Rosenson RS, Gaudet D, Ballantyne CM, Baum SJ, Bergeron J, Kershaw EE, Moriarty PM, Rubba P, Whitcomb DC, Banerjee P, Gewitz A, Gonzaga-Jauregui C, McGinniss J, Ponda MP, Pordy R, Zhao J, Rader DJ (2023)
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial
Nat Med

Khetarpal SA, Vitali C, Levin MG, Klarin D, Park J, Pampana A, Millar JS, Kuwano T, Sugasini D, Subbaiah PV, Billheimer JT, Natarajan P, Rader DJ (2021)
Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins
PLoS Genet 17: e1009802

Wu L, Soundarapandian MM, Castoreno AB, Millar JS, Rader DJ (2020)
LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase
Circulation Research 127: 1112

Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S (2017)
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease
Jama 317: 937

Zhang H, Shi J, Hachet MA, Xue C, Bauer RC, Jiang H, Li W, Tohyama J, Millar J, Billheimer J, Phillips MC, Razani B, Rader DJ, Reilly MP (2017)
CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report
Arterioscler Thromb Vasc Biol 37: 2156

Rader DJ (2015)
Lysosomal Acid Lipase Deficiency--A New Therapy for a Genetic Lipid Disease
N Engl J Med 373: 1071

Miksztowicz V, Schreier L, McCoy M, Lucero D, Fassio E, Billheimer J, Rader DJ, Berg G (2014)
Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
Arterioscler Thromb Vasc Biol 34: 669

Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ (2014)
Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species
Lipids 49: 505

Yang P, Belikova NA, Billheimer J, Rader DJ, Hill JS, Subbaiah PV (2014)
Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins
Lipids 49: 987

Keenan TE, Rader DJ (2013)
Genetics of lipid traits and relationship to coronary artery disease
Curr Cardiol Rep 15: 396

Larach DB, Cuchel M, Rader DJ (2013)
Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics
Clin Lipidol 8: 635

Stitziel NO, Fouchier SW, Sjouke B, Peloso GM, Moscoso AM, Auer PL, Goel A, Gigante B, Barnes TA, Melander O, Orho-Melander M, Duga S, Sivapalaratnam S, Nikpay M, Martinelli N, Girelli D, Jackson RD, Kooperberg C, Lange LA, Ardissino D, McPherson R, Farrall M, Watkins H, Reilly MP, Rader DJ, de Faire U, Schunkert H, Erdmann J, Samani NJ, Charnas L, Altshuler D, Gabriel S, Kastelein JJ, Defesche JC, Nederveen AJ, Kathiresan S, Hovingh GK (2013)
Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia
Arterioscler Thromb Vasc Biol 33: 2909

Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J (2013)
Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium
Arterioscler Thromb Vasc Biol 33: 1788

O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW (2012)
Design and synthesis of boronic acid inhibitors of endothelial lipase
Bioorganic & Medicinal Chemistry Lett 22: 1397

Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J (2011)
VLDL hydrolysis by hepatic lipase regulates PPARdelta transcriptional responses
PLoS ONE 6: e21209

Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Doring A, Thorand B, Li M, Reilly MP, Koenig W, Samani NJ, Rader DJ (2011)
Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol
Circ Cardiovasc Genet 4: 145

Khetarpal SA, Edmondson AC, Raghavan A, Neeli H, Jin W, Badellino KO, Demissie S, Manning AK, Derohannessian SL, Wolfe ML, Cupples LA, Li M, Kathiresan S, Rader DJ (2011)
Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol
PLoS Genet 7: e1002393

Watson CE, Weissbach N, Kjems L, Ayalasomayajula S, Zhang Y, Chang I, Navab M, Hama S, Hough G, Reddy ST, Soffer D, Rader DJ, Fogelman AM, Schecter A (2011)
Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function
J Lipid Res 52: 361

