Arylacetamide_deacetylase
Relationship
Comment
AADAC Arylacetamide deacetylase displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. NCEH1 KIAA1363 AADACL1 NCEH1 neutral cholesterol ester hydrolase 1.is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated . Sequence similarities between hormone-sensitive lipase and prokaryotic enzymes was dicovered by Langin and Holm and Hemila et al.Database
Interpro : IPR017157 Arylacetamide deacetylase , IPR013094 Alpha\/beta hydrolase fold-3
PIRSF : PIRSF037251 Arylacetamide_deacetylase
Pdoc : No Pdoc
Pfam : PF07859 Abhydrolase_3
Prints : No Print
EC Number : No EC Number
References (6)
| Title : Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer - Wang_2022_BMC.Cancer_22_635 |
| Author(s) : Wang Y , Fang T , Yin X , Zhang L , Zhang X , Zhang D , Zhang Y , Wang X , Wang H , Xue Y |
| Ref : BMC Cancer , 22 :635 , 2022 |
| Abstract : Wang_2022_BMC.Cancer_22_635 |
| ESTHER : Wang_2022_BMC.Cancer_22_635 |
| PubMedSearch : Wang_2022_BMC.Cancer_22_635 |
| PubMedID: 35681154 |
| Gene_locus related to this paper: human-AADAC |
| Title : Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans - Jiang_2017_Front.Pharmacol_8_846 |
| Author(s) : Jiang J , Chen X , Zhong D |
| Ref : Front Pharmacol , 8 :846 , 2017 |
| Abstract : Jiang_2017_Front.Pharmacol_8_846 |
| ESTHER : Jiang_2017_Front.Pharmacol_8_846 |
| PubMedSearch : Jiang_2017_Front.Pharmacol_8_846 |
| PubMedID: 29209217 |
| Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
| Ref : Eur J Pharm Sci , 78 :47 , 2015 |
| Abstract : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| ESTHER : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedID: 26164127 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification - Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| Author(s) : Nomura DK , Fujioka K , Issa RS , Ward AM , Cravatt BF , Casida JE |
| Ref : Toxicol Appl Pharmacol , 228 :42 , 2008 |
| Abstract : Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| ESTHER : Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| PubMedSearch : Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| PubMedID: 18164358 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Synthesis and function of hepatic very-low-density lipoprotein - Gibbons_2004_Biochem.Soc.Trans_32_59 |
| Author(s) : Gibbons GF , Wiggins D , Brown AM , Hebbachi AM |
| Ref : Biochemical Society Transactions , 32 :59 , 2004 |
| Abstract : Gibbons_2004_Biochem.Soc.Trans_32_59 |
| ESTHER : Gibbons_2004_Biochem.Soc.Trans_32_59 |
| PubMedSearch : Gibbons_2004_Biochem.Soc.Trans_32_59 |
| PubMedID: 14748713 |
| Title : Human liver arylacetamide deacetylase: Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone sensitive lipase - Probst_1994_J.Biol.Chem_269_21650 |
| Author(s) : Probst MR , Beer M , Beer D , Jenoe P , Meyer UA , Gasser R |
| Ref : Journal of Biological Chemistry , 34 :21650 , 1994 |
| Abstract : Probst_1994_J.Biol.Chem_269_21650 |
| ESTHER : Probst_1994_J.Biol.Chem_269_21650 |
| PubMedSearch : Probst_1994_J.Biol.Chem_269_21650 |
| PubMedID: 8063807 |
| Gene_locus related to this paper: human-AADAC |
No structure scheme yet for this family
Genes Proteins in Arylacetamide_deacetylase family (454)
Fragments of genes in Arylacetamide_deacetylase family (2)
No fragment of genesSubstrates in Arylacetamide_deacetylase family (21)
Inhibitors in Arylacetamide_deacetylase family (12)