Interpro : IPR039097 Gastric triacylglycerol lipase , IPR025483 Lipase, eukaryotic Lipase_euk , IPR000734 Lipase , IPR006693 AB-hydrolase-associated lipase region
PIRSF : PIRSF000862 lipase, eukaryotic type
Pdoc : PDOC00110
Pfam : PF04083 Abhydro_lipase
Prints : PR00821
EC Number : 3.1.1.3
Title : Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis - Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
Author(s) : Duta-Mare M , Sachdev V , Leopold C , Kolb D , Vujic N , Korbelius M , Hofer DC , Xia W , Huber K , Auer M , Gottschalk B , Magnes C , Graier WF , Prokesch A , Radovic B , Bogner-Strauss JG , Kratky D |
Ref : Biochimica & Biophysica Acta , 1863 :467 , 2018 |
Abstract : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
ESTHER : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
PubMedSearch : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
PubMedID: 29374543 |
Gene_locus related to this paper: mouse-1llip |
Title : Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages - Schlager_2017_Oncotarget_8_40037 |
Author(s) : Schlager S , Vujic N , Korbelius M , Duta-Mare M , Dorow J , Leopold C , Rainer S , Wegscheider M , Reicher H , Ceglarek U , Sattler W , Radovic B , Kratky D |
Ref : Oncotarget , 8 :40037 , 2017 |
Abstract : Schlager_2017_Oncotarget_8_40037 |
ESTHER : Schlager_2017_Oncotarget_8_40037 |
PubMedSearch : Schlager_2017_Oncotarget_8_40037 |
PubMedID: 28402950 |
Gene_locus related to this paper: mouse-1llip |
Title : Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase-deficient mice - Zhao_2017_J.Biol.Chem_292_19198 |
Author(s) : Zhao T , Ding X , Yan C , Du H |
Ref : Journal of Biological Chemistry , 292 :19198 , 2017 |
Abstract : Zhao_2017_J.Biol.Chem_292_19198 |
ESTHER : Zhao_2017_J.Biol.Chem_292_19198 |
PubMedSearch : Zhao_2017_J.Biol.Chem_292_19198 |
PubMedID: 28924047 |
Gene_locus related to this paper: mouse-1llip |
Title : Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover - Grumet_2016_J.Biol.Chem_291_17977 |
Author(s) : Grumet L , Eichmann TO , Taschler U , Zierler KA , Leopold C , Moustafa T , Radovic B , Romauch M , Yan C , Du H , Haemmerle G , Zechner R , Fickert P , Kratky D , Zimmermann R , Lass A |
Ref : Journal of Biological Chemistry , 291 :17977 , 2016 |
Abstract : Grumet_2016_J.Biol.Chem_291_17977 |
ESTHER : Grumet_2016_J.Biol.Chem_291_17977 |
PubMedSearch : Grumet_2016_J.Biol.Chem_291_17977 |
PubMedID: 27354281 |
Gene_locus related to this paper: human-LIPA , mouse-1llip |
Title : Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-\/-) Mice - Du_2015_Am.J.Pathol_185_2379 |
Author(s) : Du H , Zhao T , Ding X , Yan C |
Ref : American Journal of Pathology , 185 :2379 , 2015 |
Abstract : Du_2015_Am.J.Pathol_185_2379 |
ESTHER : Du_2015_Am.J.Pathol_185_2379 |
PubMedSearch : Du_2015_Am.J.Pathol_185_2379 |
PubMedID: 26212911 |
Gene_locus related to this paper: mouse-1llip |
Title : Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease - Sun_2014_Mol.Genet.Metab_112_229 |
Author(s) : Sun Y , Xu YH , Du H , Quinn B , Liou B , Stanton L , Inskeep V , Ran H , Jakubowitz P , Grilliot N , Grabowski GA |
Ref : Mol Genet Metab , 112 :229 , 2014 |
Abstract : Sun_2014_Mol.Genet.Metab_112_229 |
ESTHER : Sun_2014_Mol.Genet.Metab_112_229 |
PubMedSearch : Sun_2014_Mol.Genet.Metab_112_229 |
PubMedID: 24837159 |
Gene_locus related to this paper: mouse-1llip |
