Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: ATG15-related-lipase

ATG15-related-lipase



Relationship
Block L
Comment
Autophagy-related protein 15. PTHR47175 panther LIPASE ATG15-RELATED (ATG15, AUT5, CVT17), phospholipase activity, macroautophagy, cellular component disassembly. Atg15 is a lipase essential for disintegration of autophagic body membranes and has a transmembrane domain at the N-terminus and a lipase domain at the C-terminus. The N-terminal domain alone can travel to the vacuole. Targeting of the C-terminal lipase domain to the vacuole is required for degradation of autophagic bodies. H435 belongs to the catalytic triad. W466 is important for degradation of autophagic bodies.

Database
Sequences
Interpro
|
PIRSF
|
Pdoc
|
PFam
|
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
2 more
    Title: The mechanism of Atg15-mediated membrane disruption in autophagy
    Kagohashi Y, Sasaki M, May AI, Kawamata T, Ohsumi Y
    Ref: Journal of Cell Biology, 222:, 2023 : PubMed

            

    Title: Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains
    Hirata E, Shirai K, Kawaoka T, Sato K, Kodama F, Suzuki K
    Ref: Mol Biology of the cell, :mbcE20070500, 2021 : PubMed

            

    Title: ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae
    Ramya V, Rajasekharan R
    Ref: FEBS Letters, 590:3155, 2016 : PubMed

            

Other Papers


Structure scheme for ATG15-related-lipase

No Structure yet in this family

Genes Proteins in ATG15-related-lipase family (49)

Fragments of genes in ATG15-related-lipase family (1)

No Substrate

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer