Kobayashi S, Sugama N, Nagano H, Miyamori A, Takahashi M, Kushiyama A (2023) <br />Analysis of Adverse Events of Cholinesterase Inhibitors and NMDA Receptor Antagonists on Arrhythmias Using the Japanese Adverse Drug Event Report Database<br /><i>Drugs Real World Outcomes</i> <br /><br />Takahashi M, Hirota I, Nakano T, Kotani T, Takani D, Shiratori K, Choi Y, Haba M, Hosokawa M (2021) <br />Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase<br /><i>Drug Metab Pharmacokinet</i> <b>38</b>: 100391<br /><br />Takahashi M, Takani D, Haba M, Hosokawa M (2020) <br />Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters<br /><i>Chirality</i> <b>32</b>: 73<br /><br />Takahashi M, Lee YJ, Kanayama T, Kondo Y, Nishio K, Mukai K, Haba M, Hosokawa M (2020) <br />Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1<br /><i>Eur J Pharm Sci</i> <br /><br />Mizoi K, Takahashi M, Sakai S, Ogihara T, Haba M, Hosokawa M (2019) <br />Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases<br /><i>Xenobiotica</i> <br /><br />Shirayama Y, Takahashi M, Oda Y, Yoshino K, Sato K, Okubo T, Iyo M (2019) <br />rCBF and cognitive impairment changes assessed by SPECT and ADAS-cog in late-onset Alzheimer's disease after 18 months of treatment with the cholinesterase inhibitors donepezil or galantamine<br /><i>Brain Imaging Behav</i> <b>13</b>: 75<br /><br />Takahashi M, Uehara T, Nonaka M, Minagawa Y, Yamazaki R, Haba M, Hosokawa M (2019) <br />Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase<br /><i>Eur J Pharm Sci</i> <b>132</b>: 125<br /><br />Ueda K, Katayama S, Arai T, Furuta N, Ikebe S, Ishida Y, Kanaya K, Ouma S, Sakurai H, Sugitani M, Takahashi M, Tanaka T, Tsuno N, Wakutani Y, Shekhawat A, Das Gupta A, Kiyose K, Toriyama K, Nakamura Y (2019) <br />Efficacy, Safety, and Tolerability of Switching from Oral Cholinesterase Inhibitors to Rivastigmine Transdermal Patch with 1-Step Titration in Patients with Mild to Moderate Alzheimer's Disease: A 24-Week, Open-Label, Multicenter Study in Japan<br /><i>Dement Geriatr Cogn Dis Extra</i> <b>9</b>: 302<br /><br />Yamazaki H, Takahashi M, Wakabayashi T, Sakai K, Yamamuro D, Takei A, Takei S, Nagashima S, Yagyu H, Sekiya M, Ebihara K, Ishibashi S (2019) <br />Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells<br /><i>J Atheroscler Thromb</i> <b>26</b>: 246<br /><br />Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M (2018) <br />Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>28</b>: 997<br /><br />Takahashi M, Oda Y, Okubo T, Shirayama Y (2017) <br />Relationships between cognitive impairment on ADAS-cog and regional cerebral blood flow using SPECT in late-onset Alzheimer's disease<br /><i>J Neural Transm (Vienna)</i> <b>124</b>: 1109<br /><br />Hirano T, Yamashita S, Takahashi M, Hashimoto H, Mori Y, Goto M (2016) <br />Anagliptin, a dipeptidyl peptidase-4 inhibitor, decreases macrophage infiltration and suppresses atherosclerosis in aortic and coronary arteries in cholesterol-fed rabbits<br /><i>Metabolism</i> <b>65</b>: 893<br /><br />Matsumoto S, Murakami N, Koizumi H, Takahashi M, Izumi Y, Kaji R (2016) <br />Edrophonium Challenge Test for Blepharospasm<br /><i>Front Neurosci</i> <b>10</b>: 226<br /><br />Matsumoto Y, Kano M, Akutsu Y, Hanari N, Hoshino I, Murakami K, Usui A, Suito H, Takahashi M, Otsuka R, Xin H, Komatsu A, Iida K, Matsubara H (2016) <br />Quantification of plasma exosome is a potential prognostic marker for esophageal squamous cell carcinoma<br /><i>Oncol Rep</i> <b>36</b>: 2535<br /><br />Mizoi K, Takahashi M, Haba M, Hosokawa M (2016) <br />Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>26</b>: 