Dileep KV, Ihara K, Mishima-Tsumagari C, Kukimoto-Niino M, Yonemochi M, Hanada K, Shirouzu M, Zhang KYJ (2022)
Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery
Int J Biol Macromol 210: 172

Alhomida AS, Al-Rajhi AA, Kamal MA, Al-Jafari AA (2000)
Kinetic analysis of the toxicological effect of tacrine (Cognex) on human retinal acetylcholinesterase activity
Toxicology 147: 33

Camps P, Cusack B, Mallender WD, Achab RE, Morral J, Munoz-Torrero D, Rosenberry TL (2000)
Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease
Molecular Pharmacology 57: 409

Heuser G (2000)
Mass psychogenic illness attributed to toxic exposure at a high school
N Engl J Med 342: 1674; author reply 1675

Callahan MJ (1999)
Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys
Psychopharmacology (Berl) 144: 234

Traykov L, Tavitian B, Jobert A, Boller F, Forette F, Crouzel C, Di Giamberardino L, Pappata S (1999)
In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects
Eur Journal of Neurology 6: 273

Zhao S, Totleben MJ, Freeman JP, Bacon CL, Fox GB, O'Driscoll E, Foley AG, Kelly J, Farrell U, Regan C, Mizsak SA, Szmuszkovicz J (1999)
Syntheses of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents
Bioorganic & Medicinal Chemistry 7: 1637

Allal C, Lazartigues E, Tran MA, Brefel-Courbon C, Gharib C, Montastruc JL, Rascol O (1998)
Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release
European Journal of Pharmacology 348: 191

Badia A, Banos JE, Camps P, Contreras J, Gorbig DM, Munoz-Torrero D, Simon M, Vivas NM (1998)
Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease
Bioorganic & Medicinal Chemistry 6: 427

Cheng DH, Tang XC (1998)
Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities
Pharmacol Biochem Behav 60: 377

Costagli C, Galli A (1998)
Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease
Biochemical Pharmacology 55: 1733

De Ferrari GV, Von Bernhardi R, Calderon FH, Luza SC, Inestrosa NC (1998)
Responses induced by tacrine in neuronal and non-neuronal cell lines
Journal of Neuroscience Research 52: 435

Giacobini E (1998)
Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications
Neurochem Int 32: 413

Giovannini MG, Scali C, Bartolini L, Schmidt B, Pepeu G (1998)
Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats
European Journal of Pharmacology 354: 17

Gracon SI, Knapp MJ, Berghoff WG, Pierce M, DeJong R, Lobbestael SJ, Symons J, Dombey SL, Luscombe FA, Kraemer D (1998)
Safety of tacrine: clinical trials, treatment IND, and postmarketing experience
Alzheimer Disease & Associated Disorders 12: 93

Grothe DR, Piscitelli SC, Dukoff R, Fullerton T, Sunderland T, Molchan SE (1998)
Penetration of tacrine into cerebrospinal fluid in patients with Alzheimer's disease
J Clin Psychopharmacol 18: 78

Meyer EM, King MA, Meyers C (1998)
Neuroprotective effects of 2,4-dimethoxybenzylidene anabaseine (DMXB) and tetrahydroaminoacridine (THA) in neocortices of nucleus basalis lesioned rats
Brain Research 786: 252

Monteith DK, Theiss JC, Haskins JR, de la Iglesia FA (1998)
Functional and subcellular organelle changes in isolated rat and human hepatocytes induced by tetrahydroaminoacridine
Archives of Toxicology 72: 147

O'Neill J, Fitten LJ, Siembieda D, Halgren E, Kim E, Fisher A, Perryman K (1998)
Effects of AF102B and tacrine on delayed match-to-sample in monkeys
Prog Neuropsychopharmacol Biological Psychiatry 22: 665

Pavone F, Capone F, Battaglia M, Sansone M (1998)
Shuttle-box avoidance learning in mice: improvement by combined glucose and tacrine
Neurobiol Learn Mem 69: 204

Riekkinen M, Soininen H, Riekkinen P, Sr., Kuikka J, Laakso M, Helkala EL, Partanen J, Riekkinen P, Jr. (1998)
Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease
Neuroscience 83: 471

