Javed MA, Jan MS, Shbeer AM, Al-Ghorbani M, Rauf A, Wilairatana P, Mannan A, Sadiq A, Farooq U, Rashid U (2023)
Evaluation of pyrimidine/pyrrolidine-sertraline based hybrids as multitarget anti-Alzheimer agents: In-vitro, in-vivo, and computational studies
Biomed Pharmacother 159: 114239
Mahnashi MH, Ayaz M, Alqahtani YS, Alyami BA, Shahid M, Alqahtani O, Kabrah SM, Zeb A, Ullah F, Sadiq A (2023)
Quantitative-HPLC-DAD polyphenols analysis, anxiolytic and cognition enhancing potentials of Sorbaria tomentosa Lindl. Rehder
J Ethnopharmacol 317: 116786
Mahnashi MH, Ali S, O MA, Almazni IA, Asiri SA, Sadiq A, Zafar R, Jan MS (2023)
Pharmacological evaluations of amide carboxylates as potential anti-Alzheimer agents: anti-radicals, enzyme inhibition, simulation and behavioral studies in animal models
J Biomol Struct Dyn
Alshehri OM, Mahnashi MH, Sadiq A, Zafar R, Jan MS, Ullah F, Alshehri MA, Alshamrani S, Hassan EE (2022)
Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-alpha-Amylase, and Anti-alpha-Glucosidase: In Vitro and In Silico Approaches
Evid Based Complement Alternat Med 2022: 6726438
Javed MA, Bibi S, Jan MS, Ikram M, Zaidi A, Farooq U, Sadiq A, Rashid U (2022)
Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies
RSC Adv 12: 22503
Mahnashi MH, Alshahrani MA, Nahari MH, Hassan SSU, Jan MS, Ayaz M, Ullah F, Alshehri OM, Alshehri MA, Rashid U, Sadiq A (2022)
In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer's Disease
Metabolites 12:
Obaid RJ, Naeem N, Mughal EU, Al-Rooqi MM, Sadiq A, Jassas RS, Moussa Z, Ahmed SA (2022)
Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
RSC Adv 12: 19764
Waseem W, Anwar F, Saleem U, Ahmad B, Zafar R, Anwar A, Saeed Jan M, Rashid U, Sadiq A, Ismail T (2022)
Prospective Evaluation of an Amide-Based Zinc Scaffold as an Anti-Alzheimer Agent: In Vitro, In Vivo, and Computational Studies
ACS Omega 7: 26723
Javed MA, Ashraf N, Saeed Jan M, Mahnashi MH, Alqahtani YS, Alyami BA, Alqarni AO, Asiri YI, Ikram M, Sadiq A, Rashid U (2021)
Structural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with Neuroinflammation and Cholinergic Deficit in Alzheimer's Disease
ACS Chem Neurosci
Mahnashi MH, Alyami BA, Alqahtani YS, Alqarni AO, Jan MS, Ayaz M, Ullah F, Shahid M, Rashid U, Sadiq A (2021)
Neuroprotective potentials of selected natural edible oils using enzyme inhibitory, kinetic and simulation approaches
BMC Complement Med Ther 21: 248
Zafar R, Naureen H, Zubair M, Shahid K, Saeed Jan M, Akhtar S, Ahmad H, Waseem W, Haider A, Ali S, Tariq M, Sadiq A (2021)
Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer's Disease: Synthesis, Characterization, Computational and in vitro Approaches
Drug Des Devel Ther 15: 2679
Ahmad A, Ullah F, Sadiq A, Ayaz M, Saeed Jan M, Shahid M, Wadood A, Mahmood F, Rashid U, Ullah R, Sahibzada MUK, Alqahtani AS, Mahmood HM (2020)
Comparative Cholinesterase, alpha-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives
Drug Des Devel Ther 14: 2165
Amin MJ, Miana GA, Rashid U, Miraz Rahman K, Khan HU, Sadiq A (2020)
SAR based in-vitro anticholinesterase and molecular docking studies of nitrogenous progesterone derivatives
Steroids
Mughal EU, Sadiq A, Ayub M, Naeem N, Javid A, Sumrra SH, Zafar MN, Khan BA, Malik FP, Ahmed I (2020)
Exploring 3-Benzyloxyflavones as new lead cholinesterase inhibitors: synthesis, structure-activity relationship and molecular modelling simulations
J Biomol Struct Dyn
Tong X, Li X, Ayaz M, Ullah F, Sadiq A, Ovais M, Shahid M, Khayrullin M, Hazrat A (2020)
Neuroprotective Studies on Polygonum hydropiper L. Essential Oils Using Transgenic Animal Models
Front Pharmacol 11: 580069
Zafar R, Zubair M, Ali S, Shahid K, Waseem W, Naureen H, Haider A, Saeed Jan M, Ullah F, Sirajuddin M, Sadiq A (2020)
Zinc metal carboxylates as Potential anti-Alzheimer's candidate: In-vitro anticholinesterase, antioxidant and molecular docking studies
J Biomol Struct Dyn
Ahmad G, Rasool N, Rizwan K, Imran I, Zahoor AF, Zubair M, Sadiq A, Rashid U (2019)
Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs
Bioorg Chem 92: 103216
Ahmad A, Ullah F, Sadiq A, Ayaz M, Rahim H, Rashid U, Ahmad S, Jan MS, Ullah R, Shahat AA, Mahmood HM (2019)
Pharmacological Evaluation of Aldehydic-Pyrrolidinedione Against HCT-116, MDA-MB231, NIH/3T3, MCF-7 Cancer Cell Lines, Antioxidant and Enzyme Inhibition Studies
Drug Des Devel Ther 13: 4185