Title : Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations - Ramirez_2011_J.Lipid.Res_52_688 |
Author(s) : Ramirez CM , Liu B , Aqul A , Taylor AM , Repa JJ , Turley SD , Dietschy JM |
Ref : J Lipid Res , 52 :688 , 2011 |
Abstract : Ramirez_2011_J.Lipid.Res_52_688 |
ESTHER : Ramirez_2011_J.Lipid.Res_52_688 |
PubMedSearch : Ramirez_2011_J.Lipid.Res_52_688 |
PubMedID: 21289032 |
Gene_locus related to this paper: mouse-1llip |
Title : A mutation in LIPN, encoding epidermal lipase N, causes a late-onset form of autosomal-recessive congenital ichthyosis - Israeli_2011_Am.J.Hum.Genet_88_482 |
Author(s) : Israeli S , Khamaysi Z , Fuchs-Telem D , Nousbeck J , Bergman R , Sarig O , Sprecher E |
Ref : American Journal of Human Genetics , 88 :482 , 2011 |
Abstract : Israeli_2011_Am.J.Hum.Genet_88_482 |
ESTHER : Israeli_2011_Am.J.Hum.Genet_88_482 |
PubMedSearch : Israeli_2011_Am.J.Hum.Genet_88_482 |
PubMedID: 21439540 |
Gene_locus related to this paper: human-LIPN |
Title : Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo) - Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
Author(s) : Holmes RS , Cox LA , Vandeberg JL |
Ref : Comparative Biochemistry & Physiology Part D Genomics Proteomics , 5 :217 , 2010 |
Abstract : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
ESTHER : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
PubMedSearch : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
PubMedID: 20598663 |
Gene_locus related to this paper: human-LIPF , human-LIPJ , human-LIPK , human-LIPM , human-LIPN , mouse-LIPK |
Title : Critical roles of lysosomal acid lipase in myelopoiesis - Qu_2010_Am.J.Pathol_176_2394 |
Author(s) : Qu P , Shelley WC , Yoder MC , Wu L , Du H , Yan C |
Ref : American Journal of Pathology , 176 :2394 , 2010 |
Abstract : Qu_2010_Am.J.Pathol_176_2394 |
ESTHER : Qu_2010_Am.J.Pathol_176_2394 |
PubMedSearch : Qu_2010_Am.J.Pathol_176_2394 |
PubMedID: 20348241 |
Gene_locus related to this paper: mouse-1llip |
Title : Critical roles of lysosomal acid lipase in T cell development and function - Qu_2009_Am.J.Pathol_174_944 |
Author(s) : Qu P , Du H , Wilkes DS , Yan C |
Ref : American Journal of Pathology , 174 :944 , 2009 |
Abstract : Qu_2009_Am.J.Pathol_174_944 |
ESTHER : Qu_2009_Am.J.Pathol_174_944 |
PubMedSearch : Qu_2009_Am.J.Pathol_174_944 |
PubMedID: 19179613 |
Gene_locus related to this paper: mouse-1llip |
Title : Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung - Li_2007_Int.J.Exp.Pathol_88_427 |
Author(s) : Li Y , Qin Y , Li H , Wu R , Yan C , Du H |
Ref : International Journal of Experimental Pathology , 88 :427 , 2007 |
Abstract : Li_2007_Int.J.Exp.Pathol_88_427 |
ESTHER : Li_2007_Int.J.Exp.Pathol_88_427 |
PubMedSearch : Li_2007_Int.J.Exp.Pathol_88_427 |
PubMedID: 18039279 |
Gene_locus related to this paper: mouse-1llip |
Title : Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice - Lian_2005_Am.J.Pathol_167_813 |
Author(s) : Lian X , Yan C , Qin Y , Knox L , Li T , Du H |
Ref : American Journal of Pathology , 167 :813 , 2005 |
Abstract : Lian_2005_Am.J.Pathol_167_813 |
ESTHER : Lian_2005_Am.J.Pathol_167_813 |
PubMedSearch : Lian_2005_Am.J.Pathol_167_813 |
PubMedID: 16127159 |
Gene_locus related to this paper: mouse-1llip |
Title : Identification and characterization of a triacylglycerol lipase in Arabidopsis homologous to mammalian acid lipases - El-Kouhen_2005_FEBS.Lett_579_6067 |
Author(s) : El-Kouhen K , Blangy S , Ortiz E , Gardies AM , Ferte N , Arondel V |
