7 3-(((2-Cycloheptylethyl)(methyl)amino)methyl)-1H-indol-7-yl dimethylcarbamate human-BCHE Cpd14-BChEin-5-HT6 Cpd17-Tacrine-5-HT6 N1-(2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)-N2-(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine Cpd20-Benzimidazol-Oxadiazol 2-[2-(4-amino-1,2,5-oxadiazol-3-yl)benzimidazol-1-yl]-N-(3-bromo-5-cyanophenyl)acetamide human-BCHE Cpd27-BChEin-5-HT6 2-[1-(Benzenesulfonyl)indol-4-yl]oxy-N-benzylethanamine Cpd35-Rivastigmine-5-HT6 3-(((2-((2-((1-(Phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)ethyl)amino)methyl)phenyl ethyl(methyl)carbamate Cpd54-BChEin-5-HT6 Tert-butyl 3-(((2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)methyl)piperidine-1-carboxylate Cpd70-BChEin-5-HT6 Croneton [2-(ethylsulfanylmethyl)phenyl] N-methylcarbamate Crotylsarin (E)-1-[fluoro(methyl)phosphoryl]oxybut-2-ene Crystal-Violet [4-[bis[4-(dimethylamino)phenyl]methylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium;chloride mouse-ACHE Cyclosarin [fluoro(methyl)phosphoryl]oxycyclohexane mouse-ACHE Cyclosarin [fluoro(methyl)phosphoryl]oxycyclohexane human-CTSA Cymserine [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(4-propan-2-ylphenyl)carbamate DEAP-Phenothiazine 10-(2-diethylaminopropionyl)phenothiazine hydrochloride Debromoflustramine-B 3-methyl-4,8b-bis(3-methylbut-2-enyl)-2,3a-dihydro-1H-pyrrolo[2,3-b]indole Decamethonium 1,10-bis(trimethylammonium)decane torca-ACHE Decamethonium 1,10-bis(trimethylammonium)decane mouse-ACHE Decamethonium 1,10-bis(trimethylammonium)decane human-BCHE Demecarium trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium Desoxypeganine 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline DFAH-12 (E)-N-[3-(1-benzylpiperidin-4-yl)propyl]-N-[2-(2-chloro-6-methylanilino)-2-oxoethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide DFP Diisopropylphosphorofluoridate arcfu-AF1763 DFP Diisopropylphosphorofluoridate human-DPP4 DFP Diisopropylphosphorofluoridate human-ACHE DFP Diisopropylphosphorofluoridate human-BCHE DFP Diisopropylphosphorofluoridate human-PLA2G7 DFP Diisopropylphosphorofluoridate bacce-BC3734 DFP Diisopropylphosphorofluoridate ecoli-IROE DFP Diisopropylphosphorofluoridate fusso-cutas DFP Diisopropylphosphorofluoridate human-FAP DFP Diisopropylphosphorofluoridate human-CTSA Di-tert-butyl-4-Amino-2,3-cycloheptaquinoline-8c 2,6-Di-tert-butyl-4-{[2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylamino)-ethylamino]-methyl}-phenol diBu-PFP dibutyl 1,1,1,3,3,3-hexafluoropropan-2-yl phosphate Dibucaine 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide Dibutyrate-pancuronium [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-butanoyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] butanoate diEt-PFP diethyl 1,1,1,3,3,3-hexafluoropropan-2-yl phosphate Diethylmesoxalate Diethyl 2-oxomalonate Diethyltabun [diethylamino(ethoxy)phosphoryl]formonitrile Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 2-(2,4-difluorophenyl)-5-(4-pyridin-2-ylpiperazin-1-yl)-1,3,4-oxadiazole human-ACHE Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 2-(2,4-difluorophenyl)-5-(4-pyridin-2-ylpiperazin-1-yl)-1,3,4-oxadiazole