Berger N, van der Wel T, Hirschmugl B, Baernthaler T, Gindlhuber J, Fawzy N, Eichmann T, Birner-Gruenberger R, Zimmermann R, van der Stelt M, Wadsack C (2023)
Inhibition of diacylglycerol lipase beta modulates lipid and endocannabinoid levels in the ex vivo human placenta
Front Endocrinol (Lausanne) 14: 1092024
Bianco V, Korbelius M, Vujic N, Akhmetshina A, Amor M, Kolb D, Pirchheim A, Bradic I, Kuentzel KB, Buerger M, Schauer S, Phan HTT, Bulfon D, Hoefler G, Zimmermann R, Kratky D (2023)
Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration
Mol Metab
Bradic I, Kuentzel KB, Honeder S, Grabner GF, Vujic N, Zimmermann R, Birner-Gruenberger R, Kratky D (2022)
Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
Mol Metab
Grabner GF, Guttenberger N, Mayer N, Migglautsch-Sulzer AK, Lembacher-Fadum C, Fawzy N, Bulfon D, Hofer P, Zullig T, Hartig L, Kulminskaya N, Chalhoub G, Schratter M, Radner FPW, Preiss-Landl K, Masser S, Lass A, Zechner R, Gruber K, Oberer M, Breinbauer R, Zimmermann R (2022)
Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes
Journal of the American Chemical Society
Pusch LM, Riegler-Berket L, Oberer M, Zimmermann R, Taschler U (2022)
alpha/beta-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase
Metabolites 12:
Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda O, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M (2021)
Hepatocyte-specific deletion of adipose triglyceride lipase (ATGL/PNPLA2) ameliorates dietary induced steatohepatitis in mice
Hepatology
Kulminskaya N, Radler C, Viertlmayr R, Heier C, Hofer P, Colaco-Gaspar M, Owens RJ, Zimmermann R, Schreiber R, Zechner R, Oberer M (2021)
Optimized expression and purification of adipose triglyceride lipase improved hydrolysis and transacylation catalytic activities in vitro
Journal of Biological Chemistry
Mayer N, Schweiger M, Fuchs E, Migglautsch AK, Doler C, Grabner GF, Romauch M, Melcher MC, Zechner R, Zimmermann R, Breinbauer R (2020)
Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)
Bioorganic & Medicinal Chemistry 28: 115610
Syal C, Kosaraju J, Hamilton L, Aumont A, Chu A, Sarma SN, Thomas J, Seegobin M, Dilworth FJ, He L, Wondisford FE, Zimmermann R, Parent M, Fernandes K, Wang J (2020)
Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease
Theranostics 10: 6337
Wagner C, Hois V, Pajed L, Pusch LM, Wolinski H, Trauner M, Zimmermann R, Taschler U, Lass A (2020)
Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation
Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids 1865: 158730
Grabner GF, Fawzy N, Pribasnig MA, Trieb M, Taschler U, Holzer M, Schweiger M, Wolinski H, Kolb D, Horvath A, Breinbauer R, Rulicke T, Rabl R, Lass A, Stadlbauer V, Hutter-Paier B, Stauber RE, Fickert P, Zechner R, Marsche G, Eichmann TO, Zimmermann R (2019)
Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans
J Lipid Res 60: 1020
Hehlert P, Hofferek V, Heier C, Eichmann TO, Riedel D, Rosenberg J, Takacs A, Nagy HM, Oberer M, Zimmermann R, Kuhnlein RP (2019)
The alpha/beta-hydrolase domain-containing 4- and 5-related phospholipase Pummelig controls energy storage in Drosophila
J Lipid Res 60: 1365
Pajed L, Wagner C, Taschler U, Schreiber R, Kolleritsch S, Fawzy N, Pototschnig I, Schoiswohl G, Pusch LM, Wieser BI, Vesely P, Hoefler G, Eichmann TO, Zimmermann R, Lass A (2019)
Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation
Journal of Biological Chemistry 294: 9118
Aschauer P, Zimmermann R, Breinbauer R, Pavkov-Keller T, Oberer M (2018)
The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition
Sci Rep 8: 8948
