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Family Report for: ABHD10


Family ABHD10
Block X
Parent Family : Hydrolase_4

Abhydrolase domain-containing protein 10, Mycophenolic acid acyl-glucuronide esterase, mitochondrial. Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is primarily metabolized by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AcMPAG Mycophenolic-acid-acyl-glucuronide). AcMPAG, may be an immunotoxic, and is deglucuronidated by ABBHD10. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 (Cao et al.). The name of this family should not be confounded with family Abhydrolase_10 which is quite far related and contains only sequences from bacteria and fungi

no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

4 more
    Title: ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5
    Cao Y, Qiu T, Kathayat RS, Azizi SA, Thorne AK, Ahn D, Fukata Y, Fukata M, Rice PA, Dickinson BC
    Ref: Nat Chemical Biology, 15:1232, 2019 : PubMed


    Title: An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver
    Ito Y, Fukami T, Yokoi T, Nakajima M
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 42:2109, 2014 : PubMed


    Title: Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver
    Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T
    Ref: Journal of Biological Chemistry, 287:9240, 2012 : PubMed


Other Papers

No structure scheme yet for this family

Structures in ABHD10 family (1)

Genes Proteins in ABHD10 family (151)

Fragments of genes in ABHD10 family (11)

Substrates of some enzymes in the ABHD10 family (5)

Inhibitors of some enzymes in the ABHD10 family (5)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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