Dighe SN, De la Mora E, Chan S, Kantham S, McColl G, Miles JA, Veliyath SK, Sreenivas BY, Nassar ZD, Silman I, Sussman JL, Weik M, McGeary RP, Parat MO, Brazzolotto X, Ross BP (2019) <br />Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model.<br /><i>Communications chemistry</i> <b>2</b>: 35<br /><br />Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman JL, Weik M, Maurice T, Dallemagne P, Rochais C (2019) <br />Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase<br /><i>Eur Journal of Medicinal Chemistry</i> <b>162</b>: 234<br /><br />Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F (2018) <br />Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents<br /><i>Journal of Medicinal Chemistry</i> <b>61</b>: 7630<br /><br />Zorbaz T, Braiki A, Marakovic N, Renou J, De la Mora E, Macek Hrvat N, Katalinic M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Perez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY (2018) <br />Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration<br /><i>Chemistry</i> <b>24</b>: 9675<br /><br />Campbell EC, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M, Hollfelder F, Tokuriki N, Jackson CJ (2016) <br />The role of protein dynamics in the evolution of new enzyme function<br /><i>Nat Chemical Biology</i> <b>12</b>: 944<br /><br />Colletier JP, Sliwa M, Gallat FX, Sugahara M, Guillon V, Schiro G, Coquelle N, Woodhouse J, Roux L, Gotthard G, Royant A, Uriarte LM, Ruckebusch C, Joti Y, Byrdin M, Mizohata E, Nango E, Tanaka T, Tono K, Yabashi M, Adam V, Cammarata M, Schlichting I, Bourgeois D, Weik M (2016) <br />Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP<br /><i>J Phys Chem Lett</i> <b>7</b>: 882<br /><br />Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ (2016) <br />Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography<br /><i>Structure</i> <b>24</b>: 977<br /><br />Fraser NJ, Liu JW, Mabbitt PD, Correy GJ, Coppin CW, Lethier M, Perugini MA, Murphy JM, Oakeshott JG, Weik M, Jackson CJ (2016) <br />Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability<br /><i>Journal of Molecular Biology</i> <b>428</b>: 2359<br /><br />Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboleas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R (2014) <br />Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase<br /><i>Eur Journal of Medicinal Chemistry</i> <b>78C</b>: 455<br /><br />Oueis E, Santoni G, Ronco C, Syzgantseva O, Tognetti V, Joubert L, Romieu A, Weik M, Jean L, Sabot C, Nachon F, Renard PY (2014) <br />Reaction site-driven regioselective synthesis of AChE inhibitors<br /><i>Org Biomol Chem</i> <b>12</b>: 156<br /><br />Trapp M, Tehei M, Trovaslet M, Nachon F, Martinez N, Koza MM, Weik M, Masson P, Peters J (2014) <br />Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds<br /><i>J R Soc Interface</i> <b>11</b>: <br /><br />Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M (2013) <br />Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry<br /><i>Chemical Research in Toxicology</i> <b>26</b>: 280<br /><br />Jackson CJ, Liu JW, Carr PD, Younus F, Coppin C, Meirelles T, Lethier M, Pandey G, Ollis DL, Russell RJ, Weik M, Oakeshott JG (2013) <br />Structure and function of an insect alpha-carboxylesterase (alphaEsterase7) associated with insecticide resistance<br /><i>Proc Natl Acad Sci U S A</i> <b>110</b>: 10177<br /><br />Trovaslet M, Trapp M, Weik M, Nachon F, Masson P, Tehei M, Peters J (2013) <br />Relation between dynamics, activity and thermal stability within the cholinesterase family<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 14<br /><br />Ronco C, Carletti E, Colletier JP, Weik M, Nachon F, Jean L, Renard PY (2012) <br />Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography<br /><i>ChemMedChem</i> <b>7</b>: 400<br /><br />Trapp M, Trovaslet M, Nachon F, Koza MM, van Eijck L, Hill F, Weik M, Masson P, Tehei M, Peters J (2012) <br />Energy landscapes of human acetylcholinesterase and its huperzine a-inhibited counterpart<br /><i>J Phys Chem B</i> <b>116</b>: 14744<br /><br />Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P (2011) <br />Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis<br /><i>Chemical Research in Toxicology</i> <b>24</b>: 797<br /><br />Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M (2011) <br />Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations<br /><i>Protein Science</i> <b>20</b>: 1114<br /><br />Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL (2010) <br />Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase<br /><i>Biophysical Journal</i> <b>99</b>: 4003<br /><br />Gabel F, Masson P, Froment MT, Doctor BP, Saxena A, Silman I, Zaccai G, Weik M (2009) <br />Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its aged soman conjugate<br /><i>Biophysical Journal</i> <b>96</b>: 1489<br /><br />Hansmann T, Sanson B, Stojan J, Weik M, Marty JL, Fournier D (2009) <br />Kinetic insight into the mechanism of cholinesterasterase inhibition by aflatoxin B1 to develop biosensors<br /><i>Biosensors & Bioelectronics</i> <b>24</b>: 2119<br /><br />Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M (2009) <br />Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 7593<br /><br />Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M (2008) <br />Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography<br /><i>Proc Natl Acad Sci U S A</i> <b>105</b>: 11742<br /><br />Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M (2008) <br />Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design<br /><i>Protein Science</i> <b>17</b>: 601<br /><br />Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL (2008) <br />Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics<br /><i>Biophysical Journal</i> <b>95</b>: 2500<br /><br />Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M, Silman I, Bourgeois D, Weik M (2007) <br />Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography<br /><i>Acta Crystallographica D Biol Crystallogr</i> <b>63</b>: 1115<br /><br />Colletier JP, Weik M (2007) <br />[Exploring the conformational energy landscape of acetylcholinesterase by kinetic crystallography]<br /><i>Ann Pharm Fr</i> <b>65</b>: 108<br /><br />Frasco MF, Colletier JP, Weik M, Carvalho F, Guilhermino L, Stojan J, Fournier D (2007) <br />Mechanisms of cholinesterase inhibition by inorganic mercury<br /><i>Febs J</i> <b>274</b>: 1849<br /><br />Colletier JP, Sanson B, Nachon F, Gabellieri E, Fattorusso C, Campiani G, Weik M (2006) <br />Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor<br /><i>Journal of the American Chemical Society</i> <b>128</b>: 4526<br /><br />Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M (2006) <br />Structural insights into substrate traffic and inhibition in acetylcholinesterase<br /><i>EMBO Journal</i> <b>25</b>: 2746<br /><br />Gabel F, Weik M, Masson P, Renault F, Fournier D, Brochier L, Doctor BP, Saxena A, Silman I, Zaccai G (2005) <br />Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study<br /><i>Biophysical Journal</i> <b>89</b>: 3303<br /><br />Colletier JP, Fournier D, Greenblatt HM, Sussman JL, Zaccai G, Silman I, Weik M (2004) <br />Poster (74) Structural studies on torpedo californica acetylcholinesterase in complex with a substrate analogue<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 359<br /><br />Gabel F, Weik M, Doctor BP, Saxena A, Fournier D, Brochier L, Renault F, Masson P, Silman I, Zaccai G (2004) <br />The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study<br /><i>Biophysical Journal</i> <b>86</b>: 3152<br /><br />Weik M, Vernede X, Royant A, Bourgeois D (2004) <br />Temperature derivative fluorescence spectroscopy as a tool to study dynamical changes in protein crystals<br /><i>Biophysical Journal</i> <b>86</b>: 3176<br /><br />Weik M (2004) <br />Poster (54) Experimental approaches to study the dynamics of cholinesterases.<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 349<br /><br />Weik M, Berges J, Raves ML, Gros P, McSweeney S, Silman I, Sussman JL, Houee-Levin C, Ravelli RB (2002) <br />Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation<br /><i>J Synchrotron Radiat</i> <b>9</b>: 342<br /><br />Weik M, Ravelli RB, Silman I, Sussman JL, Gros P, Kroon J (2001) <br />Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes<br /><i>Protein Science</i> <b>10</b>: 1953<br /><br />Weik M, Ravelli RB, Kryger G, McSweeney S, Raves ML, Harel M, Gros P, Silman I, Kroon J, Sussman JL (2000) <br />Specific chemical and structural damage to proteins produced by synchrotron radiation<br /><i>Proceedings of the National Academy of Sciences of the United States of America</i> <b>97</b>: 623<br /><br />