Padmanabha Das KM, Wechselberger L, Liziczai M, De la Rosa Rodriguez M, Grabner GF, Heier C, Viertlmayr R, Radler C, Lichtenegger J, Zimmermann R, Borst JW, Zechner R, Kersten S, Oberer M (2018)
Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase
J Lipid Res 59: 531
Schweiger M, Romauch M, Schreiber R, Grabner GF, Hutter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R (2017)
Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
Nat Commun 8: 14859
Vujic N, Korbelius M, Leopold C, Duta-Mare M, Rainer S, Schlager S, Goeritzer M, Kolb D, Eichmann TO, Diwoky C, Zimmer A, Zimmermann R, Lass A, Radovic B, Kratky D (2017)
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice
Oncotarget 8: 33122
Aschauer P, Rengachari S, Lichtenegger J, Schittmayer M, Das KM, Mayer N, Breinbauer R, Birner-Gruenberger R, Gruber CC, Zimmermann R, Gruber K, Oberer M (2016)
Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p
Biochimica & Biophysica Acta 1861: 462
Grabner GF, Eichmann TO, Wagner B, Gao Y, Farzi A, Taschler U, Radner FP, Schweiger M, Lass A, Holzer P, Zinser E, Tschop MH, Yi CX, Zimmermann R (2016)
Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation
Journal of Biological Chemistry 291: 913
Grumet L, Eichmann TO, Taschler U, Zierler KA, Leopold C, Moustafa T, Radovic B, Romauch M, Yan C, Du H, Haemmerle G, Zechner R, Fickert P, Kratky D, Zimmermann R, Lass A (2016)
Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover
Journal of Biological Chemistry 291: 17977
Heier C, Taschler U, Radulovic M, Aschauer P, Eichmann TO, Grond S, Wolinski H, Oberer M, Zechner R, Kohlwein SD, Zimmermann R (2016)
Monoacylglycerol Lipases Act as Evolutionarily Conserved Regulators of Non-oxidative Ethanol Metabolism
Journal of Biological Chemistry 291: 11865
Eichmann TO, Grumet L, Taschler U, Hartler J, Heier C, Woblistin A, Pajed L, Kollroser M, Rechberger G, Thallinger GG, Zechner R, Haemmerle G, Zimmermann R, Lass A (2015)
ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6
J Lipid Res 56: 1972
Hofer P, Boeszoermenyi A, Jaeger D, Feiler U, Arthanari H, Mayer N, Zehender F, Rechberger G, Oberer M, Zimmermann R, Lass A, Haemmerle G, Breinbauer R, Zechner R, Preiss-Landl K (2015)
Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling
Journal of Biological Chemistry 290: 18438
Mayer N, Schweiger M, Melcher MC, Fledelius C, Zechner R, Zimmermann R, Breinbauer R (2015)
Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)
Bioorganic & Medicinal Chemistry 23: 2904
Navia-Paldanius D, Aaltonen N, Lehtonen M, Savinainen JR, Taschler U, Radner FP, Zimmermann R, Laitinen JT (2015)
Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase
Eur J Pharm Sci 77: 180
Pribasnig MA, Mrak I, Grabner GF, Taschler U, Knittelfelder O, Scherz B, Eichmann TO, Heier C, Grumet L, Kowaliuk J, Romauch M, Holler S, Anderl F, Wolinski H, Lass A, Breinbauer R, Marsche G, Brown JM, Zimmermann R (2015)
alpha/beta Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate
Journal of Biological Chemistry 290: 29869
Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R (2015)
Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity
Proc Natl Acad Sci U S A 112: 13850
Taschler U, Schreiber R, Chitraju C, Grabner GF, Romauch M, Wolinski H, Haemmerle G, Breinbauer R, Zechner R, Lass A, Zimmermann R (2015)
Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells
Biochimica & Biophysica Acta 1851: 937
Vujic N, Schlager S, Eichmann TO, Madreiter-Sokolowski CT, Goeritzer M, Rainer S, Schauer S, Rosenberger A, Woelfler A, Doddapattar P, Zimmermann R, Hoefler G, Lass A, Graier WF, Radovic B, Kratky D (2015)
Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice
Atherosclerosis 244: 9
Nagy HM, Paar M, Heier C, Moustafa T, Hofer P, Haemmerle G, Lass A, Zechner R, Oberer M, Zimmermann R (2014)
Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A
Biochimica & Biophysica Acta 1841: 588
Alsted TJ, Ploug T, Prats C, Serup AK, Hoeg L, Schjerling P, Holm C, Zimmermann R, Fledelius C, Galbo H, Kiens B (2013)
Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle
Journal of Physiology 591: 5141
Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, Ivkovic J, Heier C, Mrak I, Lass A, Hofler G, Fledelius C, Zechner R, Zimmermann R, Breinbauer R (2013)
Development of small-molecule inhibitors targeting adipose triglyceride lipase
Nat Chemical Biology 9: 785
Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM (2013)
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome
Cell Rep 5: 508
Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R (2012)
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase
Cell Metab 15: 691
Rengachari S, Bezerra GA, Riegler-Berket L, Gruber CC, Sturm C, Taschler U, Boeszoermenyi A, Dreveny I, Zimmermann R, Gruber K, Oberer M (2012)
The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes
Biochimica & Biophysica Acta 1821: 1012
Cornaciu I, Boeszoermenyi A, Lindermuth H, Nagy HM, Cerk IK, Ebner C, Salzburger B, Gruber A, Schweiger M, Zechner R, Lass A, Zimmermann R, Oberer M (2011)
The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively
PLoS ONE 6: e26349
Das SK, Eder S, Schauer S, Diwoky C, Temmel H, Guertl B, Gorkiewicz G, Tamilarasan KP, Kumari P, Trauner M, Zimmermann R, Vesely P, Haemmerle G, Zechner R, Hoefler G (2011)
Adipose triglyceride lipase contributes to cancer-associated cachexia
Science 333: 233
Lass A, Zimmermann R, Oberer M, Zechner R (2011)
Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
Prog Lipid Res 50: 14
Buchebner M, Pfeifer T, Rathke N, Chandak PG, Lass A, Schreiber R, Kratzer A, Zimmermann R, Sattler W, Koefeler H, Frohlich E, Kostner GM, Birner-Gruenberger R, Chiang KP, Haemmerle G, Zechner R, Levak-Frank S, Cravatt B, Kratky D (2010)
Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363
J Lipid Res 51: 2896
Gruber A, Cornaciu I, Lass A, Schweiger M, Poeschl M, Eder C, Kumari M, Schoiswohl G, Wolinski H, Kohlwein SD, Zechner R, Zimmermann R, Oberer M (2010)
The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
Journal of Biological Chemistry 285: 12289
Heier C, Taschler U, Rengachari S, Oberer M, Wolinski H, Natter K, Kohlwein SD, Leber R, Zimmermann R (2010)
Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae
Biochimica & Biophysica Acta 1801: 1063
Radner FP, Streith IE, Schoiswohl G, Schweiger M, Kumari M, Eichmann TO, Rechberger G, Koefeler HC, Eder S, Schauer S, Theussl HC, Preiss-Landl K, Lass A, Zimmermann R, Hoefler G, Zechner R, Haemmerle G (2010)
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
Journal of Biological Chemistry 285: 7300
Schoiswohl G, Schweiger M, Schreiber R, Gorkiewicz G, Preiss-Landl K, Taschler U, Zierler KA, Radner FP, Eichmann TO, Kienesberger PC, Eder S, Lass A, Haemmerle G, Alsted TJ, Kiens B, Hoefler G, Zechner R, Zimmermann R (2010)
Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids
J Lipid Res 51: 490
Alsted TJ, Nybo L, Schweiger M, Fledelius C, Jacobsen P, Zimmermann R, Zechner R, Kiens B (2009)
Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
American Journal of Physiology Endocrinol Metab 296: E445
Schweiger M, Lass A, Zimmermann R, Eichmann TO, Zechner R (2009)
Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5