human-BCHE Dimethylhydroxycarbaphen 2-(diethylamino)ethyl 2-[4-(dimethylcarbamoyloxy)phenyl]-2-(4-hydroxyphenyl)propanoate human-BCHE Distigmine (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate DL0410 3-piperidin-1-yl-1-[4-[4-(3-piperidin-1-ylpropanoyl)phenyl]phenyl]propan-1-one human-BCHE DL0410 3-piperidin-1-yl-1-[4-[4-(3-piperidin-1-ylpropanoyl)phenyl]phenyl]propan-1-one human-ACHE Donepezil-8-Hydroxyquinoline-2b 7-((4-(2-methoxybenzyl)piperazin-1-yl)methyl)-8-hydroxyquinoline Donepezil-idebenone-cpd9 human-BCHE Doxacurium bis[3-[(1S)-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] butanedioate dichloride DPH6 4-(1-benzylpiperidin-4-yl)-2-[(8-hydroxyquinolin-5-yl)methyl-prop-2-ynylamino]butanenitrile Duador 17a-Azonia-D-honoandrostane, 17a,17a-dimethyl-3-(1-methylpyrrolidinio)-, dibromide E2030 [2-methoxy-5-[(E)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethenyl]pyridin-4-yl]methanamine EA-3148 2-[cyclopentyloxy(methyl)phosphoryl]sulfanyl-N,N-diethylethanamine Echothiophate 2-diethoxyphosphorylsulfanylethyl(trimethyl)azanium human-BCHE EDAMP N-[2-(ethoxy-methoxy-phosphoryl)sulfanylethyl]-N-propan-2-yl-propan-2-amine Edrophonium ethyl-(3-hydroxyphenyl)-dimethylazanium torca-ACHE Edrophonium ethyl-(3-hydroxyphenyl)-dimethylazanium human-ACHE Ethopropazine 10-(2-diethylaminopropyl)phenothiazine hydrochloride human-BCHE Evodiamine (1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one Fenoverine 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenothiazin-10-ylethanone Fluoride F- human-BCHE Gallamine~Flaxedil 2-[2,3-bis[2-(triethylazaniumyl)ethoxy]phenoxy]ethyl-triethylazanium;triiodide mouse-ACHE Geneserine [(4aS,9aS)-2,4a,9-trimethyl-4,9a-dihydro-3H-oxazino[6,5-b]indol-6-yl] N-methylcarbamate Goodyschle-A (Z)-5-(4'-hydroxy-3',5'-dimethoxybenzylidene)-2(5H)-furanone human-BCHE Gramine 1-(1H-indol-3-yl)-N,N-dimethylmethanamine H34 {1-[4-(12-Amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}methanol mouse-ACHE Hup-19 3-Chloro-6,8-[2-(2-aminoethyl)-1-propene-1,3-diyl]-5,6,7,8-tetrahydroacridine-9-amine human-BCHE i-Butylsarin 1-[fluoro(methyl)phosphoryl]oxy-2-methylpropane IA4-7BO3 ~{N}-(2-cycloheptylethyl)-2-(1~{H}-indol-3-yl)-~{N}-methyl-ethanamine human-BCHE IBMPF 2-butylmethylphosphonofluoridate Idalopirdine-rivastigmine human-BCHE Imipramine 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5propanamine Indol-thioxotetrahydropyrimidine-Cpd7 1-Amino-4-(4-bromophenyl)-6-(1H-indol-3-yl)-2-thioxohydropyrimidine-5(2H)-one Isatin-thiosemicarbazone-cpd13 1-benzyl-3-[(2-hydroxy-5-methoxy-1H-indol-3-yl)imino]thiourea Iso-OMPA N-[bis(propan-2-ylamino)phosphoryloxy-(propan-2-ylamino)phosphoryl]propan-2-amine iso-Pentylsarin 1-[fluoro(methyl)phosphoryl]oxy-3-methylbutane Isosorbide-2-benzylcarbamate-5-benzoate [(3R,3aR,6S,6aR)-6-(benzylcarbamoyloxy)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] benzoate human-BCHE Isosorbide-2-benzylcarbamate-5-benzyl-ether [(3R,3aR,6S,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] N-benzylcarbamate human-BCHE Isosorbide-2-benzylcarbamate-5-salicylate [(3R,3aR,6S,6aR)-6-(benzylcarbamoyloxy)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] 