Riekkinen P, Jr., Ikonen S, Riekkinen M (1998)
Tetrahydroaminoacridine, a cholinesterase inhibitor, and D-cycloserine, a partial NMDA receptor-associated glycine site agonist, enhances acquisition of spatial navigation
Neuroreport 9: 1633

Svensson AL, Nordberg A (1998)
Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells
Neuroreport 9: 1519

Vargas MG, Havel J, Patocka J (1998)
Capillary zone electrophoretic determination of some drugs against Alzheimer's disease
Journal of Chromatography A 802: 121

Wang T, Tang XC (1998)
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine
European Journal of Pharmacology 349: 137

Al-Jafari AA, Kamal MA, Alhomida AS (1998)
Sensitivity of bovine retinal acetylcholinesterase (E.C. toward tacrine: kinetic characterization
J Biochem Mol Toxicol 12: 245

Bonan CD, Battastini AM, Schetinger MR, Moreira CM, Frassetto SS, Dias RD, Sarkis JJ (1997)
Effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) on ATP diphosphohydrolase (EC and 5'-nucleotidase (EC from rat brain synaptosomes
General Pharmacology 28: 761

Carriero DL, Outslay G, Mayorga AJ, Aberman J, Gianutsos G, Salamone JD (1997)
Motor dysfunction produced by tacrine administration in rats
Pharmacol Biochem Behav 58: 851

Cousins MS, Carriero DL, Salamone JD (1997)
Tremulous jaw movements induced by the acetylcholinesterase inhibitor tacrine: effects of antiparkinsonian drugs
European Journal of Pharmacology 322: 137

Gracon S, Smith F, Shokry A (1997)
[Advantages in long-term treatment with Cognex in Alzheimer disease]
Schweiz Rundsch Med Prax 86: 1350

Harder JA, Kelly ME (1997)
The effect of several putative cognition enhancers on a water maze acquisition deficit produced by pCPA + scopolamine combination treatment
Pharmacol Biochem Behav 56: 657

Ibebunjo C, Donati F, Fox GS, Eshelby D, Tchervenkov JI (1997)
The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat
Anesthesia & Analgesia 85: 431

Jakala P, Riekkinen P, Jr. (1997)
Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats
Pharmacol Biochem Behav 56: 713

Kojima J, Nakajima K, Ochiai M, Nakayama K (1997)
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia [published erratum appears in Methods Find Exp Clin Pharmacol 1997 Jun;19(5):364]
Methods Find Exp Clin Pharmacol 19: 245

Lahiri DK, Farlow MR, Nurnberger JI, Jr., Greig NH (1997)
Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures
Annals of the New York Academy of Sciences 826: 416

McGuffey EC (1997)
Alzheimer's disease: an overview for the pharmacist
J Am Pharm Assoc 3: 347

Pavone F, Battaglia M, Sansone M (1997)
Prevention of amitriptyline-induced avoidance impairment by tacrine in mice
Behavioural Brain Research 89: 229

Pike BR, Hamm RJ, Temple MD, Buck DL, Lyeth BG (1997)
Effect of tetrahydroaminoacridine, a cholinesterase inhibitor, on cognitive performance following experimental brain injury
Journal of Neurotrauma 14: 897

Pomponi M, Marta M, Colella A, Sacchi S, Patamia M, Gatta F, Capone F, Oliverio A, Pavone F (1997)
Studies on a new series of THA analogues: effects of the aromatic residues that line the gorge of AChE
FEBS Letters 409: 155

Pool WF, Reily MD, Bjorge SM, Woolf TF (1997)
Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons
Drug Metabolism & Disposition: The Biological Fate of Chemicals 25: 590

Riekkinen P, Jr., Riekkinen M, Soininen H, Kuikka J, Laakso M, Riekkinen P, Sr. (1997)
Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease
Neuroreport 8: 1845

Rupniak NM, Tye SJ, Field MJ (1997)
Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys
Psychopharmacology 131: 406

Sharma A, Parikh V, Singh M (1997)
Pharmacological basis of drug therapy of Alzheimer's disease
Indian J Exp Biol 35: 1146

