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Family Report for: Fusarinine_C_esterase_sidJ


Block X
Grundlingern et al. show that Aspergillus fumigatus AFUA_3G03390 gene product, SidJ (aspfu-q4wf56) is involved in hydrolysis of siderophore fusarinine C. It is the first functionally characterized member of the family. Structure of siderophore esterase AfSidJ from Aspergillus fumigatus is described by Ecker et al.. A structure of a protein of unknown fucntion is also available (2Q0X) Merritt et al. . However this protein is only representative of trypanosomatid members of this sequence family as these proteins lack some if not all of the catalytic triad residues. Fusarinine C is an intracellular siderophore (an iron-chelating compound that transports iron across membranes) that is crucial for virulence. The closely related siderophore triacetylfusarinine C is not hydrolysed by SidJ. Homologues of SidJ are found in plants and bacteria. (Not to be cofounded with SidJ Calmodulin-dependent glutamylase from Legionella pneumophila).Previously named DUF_1749

IPR013744 (Fusarinine C esterase sidJ DUF_1749)
PF08538 (DUF1749)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

    Title: Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases
    Ecker F, Haas H, Groll M, Huber EM
    Ref: Angew Chem Int Ed Engl, 57:14624, 2018 : PubMed


    Title: Aspergillus fumigatus SidJ Mediates Intracellular Siderophore Hydrolysis
    Grundlinger M, Gsaller F, Schrettl M, Lindner H, Haas H
    Ref: Applied Environmental Microbiology, 79:7534, 2013 : PubMed


    Title: Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function
    Merritt EA, Holmes M, Buckner FS, Van Voorhis WC, Quartly E, Phizicky EM, Lauricella A, Luft J, DeTitta G and Hol WG <2 more author(s)>
    Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 64:474, 2008 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Fusarinine_C_esterase_sidJ family (2)

Genes Proteins in Fusarinine_C_esterase_sidJ family (104)

Fragments of genes in Fusarinine_C_esterase_sidJ family (4)

Substrates of some enzymes in the Fusarinine_C_esterase_sidJ family (1)

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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