Wieckowski K, Szalaj N, Gryzlo B, Wichur T, Goral I, Slugocka E, Sniecikowska J, Latacz G, Siwek A, Godyn J, Bucki A, Kolaczkowski M, Wieckowska A (2022)
Serotonin 5-HT(6) Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease
Int J Mol Sci 23:

Sari S, Barut B, Marcinkowska M, Sabuncuoglu S, Avci A, Kocak Aslan E, Ozel A, Siwek A (2021)
Potential of nafimidone derivatives against co-morbidities of epilepsy: In vitro, in vivo, and in silico investigations
Drug Dev Res

Wichur T, Pasieka A, Godyn J, Panek D, Goral I, Latacz G, Honkisz-Orzechowska E, Bucki A, Siwek A, Gluch-Lutwin M, Knez D, Brazzolotto X, Gobec S, Kolaczkowski M, Sabate R, Malawska B, Wieckowska A (2021)
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau
Eur Journal of Medicinal Chemistry 225: 113783

Wichur T, Godyn J, Goral I, Latacz G, Bucki A, Siwek A, Gluch-Lutwin M, Mordyl B, Sniecikowska J, Walczak M, Knez D, Jukic M, Salat K, Gobec S, Kolaczkowski M, Malawska B, Brazzolotto X, Wieckowska A (2021)
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties
Eur Journal of Medicinal Chemistry 225: 113792

Lazewska D, Bajda M, Kaleta M, Zareba P, Doroz-Plonka A, Siwek A, Alachkar A, Mogilski S, Saad A, Kuder K, Olejarz-Maciej A, Godyn J, Stary D, Sudol S, Wiecek M, Latacz G, Walczak M, Handzlik J, Sadek B, Malawska B, Kiec-Kononowicz K (2020)
Rational design of new multitarget histamine H(3) receptor ligands as potential candidates for treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 207: 112743

Malek R, Arribas RL, Palomino-Antolin A, Totoson P, Demougeot C, Kobrlova T, Soukup O, Iriepa I, Moraleda I, Diez-Iriepa D, Godyn J, Panek D, Malawska B, Gluch-Lutwin M, Mordyl B, Siwek A, Chabchoub F, Marco-Contelles J, Kiec-Kononowicz K, Egea J, de los Rios C, Ismaili L (2019)
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
Journal of Medicinal Chemistry 62: 11416

Marcinkowska M, Bucki A, Panek D, Siwek A, Fajkis N, Bednarski M, Zygmunt M, Godyn J, Del Rio Valdivieso A, Kotanska M, Kolaczkowski M, Wieckowska A (2019)
Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity
Arch Pharm (Weinheim)

Wieckowska A, Wichur T, Godyn J, Bucki A, Marcinkowska M, Siwek A, Wieckowski K, Zareba P, Knez D, Gluch-Lutwin M, Kazek G, Latacz G, Mika K, Kolaczkowski M, Korabecny J, Soukup O, Benkova M, Kiec-Kononowicz K, Gobec S, Malawska B (2018)
Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease
ACS Chem Neurosci 9: 1195

Wieckowska A, Kolaczkowski M, Bucki A, Godyn J, Marcinkowska M, Wieckowski K, Zareba P, Siwek A, Kazek G, Gluch-Lutwin M, Mierzejewski P, Bienkowski P, Sienkiewicz-Jarosz H, Knez D, Wichur T, Gobec S, Malawska B (2016)
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation
Eur Journal of Medicinal Chemistry 124: 63