Monoglyceridelipase_lysophospholip
Relationship
Comment
This family consists of Monoglyceridelipase_lysophospholipase but different of phospholipases and carboxylesterases with broad substrate specificity. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.The closest family is CarbLipBactDatabase
Interpro : IPR022742 Alpha\/beta hydrolase, N-terminal
PIRSF : PIRSF000869 monoglyceride lipase
Pdoc : No Pdoc
Pfam : PF12146 Hydrolase_4
Prints : No Print
EC Number : 3.1.1.23
References (14)
| Title : Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan - Chen_2019_Nat.Chem.Biol_15_453 |
| Author(s) : Chen AL , Lum KM , Lara-Gonzalez P , Ogasawara D , Cognetta AB, 3rd , To A , Parsons WH , Simon GM , Desai A , Petrascheck M , Bar-Peled L , Cravatt BF |
| Ref : Nat Chemical Biology , 15 :453 , 2019 |
| Abstract : Chen_2019_Nat.Chem.Biol_15_453 |
| ESTHER : Chen_2019_Nat.Chem.Biol_15_453 |
| PubMedSearch : Chen_2019_Nat.Chem.Biol_15_453 |
| PubMedID: 30911178 |
| Title : Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase - Butler_2017_J.Med.Chem_60_9860 |
| Author(s) : Butler CR , Beck EM , Harris A , Huang Z , McAllister LA , Am Ende CW , Fennell K , Foley TL , Fonseca K , Hawrylik SJ , Johnson DS , Knafels JD , Mente S , Noell GS , Pandit J , Phillips TB , Piro JR , Rogers BN , Samad TA , Wang J , Wan S , Brodney MA |
| Ref : Journal of Medicinal Chemistry , 60 :9860 , 2017 |
| Abstract : Butler_2017_J.Med.Chem_60_9860 |
| ESTHER : Butler_2017_J.Med.Chem_60_9860 |
| PubMedSearch : Butler_2017_J.Med.Chem_60_9860 |
| PubMedID: 29148769 |
| Gene_locus related to this paper: human-MGLL |
| Title : Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice - Owens_2017_Neuropharmacol_125_80 |
| Author(s) : Owens RA , Mustafa MA , Ignatowska-Jankowska BM , Damaj MI , Beardsley PM , Wiley JL , Niphakis MJ , Cravatt BF , Lichtman AH |
| Ref : Neuropharmacology , 125 :80 , 2017 |
| Abstract : Owens_2017_Neuropharmacol_125_80 |
| ESTHER : Owens_2017_Neuropharmacol_125_80 |
| PubMedSearch : Owens_2017_Neuropharmacol_125_80 |
| PubMedID: 28673548 |
| Title : Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p - Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| Author(s) : Aschauer P , Rengachari S , Lichtenegger J , Schittmayer M , Das KM , Mayer N , Breinbauer R , Birner-Gruenberger R , Gruber CC , Zimmermann R , Gruber K , Oberer M |
| Ref : Biochimica & Biophysica Acta , 1861 :462 , 2016 |
| Abstract : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| ESTHER : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| PubMedSearch : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| PubMedID: 26869448 |
| Gene_locus related to this paper: yeast-mgll |
| Title : Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae - Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| Author(s) : Rengachari S , Aschauer P , Sturm C , Oberer M |
| Ref : Acta Crystallographica F Struct Biol Commun , 71 :243 , 2015 |
| Abstract : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| ESTHER : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| PubMedSearch : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| PubMedID: 25664804 |
| Gene_locus related to this paper: yeast-mgll |
| Title : Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents - Griebel_2015_Sci.Rep_5_7642 |
| Author(s) : Griebel G , Pichat P , Beeske S , Leroy T , Redon N , Jacquet A , Francon D , Bert L , Even L , Lopez-Grancha M , Tolstykh T , Sun F , Yu Q , Brittain S , Arlt H , He T , Zhang B , Wiederschain D , Bertrand T , Houtmann J , Rak A , Vallee F , Michot N , Auge F , Menet V , Bergis OE , George P , Avenet P , Mikol V , Didier M , Escoubet J |
| Ref : Sci Rep , 5 :7642 , 2015 |
| Abstract : Griebel_2015_Sci.Rep_5_7642 |
| ESTHER : Griebel_2015_Sci.Rep_5_7642 |
| PubMedSearch : Griebel_2015_Sci.Rep_5_7642 |
| PubMedID: 25560837 |
| Gene_locus related to this paper: mouse-ABHD6 |
| Title : Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution - Schalk-Hihi_2011_Protein.Sci_20_670 |