Wild PS, Zeller T, Schillert A, Szymczak S, Sinning CR, Deiseroth A, Schnabel RB, Lubos E, Keller T, Eleftheriadis MS, Bickel C, Rupprecht HJ, Wilde S, Rossmann H, Diemert P, Cupples LA, Perret C, Erdmann J, Stark K, Kleber ME, Epstein SE, Voight BF, Kuulasmaa K, Li M, Schafer AS, Klopp N, Braund PS, Sager HB, Demissie S, Proust C, Konig IR, Wichmann HE, Reinhard W, Hoffmann MM, Virtamo J, Burnett MS, Siscovick D, Wiklund PG, Qu L, El Mokthari NE, Thompson JR, Peters A, Smith AV, Yon E, Baumert J, Hengstenberg C, Marz W, Amouyel P, Devaney J, Schwartz SM, Saarela O, Mehta NN, Rubin D, Silander K, Hall AS, Ferrieres J, Harris TB, Melander O, Kee F, Hakonarson H, Schrezenmeir J, Gudnason V, Elosua R, Arveiler D, Evans A, Rader DJ, Illig T, Schreiber S, Bis JC, Altshuler D, Kavousi M, Witteman JC, Uitterlinden AG, Hofman A, Folsom AR, Barbalic M, Boerwinkle E, Kathiresan S, Reilly MP, O'Donnell CJ, Samani NJ, Schunkert H, Cambien F, Lackner KJ, Tiret L, Salomaa V, Munzel T, Ziegler A, Blankenberg S (2011)
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease
Circ Cardiovasc Genet 4: 403

Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ (2010)
Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins
Circulation Research 107: 357

Liu J, Afroza H, Rader DJ, Jin W (2010)
Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases
Journal of Biological Chemistry 285: 27561

Yasuda T, Ishida T, Rader DJ (2010)
Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis
Circ J 74: 2263

Brown RJ, Edmondson AC, Griffon N, Hill TB, Fuki IV, Badellino KO, Li M, Wolfe ML, Reilly MP, Rader DJ (2009)
A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis
J Lipid Res 50: 1910

Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, Derohannessian S, Li M, Reilly MP, Aberle J, Evans D, Hegele RA, Rader DJ (2009)
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
J Clinical Investigation 119: 1042

Griffon N, Jin W, Petty TJ, Millar J, Badellino KO, Saven JG, Marchadier DH, Kempner ES, Billheimer J, Glick JM, Rader DJ (2009)
Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation
Journal of Biological Chemistry 284: 23322

Jensen MK, Rimm EB, Mukamal KJ, Edmondson AC, Rader DJ, Vogel U, Tjonneland A, Sorensen TI, Schmidt EB, Overvad K (2009)
The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations
Eur Heart J 30: 1584

Badellino KO, Wolfe ML, Reilly MP, Rader DJ (2008)
Endothelial lipase is increased in vivo by inflammation in humans
Circulation 117: 678

Brown RJ, Rader DJ (2007)
Lipases as modulators of atherosclerosis in murine models
Curr Drug Targets 8: 1307

Brown RJ, Miller GC, Griffon N, Long CJ, Rader DJ (2007)
Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo
J Lipid Res 48: 1132

Skropeta D, Settasatian C, McMahon MR, Shearston K, Caiazza D, McGrath KC, Jin W, Rader DJ, Barter PJ, Rye KA (2007)
N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins
J Lipid Res 48: 2047

Wang X, Jin W, Rader DJ (2007)
Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production
Circulation Research 100: 1008

Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J (2006)
High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion
Circulation Research 98: 490

Badellino KO, Wolfe ML, Reilly MP, Rader DJ (2006)
Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
PLoS Med 3: e22

Griffon N, Budreck EC, Long CJ, Broedl UC, Marchadier DH, Glick JM, Rader DJ (2006)
Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras
J Lipid Res 47: 1803

Paradis ME, Badellino KO, Rader DJ, Tchernof A, Richard C, Luu-The V, Deshaies Y, Bergeron J, Archer WR, Couture P, Bergeron N, Lamarche B (2006)
Visceral adiposity and endothelial lipase
J Clinical Endocrinology Metab 91: 3538

Paradis ME, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, Bergeron N, Lamarche B (2006)
Endothelial lipase is associated with inflammation in humans
J Lipid Res 47: 2808

Rader DJ (2006)
Molecular regulation of HDL metabolism and function: implications for novel therapies
J Clinical Investigation 116: 3090

