Wang X, Shi J, Zhu HJ (2023)
Targeted Absolute Protein Quantification Using SILAC Internal Standard and Full-Length Protein Calibrators (TAQSI)
Methods Mol Biol 2603: 269

Her L, Shi J, Wang X, He B, Smith L, Jiang H, Zhu HJ (2022)
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms

Xiao J, Shi J, Thompson BR, Smith DE, Zhang T, Zhu HJ (2022)
Physiologically-based pharmacokinetic modeling to predict methylphenidate exposure affected by interplay among carboxylesterase 1 pharmacogenetics, drug-drug interactions, and sex
J Pharm Sci

Collins JM, Lu R, Wang X, Zhu HJ, Wang D (2021)
Transcriptional regulation of carboxylesterase 1 (CES1) in human liver: role of the nuclear receptor NR1H3 (LXRalpha) and its splice isoforms
Drug Metabolism & Disposition: The Biological Fate of Chemicals

Her LH, Wang X, Shi J, Choi HJ, Jung SM, Smith LS, Wu AH, Bleske BE, Zhu HJ (2021)
Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects
British Journal of Clinical Pharmacology

Li J, Liu S, Shi J, Zhu HJ (2021)
Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection
Pharmaceutics 13:

Li J, Shi J, Xiao J, Tran L, Wang X, Zhu HJ (2021)
Contributions of Cathepsin A and Carboxylesterase 1 to the hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis
Drug Metabolism & Disposition: The Biological Fate of Chemicals

Shi J, Xiao J, Wang X, Jung SM, Bleske BE, Markowitz JS, Patrick KS, Zhu HJ (2021)
Plasma carboxylesterase 1 predicts methylphenidate exposure: a proof-of-concept study using plasma protein biomarker for hepatic drug metabolism
Clinical Pharmacology & Therapeutics

Wang X, Her L, Xiao J, Shi J, Wu AH, Bleske BE, Zhu HJ (2021)
Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers
Clin Transl Sci

Her L, Zhu HJ (2020)
Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators
Drug Metabolism & Disposition: The Biological Fate of Chemicals 48: 230

Shenoy VM, Thompson BR, Shi J, Zhu HJ, Smith DE, Amidon GL (2020)
Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme
Mol Pharm 17: 1706

Shi J, Xiao J, Li J, Wang X, Her L, Sorensen MJ, Zhu HJ (2020)
FRACPRED-2D-PRM: A fraction prediction algorithm-assisted two-dimensional liquid chromatography-based parallel reaction monitoring-mass spectrometry approach for measuring low-abundance proteins in human plasma

He B, Shi J, Wang X, Jiang H, Zhu HJ (2019)
Label-free absolute protein quantification with data-independent acquisition
J Proteomics 200: 51

Hu Y, Epling D, Shi J, Song F, Tsume Y, Zhu HJ, Amidon GL, Smith DE (2018)
Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice
Biochemical Pharmacology 156: 147

Wang X, Shi J, Zhu HJ (2018)
Functional study of Carboxylesterase 1 protein isoforms

Wang X, Rida N, Shi J, Wu AH, Bleske BE, Zhu HJ (2017)
A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms
Drug Metabolism & Disposition: The Biological Fate of Chemicals 45: 1149

Zhu HJ, Patrick KS, Straughn AB, Reeves OT, 3rd, Bernstein H, Shi J, Johnson HJ, Knight JM, Smith AT, Malcolm RJ, Markowitz JS (2017)
Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers
J Clin Psychopharmacol 37: 419

Sanford JC, Wang X, Shi J, Barrie ES, Wang D, Zhu HJ, Sadee W (2016)
Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus
Pharmacogenet Genomics 26: 197

Shi J, Wang X, Nguyen J, Wu AH, Bleske BE, Zhu HJ (2016)
Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation
Drug Metabolism & Disposition: The Biological Fate of Chemicals 44: 554

Shi J, Wang X, Nguyen JH, Bleske BE, Liang Y, Liu L, Zhu HJ (2016)
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender
Biochemical Pharmacology 119: 76

