ABHD17-depalmitoylase
Relationship
Comment
ABHD17 proteins are protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization (Lin and Conibear 2015) They are probably themselves palmitoylated. ABHD17A, 17B, and 17C, are identified as the physiological PSD-95 (the most abundant postsynaptic density scaffolding protein) depalmitoylating enzymes in neurones (Yokoi et al.). The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. They belong to a closely related family: LYsophospholipase_carboxylesteraseDatabase
Interpro : IPR022742 Hydrolase_4 Serine aminopeptidase, S33
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12146 Hydrolase_4
Prints : No Print
EC Number : 3.1.2.22
References (11)
| Title : Attenuating ABHD17 enhances S- palmitoylation, membrane localization and signal transduction of NOD2 and Crohn's disease-associated variants - Dixon_2023_bioRxiv__ |
| Author(s) : Dixon CL , Martin NR , Niphakis MJ , Cravatt BF , Fairn GD |
| Ref : Biorxiv , : , 2023 |
| Abstract : Dixon_2023_bioRxiv__ |
| ESTHER : Dixon_2023_bioRxiv__ |
| PubMedSearch : Dixon_2023_bioRxiv__ |
| PubMedID: 38187608 |
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : Remsberg_2021_Nat.Chem.Biol__ |
| ESTHER : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation - Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| Author(s) : Suciu RM , Luvaga IK , Hazeen A , Weerasooriya C , Richardson SK , Firestone AJ , Shannon K , Howell AR , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 53 :128414 , 2021 |
| Abstract : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| ESTHER : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| PubMedSearch : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| PubMedID: 34666187 |
| Title : Site specific deacylation by ABHD17a controls BK channel splice variant activity - McClafferty_2020_J.Biol.Chem_295_16487 |
| Author(s) : McClafferty H , Runciman H , Shipston MJ |
| Ref : Journal of Biological Chemistry , 295 :16487 , 2020 |
| Abstract : McClafferty_2020_J.Biol.Chem_295_16487 |
| ESTHER : McClafferty_2020_J.Biol.Chem_295_16487 |
| PubMedSearch : McClafferty_2020_J.Biol.Chem_295_16487 |
| PubMedID: 32913120 |
| Gene_locus related to this paper: human-ABHD17A |
| Title : Systematic Screening of Depalmitoylating Enzymes and Evaluation of Their Activities by the Acyl-PEGyl Exchange Gel-Shift (APEGS) Assay - Kanadome_2019_Methods.Mol.Biol_2009_83 |
| Author(s) : Kanadome T , Yokoi N , Fukata Y , Fukata M |
| Ref : Methods Mol Biol , 2009 :83 , 2019 |
| Abstract : Kanadome_2019_Methods.Mol.Biol_2009_83 |
| ESTHER : Kanadome_2019_Methods.Mol.Biol_2009_83 |
| PubMedSearch : Kanadome_2019_Methods.Mol.Biol_2009_83 |
| PubMedID: 31152397 |
| Title : Protein depalmitoylases - Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| Author(s) : Won SJ , Cheung See Kit M , Martin BR |
| Ref : Crit Rev Biochem Mol Biol , 53 :83 , 2018 |
| Abstract : Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| ESTHER : Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| PubMedSearch : Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83 |
| PubMedID: 29239216 |
| Title : Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle - Won_2018_ACS.Chem.Biol_13_1560 |
| Author(s) : Won SJ , Martin BR |
| Ref : ACS Chemical Biology , 13 :1560 , 2018 |
| Abstract : Won_2018_ACS.Chem.Biol_13_1560 |
| ESTHER : Won_2018_ACS.Chem.Biol_13_1560 |
| PubMedSearch : Won_2018_ACS.Chem.Biol_13_1560 |
| PubMedID: 29733200 |
| Title : Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization - Tortosa_2017_Neuron_94_809 |
| Author(s) : Tortosa E , Adolfs Y , Fukata M , Pasterkamp RJ , Kapitein LC , Hoogenraad CC |
| Ref : Neuron , 94 :809 , 2017 |
| Abstract : Tortosa_2017_Neuron_94_809 |
| ESTHER : Tortosa_2017_Neuron_94_809 |
| PubMedSearch : Tortosa_2017_Neuron_94_809 |
| PubMedID: 28521134 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Identification of PSD-95 Depalmitoylating Enzymes - Yokoi_2016_J.Neurosci_36_6431 |
| Author(s) : Yokoi N , Fukata Y , Sekiya A , Murakami T , Kobayashi K , Fukata M |
| Ref : Journal of Neuroscience , 36 :6431 , 2016 |
| Abstract : Yokoi_2016_J.Neurosci_36_6431 |
| ESTHER : Yokoi_2016_J.Neurosci_36_6431 |
| PubMedSearch : Yokoi_2016_J.Neurosci_36_6431 |
| PubMedID: 27307232 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C , rat-ab17c |
| Title : ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization - Lin_2015_Elife_4_ |
| Author(s) : Lin DT , Conibear E |
| Ref : Elife , 4 : , 2015 |
| Abstract : Lin_2015_Elife_4_ |
| ESTHER : Lin_2015_Elife_4_ |
| PubMedSearch : Lin_2015_Elife_4_ |
| PubMedID: 26701913 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Large-scale profiling of protein palmitoylation in mammalian cells - Martin_2009_Nat.Methods_6_135 |
| Author(s) : Martin BR , Cravatt BF |
| Ref : Nat Methods , 6 :135 , 2009 |
| Abstract : Martin_2009_Nat.Methods_6_135 |
| ESTHER : Martin_2009_Nat.Methods_6_135 |
| PubMedSearch : Martin_2009_Nat.Methods_6_135 |
| PubMedID: 19137006 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
No structure scheme yet for this family
Genes Proteins in ABHD17-depalmitoylase family (85)
Fragments of genes in ABHD17-depalmitoylase family (2)
No fragment of genesSubstrates in ABHD17-depalmitoylase family (1)
Inhibitors in ABHD17-depalmitoylase family (10)