S9N_PREPL_Peptidase_S9
Relationship
Comment
a prolyl endopeptidase-like enzyme by name only; a (thio)esterase involved in mitochondrial respiratory chain function (Rosier et al.). PREPL Prolylendopeptidase-like. Prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme). N-terminal domain is a 7-bladed beta-propeller. In contrast to PREP and oligopeptidase B, which require both amino- and carboxy-terminal sequences for activity, PREPL activity appeared to depend only on the carboxy-terminal domain. Deletion of PREPL was found in patients with hypotonia-cystinuria syndrome Parvari et al. (2001, 2005) Jaeken et al. (2006)Database
Interpro : IPR004106 Peptidase S9A\/B\/C, oligopeptidase, N-terminal beta-propeller , IPR001375 Peptidase_S9
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00326 Peptidase_S9 , PF02897 Peptidase_S9_N
Prints : No Print
EC Number : No EC Number
References (21)
| Title : Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function - Rosier_2021_iScience_24_103460 |
| Author(s) : Rosier K , McDevitt MT , Smet J , Floyd BJ , Verschoore M , Marcaida MJ , Bingman CA , Lemmens I , Dal Peraro M , Tavernier J , Cravatt BF , Gounko NV , Vints K , Monnens Y , Bhalla K , Aerts L , Rashan EH , Vanlander AV , Van Coster R , Regal L , Pagliarini DJ , Creemers JWM |
| Ref : iScience , 24 :103460 , 2021 |
| Abstract : Rosier_2021_iScience_24_103460 |
| ESTHER : Rosier_2021_iScience_24_103460 |
| PubMedSearch : Rosier_2021_iScience_24_103460 |
| PubMedID: 34888501 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl Endopeptidase-Like Facilitates the alpha-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF - Santos_2020_Biomolecules_10_ |
| Author(s) : Santos GS , Oyadomari WY , Carvalho EA , Torquato RS , Oliveira V |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : Santos_2020_Biomolecules_10_ |
| ESTHER : Santos_2020_Biomolecules_10_ |
| PubMedSearch : Santos_2020_Biomolecules_10_ |
| PubMedID: 32630529 |
| Gene_locus related to this paper: human-PREPL |
| Title : PREPL deficiency: delineation of the phenotype and development of a functional blood assay - Regal_2018_Genet.Med_20_109 |
| Author(s) : Regal L , Martensson E , Maystadt I , Voermans N , Lederer D , Burlina A , Juan Fita MJ , Hoogeboom AJM , Olsson Engman M , Hollemans T , Schouten M , Meulemans S , Jonson T , Francois I , Gil Ortega D , Kamsteeg EJ , Creemers JWM |
| Ref : Genet Med , 20 :109 , 2018 |
| Abstract : Regal_2018_Genet.Med_20_109 |
| ESTHER : Regal_2018_Genet.Med_20_109 |
| PubMedSearch : Regal_2018_Genet.Med_20_109 |
| PubMedID: 28726805 |
| Gene_locus related to this paper: human-PREPL |
| Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387 |
| Author(s) : Waumans Y , Baerts L , Kehoe K , Lambeir AM , De Meester I |
| Ref : Front Immunol , 6 :387 , 2015 |
| Abstract : Waumans_2015_Front.Immunol_6_387 |
| ESTHER : Waumans_2015_Front.Immunol_6_387 |
| PubMedSearch : Waumans_2015_Front.Immunol_6_387 |
| PubMedID: 26300881 |
| Title : Deletion of PREPl causes growth impairment and hypotonia in mice - Lone_2014_PLoS.One_9_e89160 |
| Author(s) : Lone AM , Leidl M , McFedries AK , Horner JW , Creemers J , Saghatelian A |
| Ref : PLoS ONE , 9 :e89160 , 2014 |
| Abstract : Lone_2014_PLoS.One_9_e89160 |
| ESTHER : Lone_2014_PLoS.One_9_e89160 |
| PubMedSearch : Lone_2014_PLoS.One_9_e89160 |
| PubMedID: 24586561 |
| Gene_locus related to this paper: human-PREPL |
| Title : PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome - Regal_2014_Neurology_82_1254 |
| Author(s) : Regal L , Shen XM , Selcen D , Verhille C , Meulemans S , Creemers JW , Engel AG |
