Xu R, Bao Y, Li M, Zhang Y, Xi L, Guo J (2023)
Computational Insights into the Allosteric Modulation of a Phthalate-Degrading Hydrolase by Distal Mutations
Biomolecules 13:
Fang Q, Liu X, Ding J, Zhang Z, Chen G, Du T, Wang Y, Xu R (2022)
Soluble Epoxide Hydrolase Inhibition Protected against Diabetic Cardiomyopathy through Inducing Autophagy and Reducing Apoptosis Relying on Nrf2 Upregulation and Transcription Activation
Oxid Med Cell Longev 2022: 3773415
Fu Y, Zhao D, Zhou Y, Lu J, Kang L, Jiang X, Xu R, Ding Z, Zou Y (2022)
Identification of Differential Expression Genes between Volume and Pressure Overloaded Hearts Based on Bioinformatics Analysis
Genes (Basel) 13:
Wang L, Mirabella VR, Dai R, Su X, Xu R, Jadali A, Bernabucci M, Singh I, Chen Y, Tian J, Jiang P, Kwan KY, Pak C, Liu C, Comoletti D, Hart RP, Chen C, Sudhof TC, Pang ZP (2022)
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
Mol Psychiatry
Yuan X, Shayiranbieke A, Xu R, Jiang H, Yang Y, Zhang Y, Yin G, Zhao X (2022)
Site-selective covalently immobilized alpha 1A adrenergic receptor for thermodynamic and extra-thermodynamic study of four ligands binding to the receptor by chromatographic methods
Journal of Chromatography A 1665: 462827
Zhang X, Xu W, Xu R, Wang Z, Wang P, Peng K, Li M, Li J, Tan Y, Wang X, Pei H (2022)
Plin5 Bidirectionally Regulates Lipid Metabolism in Oxidative Tissues
Oxid Med Cell Longev 2022: 4594956
Zhu G, Bai P, Wang K, Mi J, Yang J, Hu J, Ban Y, Xu R, Chen R, Wang C, Tang L, Sang Z (2022)
Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease
J Enzyme Inhib Med Chem 37: 1375
Li X, Chen T, Xu R, Huang M, Huang J, Xie Q, Liu F, Su S, Ma K (2021)
Identification, characterization and mRNA transcript abundance profiles of the carboxylesterase (CXE5) gene in Eriocheir sinensis suggest that it may play a role in methyl farnesoate degradation
Comparative Biochemistry & Physiology B Biochem Mol Biol
Ye C, Xu R, Cao Z, Song Q, Yu G, Shi Y, Liu Z, Liu X, Deng Y (2021)
Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents
Bioorg Chem 111: 104895
Zhao X, Fu X, Yuan X, Shayiranbieke A, Xu R, Cao F, Ren J, Liang Q (2021)
Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor
Journal of Chromatography A 1653: 462443
Xu R, Xiao G, Li Y, Liu H, Song Q, Zhang X, Yang Z, Zheng Y, Tan Z, Deng Y (2018)
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and beta-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease
Bioorganic & Medicinal Chemistry 26: 1885
Zheng Y, Qiang X, Xu R, Song Q, Tian C, Liu H, Li W, Tan Z, Deng Y (2018)
Design, synthesis and evaluation of pterostilbene beta-amino alcohol derivatives as multifunctional agents for Alzheimer's disease treatment
Bioorg Chem 78: 298
Luo L, Li Y, Qiang X, Cao Z, Xu R, Yang X, Xiao G, Song Q, Tan Z, Deng Y (2017)
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and beta-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease
Bioorganic & Medicinal Chemistry 25: 1997
Sang Z, Qiang X, Li Y, Xu R, Cao Z, Song Q, Wang T, Zhang X, Liu H, Tan Z, Deng Y (2017)
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 135: 307
Xiao G, Li Y, Qiang X, Xu R, Zheng Y, Cao Z, Luo L, Yang X, Sang Z, Su F, Deng Y (2017)
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease
Bioorganic & Medicinal Chemistry 25: 1030
Yang X, Qiang X, Li Y, Luo L, Xu R, Zheng Y, Cao Z, Tan Z, Deng Y (2017)
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease
Bioorg Chem 71: 305
Martin PT, Camboni M, Xu R, Golden B, Chandrasekharan K, Wang CM, Varki A, Janssen PM (2013)
N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in alpha-sarcoglycan-deficient mice
Glycobiology 23: 833
Shi M, Zhang Z, Xu R, Lin H, Fu J, Zou Z, Zhang A, Shi J, Chen L, Lv S, He W, Geng H, Jin L, Liu Z, Wang FS (2012)
Human Mesenchymal Stem Cell Transfusion Is Safe and Improves Liver Function in Acute-on-Chronic Liver Failure Patients
Stem Cells Transl Med 1: 725
Singhal N, Xu R, Martin PT (2012)
Distinct contributions of Galgt1 and Galgt2 to carbohydrate expression and function at the mouse neuromuscular junction