Tsukada H, Kakiuchi T, Ando I, Ouchi Y (1997)
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys
Journal of Pharmacology & Experimental Therapeutics 281: 1408

Bezek S, Kukan M, Pool WF, Woolf TF (1996)
The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations
Xenobiotica 26: 935

Cheng DH, Ren H, Tang XC (1996)
Huperzine A, a novel promising acetylcholinesterase inhibitor
Neuroreport 8: 97

Forgue ST, Reece PA, Sedman AJ, deVries TM (1996)
Inhibition of tacrine oral clearance by cimetidine
Clinical Pharmacology & Therapeutics 59: 444

Foster NL, Petersen RC, Gracon SI, Lewis K (1996)
An enriched-population, double-blind, placebo-controlled, crossover study of tacrine and lecithin in Alzheimer's disease. The Tacrine 970-6 Study Group
Dementia 7: 260

Gnagey AL, Ellis J (1996)
Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors
Biochemical Pharmacology 52: 1767

Jackson JJ, Soliman MR (1996)
Effects of tacrine (THA) on spatial reference memory and cholinergic enzymes in specific rat brain regions
Life Sciences 58: 47

Loewenstein-Lichtenstein Y, Glick D, Gluzman N, Sternfeld M, Zakut H, Soreq H (1996)
Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis
Molecular Pharmacology 50: 1423

Scheen AJ (1996)
[Pharma-clinics. Drug of the month. Tacrine (Cognex)]
Rev Med Liege 51: 379

Shafazand M (1996)
[Alzheimer disease cannot be treated with Cognex]
Lakartidningen 93: 1406

Pacheco G, Palacios-Esquivel R, Moss DE (1995)
Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase
Journal of Pharmacology & Experimental Therapeutics 274: 767

Pirrung MC, Chau JH, Chen J (1995)
Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library
Chemistry & Biology 2: 621

Rouhart F (1995)
[New therapeutic prospects in Alzheimer disease]
Rev Med Interne 16: 860

Murai S, Saito H, Abe E, Masuda Y, Odashima J, Itoh T (1994)
MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice
Journal of Neural Transmission General Section 98: 1

Adem A (1993)
The next generation of cholinesterase inhibitors
Acta Neurologica Scandinavica Supplementum 149: 10

Bajgar J, Skopec F (1993)
Changes of rat blood and tissue cholinesterases following administration of tacrine derivatives in vivo
Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity 36: 73

Messamore E, Warpman U, Ogane N, Giacobini E (1993)
Cholinesterase inhibitor effects on extracellular acetylcholine in rat cortex
Neuropharmacology 32: 745

Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P (1993)
Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
Biochemistry 32: 12074

Galli A, Mori F, Gori I, Lucherini M (1992)
In vitro protection of acetylcholinesterase and butyrylcholinesterase by tetrahydroaminoacridine. Comparison with physostigmine
Biochemical Pharmacology 43: 2427

Ogane N, Giacobini E, Messamore E (1992)
Preferential inhibition of acetylcholinesterase molecular forms in rat brain
Neurochemical Research 17: 489

Braga MF, Harvey AL, Rowan EG (1991)
Effects of tacrine, velnacrine (HP029), suronacrine (HP128), and 3,4-diaminopyridine on skeletal neuromuscular transmission in vitro
British Journal of Pharmacology 102: 909

Dawson RM (1990)
Reversibility of the inhibition of acetylcholinesterase by tacrine
Neuroscience Letters 118: 85

Hunter AJ, Murray TK, Jones JA, Cross AJ, Green AR (1989)
The cholinergic pharmacology of tetrahydroaminoacridine in vivo and in vitro
British Journal of Pharmacology 98: 79

Robinson TN, De Souza RJ, Cross AJ, Green AR (1989)
The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat brain tissue prisms
British Journal of Pharmacology 98: 1127

de Belleroche J, Gardiner IM (1988)
Inhibitory effect of 1,2,3,4-tetrahydro-9-aminoacridine on the depolarization-induced release of GABA from cerebral cortex
British Journal of Pharmacology 94: 1017