ABHD11-Acetyl_transferase
Relationship
Comment
ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. ABHD11 is an enzyme acting on triacylglycerol. Many yeasts are able to produce ethyl acetate. Enzyme Eat1 from the yeast Wickerhamomyces anomalus showed alcohol acetyltransferase activity with ethanol and acetyl-CoA. Homologs of eat1 are responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts, including S. cerevisiae, and are only distantly related to known alcohol acetyltransferases. Structure of ybfF protein from Escherichia coli (esterase of the large substrates, palmitoyl coenzyme A and malonyl coenzyme A) has been solved. Liu et al. published that: ABHD11 is critical for embryonic stem cell expansion, differentiation and lipid metabolic homeostasis. ABHD11-AS1 is An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human MalignanciesDatabase
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (14)
| Title : ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies - Golla_2022_Noncoding.RNA_8_21 |
| Author(s) : Golla U , Sesham K , Dallavalasa S , Manda NK , Unnam S , Sanapala AK , Nalla S , Kondam S , Kumar R |
| Ref : Noncoding RNA , 8 : , 2022 |
| Abstract : Golla_2022_Noncoding.RNA_8_21 |
| ESTHER : Golla_2022_Noncoding.RNA_8_21 |
| PubMedSearch : Golla_2022_Noncoding.RNA_8_21 |
| PubMedID: 35314614 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex - Bailey_2020_Nat.Commun_11_4046 |
| Author(s) : Bailey PSJ , Ortmann BM , Martinelli AW , Houghton JW , Costa ASH , Burr SP , Antrobus R , Frezza C , Nathan JA |
| Ref : Nat Commun , 11 :4046 , 2020 |
| Abstract : Bailey_2020_Nat.Commun_11_4046 |
| ESTHER : Bailey_2020_Nat.Commun_11_4046 |
| PubMedSearch : Bailey_2020_Nat.Commun_11_4046 |
| PubMedID: 32792488 |
| Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
| Title : ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis - Liu_2020_Front.Cell.Dev.Biol_8_570 |
| Author(s) : Liu G , Ruan Y , Zhang J , Wang X , Wu W , He P , Wang J , Xiong J , Cheng Y , Liu L , Yang Y , Tian Y , Jian R |
| Ref : Front Cell Developmental Biology , 8 :570 , 2020 |
| Abstract : Liu_2020_Front.Cell.Dev.Biol_8_570 |
| ESTHER : Liu_2020_Front.Cell.Dev.Biol_8_570 |
| PubMedSearch : Liu_2020_Front.Cell.Dev.Biol_8_570 |
| PubMedID: 32733886 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice - Park_2019_Neurosci.Res_147_58 |
| Author(s) : Park H , Miyazaki H , Yamanaka T , Nukina N |
| Ref : Neurosci Res , 147 :58 , 2019 |
| Abstract : Park_2019_Neurosci.Res_147_58 |
| ESTHER : Park_2019_Neurosci.Res_147_58 |
| PubMedSearch : Park_2019_Neurosci.Res_147_58 |
| PubMedID: 30391555 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Ethyl acetate production by the elusive alcohol acetyltransferase from yeast - Kruis_2017_Metab.Eng_41_92 |
| Author(s) : Kruis AJ , Levisson M , Mars AE , Van der Ploeg M , Garces Daza F , Ellena V , Kengen SWM , Van der Oost J , Weusthuis RA |
| Ref : Metab Eng , 41 :92 , 2017 |
| Abstract : Kruis_2017_Metab.Eng_41_92 |
| ESTHER : Kruis_2017_Metab.Eng_41_92 |
| PubMedSearch : Kruis_2017_Metab.Eng_41_92 |
| PubMedID: 28356220 |
| Gene_locus related to this paper: wicao-a0a1e3p8s6 , wiccf-k0kpv8 , wicao-a0a1e3p8s8 , wiccf-k0ksn3 , cybfa-a0a061ayy2 |
| Title : Human alpha beta hydrolase domain containing protein 11 and its yeast homolog are lipid hydrolases - Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
| Author(s) : Arya M , Srinivasan M , Rajasekharan R |
| Ref : Biochemical & Biophysical Research Communications , 487 :875 , 2017 |
| Abstract : Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
| ESTHER : Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
| PubMedSearch : Arya_2017_Biochem.Biophys.Res.Commun_487_875 |
| PubMedID: 28465236 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Increased lncRNA ABHD11-AS1 represses the malignant phenotypes of bladder cancer - Chen_2017_Oncotarget_8_28176 |
| Author(s) : Chen M , Li J , Zhuang C , Cai Z |