Molecular & Cellular Neurosciences 51: 112
Yoon JH, Johnson E, Xu R, Martin LT, Martin PT, Montanaro F (2012)
Comparative proteomic profiling of dystroglycan-associated proteins in wild type, mdx, and Galgt2 transgenic mouse skeletal muscle
J Proteome Res 11: 4413
Zhang Z, Wallace MB, Feng J, Stafford JA, Skene RJ, Shi L, Lee B, Aertgeerts K, Jennings A, Xu R, Kassel DB, Kaldor SW, Navre M, Webb DR, Gwaltney SL (2011)
Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV
Journal of Medicinal Chemistry 54: 510
Martin PT, Xu R, Rodino-Klapac LR, Oglesbay E, Camboni M, Montgomery CL, Shontz K, Chicoine LG, Clark KR, Sahenk Z, Mendell JR, Janssen PM (2009)
Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice
American Journal of Physiology Cell Physiol 296: C476
Xu R, deVries S, Camboni M, Martin PT (2009)
Overexpression of Galgt2 reduces dystrophic pathology in the skeletal muscles of alpha sarcoglycan-deficient mice
American Journal of Pathology 175: 235
Yoon JH, Chandrasekharan K, Xu R, Glass M, Singhal N, Martin PT (2009)
The synaptic CT carbohydrate modulates binding and expression of extracellular matrix proteins in skeletal muscle: Partial dependence on utrophin
Molecular & Cellular Neurosciences 41: 448
Chen YZ, Yang CT, Ching CB, Xu R (2008)
Immobilization of lipases on hydrophobilized zirconia nanoparticles: highly enantioselective and reusable biocatalysts
Langmuir 24: 8877
Martin PT, Shelton GD, Dickinson PJ, Sturges BK, Xu R, LeCouteur RA, Guo LT, Grahn RA, Lo HP, North KN, Malik R, Engvall E, Lyons LA (2008)
Muscular dystrophy associated with alpha-dystroglycan deficiency in Sphynx and Devon Rex cats
Neuromuscular Disorders 18: 942
Wallace MB, Feng J, Zhang Z, Skene RJ, Shi L, Caster CL, Kassel DB, Xu R, Gwaltney SL, 2nd (2008)
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 18: 2362
Yang Y, Xu R, Ma CJ, Vlot AC, Klessig DF, Pichersky E (2008)
Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated by several esterases belonging to the AtMES esterase family of Arabidopsis
Plant Physiol 147: 1034
Feng J, Zhang Z, Wallace MB, Stafford JA, Kaldor SW, Kassel DB, Navre M, Shi L, Skene RJ, Asakawa T, Takeuchi K, Xu R, Webb DR, Gwaltney SL, 2nd (2007)
Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV
Journal of Medicinal Chemistry 50: 2297
Xu R, Camboni M, Martin PT (2007)
Postnatal overexpression of the CT GalNAc transferase inhibits muscular dystrophy in mdx mice without altering muscle growth or neuromuscular development: evidence for a utrophin-independent mechanism
Neuromuscular Disorders 17: 209
Xu R, Chandrasekharan K, Yoon JH, Camboni M, Martin PT (2007)
Overexpression of the cytotoxic T cell (CT) carbohydrate inhibits muscular dystrophy in the dyW mouse model of congenital muscular dystrophy 1A
American Journal of Pathology 171: 181
Ayers JT, Xu R, Dwoskin LP, Crooks PA (2005)
A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine
AAPS J 7: E752
Lou WY, Xu R, Zong MH (2005)
Hydroxynitrile lyase catalysis in ionic liquid-containing systems
Biotechnol Lett 27: 1387
Sumithran SP, Crooks PA, Xu R, Zhu J, Deaciuc AG, Wilkins LH, Dwoskin LP (2005)
Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity
AAPS J 7: E201
Crooks PA, Ayers JT, Xu R, Sumithran SP, Grinevich VP, Wilkins LH, Deaciuc AG, Allen DD, Dwoskin LP (2004)
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release
Bioorganic & Medicinal Chemistry Lett 14: 1869
Xu R, Zong MH, Liu YY, He J, Zhang YY, Lou WY (2004)
Enzymatic enantioselective transcyanation of silicon-containing aliphatic ketone with (S)-hydroxynitrile lyase from Manihot esculenta
Applied Microbiology & Biotechnology 66: 27
Xu R, Dwoskin LP, Grinevich VP, Deaciuc G, Crooks PA (2001)
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues
Bioorganic & Medicinal Chemistry Lett 11: 1245
Salpeter MM, Andreose J, O'Malley JP, Xu R, Fumagalli G, Lomo T (1993)
Degradation of acetylcholine receptors at vertebrate neuromuscular junctions
Annals of the New York Academy of Sciences 681: 155