2-hydroxybenzoate human-BCHE JS0-7ZPB 8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinoline-2-carbaldehyde JU5 N-((1-((2-(7-(Diethylamino)-2-oxo-2H-chromen-3-yl)thiazol-4-yl)methyl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide human-BCHE JUB N-((1-Benzylpiperidin-3-yl)methyl)-N-(2-(4-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)piperazin-1-yl)ethyl)naphthalene-2-sulfonamide human-BCHE Ladostigil [(3R)-3-(prop-2-ynylamino)-2,3-dihydro-1H-inden-5-yl] N-ethyl-N-methylcarbamate Malachite-Green [4-[[4-(dimethylamino)phenyl]-phenylmethylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium;chloride human-BCHE Meperidine 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester human-BCHE Meperidine ethyl 1-methyl-4-phenylpiperidine-4-carboxylate human-BCHE Methiocarb (3,5-dimethyl-4-methylsulfanylphenyl) N-methylcarbamate Methylene-blue [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium torca-ACHE Methylene-blue-carboline-2 1-[3,7-bis(dimethylamino)phenothiazin-10-yl]-3-(2-ethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)propan-1-one Methylprednisolone (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one Methylprednisolone-acetate [2-[(6S,10R,11S,13S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate Metoclopramide 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide Mivacurium bis[3-[(1S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] oct-4-enedioate dichloride human-BCHE MSPI 1-Methyl-S-(3-methylthiophosphoryl)imidazolium MT-031 [3-[(1R)-1-[methyl(prop-2-ynyl)amino]ethyl]phenyl] N-ethyl-N-methylcarbamate human-ACHE MT-031 [3-[(1R)-1-[methyl(prop-2-ynyl)amino]ethyl]phenyl] N-ethyl-N-methylcarbamate human-BCHE MTDL-cpd36-diphenylacetamide N-((2S,3R)-4-((3-(tert-butyl)benzyl)amino)-3-hydroxy-1-phenylbutan-2-yl)-2,2-diphenylacetamide human-BCHE MTDL-cpd51-diphenylacetamide N-((2S,3R)-3-hydroxy-4-(neopentylamino)-1-phenylbutan-2-yl)-2,2-diphenylacetamide human-BCHE MTDL-cpd51-diphenylacetamide 2,2-dimethylpropyl-[(2~{R},3~{S})-3-(2,2-diphenylethanoylamino)-2-oxidanyl-4-phenyl-butyl]azanium human-BCHE Mylaxen 9H-fluoren-9-yl-[6-[9H-fluoren-9-yl(dimethyl)azaniumyl]hexyl]-dimethylazanium;dibromide N-10-Phenothiazine-1-Naphtyl-carbamate naphthalen-1-yl phenothiazine-10-carboxylate human-BCHE N-10-Phenothiazine-2-Pyrrlidinylethyl-carbamate 2-pyrrolidin-1-ylethyl phenothiazine-10-carboxylate N-10-Phenothiazine-3-(dimethylamino)phenyl-carbamate [3-(dimethylamino)phenyl] phenothiazine-10-carboxylate N-10-Phenothiazine-isopropyl-carbamate propan-2-yl phenothiazine-10-carboxylate human-ACHE n-Butylsarin 1-[fluoro(methyl)phosphoryl]oxybutane N-demethylhuperzinine (1R,9R,13R)-13-ethenyl-11-methyl-1-(methylamino)-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one human-BCHE N-demethylhuperzinine (1R,9R,13R)-13-ethenyl-11-methyl-1-(methylamino)-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one human-ACHE N-Methyl-7-dimethylcarbamoxyquinolinium N-Methyl-7-dimethylcarbamoxyquinolinium N-Methyl-7-hydroxyquinolinium 1-methylquinolin-1-ium-7-ol n-Pentylsarin 1-[fluoro(methyl)phosphoryl]oxypentane