American Journal of Physiology Endocrinol Metab 297: E289
Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A (2009)
Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
J Lipid Res 50: 3
Zimmermann R, Lass A, Haemmerle G, Zechner R (2009)
Fate of fat: the role of adipose triglyceride lipase in lipolysis
Biochimica & Biophysica Acta 1791: 494
Kienesberger PC, Lass A, Preiss-Landl K, Wolinski H, Kohlwein SD, Zimmermann R, Zechner R (2008)
Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase
Journal of Biological Chemistry 283: 5908
Schweiger M, Schoiswohl G, Lass A, Radner FP, Haemmerle G, Malli R, Graier W, Cornaciu I, Oberer M, Salvayre R, Fischer J, Zechner R, Zimmermann R (2008)
The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding
Journal of Biological Chemistry 283: 17211
Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R (2006)
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
Science 312: 734
Kurat CF, Natter K, Petschnigg J, Wolinski H, Scheuringer K, Scholz H, Zimmermann R, Leber R, Zechner R, Kohlwein SD (2006)
Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast
Journal of Biological Chemistry 281: 491
Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, Kienesberger P, Strauss JG, Gorkiewicz G, Zechner R (2006)
Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
Cell Metab 3: 309
Schoenborn V, Heid IM, Vollmert C, Lingenhel A, Adams TD, Hopkins PN, Illig T, Zimmermann R, Zechner R, Hunt SC, Kronenberg F (2006)
The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
Diabetes 55: 1270
Schweiger M, Schreiber R, Haemmerle G, Lass A, Fledelius C, Jacobsen P, Tornqvist H, Zechner R, Zimmermann R (2006)
Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
Journal of Biological Chemistry 281: 40236
Tschernatsch MM, Mlecnik B, Trajanoski Z, Zechner R, Zimmermann R (2006)
LPL-mediated lipolysis of VLDL induces an upregulation of AU-rich mRNAs and an activation of HuR in endothelial cells
Atherosclerosis 189: 310
Birner-Gruenberger R, Susani-Etzerodt H, Waldhuber M, Riesenhuber G, Schmidinger H, Rechberger G, Kollroser M, Strauss JG, Lass A, Zimmermann R, Haemmerle G, Zechner R, Hermetter A (2005)
The lipolytic proteome of mouse adipose tissue
Mol Cell Proteomics 4: 1710
Jandrositz A, Petschnigg J, Zimmermann R, Natter K, Scholze H, Hermetter A, Kohlwein SD, Leber R (2005)
The lipid droplet enzyme Tgl1p hydrolyzes both steryl esters and triglycerides in the yeast, Saccharomyces cerevisiae
Biochimica & Biophysica Acta 1735: 50
Kratky D, Zimmermann R, Wagner EM, Strauss JG, Jin W, Kostner GM, Haemmerle G, Rader DJ, Zechner R (2005)
Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue
J Clinical Investigation 115: 161
Zechner R, Strauss JG, Haemmerle G, Lass A, Zimmermann R (2005)
Lipolysis: pathway under construction
Curr Opin Lipidol 16: 333
Haemmerle G, Zimmermann R, Zechner R (2003)
Letting lipids go: hormone-sensitive lipase
Curr Opin Lipidol 14: 289
Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA (2003)
Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
Endocrinology 144: 3456
Haemmerle G, Zimmermann R, Strauss JG, Kratky D, Riederer M, Knipping G, Zechner R (2002)
Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle
Journal of Biological Chemistry 277: 12946
Preiss-Landl K, Zimmermann R, Hammerle G, Zechner R (2002)
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism
Curr Opin Lipidol 13: 471
Wang X, Greilberger J, Levak-Frank S, Zimmermann R, Zechner R, Jurgens G (1999)
Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages
Biochemical Journal 343 Pt 2: 347