| Ref : Neurology , 82 :1254 , 2014 |
| Abstract : Regal_2014_Neurology_82_1254 |
| ESTHER : Regal_2014_Neurology_82_1254 |
| PubMedSearch : Regal_2014_Neurology_82_1254 |
| PubMedID: 24610330 |
| Gene_locus related to this paper: human-PREPL |
| Title : Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit 1A - Radhakrishnan_2013_J.Cell.Sci_126_1155 |
| Author(s) : Radhakrishnan K , Baltes J , Creemers JW , Schu P |
| Ref : Journal of Cell Science , 126 :1155 , 2013 |
| Abstract : Radhakrishnan_2013_J.Cell.Sci_126_1155 |
| ESTHER : Radhakrishnan_2013_J.Cell.Sci_126_1155 |
| PubMedSearch : Radhakrishnan_2013_J.Cell.Sci_126_1155 |
| PubMedID: 23321636 |
| Gene_locus related to this paper: human-PREPL |
| Title : Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons - Morawski_2013_Neurosci_242_128 |
| Author(s) : Morawski M , Nuytens K , Juhasz T , Zeitschel U , Seeger G , Waelkens E , Regal L , Schulz I , Arendt T , Szeltner Z , Creemers J , Rossner S |
| Ref : Neuroscience , 242 :128 , 2013 |
| Abstract : Morawski_2013_Neurosci_242_128 |
| ESTHER : Morawski_2013_Neurosci_242_128 |
| PubMedSearch : Morawski_2013_Neurosci_242_128 |
| PubMedID: 23485813 |
| Gene_locus related to this paper: human-PREPL |
| Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665 |
| Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A |
| Ref : Journal of the American Chemical Society , 133 :11665 , 2011 |
| Abstract : Lone_2011_J.Am.Chem.Soc_133_11665 |
| ESTHER : Lone_2011_J.Am.Chem.Soc_133_11665 |
| PubMedSearch : Lone_2011_J.Am.Chem.Soc_133_11665 |
| PubMedID: 21692504 |
| Gene_locus related to this paper: human-PREPL |
| Title : PREPL, a prolyl endopeptidase-like enzyme by name only?--Lessons from patients - Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355 |
| Author(s) : Boonen K , Regal L , Jaeken J , Creemers JW |
| Ref : CNS Neurol Disord Drug Targets , 10 :355 , 2011 |
| Abstract : Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355 |
| ESTHER : Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355 |
| PubMedSearch : Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355 |
| PubMedID: 21222627 |
| Gene_locus related to this paper: human-PREPL |
| Title : Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor - McLuskey_2010_J.Biol.Chem_285_39249 |
| Author(s) : McLuskey K , Paterson NG , Bland ND , Isaacs NW , Mottram JC |
| Ref : Journal of Biological Chemistry , 285 :39249 , 2010 |
| Abstract : McLuskey_2010_J.Biol.Chem_285_39249 |
| ESTHER : McLuskey_2010_J.Biol.Chem_285_39249 |
| PubMedSearch : McLuskey_2010_J.Biol.Chem_285_39249 |
| PubMedID: 20926390 |
| Gene_locus related to this paper: leima-OPB |
| Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2009_BMJ.Case.Rep_2009_ |
| Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW |
| Ref : BMJ Case Rep , 2009 : , 2009 |
| Abstract : Chabrol_2009_BMJ.Case.Rep_2009_ |
| ESTHER : Chabrol_2009_BMJ.Case.Rep_2009_ |
| PubMedSearch : Chabrol_2009_BMJ.Case.Rep_2009_ |
| PubMedID: 21686663 |
| Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2008_J.Med.Genet_45_314 |
| Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW |
| Ref : Journal of Medical Genetics , 45 :314 , 2008 |
| Abstract : Chabrol_2008_J.Med.Genet_45_314 |
| ESTHER : Chabrol_2008_J.Med.Genet_45_314 |
| PubMedSearch : Chabrol_2008_J.Med.Genet_45_314 |
| PubMedID: 18234729 |
| Gene_locus related to this paper: human-PREPL |
| Title : Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome - Jaeken_2006_Am.J.Hum.Genet_78_38 |