| Ref : Oncotarget , 8 :28176 , 2017 |
| Abstract : Chen_2017_Oncotarget_8_28176 |
| ESTHER : Chen_2017_Oncotarget_8_28176 |
| PubMedSearch : Chen_2017_Oncotarget_8_28176 |
| PubMedID: 28157695 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha\/beta-hydrolase domain containing 11 (ABHD11) - Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
| Author(s) : Navia-Paldanius D , Patel JZ , Lopez Navarro M , Jakupovic H , Goffart S , Pasonen-Seppanen S , Nevalainen TJ , Jaaskelainen T , Laitinen T , Laitinen JT , Savinainen JR |
| Ref : Eur J Pharm Sci , 93 :253 , 2016 |
| Abstract : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
| ESTHER : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
| PubMedSearch : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
| PubMedID: 27544863 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker in the screening of gastric cancer - Yang_2016_Tumour.Biol_37_1183 |
| Author(s) : Yang Y , Shao Y , Zhu M , Li Q , Yang F , Lu X , Xu C , Xiao B , Sun Y , Guo J |
| Ref : Tumour Biol , 37 :1183 , 2016 |
| Abstract : Yang_2016_Tumour.Biol_37_1183 |
| ESTHER : Yang_2016_Tumour.Biol_37_1183 |
| PubMedSearch : Yang_2016_Tumour.Biol_37_1183 |
| PubMedID: 26280398 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : The Arabidopsis ABHD11 Mutant Accumulates Polar Lipids in Leaves as a Consequence of Absent Acylhydrolase Activity - Vijayakumar_2016_Plant.Physiol_170_180 |
| Author(s) : Vijayakumar A , Vijayaraj P , Vijayakumar AK , Rajasekharan R |
| Ref : Plant Physiol , 170 :180 , 2016 |
| Abstract : Vijayakumar_2016_Plant.Physiol_170_180 |
| ESTHER : Vijayakumar_2016_Plant.Physiol_170_180 |
| PubMedSearch : Vijayakumar_2016_Plant.Physiol_170_180 |
| PubMedID: 26589672 |
| Gene_locus related to this paper: arath-AT4G10030 |
| Title : Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo - Francelle_2015_Neurobiol.Aging_36_1601.e7 |
| Author(s) : Francelle L , Galvan L , Gaillard MC , Petit F , Bernay B , Guillermier M , Bonvento G , Dufour N , Elalouf JM , Hantraye P , Deglon N , de Chaldee M , Brouillet E |
| Ref : Neurobiology of Aging , 36 :1601 e7 , 2015 |
| Abstract : Francelle_2015_Neurobiol.Aging_36_1601.e7 |
| ESTHER : Francelle_2015_Neurobiol.Aging_36_1601.e7 |
| PubMedSearch : Francelle_2015_Neurobiol.Aging_36_1601.e7 |
| PubMedID: 25619660 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance - Lin_2014_Med.Oncol_31_42 |
| Author(s) : Lin X , Yang M , Xia T , Guo J |
| Ref : Med Oncol , 31 :42 , 2014 |
| Abstract : Lin_2014_Med.Oncol_31_42 |
| ESTHER : Lin_2014_Med.Oncol_31_42 |
| PubMedSearch : Lin_2014_Med.Oncol_31_42 |
| PubMedID: 24984296 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Activity-based proteomics: identification of ABHD11 and ESD activities as potential biomarkers for human lung adenocarcinoma - Wiedl_2011_J.Proteomics_74_1884 |
| Author(s) : Wiedl T , Arni S , Roschitzki B , Grossmann J , Collaud S , Soltermann A , Hillinger S , Aebersold R , Weder W |
| Ref : J Proteomics , 74 :1884 , 2011 |
| Abstract : Wiedl_2011_J.Proteomics_74_1884 |
| ESTHER : Wiedl_2011_J.Proteomics_74_1884 |
| PubMedSearch : Wiedl_2011_J.Proteomics_74_1884 |
| PubMedID: 21596165 |
| Title : High-resolution structure of ybfF from Escherichia coli K12: a unique substrate-binding crevice generated by domain arrangement. - Park_2008_J.Mol.Biol_376_1426 |
| Author(s) : Park SY , Lee SH , Lee J , Nishi K , Kim YS , Jung CH , Kim JS |
| Ref : Journal of Molecular Biology , 376 :1426 , 2008 |
| Abstract : Park_2008_J.Mol.Biol_376_1426 |
| ESTHER : Park_2008_J.Mol.Biol_376_1426 |
| PubMedSearch : Park_2008_J.Mol.Biol_376_1426 |
| PubMedID: 18215690 |
| Gene_locus related to this paper: ecoli-ybff |
Structures (3)
Genes Proteins in ABHD11-Acetyl_transferase family (423)
Fragments of genes in ABHD11-Acetyl_transferase family (31)
Structures in ABHD11-Acetyl_transferase family (3)Substrates in ABHD11-Acetyl_transferase family (7)
Inhibitors in ABHD11-Acetyl_transferase family (6)