Guimaraes DA, Aquino NSS, Rocha-Resende C, Jesus ICG, Silva MM, Scalzo SA, Fonseca RC, Durand MT, Pereira V, Tezini G, Oliveira A, Prado VF, Stefanon I, Salgado HC, Prado MAM, Szawka RE, Guatimosim S (2022)
Neuronal cholinergic signaling constrains norepinephrine activity in the heart
American Journal of Physiology Cell Physiol

Joviano-Santos JV, Kljakic O, Magalhaes-Gomes MPS, Valadao PAC, de Oliveira LR, Prado MAM, Prado VF, Guatimosim C (2021)
Motoneuron-specific loss of VAChT mimics neuromuscular defects seen in Congenital Myasthenic Syndrome
Febs J

Magalhaes-Gomes MPS, Camargos W, Valadao PAC, Garcias RS, Rodrigues HA, Andrade JN, Teixeira VP, Kushmerick LAN, Cavalcante WLG, Gallaci M, Guatimosim S, Prado VF, Prado MAM, Guatimosim C (2021)
Increasead cholinergic tone causes pre-synaptic neuromuscular degeneration and is associated with impaired diaphragm function
Neuroscience

Jing M, Li Y, Zeng J, Huang P, Skirzewski M, Kljakic O, Peng W, Qian T, Tan K, Zou J, Trinh S, Wu R, Zhang S, Pan S, Hires SA, Xu M, Li H, Saksida LM, Prado VF, Bussey TJ, Prado MAM, Chen L, Cheng H (2020)
An optimized acetylcholine sensor for monitoring in vivo cholinergic activity
Nat Methods 17: 1139

Lackie RE, Razzaq AR, Farhan SMK, Qiu LR, Moshitzky G, Beraldo FH, Lopes MH, Maciejewski A, Gros R, Fan J, Choy WY, Greenberg DS, Martins VR, Duennwald ML, Lerch JP, Soreq H, Prado VF, Prado MAM (2020)
Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1
Journal of Neurochemistry 153: 727

Magalhaes-Gomes MPS, Motta-Santos D, Schetino LPL, Andrade JN, Bastos CP, Guimaraes DAS, Vaughan SK, Martinelli PM, Guatimosim S, Pereira GS, Coimbra CC, Prado VF, Prado MAM, Valdez G, Guatimosim C (2018)
Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia
Neurochem Int 120: 1

Al-Onaizi MA, Parfitt GM, Kolisnyk B, Law CS, Guzman MS, Barros DM, Leung LS, Prado MAM, Prado VF (2017)
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone
Cerebral Cortex 27: 1615

Janickova H, Rosborough K, Al-Onaizi M, Kljakic O, Guzman MS, Gros R, Prado MAM, Prado VF (2017)
Deletion of the vesicular acetylcholine transporter from pedunculopontine/laterodorsal tegmental neurons modifies gait
Journal of Neurochemistry 140: 787

Kljakic O, Janickova H, Prado VF, Prado MAM (2017)
Cholinergic/glutamatergic co-transmission in striatal cholinergic interneurons: new mechanisms regulating striatal computation
Journal of Neurochemistry 142 Suppl 2: 90

Kolisnyk B, Al-Onaizi M, Soreq L, Barbash S, Bekenstein U, Haberman N, Hanin G, Kish MT, Souza da Silva J, Fahnestock M, Ule J, Soreq H, Prado VF, Prado MAM (2017)
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology
Cerebral Cortex 27: 3553

Padua-Reis M, Aquino NS, Oliveira VEM, Szawka RE, Prado MAM, Prado VF, Pereira GS (2017)
Reduced Vesicular Acetylcholine Transporter favors antidepressant behaviors and modulates serotonin and dopamine in female mouse brain
Behavioural Brain Research 330: 127

Pinheiro NM, Santana FP, Almeida RR, Guerreiro M, Martins MA, Caperuto LC, Camara NO, Wensing LA, Prado VF, Tiberio IF, Prado MAM, Prado CM (2017)
Acute lung injury is reduced by the alpha7nAChR agonist PNU-282987 through changes in the macrophage profile
FASEB Journal 31: 320

Prado VF, Janickova H, Al-Onaizi MA, Prado MAM (2017)
Cholinergic circuits in cognitive flexibility
Neuroscience 345: 130

Amaral FA, Fagundes CT, Miranda AS, Costa VV, Resende L, Gloria de Souza D, Prado VF, Teixeira MM, Maximo Prado MA, Teixeira AL (2016)
Endogenous Acetylcholine Controls the Severity of Polymicrobial Sepsisassociated Inflammatory Response in Mice
Curr Neurovasc Res 13: 4

Beraldo FH, Ostapchenko VG, Caetano FA, Guimaraes AL, Ferretti GD, Daude N, Bertram L, Nogueira KO, Silva JL, Westaway D, Cashman NR, Martins VR, Prado VF, Prado MAM (2016)
Regulation of Amyloid beta Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex
Journal of Biological Chemistry 291: 21945

