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Disease Report for: Gilles de la Tourette syndrome (GTS)

Alternative name(s)|Tourette syndrome;TS
Tourette disorder
Chronic motor tics,included
Mutation|1 mutation:
OMIM: |137580, 126141

( From OMIM) Evidence suggests that mutations in more than one gene can cause Gilles de la Tourette syndrome. Tourette syndrome is a neurobehavioral disorder manifest particularly by motor and vocal tics and associated with behavioral abnormalities. Tics are sudden, brief, intermittent, involuntary or semi-voluntary movements (motor tics) or sounds (phonic or vocal tics). They typically consist of simple, coordinated, repetitive movements, gestures, or utterances that mimic fragments of normal behavior. Motor tics may range from simple blinking, nose twitching, and head jerking to more complex throwing, hitting, or making rude gestures. Prontera et al. showed a heterozygous microdeletion of 135 kb at the 7q36.2 locus in an 8-year-old boy and his father

    Title: DPP6 gene disruption in a family with Gilles de la Tourette syndrome
    Prontera P, Napolioni V, Ottaviani V, Rogaia D, Fusco C, Augello B, Serino D, Parisi V, Bernardini L and Donti E <2 more author(s)>
    Ref: Neurogenetics, 15:237, 2014 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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