n-Propylsarin 1-[fluoro(methyl)phosphoryl]oxypropane neo-Pentylsarin 1-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylpropane Neostigmine~Prostigmine [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium Nicotine [-]-1-Methyl-2-[3-pyridyl]pyrrolidine human-NOTUM Nicotine 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine human-NOTUM NIK-247 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline monohydrochloride monohydrate NIK-247 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine Nitrophenyl-methyl-p-biotinamidophenylmethylphosphonate Nitrophenyl-methyl-p-biotinamidophenylmethylphosphonate NMDA-BCHE-C-2h Novichok-5~A-232 3-chloro-2-methylpropyl ((chlorofluoromethylene)amino)oxyphosphonofluoridate human-ACHE Novichok-5~A-232 (1E)-1-chloro-N-[1-chloropropan-2-yloxy(fluoro)phosphoryl]oxymethanimidoyl fluoride human-ACHE Novichok-7~A-234 3-chloro-2-methylbutyl((chlorofluoromethylene)amino)oxyphosphonofluoridate NP61 N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]-3-(1H-indol-3-yl)propanamide Omethoate O,O-dimethyl S-(2-methylamino)-2-oxoethyl phosphorothioate; OMPA N-[bis(dimethylamino)phosphoryloxy-(dimethylamino)phosphoryl]-N-methylmethanamine Oxamyl methyl (1Z)-2-(dimethylamino)-N-(methylcarbamoyloxy)-2-oxoethanimidothioate P-10358 [1-[(3-fluoropyridin-4-yl)amino]-3-methylindol-5-yl] N-methylcarbamate Pancuronium 1,1'-[(2beta,3alpha,5alpha16beta,17beta)-3, 17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methylpiperidinium] Paraoxon diethyl (4-nitrophenyl) phosphate human-PLA2G7 Paraoxon diethyl (4-nitrophenyl) phosphate human-PNLIPRP2 Paraoxon diethyl (4-nitrophenyl) phosphate humin-cut Paraoxon diethyl (4-nitrophenyl) phosphate human-ACHE Paraoxon diethyl (4-nitrophenyl) phosphate promi-c2lfd0 Paraoxon diethyl (4-nitrophenyl) phosphate yeast-yjg8 Paraoxon diethyl (4-nitrophenyl) phosphate bacpu-AXE Paraoxon diethyl (4-nitrophenyl) phosphate sulto-ST0071 Paraoxon diethyl (4-nitrophenyl) phosphate aspor-cutas Paraoxon diethyl (4-nitrophenyl) phosphate pig-1plip Paraoxon diethyl (4-nitrophenyl) phosphate fusso-cutas Paraoxon diethyl (4-nitrophenyl) phosphate lacrh-B2CZF3 Paraoxon diethyl (4-nitrophenyl) phosphate thema-TM0033 Paraoxon diethyl (4-nitrophenyl) phosphate colgl-cutas Paraoxon diethyl (4-nitrophenyl) phosphate psesp-Q9RBY1 Paraoxon diethyl (4-nitrophenyl) phosphate actde-CXE1 Paraoxon diethyl (4-nitrophenyl) phosphate myctu-a85c Paraoxon diethyl (4-nitrophenyl) phosphate thema-TM0077 Paraoxon diethyl (4-nitrophenyl) phosphate rhimi-lipas Paraoxon diethyl (4-nitrophenyl) phosphate bacpu-w8fke7 Paraoxon diethyl (4-nitrophenyl) phosphate 9bact-KP212148 Paraquat 1,1'-Dimethyl-4,4'-bipyridinium; N,N'-dimethyl-gamma,gamma'-dipyridylium Paraquat 1,1'Dimethyl-4,4'bipyridinium dichloride Parathion diethoxy-(4-nitrophenoxy)-sulfanylidene-$l^{5}-phosphane PE154 2-[4-[[7-(diethylamino)-4-hydroxy-2-oxochromen-3-yl]methylideneamino]phenyl]-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide human-ACHE PE154 2-[4-[[7-(diethylamino)-4-hydroxy-2-oxochromen-3-yl]methylideneamino]phenyl]-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide human-BCHE Peganine (R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro- PGN33 N-[2-[3-[(4-methoxyphenyl)methoxy]indazol-1-yl]ethyl]-N-propan-2-ylpropan-2-amine human-BCHE Phenmedipham [3-(methoxycarbonylamino)phenyl] N-(3-methylphenyl)carbamate Phenyl-saligenin-phosphate~PSP 9-phenoxy-8,10-dioxa-9Nk5-phosphabicyclo[4.4.0]deca-1,3,5-triene 9-oxide PhX N-[2-(ethoxy-oxido-phenylphosphaniumyl)sulfanylethyl]-N-propan-2-ylpropan-2-amine Physostigmine~Eserine 1'methylpyrrolidino (2':3':2:3) 1,3-dimethylindolin-%-yl N-methylcarbamate Pipecuronium [(2R,3R,5R,8R,9R,10S,13S,14R,16R,17S) -17-acetyloxy-2,16-bis(4,4-dimethyl-2,3,5,6-tetrahydropyrazin-1-yl) -10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17 -tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate PMSF Phenylmethylsulfonyl fluoride theet-q3ch51 PMSF Phenylmethylsulfonyl fluoride emeni-q5avy9 PMSF Phenylmethylsulfonyl fluoride human-ABHD10 PMSF Phenylmethylsulfonyl fluoride human-PREPL PMSF Phenylmethylsulfonyl fluoride myctu-Rv1430 PMSF Phenylmethylsulfonyl fluoride psefl-cxest PMSF Phenylmethylsulfonyl fluoride 9bact-E40 PMSF Phenylmethylsulfonyl fluoride thefu-q6a0i4 PMSF Phenylmethylsulfonyl fluoride ecoli-Aes PMSF Phenylmethylsulfonyl fluoride orysj-Q10QA5 PMSF Phenylmethylsulfonyl fluoride bac25-mglp PMSF Phenylmethylsulfonyl fluoride 9bact-Q0GMU2 PMSF Phenylmethylsulfonyl fluoride bacsu-FENB PMSF Phenylmethylsulfonyl fluoride psepu-clcd1 PMSF Phenylmethylsulfonyl fluoride thema-TM0077 PMSF Phenylmethylsulfonyl fluoride bacsu-yvfQ PMSF Phenylmethylsulfonyl fluoride ecoli-bioh PMSF Phenylmethylsulfonyl fluoride drome-CG9542 PMSF Phenylmethylsulfonyl fluoride human-FAP PMSF Phenylmethylsulfonyl fluoride tubmm-TmEst2 PMSF Phenylmethylsulfonyl fluoride human-NOTUM PMSF Phenylmethylsulfonyl fluoride cutac-e6dae5 PMSF Phenylmethylsulfonyl fluoride 9gamm-urc15994 PMSF Phenylmethylsulfonyl fluoride 9baci-EstD9 PrDChVP 2,2-dichloroethenyl dipropyl phosphate Procainamide 4-Amino-N-[2-(diethylamino) ethyl]benzamide monohydrochloride Procaine 4-Aminobenzoic acid 2-(diethylamino) ethyl ester hydrochloride Promazine 10-[3-(dimethylamino)propyl]phenothiazine Promethazine 10-[2-(dimethylamino)propyl]phenothiazine Propaphos (4-methylsulfanylphenyl) dipropyl phosphate Propargyl-Tacrine-15 human-BCHE Propargyl-Tacrine-15 human-ACHE Propetamphos propan-2-yl (E)-3-[ethylamino(methoxy)phosphinothioyl]oxybut-2-enoate Propidium 3,8-diamino-5[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide human-BCHE Propidium 3,8-diamino-5[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide mouse-ACHE Propoxur o Isopropoxyphenyl Methyl Carbamate; 2-(1-Methylethoxy)phenol methylcarbamate Psilocybin [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate Pyridostigmine 3-[[(Dimethylamino)-carbonyl]oxy]-1-methylpyridinium bromide human-ACHE Pyridostigmine 3-[[(Dimethylamino)-carbonyl]oxy]-1-methylpyridinium bromide human-BCHE Quinazolin-carbamate-2p (1,3-dimethyl-2-thiophen-2-yl-2,4-dihydroquinazolin-6-yl) N-heptylcarbamate Quinone-polyamine-NSAID-4 2-[2-(2,6-dichloroanilino)phenyl]-N-[3-[3-[[4-[3-[3-[[2-[2-(2,6-dichloroanilino)phenyl]acetyl]amino]propylamino]propylamino]-3,6-dioxocyclohexa-1,4-dien-1-yl]amino]propylamino]propyl]acetamide