Shi J, Wang X, Eyler RF, Liang Y, Liu L, Mueller BA, Zhu HJ (2016)
Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms
Basic Clin Pharmacol Toxicol 119: 555

Wang X, Liang Y, Liu L, Shi J, Zhu HJ (2016)
Targeted absolute quantitative proteomics with SILAC internal standards and unlabeled full-length protein calibrators (TAQSI)
Rapid Commun Mass Spectrom 30: 553

Wang X, Wang G, Shi J, Aa JY, Comas R, Liang Y, Zhu HJ (2016)
CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors
Pharmacogenomics J 16: 220

Zhu HJ, Langaee TY, Gong Y, Wang X, Pepine CJ, Cooper-DeHoff RM, Johnson JA, Markowitz JS (2016)
CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril
European Journal of Clinical Pharmacology 72: 681

Wang X, Zhu HJ, Markowitz JS (2015)
Carboxylesterase 1-Mediated Drug-Drug Interactions between Clopidogrel and Simvastatin
Biol Pharm Bull 38: 292

Kristensen KE, Zhu HJ, Wang X, Gislason GH, Torp-Pedersen C, Rasmussen HB, Markowitz JS, Hansen PR (2014)
Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study
Clinical Pharmacology & Therapeutics 96: 713

Markowitz JS, Zhu HJ, Patrick KS (2013)
Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability
J Child Adolesc Psychopharmacol 23: 648

Zhu HJ, Markowitz JS (2013)
Carboxylesterase 1 (CES1) genetic polymorphisms and oseltamivir activation
European Journal of Clinical Pharmacology 69: 733

Zhu HJ, Wang X, Gawronski BE, Brinda BJ, Angiolillo DJ, Markowitz JS (2013)
Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation
Journal of Pharmacology & Experimental Therapeutics 344: 665

Rhoades JA, Peterson YK, Zhu HJ, Appel DI, Peloquin CA, Markowitz JS (2012)
Prediction and in vitro evaluation of selected protease inhibitor antiviral drugs as inhibitors of carboxylesterase 1: a potential source of drug-drug interactions
Pharm Res 29: 972

Zhu HJ, Brinda B, Froehlich TE, Markowitz JS (2012)
A discriminative analytical method for detection of CES1A1 and CES1A2/CES1A3 genetic variants
Pharmacogenet Genomics 22: 215

Zhu HJ, Patrick KS, Markowitz JS (2011)
Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography-tandem mass spectrometry: Application to human ethanol interactions
Journal of Chromatography B Analyt Technol Biomed Life Sciences 879: 783

Zhu HJ, Appel DI, Peterson YK, Wang Z, Markowitz JS (2010)
Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions
Toxicology 270: 59

Zhu HJ, Appel DI, Johnson JA, Chavin KD, Markowitz JS (2009)
Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril
Biochemical Pharmacology 77: 1266

Zhu HJ, Markowitz JS (2009)
Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants
Drug Metabolism & Disposition: The Biological Fate of Chemicals 37: 264

Zhu HJ, Appel DI, Jiang Y, Markowitz JS (2009)
Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver
Drug Metabolism & Disposition: The Biological Fate of Chemicals 37: 1819

Jiang MY, Wang F, Yang XL, Fang LZ, Dong ZJ, Zhu HJ, Liu JK (2008)
Derivatives of vibralactone from cultures of the basidiomycete Boreostereum vibrans
Chem Pharm Bull (Tokyo) 56: 1286

LeVasseur NL, Zhu HJ, Markowitz JS, DeVane CL, Patrick KS (2008)
Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping
Journal of Chromatography B Analyt Technol Biomed Life Sciences 862: 140

Tang NP, Wang LS, Yang L, Zhou B, Gu HJ, Sun QM, Cong RH, Zhu HJ, Wang B (2008)
Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
J Lipid Res 49: 369

Zhu HJ, Patrick KS, Yuan HJ, Wang JS, Donovan JL, DeVane CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS (2008)
Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis
American Journal of Human Genetics 82: 1241

Liu DZ, Wang F, Liao TG, Tang JG, Steglich W, Zhu HJ, Liu JK (2006)
Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans
Org Lett 8: 5749