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Family Report for: A85-IroE-IroD-Fes-Yiel


Block X
Parent Family : Antigen85c

This family contains enterobactin esterase IroD, enterochelin Esterase FES enterobactin and salmochelin esterase IroE; The proliferation of many pathogenic bacteria is limited by the scarcity of soluble iron in their environment Many of these bacteria scavenge iron by synthesizing and exporting small molecule siderophores that chelate iron Iron-bound siderophores are subsequently imported for metabolic processing. Three related serine hydrolases have been characterized biochemically in this pathway Fes IroD and IroE; This family corresponds to a subset ofthe Carbohydrate Esterase family CE1 in CAZy - Carbohydrate-Active enZYmes database (CE_1). Active site Ser His Asp or Glu or nothing

IPR000801 (Esterase_put)
PF00756 (Esterase)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

    Title: Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases
    Ecker F, Haas H, Groll M, Huber EM
    Ref: Angew Chem Int Ed Engl, 57:14624, 2018 : PubMed


    Title: A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa
    Perraud Q, Moynie L, Gasser V, Munier M, Godet J, Hoegy F, Mely Y, Mislin GLA, Naismith JH, Schalk IJ
    Ref: ACS Chemical Biology, 13:2603, 2018 : PubMed


    Title: Structural characterization of enterobactin hydrolase IroE
    Larsen NA, Lin H, Wei R, Fischbach MA, Walsh CT
    Ref: Biochemistry, 45:10184, 2006 : PubMed


Other Papers

No structure scheme yet for this family

Structures in A85-IroE-IroD-Fes-Yiel family (21)

Genes Proteins in A85-IroE-IroD-Fes-Yiel family (695)

Fragments of genes in A85-IroE-IroD-Fes-Yiel family (48)

Substrates of some enzymes in the A85-IroE-IroD-Fes-Yiel family (5)

Inhibitors of some enzymes in the A85-IroE-IroD-Fes-Yiel family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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