Ayaz M, Sadiq A, Junaid M, Ullah F, Ovais M, Ullah I, Ahmed J, Shahid M (2019)
Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders
Front Aging Neurosci 11: 155
Mughal EU, Sadiq A, Ashraf J, Zafar MN, Sumrra SH, Tariq R, Mumtaz A, Javid A, Khan BA, Ali A, Javed CO (2019)
Flavonols and 4-thioflavonols as potential acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, structure-activity relationship and molecular docking studies
Bioorg Chem 91: 103124
Zafar R, Ullah H, Zahoor M, Sadiq A (2019)
Isolation of bioactive compounds from Bergenia ciliata (haw.) Sternb rhizome and their antioxidant and anticholinesterase activities
BMC Complement Altern Med 19: 296
Mughal EU, Javid A, Sadiq A, Murtaza S, Zafar MN, Khan BA, Sumrra SH, Tahir MN, Kanwal, Khan KM (2018)
Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors
Bioorganic & Medicinal Chemistry 26: 3696
Sadiq A, Zeb A, Ullah F, Ahmad S, Ayaz M, Rashid U, Muhammad N (2018)
Chemical Characterization, Analgesic, Antioxidant, and Anticholinesterase Potentials of Essential Oils From Isodon rugosus Wall. ex. Benth
Front Pharmacol 9: 623
Tanoli ST, Ramzan M, Hassan A, Sadiq A, Jan MS, Khan FA, Ullah F, Ahmad H, Bibi M, Mahmood T, Rashid U (2018)
Design, synthesis and bioevaluation of tricyclic fused ring system as dual binding site acetylcholinesterase inhibitors
Bioorg Chem 83: 336
Ali M, Muhammad S, Shah MR, Khan A, Rashid U, Farooq U, Ullah F, Sadiq A, Ayaz M, Ahmad M, Latif A (2017)
Neurologically Potent Molecules from Crataegus oxyacantha; Isolation, Anticholinesterase Inhibition, and Molecular Docking
Front Pharmacol 8: 327
Ayaz M, Sadiq A, Junaid M, Ullah F, Subhan F, Ahmed J (2017)
Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants
Front Aging Neurosci 9: 168
Ayaz M, Junaid M, Ullah F, Subhan F, Sadiq A, Ali G, Ovais M, Shahid M, Ahmad A, Wadood A, El-Shazly M, Ahmad N, Ahmad S (2017)
Anti-Alzheimer's Studies on beta-Sitosterol Isolated from Polygonum hydropiper L
Front Pharmacol 8: 697
Imran M, Ullah F, Ayaz M, Sadiq A, Shah MR, Jan MS (2017)
Anticholinesterase and antioxidant potentials of Nonea micrantha Bioss. & Reut along with GC-MS analysis
BMC Complement Altern Med 17: 499
Mughal EU, Sadiq A, Murtaza S, Rafique H, Zafar MN, Riaz T, Khan BA, Hameed A, Khan KM (2017)
Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry 25: 100
Sarfraz M, Sultana N, Rashid U, Akram MS, Sadiq A, Tariq MI (2017)
Synthesis, biological evaluation and docking studies of 2,3-dihydroquinazolin-4(1H)-one derivatives as inhibitors of cholinesterases
Bioorg Chem 70: 237
Sultana N, Sarfraz M, Tanoli ST, Akram MS, Sadiq A, Rashid U, Tariq MI (2017)
Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases
Bioorg Chem 72: 256
Ahmad S, Ullah F, Sadiq A, Ayaz M, Imran M, Ali I, Zeb A, Shah MR (2016)
Chemical composition, antioxidant and anticholinesterase potentials of essential oil of Rumex hastatus D. Don collected from the North West of Pakistan
BMC Complement Altern Med 16: 29
Ahmad S, Ullah F, Ayaz M, Sadiq A, Imran M (2015)
Antioxidant and anticholinesterase investigations of Rumex hastatus D. Don: potential effectiveness in oxidative stress and neurological disorders
Biol Res 48: 20
Ayaz M, Junaid M, Ullah F, Sadiq A, Khan MA, Ahmad W, Shah MR, Imran M, Ahmad S (2015)
Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: A Preliminary anti- Alzheimer's study
Lipids Health Dis 14: 141
Kamal Z, Ullah F, Ayaz M, Sadiq A, Ahmad S, Zeb A, Hussain A, Imran M (2015)
Anticholinesterse and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of atriplex laciniata L.: potential effectiveness in Alzheimer's and other neurological disorders
Biol Res 48: 21
Sadiq A, Mahmood F, Ullah F, Ayaz M, Ahmad S, Haq FU, Khan G, Jan MS (2015)
Synthesis, anticholinesterase and antioxidant potentials of ketoesters derivatives of succinimides: a possible role in the management of Alzheimer's
Chem Cent J 9: 31
Ullah F, Ayaz M, Sadiq A, Hussain A, Ahmad S, Imran M, Zeb A (2015)
Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var; florentina
Nat Prod Res
Ayaz M, Junaid M, Ahmed J, Ullah F, Sadiq A, Ahmad S, Imran M (2014)
Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L
BMC Complement Altern Med 14: 145
Zeb A, Sadiq A, Ullah F, Ahmad S, Ayaz M (2014)
Investigations of anticholinestrase and antioxidant potentials of methanolic extract, subsequent fractions, crude saponins and flavonoids isolated from Isodon rugosus
Biol Res 47: 76