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Family Report for: ACPH_Peptidase_S9


Block X
Parent Family : Peptidase_S9

Merops Subfamily S9C. Acylamino-acid-releasing enzyme ACPH APEH. This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. ACPH_Peptidase_S9: VPA-glucuronidase is responsible for maintaining the serum concentration of VPA, by cleaving its major metabolic product, valproic acid-beta-(d)-glucuronide (VPA-G),2 releasing VPA allowing its reabsorption. This enzyme is inhibited by carbapenems. Other names: oxidized protein hydrolase (OPH), acylamino-acid-releasing enzyme, N-formylmethionyl-peptidase, acylpeptide-hydrolase (APEH)acylaminoacyl peptidase (AAP)

IPR001375 (Peptidase_S9), IPR011042 (6-blade_b-propeller_TolB-like)
PF00326 (Peptidase_S9)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

5 more
    Title: A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization
    Menyhard DK, Kiss-Szeman A, Tichy-Racs E, Hornung B, Radi K, Szeltner Z, Domokos K, Szamosi I, Naray-Szabo G and Harmat V <1 more author(s)>
    Ref: Journal of Biological Chemistry, 288:17884, 2013 : PubMed


    Title: Discrimination of esterase and peptidase activities of acylaminoacyl peptidase from hyperthermophilic Aeropyrum pernix K1 by a single mutation
    Wang Q, Yang G, Liu Y, Feng Y
    Ref: Journal of Biological Chemistry, 281:18618, 2006 : PubMed


    Title: Crystal Structure of an Acylpeptide Hydrolase/Esterase from Aeropyrum pernix K1.
    Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z
    Ref: Structure(Camb), 12:1481, 2004 : PubMed


Other Papers

No structure scheme yet for this family

Structures in ACPH_Peptidase_S9 family (30)

Genes Proteins in ACPH_Peptidase_S9 family (139)

Fragments of genes in ACPH_Peptidase_S9 family (6)

Substrates of some enzymes in the ACPH_Peptidase_S9 family (8)

Inhibitors of some enzymes in the ACPH_Peptidase_S9 family (19)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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