| Author(s) : Jaeken J , Martens K , Francois I , Eyskens F , Lecointre C , Derua R , Meulemans S , Slootstra JW , Waelkens E , de Zegher F , Creemers JW , Matthijs G |
| Ref : American Journal of Human Genetics , 78 :38 , 2006 |
| Abstract : Jaeken_2006_Am.J.Hum.Genet_78_38 |
| ESTHER : Jaeken_2006_Am.J.Hum.Genet_78_38 |
| PubMedSearch : Jaeken_2006_Am.J.Hum.Genet_78_38 |
| PubMedID: 16385448 |
| Gene_locus related to this paper: human-PREPL |
| Title : PREPL: a putative novel oligopeptidase propelled into the limelight - Martens_2006_Biol.Chem_387_879 |
| Author(s) : Martens K , Derua R , Meulemans S , Waelkens E , Jaeken J , Matthijs G , Creemers JW |
| Ref : Biol Chem , 387 :879 , 2006 |
| Abstract : Martens_2006_Biol.Chem_387_879 |
| ESTHER : Martens_2006_Biol.Chem_387_879 |
| PubMedSearch : Martens_2006_Biol.Chem_387_879 |
| PubMedID: 16913837 |
| Gene_locus related to this paper: human-PREPL |
| Title : Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts - Morty_2005_J.Biol.Chem_280_10925 |
| Author(s) : Morty RE , Pelle R , Vadasz I , Uzcanga GL , Seeger W , Bubis J |
| Ref : Journal of Biological Chemistry , 280 :10925 , 2005 |
| Abstract : Morty_2005_J.Biol.Chem_280_10925 |
| ESTHER : Morty_2005_J.Biol.Chem_280_10925 |
| PubMedSearch : Morty_2005_J.Biol.Chem_280_10925 |
| PubMedID: 15644339 |
| Gene_locus related to this paper: trybr-PEPTB |
| Title : The prolyl oligopeptidase family - Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| Author(s) : Polgar L |
| Ref : Cell Mol Life Sciences , 59 :349 , 2002 |
| Abstract : Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| ESTHER : Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| PubMedSearch : Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| PubMedID: 11915948 |
| Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277 |
| Author(s) : Fulop V , Szeltner Z , Polgar L |
| Ref : EMBO Rep , 1 :277 , 2000 |
| Abstract : Fulop_2000_EMBO.Rep_1_277 |
| ESTHER : Fulop_2000_EMBO.Rep_1_277 |
| PubMedSearch : Fulop_2000_EMBO.Rep_1_277 |
| PubMedID: 11256612 |
| Gene_locus related to this paper: pig-ppce |
| Title : Oligopeptidase B from Trypanosoma brucei, a new member of an emerging subgroup of serine oligopeptidases - Morty_1999_J.Biol.Chem_274_26149 |
| Author(s) : Morty RE , Lonsdale-Eccles JD , Morehead J , Caler EV , Mentele R , Auerswald EA , Coetzer TH , Andrews NW , Burleigh BA |
| Ref : Journal of Biological Chemistry , 274 :26149 , 1999 |
| Abstract : Morty_1999_J.Biol.Chem_274_26149 |
| ESTHER : Morty_1999_J.Biol.Chem_274_26149 |
| PubMedSearch : Morty_1999_J.Biol.Chem_274_26149 |
| PubMedID: 10473566 |
| Gene_locus related to this paper: leima-OPB , trybr-PEPTB |
| Title : Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis - Fulop_1998_Cell_94_161 |
| Author(s) : Fulop V , Bocskei Z , Polgar L |
| Ref : Cell , 94 :161 , 1998 |
| Abstract : Fulop_1998_Cell_94_161 |
| ESTHER : Fulop_1998_Cell_94_161 |
| PubMedSearch : Fulop_1998_Cell_94_161 |
| PubMedID: 9695945 |
| Gene_locus related to this paper: pig-ppce |
| Title : Structural relationship between lipases and peptidases of the prolyl oligopeptidase family - Polgar_1992_FEBS.Lett_311_281 |
| Author(s) : Polgar L |
| Ref : FEBS Letters , 311 :281 , 1992 |
| Abstract : Polgar_1992_FEBS.Lett_311_281 |
| ESTHER : Polgar_1992_FEBS.Lett_311_281 |
| PubMedSearch : Polgar_1992_FEBS.Lett_311_281 |
| PubMedID: 1397329 |
Structures (15)
Genes Proteins in S9N_PREPL_Peptidase_S9 family (204)
Fragments of genes in S9N_PREPL_Peptidase_S9 family (6)
Structures in S9N_PREPL_Peptidase_S9 family (15)Substrates in S9N_PREPL_Peptidase_S9 family (9)
Inhibitors in S9N_PREPL_Peptidase_S9 family (13)