Misiachna A, Svobodova B, Netolicky J, Chvojkova M, Kleteckova L, Prchal L, Novak M, Hrabinova M, Kucera T, Muckova L, Moravcova Z, Karasova JZ, Pejchal J, Blazek F, Malinak D, Hakenova K, Krausova BH, Kolcheva M, Ladislav M, Korabecny J, Pahnke J, Vales K, Horak M, Soukup O (2024)
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
Eur Journal of Medicinal Chemistry 266: 116130

Kapitanov IV, Spulak M, Pour M, Soukup O, Marek J, Jun D, Novak M, Diz de Almeida JSF, Costa Franca TC, Gathergood N, Kuca K, Karpichev Y (2023)
Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators
Chemico-Biological Interactions

Novak M, Svobodova B, Konecny J, Kuratkova A, Nevosadova L, Prchal L, Korabecny J, Lauschke VM, Soukup O, Kucera R (2023)
UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes
J Pharm Biomed Anal 224: 115154

Novak M, Vajrychova M, Koutsilieri S, Sismanoglou DC, Kobrlova T, Prchal L, Svobodova B, Korabecny J, Zarybnicky T, Raisova-Stuchlikova L, Skalova L, Lauschke VM, Kucera R, Soukup O (2023)
Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation
ACS Chemical Biology 18: 1993

Opravil J, Pejchal J, Finger V, Korabecny J, Rozsypal T, Hrabinova M, Muckova L, Hepnarova V, Konecny J, Soukup O, Jun D (2023)
A-agents, misleadingly known as Novichoks: a narrative review
Archives of Toxicology

Pidany F, Kroustkova J, Al Mamun A, Suchankova D, Brazzolotto X, Nachon F, Chantegreil F, Dolezal R, Pulkrabkova L, Muckova L, Hrabinova M, Finger V, Kufa M, Soukup O, Jun D, Jenco J, Kunes J, Novakova L, Korabecny J, Cahlikova L (2023)
Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation
Eur Journal of Medicinal Chemistry 252: 115301

Pulkrabkova L, Muckova L, Hrabinova M, Sorf A, Kobrlova T, Jost P, Bezdekova D, Korabecny J, Jun D, Soukup O (2023)
Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity
Archives of Toxicology

Svobodova B, Pulkrabkova L, Panek D, Misiachna A, Kolcheva M, Andrys R, Handl J, Capek J, Nyvltova P, Rousar T, Prchal L, Hepnarova V, Hrabinova M, Muckova L, Tosnerova D, Karabanovich G, Finger V, Soukup O, Horak M, Korabecny J (2023)
Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
Int J Mol Sci 24:

Tsianou CC, Kvetina J, Radochova V, Kohoutova D, Rejchrt S, Valis M, Karasova JZ, Tacheci I, Knoblochova V, Soukup O, Bures J (2023)
The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
PLoS ONE 18: e0286386

Bondar D, Kapitanov I, Pulkrabkova L, Soukup O, Jun D, Diniz FB, Franca TCC, Kuca K, Karpichev Y (2022)
N-substituted arylhydroxamic acids as acetylcholinesterase reactivators
Chemico-Biological Interactions

Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P, Valis M, Korabecny J, Marco-Contelles J, Kuca K (2022)
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
J Enzyme Inhib Med Chem 37: 2605

Gorecki L, Soukup O, Korabecny J (2022)
Countermeasures in organophosphorus intoxication: pitfalls and prospects
Trends in Pharmacological Sciences

Makhaeva GF, Kovaleva NV, Boltneva NP, Rudakova EV, Lushchekina SV, Astakhova TY, Serkov IV, Proshin AN, Radchenko EV, Palyulin VA, Korabecny J, Soukup O, Bachurin SO, Richardson RJ (2022)
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile
Molecules 27:

Pulkrabkova L, Svobodova B, Konecny J, Kobrlova T, Muckova L, Janousek J, Pejchal J, Korabecny J, Soukup O (2022)
Neurotoxicity evoked by organophosphates and available countermeasures
Archives of Toxicology

Gorecki L, Hepnarova V, Karasova JZ, Hrabinova M, Courageux C, Dias J, Kucera T, Kobrlova T, Muckova L, Prchal L, Malinak D, Jun D, Musilek K, Worek F, Nachon F, Soukup O, Korabecny J (2021)
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
Archives of Toxicology

