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Family Report for: ABHD6-Lip


Family ABHD6-Lip
Block X
Parent Family : Epoxide-hydrolase_like

Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzyme hydrolyzing 26AG (belongs to Monoglyceridelipase_lysophospholip family). . Alpha/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.. A study by Wei et al. shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity. ABHD6 hydrolyzes Bis(monoacylglycerol)phosphate (BMP): a phospholipid crucial for lipid degradation and sorting in acidic organelles and accumulating in Lysosomal storage disorders Pribasnig et al. ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification of Arpigny and Jaeger 1999 Membrane phospholipid remodeling by a bacterial Lands cycle phospholipase A is published by Bleffert et al. PlaF dimerization, mediated solely through the intermolecular interactions of TM and juxtamembrane regions, inhibits its activity. (6I8W). Main substrates include: diacylglycerols, 1(3)-monoacylglycerols with saturated medium or long acyl chains, 2-arachidonoylglycerol, lysophosphatidylinositols, bis(monoacylglycero)phosphate. ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility Wei et al.

no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

26 more
    Title: ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice
    Poursharifi P, Schmitt C, Chenier I, Leung YH, Oppong AK, Bai Y, Klein LL, Al-Mass A, Lussier R and Prentki M <5 more author(s)>
    Ref: Mol Metab, :101822, 2023 : PubMed


    Title: ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility
    Wei M, Yang L, Su F, Liu Y, Zhao X, Luo L, Sun X, Liu S, Dong Z and Zhang C <3 more author(s)>
    Ref: Prog Neurobiol, :102559, 2023 : PubMed


    Title: The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome
    Westenbroek R, Kaplan J, Viray K, Stella N
    Ref: Neurobiol Dis, 180:106099, 2023 : PubMed


Other Papers

No structure scheme yet for this family

Structures in ABHD6-Lip family (4)

Genes Proteins in ABHD6-Lip family (156)

Fragments of genes in ABHD6-Lip family (3)

Substrates of some enzymes in the ABHD6-Lip family (11)

Inhibitors of some enzymes in the ABHD6-Lip family (34)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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