Jackson MF, Prado VF, Prado MAM (2016)
Commemorating John F. MacDonald and the Art of Being a Mentor
Can Journal of Neurology Sci 43: 735

Kolisnyk B, Al-Onaizi MA, Xu J, Parfitt GM, Ostapchenko VG, Hanin G, Soreq H, Prado MAM, Prado VF (2016)
Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors
Journal of Neuroscience 36: 6287

Leite HR, Oliveira-Lima OC, Pereira Lde M, Oliveira VE, Prado VF, Prado MAM, Pereira GS, Massensini AR (2016)
Vesicular acetylcholine transporter knock down-mice are more susceptible to inflammation, c-Fos expression and sickness behavior induced by lipopolysaccharide
Brain Behavior & Immunity 57: 282

Palmer D, Creighton S, Prado VF, Prado MAM, Choleris E, Winters BD (2016)
Mice deficient for striatal Vesicular Acetylcholine Transporter (VAChT) display impaired short-term but normal long-term object recognition memory
Behavioural Brain Research 311: 267

Roy A, Dakroub M, Tezini GC, Liu Y, Guatimosim S, Feng Q, Salgado HC, Prado VF, Prado MAM, Gros R (2016)
Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions
FASEB Journal 30: 688

Silva RC, Terra FF, Guise YF, Prado MAM, Prado VF, Hiyane MI, Costa Malheiros DM, Prado CM, Camara NO, Braga TT (2016)
Reduced expression of VAChT increases renal fibrosis
Pathophysiology 23: 229

Sugita S, Fleming LL, Wood C, Vaughan SK, Gomes MP, Camargo W, Naves LA, Prado VF, Prado MAM, Guatimosim C, Valdez G (2016)
VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions
Skelet Muscle 6: 31

Kolisnyk B, Al-Onaizi MA, Prado VF, Prado MAM (2015)
alpha7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by beta2 nicotinic ACh receptor activation
British Journal of Pharmacology 172: 4919

Ostapchenko VG, Chen M, Guzman MS, Xie YF, Lavine N, Fan J, Beraldo FH, Martyn AC, Belrose JC, Mori Y, MacDonald JF, Prado VF, Prado MAM, Jackson MF (2015)
The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to beta-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment
Journal of Neuroscience 35: 15157

Pinheiro NM, Miranda CJ, Perini A, Camara NO, Costa SK, Alonso-Vale MI, Caperuto LC, Tiberio IF, Prado MAM, Martins MA, Prado VF, Prado CM (2015)
Pulmonary inflammation is regulated by the levels of the vesicular acetylcholine transporter
PLoS ONE 10: e0120441

Roy A, Guatimosim S, Prado VF, Gros R, Prado MAM (2015)
Cholinergic activity as a new target in diseases of the heart
Mol Med 20: 527

De Jaeger X, Cammarota M, Prado MAM, Izquierdo I, Prado VF, Pereira GS (2013)
Decreased acetylcholine release delays the consolidation of object recognition memory
Behavioural Brain Research 238: 62

Guzman MS, De Jaeger X, Drangova M, Prado MAM, Gros R, Prado VF (2013)
Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle
Journal of Neurochemistry 124: 658

Kolisnyk B, Guzman MS, Raulic S, Fan J, Magalhaes AC, Feng G, Gros R, Prado VF, Prado MAM (2013)
ChAT-ChR2-EYFP Mice Have Enhanced Motor Endurance But Show Deficits in Attention and Several Additional Cognitive Domains
Journal of Neuroscience 33: 10427

Kolisnyk B, Al-Onaizi MA, Hirata PH, Guzman MS, Nikolova S, Barbash S, Soreq H, Bartha R, Prado MAM, Prado VF (2013)
Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortex
Journal of Neuroscience 33: 14908

Ostapchenko VG, Beraldo FH, Mohammad AH, Xie YF, Hirata PH, Magalhaes AC, Lamour G, Li H, Maciejewski A, Belrose JC, Teixeira BL, Fahnestock M, Ferreira ST, Cashman NR, Hajj GN, Jackson MF, Choy WY, MacDonald JF, Martins VR, Prado VF, Prado MAM (2013)
The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-beta oligomer toxicity
Journal of Neuroscience 33: 16552

Prado VF, Roy A, Kolisnyk B, Gros R, Prado MAM (2013)
Regulation of cholinergic activity by the vesicular acetylcholine transporter
Biochemical Journal 450: 265

Queiroz CM, Tiba PA, Moreira KM, Guidine PA, Rezende GH, Moraes MF, Prado MAM, Prado VF, Tufik S, Mello LE (2013)
Sleep pattern and learning in knockdown mice with reduced cholinergic neurotransmission
Brazilian Journal of Medical & Biological Research 46: 844

Santos TG, Beraldo FH, Hajj GN, Lopes MH, Roffe M, Lupinacci FC, Ostapchenko VG, Prado VF, Prado MAM, Martins VR (2013)
Laminin-gamma1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons
Journal of Neurochemistry 124: 210