921<br /><br />Ohnishi T, Sakiyama Y, Okuri Y, Kimura Y, Sugiyama N, Saito T, Takahashi M, Kobayashi T (2014) <br />The prediction of response to Galantamine treatment in Patients with mild to moderate Alzheimer's Disease<br /><i>Curr Alzheimer Res</i> <b>11</b>: 110<br /><br />Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S (2014) <br />Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages<br /><i>J Lipid Res</i> <b>55</b>: 2033<br /><br />Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S (2014) <br />Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages<br /><i>J Lipid Res</i> <b>55</b>: 2082<br /><br />Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S (2013) <br />Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity<br /><i>J Lipid Res</i> <b>54</b>: 1124<br /><br />Masai E, Kamimura N, Kasai D, Oguchi A, Ankai A, Fukui S, Takahashi M, Yashiro I, Sasaki H, Harada T, Nakamura S, Katano Y, Narita-Yamada S, Nakazawa H, Hara H, Katayama Y, Fukuda M, Yamazaki S, Fujita N (2012) <br />Complete genome sequence of Sphingobium sp. strain SYK-6, a degrader of lignin-derived biaryls and monoaryls<br /><i>Journal of Bacteriology</i> <b>194</b>: 534<br /><br />Sekizuka T, Yamamoto A, Komiya T, Kenri T, Takeuchi F, Shibayama K, Takahashi M, Kuroda M, Iwaki M (2012) <br />Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage<br /><i>BMC Microbiol</i> <b>12</b>: 72<br /><br />Nagashima S, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, Tazoe F, Wang XL, Bayasgalan T, Sato N, Okada K, Nagasaka S, Gotoh T, Kojima M, Hyodo M, Horie H, Hosoya Y, Okada M, Yasuda Y, Fujiwara H, Ohwada M, Iwamoto S, Suzuki M, Nagai H, Ishibashi S (2011) <br />Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity<br /><i>J Atheroscler Thromb</i> <b>18</b>: 190<br /><br />Prakash T, Oshima K, Morita H, Fukuda S, Imaoka A, Kumar N, Sharma VK, Kim SW, Takahashi M, Saitou N, Taylor TD, Ohno H, Umesaki Y, Hattori M (2011) <br />Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation<br /><i>Cell Host Microbe</i> <b>10</b>: 273<br /><br />Takahashi M, Ubukata S, Sato E, Shoji M, Morikawa N, Watanabe H, Takahashi H (2011) <br />[Acute respiratory failure associated with cholinergic crisis: report of five cases and review of the literature]<br /><i>Nihon Kokyuki Gakkai Zasshi</i> <b>49</b>: 877<br /><br />Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Ishibashi S (2011) <br />Molecular analysis of a novel LCAT mutation (Gly179 --> Arg) found in a patient with complete LCAT deficiency<br /><i>J Atheroscler Thromb</i> <b>18</b>: 713<br /><br />Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S (2010) <br />The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages<br /><i>Circulation Research</i> <b>107</b>: 1387<br /><br />Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T (2010) <br />Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia<br /><i>Neuropsychopharmacology</i> <b>35</b>: 1155<br /><br />Koyama K, Takahashi M, Oitate M, Nakai N, Takakusa H, Miura S, Okazaki O (2009) <br />CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract<br /><i>Antimicrobial Agents & Chemotherapy</i> <b>53</b>: 4845<br /><br />Sekiya M, Osuga J, Nagashima S, Ohshiro T, Igarashi M, Okazaki H, Takahashi M, Tazoe F, Wada T, Ohta K, Takanashi M, Kumagai M, Nishi M, Takase S, Yahagi N, Yagyu H, Ohashi K, Nagai R, Kadowaki T, Furukawa Y, Ishibashi S (2009) <br />Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis<br /><i>Cell Metab</i> <b>10</b>: 219<br /><br />Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga J, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I (2009) <br />Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding<br /><i>American Journal of Physiology Endocrinol Metab</i> <b>297</b>: E1115<br /><br />Fukushima H, Hiratate A, Takahashi M, Saito-Hori M, Munetomo E, Kitano K, Saito H, Takaoka Y, Yamamoto K (2008) <br />Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors<br /><i>Chem Pharm Bull (Tokyo)</i> <b>56</b>: 1110<br /><br />Fukushima H, Hiratate A, Takahashi M, Mikami A, Saito-Hori M, Munetomo E, Kitano K, Chonan S, Saito H, Suzuki A, Takaoka Y, Yamamoto K (2008) <br />Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors<br /><i>Bioorganic & Medicinal Chemistry</i> <b>16</b>: 4093<br /><br />Hitsumoto T, Takahashi M, Iizuka T, Shirai K (2008) <br />Effect of the angiotensin II receptor antagonist telmisartan on lipoprotein lipase mass in preheparin serum<br /><i>J Atheroscler Thromb</i> <b>15</b>: 138<br /><br />Liu Y, Padgett D, Takahashi M, Li H, Sayeed A, Teichert RW, Olivera BM, McArdle JJ, Green WN, Lin W (2008) <br />Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning<br /><i>Development</i> <b>135</b>: 1957<br /><br />Takahashi M, Hiyama Y, Yokoyama M, Yu S, Hu Y, Melford K, Bensadoun A, Goldberg IJ (2008) <br />In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation<br /><i>Arterioscler Thromb Vasc Biol</i> <b>28</b>: 455<br /><br />Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL (2007) <br />Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function<br /><i>Anesthesiology</i> <b>107</b>: 621<br /><br />Hikage T, Saitoh Y, Tanaka-Saito C, Hagami H, Satou F, Shimotai Y, Nakano Y, Takahashi M, Takahata Y, Tsutsumi K (2007) <br />Structure and allele-specific expression variation of novel alpha/beta hydrolase fold proteins in gentian plants<br /><i>Mol Genet Genomics</i> <b>278</b>: 95<br /><br />Kamimura M, Takahashi M, Kikuchi K, Reza AM, Kiuchi M (2007) <br />Tissue-specific regulation of juvenile hormone esterase gene expression by 20-hydroxyecdysone and juvenile hormone in Bombyx mori<br /><i>Archives of Insect Biochemistry & Physiology</i> <b>65</b>: 143<br /><br />Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, Kusumoto K, Arima T, Akita O, Kashiwagi Y, Abe K, Gomi K, Horiuchi H, Kitamoto K, Kobayashi T, Takeuchi M, Denning DW, Galagan JE, Nierman WC, Yu J, Archer DB, Bennett JW, Bhatnagar D, Cleveland TE, Fedorova ND, Gotoh O, Horikawa H, Hosoyama A, Ichinomiya M, Igarashi R, Iwashita K, Juvvadi PR, Kato M, Kato Y, Kin T, Kokubun A, Maeda H, Maeyama N, Maruyama J, Nagasaki H, Nakajima T, Oda K, Okada K, Paulsen I, Sakamoto K, Sawano T, Takahashi M, Takase K, Terabayashi Y, Wortman JR, Yamada O, Yamagata Y, Anazawa H, Hata Y, Koide Y, Komori T, Koyama Y, Minetoki T, Suharnan S, Tanaka A, Isono K, Kuhara S, Ogasawara N, Kikuchi H (2005) <br />Genome sequencing and analysis of Aspergillus oryzae<br /><i>Nature</i> <b>438</b>: 1157<br /><br />Niho N, Mutoh M, Takahashi M, Tsutsumi K, Sugimura T, Wakabayashi K (2005) <br />Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice<br /><i>Proc Natl Acad Sci U S A</i> <b>102</b>: 2970<br /><br />Takahashi M, Kamei Y, Ezaki O (2005) <br />Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size<br /><i>American Journal of Physiology Endocrinol Metab</i> <b>288</b>: E117<br /><br />Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K (2005) <br />Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species<br /><i>Journal of Bacteriology</i> <b>187</b>: 7292<br /><br />Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Ohara O, Isogai