Broedl UC, Jin W, Marchadier D, Secreto A, Rader DJ (2005)
Tissue-specific expression pattern of human endothelial lipase in transgenic mice
Atherosclerosis 181: 271

Jahangiri A, Rader DJ, Marchadier D, Curtiss LK, Bonnet DJ, Rye KA (2005)
Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I
J Lipid Res 46: 896

Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ (2005)
Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase
Journal of Biological Chemistry 280: 36551

Kratky D, Zimmermann R, Wagner EM, Strauss JG, Jin W, Kostner GM, Haemmerle G, Rader DJ, Zechner R (2005)
Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue
J Clinical Investigation 115: 161

Moore RE, Navab M, Millar JS, Zimetti F, Hama S, Rothblat GH, Rader DJ (2005)
Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation
Circulation Research 97: 763

Rader DJ (2005)
Gene therapy for genetic lipid disorders: lipoprotein lipase deficiency as a paradigm
Neth J Med 63: 2

Rader DJ (2005)
Gain-of-function mutations and therapeutic implications: lipoprotein lipase S447X to the rescue
Arterioscler Thromb Vasc Biol 25: 2018

Reilly MP, Foulkes AS, Wolfe ML, Rader DJ (2005)
Higher order lipase gene association with plasma triglycerides
J Lipid Res 46: 1914

Sovic A, Panzenboeck U, Wintersperger A, Kratzer I, Hammer A, Levak-Frank S, Frank S, Rader DJ, Malle E, Sattler W (2005)
Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier
Journal of Neurochemistry 94: 109

Badellino KO, Rader DJ (2004)
The role of endothelial lipase in high-density lipoprotein metabolism
Curr Opin Cardiol 19: 392

Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, Fuki IV, Marchadier D, Glick JM, Rader DJ (2004)
Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins
Circulation Research 94: 1554

Broedl UC, Jin W, Fuki IV, Glick JM, Rader DJ (2004)
Structural basis of endothelial lipase tropism for HDL
FASEB Journal 18: 1891

Broedl UC, Jin W, Rader DJ (2004)
Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation
Trends Cardiovasc Med 14: 202

Duong M, Psaltis M, Rader DJ, Marchadier D, Barter PJ, Rye KA (2003)
Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids
Biochemistry 42: 13778

Fuki IV, Blanchard N, Jin W, Marchadier DH, Millar JS, Glick JM, Rader DJ (2003)
Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway
Journal of Biological Chemistry 278: 34331

Jin W, Millar JS, Broedl U, Glick JM, Rader DJ (2003)
Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo
J Clinical Investigation 111: 357

Maugeais C, Tietge UJ, Broedl UC, Marchadier D, Cain W, McCoy MG, Lund-Katz S, Glick JM, Rader DJ (2003)
Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase
Circulation 108: 2121

Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (2002)
Lipase H, a new member of the triglyceride lipase family synthesized by the intestine
Genomics 80: 268

McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ (2002)
Characterization of the lipolytic activity of endothelial lipase
J Lipid Res 43: 921

deLemos AS, Wolfe ML, Long CJ, Sivapackianathan R, Rader DJ (2002)
Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol
Circulation 106: 1321

Tietge UJ, Sun G, Czarnecki S, Yu Q, Lohse P, Du H, Grabowski GA, Glick JM, Rader DJ (2001)
Phenotypic correction of lipid storage and growth arrest in wolman disease fibroblasts by gene transfer of lysosomal acid lipase
Hum Gene Therapy 12: 279

Rader DJ, Jaye M (2000)
Endothelial lipase: a new member of the triglyceride lipase gene family
Curr Opin Lipidol 11: 141

Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ (1999)
A novel endothelial-derived lipase that modulates HDL metabolism
Nat Genet 21: 424

Rader DJ, Ikewaki K, Duverger N, Schmidt H, Pritchard H, Frohlich J, Clerc M, Dumon MF, Fairwell T, Zech L, Santamarina-Fojo S, Brewer HB, Jr., et al. (1994)
Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease
J Clinical Investigation 93: 321

Klein HG, Lohse P, Duverger N, Albers JJ, Rader DJ, Zech LA, Santamarina-Fojo S, Brewer HB, Jr. (1993)
Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn)
J Lipid Res 34: 49