Gorecki L, Uliassi E, Bartolini M, Janockova J, Hrabinova M, Hepnarova V, Prchal L, Muckova L, Pejchal J, Karasova JZ, Mezeiova E, Benkova M, Kobrlova T, Soukup O, Petralla S, Monti B, Korabecny J, Bolognesi ML (2021)
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease
ACS Chem Neurosci

Gorecki L, Misiachna A, Damborsky J, Dolezal R, Korabecny J, Cejkova L, Hakenova K, Chvojkova M, Karasova JZ, Prchal L, Novak M, Kolcheva M, Kortus S, Vales K, Horak M, Soukup O (2021)
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors
Eur Journal of Medicinal Chemistry 219: 113434

Hamulakova S, Kudlickova Z, Janovec L, Mezencev R, Deckner ZJ, Chernoff YO, Janockova J, Ihnatova V, Bzonek P, Novakova N, Hepnarova V, Hrabinova M, Jun D, Korabecny J, Soukup O, Kuca K (2021)
Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
Future Med Chem

Hudacova M, Hamuakova S, Konkoova E, Jendzelovsky R, Vargova J, Sevc J, Fedorocko P, Soukup O, Janockova J, Ihnatova V, Kucera T, Bzonek P, Novakova N, Jun D, Junova L, Korabecny J, Kuca K, Kozurkova M (2021)
Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells
Int J Mol Sci 22:

Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V, Korabecny J, Kucera T, Jun D, Andrys R, Musilek K, Baguet A, Garcia-Frutos EM, De Simone A, Andrisano V, Bartolini M, de los Rios C, Marco-Contelles J, Haffen E (2021)
(+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
ACS Chem Neurosci

Kaniakova M, Korabecny J, Holubova K, Kleteckova L, Chvojkova M, Hakenova K, Prchal L, Novak M, Dolezal R, Hepnarova V, Svobodova B, Kucera T, Lichnerova K, Krausova B, Horak M, Vales K, Soukup O (2021)
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo
Biochemical Pharmacology

Korabecny J, Soukup O (2021)
Cholinesterase Research
Biomolecules 11:

Makhaeva GF, Lushchekina SV, Kovaleva NV, Yu Astakhova T, Boltneva NP, Rudakova EV, Serebryakova OG, Proshin AN, Serkov IV, Trofimova TP, Tafeenko VA, Radchenko EV, Palyulin VA, Fisenko VP, Korabecny J, Soukup O, Richardson RJ (2021)
Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment
Bioorg Chem 112: 104974

Mamun AA, Pidany F, Hulcova D, Marikova J, Kucera T, Schmidt M, Catapano MC, Hrabinova M, Jun D, Muckova L, Kunes J, Janousek J, Andrys R, Novakova L, Perinova R, Maafi N, Soukup O, Korabecny J, Cahlikova L (2021)
Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
Int J Mol Sci 22:

Markova A, Hympanova M, Matula M, Prchal L, Sleha R, Benkova M, Pulkrabkova L, Soukup O, Krocova Z, Jun D, Marek J (2021)
Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts
Toxics 9:

Mezeiova E, Hrabinova M, Hepnarova V, Jun D, Janockova J, Muckova L, Prchal L, Kristofikova Z, Kucera T, Gorecki L, Chalupova K, Kunes J, Hroudova J, Soukup O, Korabecny J (2021)
Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment
Bioorganic & Medicinal Chemistry Lett

Perone R, Albertini C, Uliassi E, Di Pietri F, de Sena Murteira Pinheiro P, Petralla S, Rizzardi N, Fato R, Pulkrabkova L, Soukup O, Tramarin A, Bartolini M, Bolognesi ML (2021)
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy
ChemMedChem 16: 187

Rossi M, Freschi M, de Camargo Nascente L, Salerno A, de Melo Viana Teixeira S, Nachon F, Chantegreil F, Soukup O, Prchal L, Malaguti M, Bergamini C, Bartolini M, Angeloni C, Hrelia S, Soares Romeiro LA, Bolognesi ML (2021)
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease
Journal of Medicinal Chemistry 64: 4972

