Go to basket

Tree Display

AceDB Schema

XML Display


Family Report for: Arylacetamide_deacetylase


Block H
AADAC Arylacetamide deacetylase displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. NCEH1 KIAA1363 AADACL1 NCEH1 neutral cholesterol ester hydrolase highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated . Sequence similarities between hormone-sensitive lipase and prokaryotic enzymes was dicovered by Langin and Holm and Hemila et al.

IPR017157 (Arylacetamide deacetylase), IPR013094 (Alpha/beta hydrolase fold-3)
PF07859 (Abhydrolase_3)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

3 more
    Title: Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer
    Wang Y, Fang T, Yin X, Zhang L, Zhang X, Zhang D, Zhang Y, Wang X, Wang H, Xue Y
    Ref: BMC Cancer, 22:635, 2022 : PubMed


    Title: Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans
    Jiang J, Chen X, Zhong D
    Ref: Front Pharmacol, 8:846, 2017 : PubMed


    Title: Synthesis and function of hepatic very-low-density lipoprotein
    Gibbons GF, Wiggins D, Brown AM, Hebbachi AM
    Ref: Biochemical Society Transactions, 32:59, 2004 : PubMed


Other Papers

Structure scheme for Arylacetamide_deacetylase

No Structure yet in this family

Genes Proteins in Arylacetamide_deacetylase family (454)

Fragments of genes in Arylacetamide_deacetylase family (2)

Substrates of some enzymes in the Arylacetamide_deacetylase family (11)

Inhibitors of some enzymes in the Arylacetamide_deacetylase family (12)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

Acknowledgements and disclaimer