Sternfeld M, Rachmilewitz J, Loewenstein-Lichtenstein Y, Andres C, Timberg R, Ben-Ari S, Glick C, Soreq H, Zakut H (1997)
Normal and atypical butyrylcholinesterases in placental development, function, and malfunction
Cellular Molecular Neurobiology 17: 315
Loewenstein-Lichtenstein Y, Glick D, Gluzman N, Sternfeld M, Zakut H, Soreq H (1996)
Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis
Molecular Pharmacology 50: 1423
Dobianer K, Hruza C, Ehrlich G, Sevelda P, Czerwenka K, Soreq H, Spona J, Zakut H (1995)
HER-2 amplification but not butyrylcholinesterase multability reflects aggressiveness of European-originated ovarian tumors
Gynecologic Oncology 56: 200
Loewenstein Y, Schwarz M, Glick D, Norgaard-Pedersen B, Zakut H, Soreq H (1995)
Genetic Predisposition for Variable Response to Anticholinesterase Therapy Anticipated in Carriers of the Butyrylcholinesterase Atypical Mutation
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 471
Loewenstein-Lichtenstein Y, Schwarz M, Glick D, Norgaard-Pedersen B, Zakut H, Soreq H (1995)
Genetic predisposition to adverse consequences of anti-cholinesterases in 'atypical' BCHE carriers
Nat Med 1: 1082
Soreq H, Lev-Lehman E, Patinkin D, Grifman M, Ehrlich G, Ginzberg D, Eckstein F, Zakut H (1995)
Antisense Oligonucleotides Suppressing Expression of Cholinesterase Genes Modulate Hematopoiesis in Vivo and ex Vivo
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 1
Beeri R, Gnatt A, Lapidot-Lifson Y, Ginzberg D, Shani M, Soreq H, Zakut H (1994)
Testicular amplification and impaired transmission of human butyrylcholinesterase cDNA in transgenic mice
Hum Reprod 9: 284
Ehrlich G, Patinkin D, Ginzberg D, Zakut H, Eckstein F, Soreq H (1994)
Use of partially phosphorothioated antisense oligodeoxynucleotides for sequence-dependent modulation of hematopoiesis in culture
Antisense Research Development 4: 173
Ehrlich G, Ginzberg D, Loewenstein Y, Glick D, Kerem B, Ben-Ari S, Zakut H, Soreq H (1994)
Population diversity and distinct haplotype frequencies associated with ACHE and BCHE genes of Israeli Jews from trans-Caucasian Georgia and from Europe
Genomics 22: 288
Karpel R, Ben-Aziz-Aloya R, Sternfeld M, Ehrlich G, Ginzberg D, Tarroni P, Clementi F, Zakut H, Soreq H (1994)
Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins
Experimental Cell Research 210: 268
Lev-Lehman E, Ginzberg D, Hornreich G, Ehrlich G, Meshorer A, Eckstein F, Soreq H, Zakut H (1994)
Antisense inhibition of acetylcholinesterase gene expression causes transient hematopoietic alterations in vivo
Gene Therapy 1: 127
Patinkin D, Lev-Lehman E, Zakut H, Eckstein F, Soreq H (1994)
Antisense inhibition of butyrylcholinesterase gene expression predicts adverse hematopoietic consequences to cholinesterase inhibitors
Cellular Molecular Neurobiology 14: 459
Soreq H, Patinkin D, Lev-Lehman E, Grifman M, Ginzberg D, Eckstein F, Zakut H (1994)
Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo
Proc Natl Acad Sci U S A 91: 7907
Soreq H, Ehrlich G, Schwarz M, Loewenstein Y, Glick D, Zakut H (1994)
Mutations and impaired expression in the ACHE and BCHE genes: neurological implications
Biomed Pharmacother 48: 253
Ben-Aziz-Aloya R, Seidman S, Timberg R, Sternfeld M, Zakut H, Soreq H (1993)
Expression of a human acetylcholinesterase promoter-reporter construct in developing neuromuscular junctions of Xenopus embryos
Proceedings of the National Academy of Sciences of the United States of America 90: 2471
Loewenstein Y, Denarie M, Zakut H, Soreq H (1993)
Molecular dissection of cholinesterase domains responsible for carbamate toxicity
Chemico-Biological Interactions 87: 209
Loewenstein Y, Gnatt A, Neville LF, Zakut H, Soreq H (1993)
Structure-function relationship studies in human cholinesterases reveal genomic origins for individual variations in cholinergic drug responses.