Vrabec R, Marikova J, Locarek M, Korabecny J, Hulcova D, Hosalkova A, Kunes J, Chlebek J, Kucera T, Hrabinova M, Jun D, Soukup O, Andrisano V, Jenco J, Safratova M, Novakova L, Opletal L, Cahlikova L (2021)
Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease
Phytochemistry 194: 113017

de Andrade Ramos G, Souza de Oliveira A, Bartolini M, Naldi M, Liparulo I, Bergamini C, Uliassi E, Wu L, Fraser PE, Abreu M, Kiametis AS, Gargano R, Silveira ER, Brand GD, Prchal L, Soukup O, Korabecny J, Bolognesi ML, Soares Romeiro LA (2021)
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties
RSC Med Chem 12: 1154

Kobrlova T, Soukup O (2020)
Effect of P-glycoprotein on the availability of oxime reactivators in the brain
Toxicology

Konecny J, Misiachna A, Hrabinova M, Pulkrabkova L, Benkova M, Prchal L, Kucera T, Kobrlova T, Finger V, Kolcheva M, Kortus S, Jun D, Valko M, Horak M, Soukup O, Korabecny J (2020)
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists
Biomolecules 11:

Mezeiova E, Janockova J, Konecny J, Kobrlova T, Benkova M, Dolezal R, Prchal L, Karasova-Zdarova J, Soukup O, Korabecny J (2020)
From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia
Bioorg Chem 103: 104179

Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z, Motykova K, Kubackova J, Bednarikova Z, Janockova J, Jesus C, Cortes L, Pina J, Rostohar D, Serpa C, Soukup O, Aitken L, Hughes RE, Musilek K, Muckova L, Jost P, Chvojkova M, Vales K, Valis M, Chrienova Z, Chalupova K, Kuca K (2020)
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems
Bioorg Chem 107: 104596

Sobolova K, Hrabinova M, Hepnarova V, Kucera T, Kobrlova T, Benkova M, Janockova J, Dolezal R, Prchal L, Benek O, Mezeiova E, Jun D, Soukup O, Korabecny J (2020)
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
Eur Journal of Medicinal Chemistry 203: 112593

AlFadly ED, Elzahhar PA, Tramarin A, Elkazaz S, Shaltout H, Abu-Serie MM, Janockova J, Soukup O, Ghareeb DA, El-Yazbi AF, Rafeh RW, Bakkar NZ, Kobeissy F, Iriepa I, Moraleda I, Saudi MNS, Bartolini M, Belal ASF (2019)
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
Eur Journal of Medicinal Chemistry 167: 161

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Karasova JZ, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K (2019)
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Eur Journal of Medicinal Chemistry 168: 491

Dgachi Y, Martin H, Malek R, Jun D, Janockova J, Sepsova V, Soukup O, Iriepa I, Moraleda I, Maalej E, Carreiras MC, Refouvelet B, Chabchoub F, Marco-Contelles J, Ismaili L (2019)
Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy
J Enzyme Inhib Med Chem 34: 163

Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J (2019)
Oxime K203: a drug candidate for the treatment of tabun intoxication
Archives of Toxicology 93: 673

Gorecki L, Junova L, Kucera T, Hepnarova V, Prchal L, Kobrlova T, Muckova L, Soukup O, Korabecny J (2019)
Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase
Future Med Chem 11: 2625

Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O (2019)
Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators
Toxicol Appl Pharmacol

Janockova J, Korabecny J, Plsikova J, Babkova K, Konkolova E, Kucerova D, Vargova J, Koval J, Jendzelovsky R, Fedorocko P, Kasparkova J, Brabec V, Rosocha J, Soukup O, Hamulakova S, Kuca K, Kozurkova M (2019)
In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
J Enzyme Inhib Med Chem 34: 877

Jonczyk J, Lodarski K, Staszewski M, Godyn J, Zareba P, Soukup O, Janockova J, Korabecny J, Salat K, Malikowska-Racia N, Hebda M, Szalaj N, Filipek B, Walczynski K, Malawska B, Bajda M (2019)
Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives
Bioorg Chem 90: 103084

Kaniakova M, Nepovimova E, Kleteckova L, Skrenkova K, Holubova K, Chrienova Z, Hepnarova V, Kucera T, Kobrlova T, Vales K, Korabecny J, Soukup O, Horak M (2019)
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
Curr Alzheimer Res 16: 821

Karasova JZ, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K (2019)
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
Drug & Chemical Toxicology

Kobrlova T, Korabecny J, Soukup O (2019)
Current approaches to enhancing oxime reactivator delivery into the brain
Toxicology 423: 75

Korabecny J, Spilovska K, Mezeiova E, Benek O, Juza R, Kaping D, Soukup O (2019)
A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer's Disease
Curr Med Chem 26: 5625