Ref : FEBS Letters , 579 :6067 , 2005 |
Abstract : El-Kouhen_2005_FEBS.Lett_579_6067 |
ESTHER : El-Kouhen_2005_FEBS.Lett_579_6067 |
PubMedSearch : El-Kouhen_2005_FEBS.Lett_579_6067 |
PubMedID: 16226259 |
Gene_locus related to this paper: arath-At2g15230 |
Title : Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung - Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
Author(s) : Lian X , Yan C , Yang L , Xu Y , Du H |
Ref : American Journal of Physiology Lung Cell Mol Physiol , 286 :L801 , 2004 |
Abstract : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
ESTHER : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
PubMedSearch : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
PubMedID: 14644759 |
Gene_locus related to this paper: mouse-1llip |
Title : Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor - Roussel_2002_J.Biol.Chem_277_2266 |
Author(s) : Roussel A , Miled N , Berti-Dupuis L , Riviere M , Spinelli S , Berna P , Gruber V , Verger R , Cambillau C |
Ref : Journal of Biological Chemistry , 277 :2266 , 2002 |
Abstract : Roussel_2002_J.Biol.Chem_277_2266 |
ESTHER : Roussel_2002_J.Biol.Chem_277_2266 |
PubMedSearch : Roussel_2002_J.Biol.Chem_277_2266 |
PubMedID: 11689574 |
Gene_locus related to this paper: canfa-1lipg |
Title : Gastric lipase: crystal structure and activity - Canaan_1999_Biochim.Biophys.Acta_1441_197 |
Author(s) : Canaan S , Roussel A , Verger R , Cambillau C |
Ref : Biochimica & Biophysica Acta , 1441 :197 , 1999 |
Abstract : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
ESTHER : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
PubMedSearch : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
PubMedID: 10570247 |
Gene_locus related to this paper: human-LIPF |
Title : Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest - Roussel_1999_J.Biol.Chem_274_16995 |
Author(s) : Roussel A , Canaan S , Egloff MP , Riviere M , Dupuis L , Verger R , Cambillau C |
Ref : Journal of Biological Chemistry , 274 :16995 , 1999 |
Abstract : Roussel_1999_J.Biol.Chem_274_16995 |
ESTHER : Roussel_1999_J.Biol.Chem_274_16995 |
PubMedSearch : Roussel_1999_J.Biol.Chem_274_16995 |
PubMedID: 10358049 |
Gene_locus related to this paper: human-LIPF |
Title : Occurrence of a mutation associated with Wolman disease in a family with cholesteryl ester storage disease - Maslen_1995_J.Inherit.Metab.Dis_18_620 |
Author(s) : Maslen CL , Babcock D , Illingworth DR |
Ref : J Inherit Metab Dis , 18 :620 , 1995 |
Abstract : Maslen_1995_J.Inherit.Metab.Dis_18_620 |
ESTHER : Maslen_1995_J.Inherit.Metab.Dis_18_620 |
PubMedSearch : Maslen_1995_J.Inherit.Metab.Dis_18_620 |
PubMedID: 8598644 |
Title : Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease - Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
Author(s) : Anderson RA , Byrum RS , Coates PM , Sando GN |
Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :2718 , 1994 |
Abstract : Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
ESTHER : Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
PubMedSearch : Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
PubMedID: 8146180 |
Gene_locus related to this paper: human-LIPA |
Structures (3)
Genes Proteins in Acidic_Lipase family (672)
Fragments of genes in Acidic_Lipase family (83)
Structures in Acidic_Lipase family (3)Substrates in Acidic_Lipase family (38)
Inhibitors in Acidic_Lipase family (15)