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Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors
Bioorganic & Medicinal Chemistry Lett 19: 4097
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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 18: 2409
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Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines
Journal of Medicinal Chemistry 51: 589
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Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Bioorganic & Medicinal Chemistry Lett 17: 5853
Cox JM, Harper B, Mastracchio A, Leiting B, Sinha Roy R, Patel RA, Wu JK, Lyons KA, He H, Xu S, Zhu B, Thornberry NA, Weber AE, Edmondson SD (2007)
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 17: 4579
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4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV
Bioorganic & Medicinal Chemistry Lett 17: 2879
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Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors
Bioorganic & Medicinal Chemistry Lett 17: 3877
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4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV
Bioorganic & Medicinal Chemistry Lett 17: 5806
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Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate)
Bioorganic & Medicinal Chemistry Lett 17: 3373
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Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors
Bioorganic & Medicinal Chemistry Lett 17: 5934
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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Journal of Medicinal Chemistry 49: 3614
Xu J, Wei L, Mathvink R, Edmondson SD, Mastracchio A, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Petrov A, Wu JK, Thornberry NA, Weber AE (2006)
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors
Bioorganic & Medicinal Chemistry Lett 16: 1346
Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE (2006)
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 16: 5373
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Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole
Bioorganic & Medicinal Chemistry Lett 15: 2253
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Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 15: 3048
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(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Journal of Medicinal Chemistry 48: 141
Lankas GR, Leiting B, Roy RS, Eiermann GJ, Beconi MG, Biftu T, Chan CC, Edmondson S, Feeney WP, He H, Ippolito DE, Kim D, Lyons KA, Ok HO, Patel RA, Petrov AN, Pryor KA, Qian X, Reigle L, Woods A, Wu JK, Zaller D, Zhang X, Zhu L, Weber AE, Thornberry NA (2005)
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9
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Xu J, Wei L, Mathvink R, He J, Park YJ, He H, Leiting B, Lyons KA, Marsilio F, Patel RA, Wu JK, Thornberry NA, Weber AE (2005)
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 15: 2533
Edmondson SD, Mastracchio A, Beconi M, Colwell LF, Jr., Habulihaz B, He H, Kumar S, Leiting B, Lyons KA, Mao A, Marsilio F, Patel RA, Wu JK, Zhu L, Thornberry NA, Weber AE, Parmee ER (2004)
Potent and selective proline derived dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 14: 5151
Parmee ER, He J, Mastracchio A, Edmondson SD, Colwell L, Eiermann G, Feeney WP, Habulihaz B, He H, Kilburn R, Leiting B, Lyons K, Marsilio F, Patel RA, Petrov A, Di Salvo J, Wu JK, Thornberry NA, Weber AE (2004)
4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 14: 43