Prog Neuropsychopharmacol Biological Psychiatry 17: 905
Ehrlich G, Viegas-Pequignot E, Ginzberg D, Sindel L, Soreq H, Zakut H (1992)
Mapping the human acetylcholinesterase gene to chromosome 7q22 by fluorescent in situ hybridization coupled with selective PCR amplification from a somatic hybrid cell panel and chromosome-sorted DNA libraries
Genomics 13: 1192
Lapidot-Lifson Y, Patinkin D, Prody CA, Ehrlich G, Seidman S, Ben-Aziz R, Benseler F, Eckstein F, Zakut H, Soreq H (1992)
Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis
Proc Natl Acad Sci U S A 89: 579
Soreq H, Meir R, Zakut H (1992)
[Medical aspects and structural implications of cholinesterase inhibitors]
Harefuah 123: 100
Zakut H, Lapidot-Lifson Y (1992)
Clinical Implications of Cholinesterase Aberrations in Syndromes of Hemopoietic Cell Division
In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases (Shafferman, A. and Velan, B., Eds) Plenum Press, New York: 269
Zakut H, Lapidot-Lifson Y, Beeri R, Ballin A, Soreq H (1992)
In vivo gene amplification in non-cancerous cells: cholinesterase genes and oncogenes amplify in thrombocytopenia associated with lupus erythematosus
Mutation Research 276: 275
Ben-Aziz R, Gnatt A, Prody C, Lev-Lehman E, Neville LF, Seidman S, Ginzberg D, Soreq H, Lapidot-Lifson Y, Zakut H (1991)
Differential Codon Usage and Distinct Surface Probabilities in Human Acetylcholinesterase and Butyrylcholinesterase
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 172
Dreyfus PA, Pincon-Raymond M, Zakut H, Seidman S, Soreq H (1991)
Search for the Molecular Origins of Butyrylcholinesterase Polymorphism by cDNA Screening, Deletion Mutagenesis, and Xenopus Oocyte Co-Injections
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 162
Gnatt A, Ginzberg D, Lieman-Hurwitz J, Zamir R, Zakut H, Soreq H (1991)
Human acetylcholinesterase and butyrylcholinesterase are encoded by two distinct genes
Cellular Molecular Neurobiology 11: 91
Soreq H, Lapidot-Lifson Y, Zakut H (1991)
A role for cholinesterases in tumorigenesis?. [Review] [48 refs]
Cancer Cells 3: 511
Zakut H, Lieman-Hurwitz J, Zamir R, Sindell L, Ginzberg D, Soreq H (1991)
Chorionic villus cDNA library displays expression of butyrylcholinesterase: putative genetic disposition for ecological danger
Prenat Diagnos 11: 597
Gnatt A, Prody CA, Zamir R, Lieman-Hurwitz J, Zakut H, Soreq H (1990)
Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors
Cancer Research 50: 1983
Patinkin D, Seidman S, Eckstein F, Benseler F, Zakut H, Soreq H (1990)
Manipulations of cholinesterase gene expression modulate murine megakaryocytopoiesis in vitro
Molecular & Cellular Biology 10: 6046
Soreq H, Zakut H (1990)
Amplification of butyrylcholinesterase and acetylcholinesterase genes in normal and tumor tissues: putative relationship to organophosphorous poisoning
Pharm Res 7: 1
Soreq H, Zakut H (1990)
Expression and in vivo amplification of the human acetylcholinesterase and butyrylcholinesterase genes
Prog Brain Res 84: 51
Zakut H, Ehrlich G, Ayalon A, Prody CA, Malinger G, Seidman S, Ginzberg D, Kehlenbach R, Soreq H (1990)
Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas
Journal of Clinical Investigation 86: 900
Dreyfus PA, Seidman S, Pincon-Raymond M, Murawsky M, Rieger F, Schejter E, Zakut H, Soreq H (1989)
Tissue-specific processing and polarized compartmentalization of clone-produced cholinesterase in microinjected Xenopus oocytes