human-BCHE Ro-2-0683 [2-(dimethylcarbamoyloxy)-5-phenylphenyl]methyl-trimethylazanium;bromide Russian-VX S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate mouse-ACHE Russian-VX S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate human-BCHE S06-1011 2-[2-(4-amino-1,2,5-oxadiazol-3-yl)benzimidazol-1-yl]-N-quinolin-3-ylacetamide human-BCHE S11-1014 N-[[2-(diethylaminomethyl)phenyl]methyl]-3-[(4-fluorobenzoyl)amino]benzamide human-BCHE S17-1001 2-[furan-2-ylmethyl-[(2-nitrophenyl)methyl]amino]-N-phenylacetamide human-BCHE Salicylamide-8-Tacrine N-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl)salicylamide human-ACHE Salicylamide-8-Tacrine N-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl)salicylamide human-BCHE Salioxon 2-methoxy-4H-1,3,2$l^{5}-benzodioxaphosphinine 2-oxide Salithion 2-methoxy-2-sulfanylidene-4H-1,3,2$l^{5}-benzodioxaphosphinine Sarin 2-[fluoro(methyl)phosphoryl]oxypropane human-ACHE Sarin 2-[fluoro(methyl)phosphoryl]oxypropane human-BCHE Sarin 2-[fluoro(methyl)phosphoryl]oxypropane human-CTSA sec-Pentylsarin 1-[fluoro(methyl)phosphoryl]oxy-2-methylbutane Solanidine (1S,2S,7S,10R,11S,14S,15R,16S,17R,20S,23S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-4-en-7-ol Solanine beta-D-Glucopyranoside, (3beta)-solanid-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(6-deoxy-alpha-L-mannopyranosyl-(1-4)) Soman 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane torca-ACHE Soman 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane human-BCHE Soman 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane human-PLA2G7 Soman 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane human-CES1 Soman 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane human-CTSA ST052207 oxolan-2-ylmethyl 4-(9-ethylcarbazol-3-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate human-BCHE Succinylcholine~Suxamethonium 2,2'-[(1,4-Dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium]di-bromide 6101-15-1 or Chloride 71-27-2 or Iodide mouse-ACHE Tabun [dimethylamino(ethoxy)phosphoryl]formonitrile mouse-ACHE Tacrine-Melatonin-Feruloyl-5c Tacrine-methylanacardate-cpd5 Methyl 2-Methoxy-6-(8-((1,2,3,4-tetrahydroacridin-9-yl)amino)octyl)benzoate human-BCHE TADE N'-(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine Tebupirimfos O-Ethyl O-isopropyl O-[2-(2-methyl-2-propanyl)-5-pyrimidinyl] phosphorothioate Tetracaine 4-(Butylamino)benzoicacid 2-(dimethylamino)ehtyl ester Tetracyclic-carbamate-cp8 13-Methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[1,2-b]quinazolin-10-yl (7-[18F]fluoroheptyl)carbamate human-BCHE Tetraethylammonium N,N,N-Triethylethanaminium bromide or chloride or hydroxyde Tetraethylpyrophosphate diethoxyphosphoryl diethyl phosphate TFAH-tacrine-ferulic-acid-hybrid-10n (E)-3-(4-hydroxy-3-methoxyphenyl)-N-[8-[(7-methoxy-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-N-[2-(naphthalen-2-ylamino)-2-oxoethyl]prop-2-enamide Thalictricavine (1R,21S)-16,17-dimethoxy-21-methyl-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene Thioflavin-T 