Malek R, Arribas RL, Palomino-Antolin A, Totoson P, Demougeot C, Kobrlova T, Soukup O, Iriepa I, Moraleda I, Diez-Iriepa D, Godyn J, Panek D, Malawska B, Gluch-Lutwin M, Mordyl B, Siwek A, Chabchoub F, Marco-Contelles J, Kiec-Kononowicz K, Egea J, de los Rios C, Ismaili L (2019)
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
Journal of Medicinal Chemistry 62: 11416

Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J (2019)
Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
Curr Alzheimer Res 16: 772

Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J, Pham NL, Nguyen TD, Valis M, Kuca K (2019)
N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy
Curr Alzheimer Res 16: 333

Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R, Soukup O, Kobrlova T, Pham NL, Nguyen TD, Konecny J, Kuca K (2019)
Orexin supplementation in narcolepsy treatment: A review
Med Res Rev 39: 961

Svobodova B, Mezeiova E, Hepnarova V, Hrabinova M, Muckova L, Kobrlova T, Jun D, Soukup O, Jimeno ML, Marco-Contelles J, Korabecny J (2019)
Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
Biomolecules 9:

Hamulakova S, Janovec L, Soukup O, Jun D, Janockova J, Hrabinova M, Sepsova V, Kuca K (2018)
Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
Curr Alzheimer Res 15: 1096

Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O (2018)
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
Eur Journal of Medicinal Chemistry 150: 292

Janockova J, Dolezal R, Nepovimova E, Kobrlova T, Benkova M, Kuca K, Konecny J, Mezeiova E, Melikova M, Hepnarova V, Ring A, Soukup O, Korabecny J (2018)
Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
Molecules 23:

Kuca K, Musilek K, Jun D, Karasova JZ, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC, da Cunha EFF, de Castro AA, Valis M, Ramalho TC (2018)
A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
BMC Pharmacol Toxicol 19: 8

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K (2018)
Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
Drug Des Devel Ther 12: 505

Malinak D, Korabecny J, Soukup O, Gorecki L, Nepovimova E, Psotka M, Dolezal R, Nguyen TD, Mezeiova E, Musilek K, Kuca K (2018)
A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators
Current Organic Chemistry 22": 1619

Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D, Kuca K, Korabecny J (2018)
Profiling donepezil template into multipotent hybrids with antioxidant properties
J Enzyme Inhib Med Chem 33: 583

Misik J, Nepovimova E, Pejchal J, Kassa J, Korabecny J, Soukup O (2018)
Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects
Curr Alzheimer Res 15: 552

Panek D, Wieckowska A, Jonczyk J, Godyn J, Bajda M, Wichur T, Pasieka A, Knez D, Pislar A, Korabecny J, Soukup O, Sepsova V, Sabate R, Kos J, Gobec S, Malawska B (2018)
Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents
ACS Chem Neurosci 9: 1074

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K (2018)
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Med Chem 14: 281

Wieckowska A, Wichur T, Godyn J, Bucki A, Marcinkowska M, Siwek A, Wieckowski K, Zareba P, Knez D, Gluch-Lutwin M, Kazek G, Latacz G, Mika K, Kolaczkowski M, Korabecny J, Soukup O, Benkova M, Kiec-Kononowicz K, Gobec S, Malawska B (2018)
Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease
ACS Chem Neurosci 9: 1195

Zorbaz T, Malinak D, Marakovic N, Macek Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinic M, Kuca K, Kovarik Z, Musilek K (2018)
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents
Journal of Medicinal Chemistry 61: 10753

Babkova K, Korabecny J, Soukup O, Nepovimova E, Jun D, Kuca K (2017)
Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
Future Med Chem 9: 1015

Bautista-Aguilera OM, Hagenow S, Palomino-Antolin A, Farre-Alins V, Ismaili L, Joffrin PL, Jimeno ML, Soukup O, Janockova J, Kalinowsky L, Proschak E, Iriepa I, Moraleda I, Schwed JS, Romero Martinez A, Lopez-Munoz F, Chioua M, Egea J, Ramsay RR, Marco-Contelles J, Stark H (2017)
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases
Angew Chem Int Ed Engl 56: 12765

Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E, Fedunova D, Horak M, Kaniakova M, Wang ZJ, Hamouda AK, Kuca K (2017)
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
Biochimica & Biophysica Acta Mol Basis Dis 1863: 607

Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, Dolezal R, Jun D, Soukup O, Kuca K (2017)
Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)
Expert Opin Ther Pat 27: 971

Hamulakova S, Janovec L, Soukup O, Jun D, Kuca K (2017)
Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
Int J Biol Macromol 104: 333

Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A, Ricny J, Vales K, Soukup O (2017)
The pharmacology of tacrine at N-methyl-d-aspartate receptors
Prog Neuropsychopharmacol Biological Psychiatry 75: 54

Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K (2017)
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
Molecules 22:

Psotka M, Malinak D, Gorecki L, Nguyen TD, Soukup O, Jun D, Kuca K, Musilek K, Korabecny J (2017)
HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication
Military Medical Science Letters 86: 70

Soukup O, Winder M, Killi UK, Wsol V, Jun D, Kuca K, Tobin G (2017)
Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment
Curr Neuropharmacol 15: 637

Spilovska K, Korabecny J, Sepsova V, Jun D, Hrabinova M, Jost P, Muckova L, Soukup O, Janockova J, Kucera T, Dolezal R, Mezeiova E, Kaping D, Kuca K (2017)
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation
Molecules 22:

Spilovska K, Korabecny J, Nepovimova E, Dolezal R, Mezeiova E, Soukup O, Kuca K (2017)
Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease
Curr Top Med Chem 17: 1006

Benchekroun M, Romero A, Egea J, Leon R, Michalska P, Buendia I, Jimeno ML, Jun D, Janockova J, Sepsova V, Soukup O, Bautista-Aguilera OM, Refouvelet B, Ouari O, Marco-Contelles J, Ismaili L (2016)
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
Journal of Medicinal Chemistry 59: 9967

Benek O, Soukup O, Pasdiorova M, Hroch L, Sepsova V, Jost P, Hrabinova M, Jun D, Kuca K, Zala D, Ramsay RR, Marco-Contelles J, Musilek K (2016)
Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
ChemMedChem 11: 1264

Dgachi Y, Bautista-Aguilera OM, Benchekroun M, Martin H, Bonet A, Knez D, Godyn J, Malawska B, Gobec S, Chioua M, Janockova J, Soukup O, Chabchoub F, Marco-Contelles J, Ismaili L (2016)
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease
Molecules 21:

Dgachi Y, Sokolov O, Luzet V, Godyn J, Panek D, Bonet A, Martin H, Iriepa I, Moraleda I, Garcia-Iriepa C, Janockova J, Richert L, Soukup O, Malawska B, Chabchoub F, Marco-Contelles J, Ismaili L (2016)
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy
Eur Journal of Medicinal Chemistry 126: 576

Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, Pasdiorova M, Salajkova S, Korabecny J, Honegr J, Ramalho TC, Kuca K (2016)
Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies
Eur Journal of Medicinal Chemistry 121: 699

Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K (2016)
SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
Archives of Toxicology 90: 2831

Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M, Soukup O, Kristian P, Gazova Z, Bednarikova Z, Kuca K, Valko M (2016)
Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
J Inorg Biochem 161: 52

Janockova J, Zilecka E, Kasparkova J, Brabec V, Soukup O, Kuca K, Kozurkova M (2016)
Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity
Mol Biosyst 12: 2910

Jerabek J, Uliassi E, Guidotti L, Korabecny J, Soukup O, Sepsova V, Hrabinova M, Kuca K, Bartolini M, Pena-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML (2016)
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
Eur Journal of Medicinal Chemistry 127: 250

Kristofikova Z, Ricny J, Soukup O, Korabecny J, Nepovimova E, Kuca K, Ripova D (2016)
Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1
Dementia & Geriatric Cognitive Disorders 43: 45

Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K (2016)
A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
Toxicol Res (Camb) 5: 1012

Panek D, Wieckowska A, Wichur T, Bajda M, Godyn J, Jonczyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B (2016)
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
Eur Journal of Medicinal Chemistry 125: 676

Prati F, Bergamini C, Fato R, Soukup O, Korabecny J, Andrisano V, Bartolini M, Bolognesi ML (2016)
Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease
ChemMedChem 11: 1284

Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L, Sepsova V, Hrabinova M, Soukup O, Jun D, Kuca K (2015)
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
Molecules 20: 22084

Kuca K, Hrabinova M, Jun D, Musilek K, Penhaker M, Krejcar O, Soukup O (2015)
Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE
Med Chem 11: 683

Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimaraes MJ, Souza IN, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korabecny J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LA (2015)
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease
Eur Journal of Medicinal Chemistry 108: 687

Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M, Soukup O, Bukum N, Jost P, Muckova L, Kassa J, Malinak D, Andrs M, Kuca K (2015)
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
Journal of Medicinal Chemistry 58: 8985

Sepsova V, Karasova JZ, Tobin G, Jun D, Korabecny J, Cabelova P, Janska K, Krusek J, Skrenkova K, Kuca K, Soukup O (2015)
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives
Gen Physiol Biophys 34: 189

Killi UK, Wsol V, Soukup O, Kuca K, Winder M, Tobin G (2014)
In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat
Clinical & Experimental Pharmacology & Physiology 41: 139

Korabecny J, Soukup O, Dolezal R, Spilovska K, Nepovimova E, Andrs M, Nguyen TD, Jun D, Musilek K, Kucerova-Chlupacova M, Kuca K (2014)
From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators
Mini Rev Med Chem 14: 215

Sepsova V, Krusek J, Karasova JZ, Zemek F, Musilek K, Kuca K, Soukup O (2014)
The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor
Physiol Res 63: 771

Kuca K, Musilek K, Jun D, Karasova J, Soukup O, Pejchal J, Hrabinova M (2013)
Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX
Med Chem 9: 689

Kuca K, Jun D, Musilek K, Pohanka M, Karasova JZ, Soukup O (2013)
Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides
Mini Rev Med Chem 13: 2102

Soukup O, Jun D, Tobin G, Kuca K (2013)
The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors
Archives of Toxicology 87: 711

Soukup O, Jun D, Karasova JZ, Patocka J, Musilek K, Korabecny J, Krusek J, Kaniakova M, Sepsova V, Mandikova J, Trejtnar F, Pohanka M, Drtinova L, Pavlik M, Tobin G, Kuca K (2013)
A Resurrection of 7-MEOTA: A Comparison with Tacrine
Curr Alzheimer Res 10: 893

Spilovska K, Korabecny J, Kral J, Horova A, Musilek K, Soukup O, Drtinova L, Gazova Z, Siposova K, Kuca K (2013)
7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies
Molecules 18: 2397

Korabecny J, Spilovska K, Benek O, Musilek K, Soukup O, Kuca K (2012)
[Tacrine and its derivatives in the therapy of Alzheimers disease]
Ceska a Slovenska Farmacie 61: 210

Soukup O, Kristofikova Z, Jun D, Tambor V, Ripova D, Kuca K (2012)
The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers
Toxicol Lett 212: 315

Kuca K, Musilek K, Karasova J, Jun D, Soukup O, Pohanka M, Ghosh KK, Hrabinova M (2011)
On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning
Military Medical Science Letters 80: 80

Soukup O, Kumar UK, Proska J, Bratova L, Adem A, Jun D, Fusek J, Kuca K, Tobin G (2011)
The effect of oxime reactivators on muscarinic receptors: functional and binding examinations
Environ Toxicol Pharmacol 31: 364

Soukup O, Krusek J, Kaniakova M, Kumar UK, Oz M, Jun D, Fusek J, Kuca K, Tobin G (2011)
Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors
Physiol Res 60: 679

Kuca K, Hrabinova M, Soukup O, Tobin G, Karasova J, Pohanka M (2010)
Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy
Bratislavske Lekarske Listy 111: 502

Soukup O, Kristofikova Z, Proska J, Tobin G, Patocka J, Marek J, Jun D, Fusek J, Ripova D, Kuca K (2010)
Novel acetylcholinesterase reactivator K112 and its cholinergic properties
Biomed Pharmacother 64: 541

Soukup O, Tobin G, Kumar UK, Binder J, Proska J, Jun D, Fusek J, Kuca K (2010)
Interaction of nerve agent antidotes with cholinergic systems
Curr Med Chem 17: 1708

Soukup O, Tobin G, Kumar UK, Jun D, Fusek J, Kuca K (2010)
Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder
Toxicol Mech Methods 20: 428

Kuca K, Cabal J, Jung YS, Musilek K, Soukup O, Jun D, Pohanka M, Musilova L, Karasova J, Novotny L, Hrabinova M (2009)
Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127
Basic Clin Pharmacol Toxicol 105: 207

Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K (2008)
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder
Neuro Endocrinol Lett 29: 759