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Family Report for: NLS3-Tex30


Family NLS3-Tex30
Block X
This entry consists of the KAT8 regulatory NSL complex subunit 3 (KANSL3 or NSL3, also known as testis development protein PRTD) and the testis-expressed sequence 30 proteins (TEX30). KAT8 regulatory NSL complex subunit 3 is part of the NSL complex that is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Meunier et al identified KANSL3 as a microtubule minus-end-binding protein. In C. Elegans SUMV-2 interacts with SUMV-1, and they may function together with MYS-2 in a nematode KAT8/MOF-like complex to antagonise the activity of the synMuv (synthetic multivulva) genes. The function of the testis-expressed sequence 30 protein is not known.

IPR026555 (KAT8 regulatory NSL complex subunit 3/Testis-expressed sequence 30 protein), IPR046879 (KANL3/Tex30, alpha/beta hydrolase-like domain)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

    Title: An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
    Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A
    Ref: Nat Commun, 6:7889, 2015 : PubMed


    Title: SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
    Yucel D, Hoe M, Llamosas E, Kant S, Jamieson C, Young PA, Crossley M, Nicholas HR
    Ref: Developmental Biology, 392:266, 2014 : PubMed


    Title: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex
    Cai Y, Jin J, Swanson SK, Cole MD, Choi SH, Florens L, Washburn MP, Conaway JW, Conaway RC
    Ref: Journal of Biological Chemistry, 285:4268, 2010 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in NLS3-Tex30 family (676)

Fragments of genes in NLS3-Tex30 family (58)

No Substrate

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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