2-[4-(dimethylamino)phenyl]-3-methyl-1,3-benzothiazol-3-ium-6-ol human-BCHE Thioflavin-T 2-[4-(dimethylamino)phenyl]-3-methyl-1,3-benzothiazol-3-ium-6-ol torca-ACHE Tolserine [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(2-methylphenyl)carbamate Toluidine-Blue (7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium human-ACHE Toluidine-Blue (7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium human-BCHE Tosyl-L-lysine-chloromethyl-ketone N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide entcl-PRBA Tosyl-L-lysine-chloromethyl-ketone N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide human-BCHE Tosyl-L-lysine-chloromethyl-ketone N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide 9gamm-b3vi58 Tri-o-cresylphosphate tris(2-methylphenyl) phosphate Tribufos S,S,S-Tributyltrithiophosphate human-APEH Trichlorfon~Metrifonate (2,2,2-Trichloro-1-hydroxyethyl)-phosphonic acid dimethyl ester human-APEH Trifluoro-6-dimethyl-2-heptanone 2-Heptanone, 1,1,1-trifluoro-6,6-dimethyl- Triton-X-100 t-Octylphenoxypolyethoxyethanol ; 14-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]-3,6,9,12-tetraoxatetradecan-1-ol bactc-lipas Triton-X-100 t-Octylphenoxypolyethoxyethanol ; 14-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]-3,6,9,12-tetraoxatetradecan-1-ol tubmm-TmEst2 Triton-X-100 t-Octylphenoxypolyethoxyethanol ; 14-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]-3,6,9,12-tetraoxatetradecan-1-ol strhe-ShHTL7 Tyramine 4-(2-aminoethyl)phenol UW-MD-71 (7-(3-(piperidin-1-yl)propoxy)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline VE 2-[ethoxy(ethyl)phosphoryl]sulfanyl-N,N-diethylethanamine Vecuronium [(2R,3R,5R,8R,9R,10S,13S,14R,16R,17S)- 17-acetyloxy-10,13-dimethyl-16-(1-methyl-3,4,5,6-tetrahydro-2H-pyridin-1-yl)-2- (1-piperidyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro- 1H-cyclopenta[a]phenanthren-3-yl] acetate VG 2-diethoxyphosphorylsulfanyl-N,N-diethylethanamine VM 2-[ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethylethanamine VS N-[2-[ethoxy(ethyl)phosphoryl]sulfanylethyl]-N-propan-2-ylpropan-2-amine VX N-[2-[ethoxy(methyl)phosphoryl]sulfanylethyl]-N-propan-2-ylpropan-2-amine torca-ACHE VX N-[2-[ethoxy(methyl)phosphoryl]sulfanylethyl]-N-propan-2-ylpropan-2-amine human-ACHE VX N-[2-[ethoxy(methyl)phosphoryl]sulfanylethyl]-N-propan-2-ylpropan-2-amine mouse-ACHE VX N-[2-[ethoxy(methyl)phosphoryl]sulfanylethyl]-N-propan-2-ylpropan-2-amine human-BCHE VX-Biotin human-CTSA VX-Biotin human-ACHE VX-Biotin human-BCHE VXS ethyl methyl (4-nitrophenyl) phosphate human-ACHE Win4510 2-(diethylamino)ethyl 4-amino-2-hexoxybenzoate Win4510S 2-{[4-amino-2-(hexyloxy)benzoyl]sulfanyl}-N,N-diethylethanaminium chloride Win5303 2-(diethylamino)ethyl 4-amino-2-pentoxybenzoate ZINC20166201-cpd8 (4-benzylpiperazin-1-yl)-[2-(4-methoxyphenyl)quinolin-4-yl]methanone human-BCHE ZINC22029744 3-[(4-benzylpiperazin-1-yl)methyl]-5-phenyl-1,3,4-oxadiazole-2-thione ZINC59501712 4-(1,3-dioxoisoindol-2-yl)-N,N-diethylbenzenesulfonamide human-BCHE ZT-1 (5R,9R)-5-(r-chloro-2-hydroxy-3-methoxybenzylidene-amino)-11-ethlidene-7-methyl-1,2,5,6,9,10-hexahydro-5,9-methanocycloocta[b]pyridin-2-one
