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Family Report for: PolyAspartate-hydrolase


Block X
Parent Family : Abhydrolase_5

Poly(aspartate) (PAA) is a bio-based, biocompatible, biodegradable alternative to polycarboxylate of poly(acrylate). Bacterial PAA-hydrolyzing enzyme can also perform synthesis of poly(alpha-ethyl beta-aspartate). This family is close to PHB depolymerase. The LpqC, poly(3-hydroxybutyrate) depolymerase from Bordetella parapertussis (CASP Target) (structure 3D0K) belongs to this family. Polyaspartic acid (PASA) is also a natural polymer as fragment of larger proteins with length up to 50 amino acids. Synthetic tPAA(thermally synthesized PAA) consists of beta-amide (70%) and alpha-amide,(30%) D- and L-aspartate units; the alpha- and beta-amide units are randomly distributed. PAA hydrolase-1 is an alpha beta hydrolase inhibited by PMSF and DFP. PAA hydrolase-2 is closer to metallo carboxypeptidase inhibited by DFP and PMSF

PF12695 (Abhydrolase_5)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

    Title: Poly(aspartate) hydrolases: biochemical properties and applications
    Hiraishi T, Maeda M
    Ref: Applied Microbiology & Biotechnology, 91:895, 2011 : PubMed


    Title: Cloning of poly(aspartic acid) (PAA) hydrolase-1 gene from Pedobacter sp. KP-2 and hydrolysis of thermally synthesized PAA by its gene product
    Hiraishi T, Masuda E, Kanayama N, Nagata M, Doi Y, Abe H, Maeda M
    Ref: Macromol Biosci, 9:10, 2009 : PubMed


    Title: Genetic Analysis and Characterization of Poly(aspartic acid) Hydrolase-1 from Sphingomonas sp. KT-1
    Hiraishi T, Kajiyama M, Tabata K, Yamato I, Doi Y
    Ref: Biomacromolecules, 4:80, 2003 : PubMed


Other Papers

No structure scheme yet for this family

Structures in PolyAspartate-hydrolase family (3)

Genes Proteins in PolyAspartate-hydrolase family (56)

No fragments
Substrates of some enzymes in the PolyAspartate-hydrolase family (2)

Inhibitors of some enzymes in the PolyAspartate-hydrolase family (2)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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