Valacyclovir-hydrolase
Relationship
Comment
Biphenyl hydrolase-like; BPHL, Valacyclovirase, Mucin-associated antigen, MCNAA, Breast epithelial Mucin-associated antigen. Alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Valacyclovir (VACV) is the 5-prime valyl ester prodrug of acyclovir, an effective antiherpetic drug. VACV is relatively stable in gut lumen while very susceptible to intracellular enzymatic hydrolysis.Database
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12697 Abhydrolase_6
Prints : No Print
EC Number : No EC Number
References (8)
| Title : Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice - Hu_2018_Biochem.Pharmacol_156_147 |
| Author(s) : Hu Y , Epling D , Shi J , Song F , Tsume Y , Zhu HJ , Amidon GL , Smith DE |
| Ref : Biochemical Pharmacology , 156 :147 , 2018 |
| Abstract : Hu_2018_Biochem.Pharmacol_156_147 |
| ESTHER : Hu_2018_Biochem.Pharmacol_156_147 |
| PubMedSearch : Hu_2018_Biochem.Pharmacol_156_147 |
| PubMedID: 30121252 |
| Gene_locus related to this paper: human-BPHL |
| Title : Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect - Sun_2010_Mol.Pharm_7_2362 |
| Author(s) : Sun J , Dahan A , Walls ZF , Lai L , Lee KD , Amidon GL |
| Ref : Mol Pharm , 7 :2362 , 2010 |
| Abstract : Sun_2010_Mol.Pharm_7_2362 |
| ESTHER : Sun_2010_Mol.Pharm_7_2362 |
| PubMedSearch : Sun_2010_Mol.Pharm_7_2362 |
| PubMedID: 21028903 |
| Gene_locus related to this paper: human-BPHL |
| Title : Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase - Lai_2008_J.Biol.Chem_283_9318 |
| Author(s) : Lai L , Xu Z , Zhou J , Lee KD , Amidon GL |
| Ref : Journal of Biological Chemistry , 283 :9318 , 2008 |
| Abstract : Lai_2008_J.Biol.Chem_283_9318 |
| ESTHER : Lai_2008_J.Biol.Chem_283_9318 |
| PubMedSearch : Lai_2008_J.Biol.Chem_283_9318 |
| PubMedID: 18256025 |
| Gene_locus related to this paper: human-BPHL |
| Title : A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein - Kim_2004_Mol.Pharm_1_117 |
| Author(s) : Kim I , Song X , Vig BS , Mittal S , Shin HC , Lorenzi PJ , Amidon GL |
| Ref : Mol Pharm , 1 :117 , 2004 |
| Abstract : Kim_2004_Mol.Pharm_1_117 |
| ESTHER : Kim_2004_Mol.Pharm_1_117 |
| PubMedSearch : Kim_2004_Mol.Pharm_1_117 |
| PubMedID: 15832508 |
| Gene_locus related to this paper: human-BPHL |
| Title : Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase - Kim_2003_J.Biol.Chem_278_25348 |
| Author(s) : Kim I , Chu XY , Kim S , Provoda CJ , Lee KD , Amidon GL |
| Ref : Journal of Biological Chemistry , 278 :25348 , 2003 |
| Abstract : Kim_2003_J.Biol.Chem_278_25348 |
| ESTHER : Kim_2003_J.Biol.Chem_278_25348 |
| PubMedSearch : Kim_2003_J.Biol.Chem_278_25348 |
| PubMedID: 12732646 |
| Gene_locus related to this paper: human-BPHL |
| Title : Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL) - Puente_1998_Genomics_51_459 |
| Author(s) : Puente XS , Pendas AM , Lopez-Otin C |
| Ref : Genomics , 51 :459 , 1998 |
| Abstract : Puente_1998_Genomics_51_459 |
| ESTHER : Puente_1998_Genomics_51_459 |
| PubMedSearch : Puente_1998_Genomics_51_459 |
| PubMedID: 9721218 |
| Gene_locus related to this paper: human-BPHL |
| Title : Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds - Puente_1995_J.Biol.Chem_270_12926 |
| Author(s) : Puente XS , Lopez-Otin C |
| Ref : Journal of Biological Chemistry , 270 :12926 , 1995 |
| Abstract : Puente_1995_J.Biol.Chem_270_12926 |
| ESTHER : Puente_1995_J.Biol.Chem_270_12926 |
| PubMedSearch : Puente_1995_J.Biol.Chem_270_12926 |
| PubMedID: 7759552 |
| Gene_locus related to this paper: human-BPHL |
| Title : Cloning and sequencing of a complementary DNA encoding a Mr 70,000 human breast epithelial mucin-associated antigen - Larocca_1990_Cancer.Res_50_5925 |
| Author(s) : Larocca D , Peterson JA , Walkup G , Urrea R , Ceriani RL |
| Ref : Cancer Research , 50 :5925 , 1990 |
| Abstract : Larocca_1990_Cancer.Res_50_5925 |
| ESTHER : Larocca_1990_Cancer.Res_50_5925 |
| PubMedSearch : Larocca_1990_Cancer.Res_50_5925 |
| PubMedID: 2393862 |
| Gene_locus related to this paper: human-BPHL |
Structures (4)
Genes Proteins in Valacyclovir-hydrolase family (99)
Fragments of genes in Valacyclovir-hydrolase family (9)
Structures in Valacyclovir-hydrolase family (4)Substrates in Valacyclovir-hydrolase family (2)
Inhibitors in Valacyclovir-hydrolase family (1)