T, Sugano S (2004) <br />Complete sequencing and characterization of 21,243 full-length human cDNAs<br /><i>Nat Genet</i> <b>36</b>: 40<br /><br />Saika Y, Sakai N, Takahashi M, Maruyama T, Kihara S, Ouchi N, Ishigami M, Hiraoka H, Nakamura T, Yamashita S, Matsuzawa Y (2003) <br />Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis<br /><i>European Journal of Clinical Investigation</i> <b>33</b>: 216<br /><br />Takahashi M, Saibara T, Nemoto Y, Ono M, Akisawa N, Iwasaki S, Toda K, Ogawa Y, Wakatsuki A, Inagaki S, Onishi S (2003) <br />A novel type hypertriglyceridemia observed in FLS mice<br /><i>Lipids</i> <b>38</b>: 687<br /><br />Mima J, Suzuki H, Takahashi M, Hayashi R (2002) <br />Overexpression and functional characterization of a serine carboxypeptidase inhibitor (I(C)) from Saccharomyces cerevisiae<br /><i>J Biochem</i> <b>132</b>: 967<br /><br />Ishii K, Kondo K, Takahashi M, Kimura M, Endoh M (2001) <br />An amino acid residue whose change by mutation affects drug binding to the HERG channel<br /><i>FEBS Letters</i> <b>506</b>: 191<br /><br />Kawarabayasi Y, Hino Y, Horikawa H, Jin-no K, Takahashi M, Sekine M, Baba S, Ankai A, Kosugi H, Hosoyama A, Fukui S, Nagai Y, Nishijima K, Otsuka R, Nakazawa H, Takamiya M, Kato Y, Yoshizawa T, Tanaka T, Kudoh Y, Yamazaki J, Kushida N, Oguchi A, Aoki K, Masuda S, Yanagii M, Nishimura M, Yamagishi A, Oshima T, Kikuchi H (2001) <br />Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7<br /><i>DNA Research</i> <b>8</b>: 123<br /><br />Tojima T, Yamane Y, Takahashi M, Ito E (2000) <br />Acquisition of neuronal proteins during differentiation of NG108-15 cells<br /><i>Neurosci Res</i> <b>37</b>: 153<br /><br />Kawarabayasi Y, Hino Y, Horikawa H, Yamazaki S, Haikawa Y, Jin-no K, Takahashi M, Sekine M, Baba S, Ankai A, Kosugi H, Hosoyama A, Fukui S, Nagai Y, Nishijima K, Nakazawa H, Takamiya M, Masuda S, Funahashi T, Tanaka T, Kudoh Y, Yamazaki J, Kushida N, Oguchi A, Aoki KI, Kubota K, Nakamura Y, Nomura N, Sako Y, Kikuchi H (1999) <br />Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1<br /><i>DNA Research</i> <b>6</b>: 83<br /><br />Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T (1994) <br />Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues<br /><i>Brain Research</i> <b>658</b>: 163<br /><br />Morinobu S, Kuwayama N, Kawanami T, Okuyama N, Takahashi M, Totsuka S, Endoh M (1992) <br />Influence of the acute stress on agonist-stimulated phosphoinositide hydrolysis in the rat cerebral cortex<br /><i>Prog Neuropsychopharmacol Biological Psychiatry</i> <b>16</b>: 561<br /><br />Catterall WA, Seagar MJ, Takahashi M, Nunoki K (1989) <br />Molecular properties of dihydropyridine-sensitive calcium channels<br /><i>Annals of the New York Academy of Sciences</i> <b>560</b>: 1<br /><br />Seagar MJ, Takahashi M, Catterall WA (1988) <br />Molecular properties of dihydropyridine-sensitive calcium channels<br /><i>Annals of the New York Academy of Sciences</i> <b>522</b>: 162<br /><br />Takahashi M, Catterall WA (1987) <br />Identification of an alpha subunit of dihydropyridine-sensitive brain calcium channels<br /><i>Science</i> <b>236</b>: 88<br /><br />Nakamura K, Koide M, Imanaga T, Ogasawara H, Takahashi M, Yoshikawa M (1980) <br />Prolonged neuromuscular blockade following trimetaphan infusion. A case report and in vitro study of cholinesterase inhibition<br /><i>Anaesthesia</i> <b>35</b>: 1202<br /><br />Yamamoto A, Adachi S, Kawamura S, Takahashi M, Kitani T (1974) <br />Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?<br /><i>Archives of Internal Medicine</i> <b>134</b>: 627<br /><br />