Cellular Molecular Neurobiology 9: 323
Lapidot-Lifson Y, Prody CA, Ginzberg D, Meytes D, Zakut H, Soreq H (1989)
Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis
Proceedings of the National Academy of Sciences of the United States of America 86: 4715
Ludgate M, Dong Q, Dreyfus PA, Zakut H, Taylor P, Vassart G, Soreq H (1989)
Definition, at the molecular level, of a thyroglobulin- acetylcholinesterase shared epitope: study of its pathophysiological significance in patients with Graves' ophthalmopathy
Autoimmunity 3: 167
Malinger G, Zakut H, Soreq H (1989)
Cholinoceptive properties of human primordial, preantral, and antral oocytes: in situ hybridization and biochemical evidence for expression of cholinesterase genes
Journal of Molecular Neuroscience 1: 77
Prody CA, Dreyfus PA, Zamir R, Zakut H, Soreq H (1989)
De novo amplification within a silent human cholinesterase gene in a family subjected to prolonged exposure to organophosphorous insecticides
Proceedings of the National Academy of Sciences of the United States of America 86: 690
Soreq H, Seidman S, Dreyfus PA, Zevin-Sonkin D, Zakut H (1989)
Expression and tissue-specific assembly of human butyrylcholine esterase in microinjected Xenopus laevis oocytes
Journal of Biological Chemistry 264: 10608
Zakut H, Zamir R, Sindel L, Soreq H (1989)
Gene mapping on chorionic villi chromosomes by hybridization in situ: localization of cholinesterase cDNA binding sites to chromosomes 3q21, 3q26-ter and 16q21
Hum Reprod 4: 941
Zakut H, Zamir R, Soreq H (1989)
[In-situ hybridization on chorionic villi chromosomes]. [Hebrew]
Harefuah 116: 81
Dreyfus PA, Zevin-Sonkin D, Seidman S, Prody CA, Zisling R, Zakut H, Soreq H (1988)
Cross-homologies and structural differences between human cholinesterases revealed by antibodies against cDNA-produced human butyrylcholinesterase peptides
Journal of Neurochemistry 51: 1858
Livneh A, Sarova I, Michaeli D, Pras M, Wagner K, Zakut H, Soreq H (1988)
Antibodies against acetylcholinesterase and low levels of cholinesterases in a patient with an atypical neuromuscular disorder
Clinical Immunology & Immunopathology 48: 119
Zakut H, Even L, Birkenfeld S, Malinger G, Zisling R, Soreq H (1988)
Modified properties of serum cholinesterases in primary carcinomas
Cancer 61: 727
Soreq H, Zamir R, Zevin-Sonkin D, Zakut H (1987)
Human cholinesterase genes localized by hybridization to chromosomes 3 and 16
Hum Genet 77: 325
Soreq H, Malinger G, Zakut H (1987)
Expression of cholinesterase genes in human oocytes revealed by in-situ hybridization
Hum Reprod 2: 689
Dziegielewska KM, Saunders NR, Schejter EJ, Zakut H, Zevin-Sonkin D, Zisling R, Soreq H (1986)
Synthesis of plasma proteins in fetal, adult, and neoplastic human brain tissue
Developmental Biology 115: 93
Egozi Y, Sokolovsky M, Schejter E, Blatt I, Zakut H, Matzkel A, Soreq H (1986)
Divergent regulation of muscarinic binding sites and acetylcholinesterase in discrete regions of the developing human fetal brain
Cellular Molecular Neurobiology 6: 55
Soreq H, Dziegielewska KM, Zevin-Sonkin D, Zakut H (1986)
The use of mRNA translation in vitro and in ovo followed by crossed immunoelectrophoretic autoradiography to study the biosynthesis of human cholinesterases
Cellular Molecular Neurobiology 6: 227
Zakut H, Matzkel A, Schejter E, Avni A, Soreq H (1985)
Polymorphism of acetylcholinesterase in discrete regions of the developing human fetal brain
Journal of Neurochemistry 45: 382