| Author(s) : Schalk-Hihi C , Schubert C , Alexander R , Bayoumy S , Clemente JC , Deckman I , Desjarlais RL , Dzordzorme KC , Flores CM , Grasberger B , Kranz JK , Lewandowski F , Liu L , Ma H , Maguire D , Macielag MJ , McDonnell ME , Mezzasalma Haarlander T , Miller R , Milligan C , Reynolds C , Kuo LC |
| Ref : Protein Science , 20 :670 , 2011 |
| Abstract : Schalk-Hihi_2011_Protein.Sci_20_670 |
| ESTHER : Schalk-Hihi_2011_Protein.Sci_20_670 |
| PubMedSearch : Schalk-Hihi_2011_Protein.Sci_20_670 |
| PubMedID: 21308848 |
| Gene_locus related to this paper: human-MGLL |
| Title : Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice - Pan_2011_J.Neurosci_31_13420 |
| Author(s) : Pan B , Wang W , Zhong P , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal of Neuroscience , 31 :13420 , 2011 |
| Abstract : Pan_2011_J.Neurosci_31_13420 |
| ESTHER : Pan_2011_J.Neurosci_31_13420 |
| PubMedSearch : Pan_2011_J.Neurosci_31_13420 |
| PubMedID: 21940435 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum - Zhong_2011_J.Physiol_589_4847 |
| Author(s) : Zhong P , Pan B , Gao XP , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal de Physiologie , 589 :4847 , 2011 |
| Abstract : Zhong_2011_J.Physiol_589_4847 |
| ESTHER : Zhong_2011_J.Physiol_589_4847 |
| PubMedSearch : Zhong_2011_J.Physiol_589_4847 |
| PubMedID: 21911610 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling - Labar_2010_Chembiochem_11_218 |
| Author(s) : Labar G , Bauvois C , Borel F , Ferrer JL , Wouters J , Lambert DM |
| Ref : Chembiochem , 11 :218 , 2010 |
| Abstract : Labar_2010_Chembiochem_11_218 |
| ESTHER : Labar_2010_Chembiochem_11_218 |
| PubMedSearch : Labar_2010_Chembiochem_11_218 |
| PubMedID: 19957260 |
| Gene_locus related to this paper: human-MGLL |
| Title : Structural basis for human monoglyceride lipase inhibition - Bertrand_2010_J.Mol.Biol_396_663 |
| Author(s) : Bertrand T , Auge F , Houtmann J , Rak A , Vallee F , Mikol V , Berne PF , Michot N , Cheuret D , Hoornaert C , Mathieu M |
| Ref : Journal of Molecular Biology , 396 :663 , 2010 |
| Abstract : Bertrand_2010_J.Mol.Biol_396_663 |
| ESTHER : Bertrand_2010_J.Mol.Biol_396_663 |
| PubMedSearch : Bertrand_2010_J.Mol.Biol_396_663 |
| PubMedID: 19962385 |
| Gene_locus related to this paper: human-MGLL |
| Title : Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae - Heier_2010_Biochim.Biophys.Acta_1801_1063 |
| Author(s) : Heier C , Taschler U , Rengachari S , Oberer M , Wolinski H , Natter K , Kohlwein SD , Leber R , Zimmermann R |
| Ref : Biochimica & Biophysica Acta , 1801 :1063 , 2010 |
| Abstract : Heier_2010_Biochim.Biophys.Acta_1801_1063 |
| ESTHER : Heier_2010_Biochim.Biophys.Acta_1801_1063 |
| PubMedSearch : Heier_2010_Biochim.Biophys.Acta_1801_1063 |
| PubMedID: 20554061 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL , yeast-mgll |
| Title : Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis - Nomura_2010_Cell_140_49 |
| Author(s) : Nomura DK , Long JZ , Niessen S , Hoover HS , Ng SW , Cravatt BF |
| Ref : Cell , 140 :49 , 2010 |
| Abstract : Nomura_2010_Cell_140_49 |
| ESTHER : Nomura_2010_Cell_140_49 |
| PubMedSearch : Nomura_2010_Cell_140_49 |
| PubMedID: 20079333 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase - Vila_2007_Biochemistry_46_9578 |
| Author(s) : Vila A , Rosengarth A , Piomelli D , Cravatt B , Marnett LJ |
| Ref : Biochemistry , 46 :9578 , 2007 |
| Abstract : Vila_2007_Biochemistry_46_9578 |
| ESTHER : Vila_2007_Biochemistry_46_9578 |
| PubMedSearch : Vila_2007_Biochemistry_46_9578 |
| PubMedID: 17649977 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
Structures (30)
Genes Proteins in Monoglyceridelipase_lysophospholip family (1182)
Fragments of genes in Monoglyceridelipase_lysophospholip family (102)
Structures in Monoglyceridelipase_lysophospholip family (30)Substrates in Monoglyceridelipase_lysophospholip family (24)
Inhibitors in Monoglyceridelipase_lysophospholip family (77)