Scheiner M, Sink A, Hoffmann M, Vrigneau C, Endres E, Carles A, Sotriffer C, Maurice T, Decker M (2022)
Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation
Journal of the American Chemical Society

Hofmann J, Ginex T, Espargaro A, Scheiner M, Gunesch S, Arago M, Stigloher C, Sabate R, Luque FJ, Decker M (2021)
Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation
Chemistry 27: 6015

Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M, De Simone A, Barenys M, Gomez-Catalan J, Perez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallas M, Luque FJ, Munoz-Torrero D (2021)
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
Eur Journal of Medicinal Chemistry 225: 113779

Scheiner M, Hoffmann M, He F, Poeta E, Chatonnet A, Monti B, Maurice T, Decker M (2021)
Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model
Journal of Medicinal Chemistry 64(13):: 9302

Scheiner M, Sink A, Spatz P, Endres E, Decker M (2021)
Photopharmacology on Acetylcholinesterase: Novel Photoswitchable Inhibitors with Improved Pharmacological Profiles
ChemPhotoChem 5: 149

Hofmann J, Fayez S, Scheiner M, Hoffmann M, Oerter S, Appelt-Menzel A, Maher P, Maurice T, Bringmann G, Decker M (2020)
Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo
Chemistry 26: 7299

Hoffmann M, Stiller C, Endres E, Scheiner M, Gunesch S, Sotriffer C, Maurice T, Decker M (2019)
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model
Journal of Medicinal Chemistry 62: 9116

Rodriguez-Soacha DA, Scheiner M, Decker M (2019)
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands
Eur Journal of Medicinal Chemistry 180: 690

Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hubner H, Gmeiner P, Maitra R, Maurice T, Decker M (2019)
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo
Journal of Medicinal Chemistry 62: 9078

Dolles D, Nimczick M, Scheiner M, Ramler J, Stadtmuller P, Sawatzky E, Drakopoulos A, Sotriffer C, Wittmann HJ, Strasser A, Decker M (2016)
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2 R Ligands To Combat Neurodegenerative Disorders
ChemMedChem 11: 1270