Machado MP, Rocha AM, de Oliveira LF, de Cuba MB, de Oliveira Loss I, Castellano LR, Silva MV, Machado JR, Nascentes GA, Paiva LH, Savino W, Junior VR, Brum PC, Prado VF, Prado MAM, Silva EL, Montano N, Ramirez LE, Dias da Silva VJ (2012)
Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease
Exp Physiol 97: 1186

Martyn AC, De Jaeger X, Magalhaes AC, Kesarwani R, Goncalves DF, Raulic S, Guzman MS, Jackson MF, Izquierdo I, MacDonald JF, Prado MAM, Prado VF (2012)
Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation
Proc Natl Acad Sci U S A 109: 17651

Rocha-Resende C, Roy A, Resende R, Ladeira MS, Lara A, de Morais Gomes ER, Prado VF, Gros R, Guatimosim C, Prado MAM, Guatimosim S (2012)
Non-neuronal cholinergic machinery present in cardiomyocytes offsets hypertrophic signals
Journal of Molecular & Cellular Cardiology 53: 206

Roy A, Lara A, Guimaraes D, Pires R, Gomes ER, Carter DE, Gomez MV, Guatimosim S, Prado VF, Prado MAM, Gros R (2012)
An analysis of the myocardial transcriptome in a mouse model of cardiac dysfunction with decreased cholinergic neurotransmission
PLoS ONE 7: e39997

Almeida AP, Andrade AB, Ferreira AJ, Pires AC, Damasceno DD, Alves MN, Gomes ER, Kushmerick C, Lima RF, Prado MAM, Prado VF, Richardson M, Cordeiro MN, Guatimosim S, Gomez M (2011)
Antiarrhythmogenic effects of a neurotoxin from the spider Phoneutria nigriventer
Toxicon 57: 217

Caetano FA, Beraldo FH, Hajj GN, Guimaraes AL, Jurgensen S, Wasilewska-Sampaio AP, Hirata PH, Souza I, Machado CF, Wong DY, De Felice FG, Ferreira ST, Prado VF, Rylett RJ, Martins VR, Prado MAM (2011)
Amyloid-beta oligomers increase the localization of prion protein at the cell surface
Journal of Neurochemistry 117: 538

Capettini SB, Moraes MF, Prado VF, Prado MAM, Pereira GS (2011)
Vesicular acetylcholine transporter knock-down mice show sexual dimorphism on memory
Brain Research Bulletin 85: 54

Guzman MS, De Jaeger X, Raulic S, Souza IA, Li AX, Schmid S, Menon RS, Gainetdinov RR, Caron MG, Bartha R, Prado VF, Prado MAM (2011)
Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission
PLoS Biol 9: e1001194

Martins-Silva C, De Jaeger X, Guzman MS, Lima RD, Santos MS, Kushmerick C, Gomez MV, Caron MG, Prado MAM, Prado VF (2011)
Novel strains of mice deficient for the vesicular acetylcholine transporter: insights on transcriptional regulation and control of locomotor behavior
PLoS ONE 6: e17611

Schmid S, Azzopardi E, De Jaeger X, Prado MAM, Prado VF (2011)
VAChT knock-down mice show normal prepulse inhibition but disrupted long-term habituation
Genes Brain Behav 10: 457

Lara A, Damasceno DD, Pires R, Gros R, Gomes ER, Gavioli M, Lima RF, Guimaraes D, Lima P, Bueno CR, Jr., Vasconcelos A, Roman-Campos D, Menezes CA, Sirvente RA, Salemi VM, Mady C, Caron MG, Ferreira AJ, Brum PC, Resende RR, Cruz JS, Gomez MV, Prado VF, de Almeida AP, Prado MAM, Guatimosim S (2010)
Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure
Molecular & Cellular Biology 30: 1746

Lima Rde F, Prado VF, Prado MAM, Kushmerick C (2010)
Quantal release of acetylcholine in mice with reduced levels of the vesicular acetylcholine transporter
Journal of Neurochemistry 113: 943

de Castro BM, De Jaeger X, Martins-Silva C, Lima RD, Amaral E, Menezes C, Lima P, Neves CM, Pires RG, Gould TW, Welch I, Kushmerick C, Guatimosim C, Izquierdo I, Cammarota M, Rylett RJ, Gomez MV, Caron MG, Oppenheim RW, Prado MAM, Prado VF (2009)
The vesicular acetylcholine transporter is required for neuromuscular development and function
Molecular & Cellular Biology 29: 5238

de Castro BM, Pereira GS, Magalhaes V, Rossato JI, De Jaeger X, Martins-Silva C, Leles B, Lima P, Gomez MV, Gainetdinov RR, Caron MG, Izquierdo I, Cammarota M, Prado VF, Prado MAM (2009)
Reduced expression of the vesicular acetylcholine transporter causes learning deficits in mice
Genes Brain Behav 8: 23

Guidine PA, Rezende GH, Queiroz CM, Mello LE, Prado VF, Prado MAM, Pereira GS, Moraes MF (2008)
Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus
Neuroscience Letters 436: 201

Ribeiro FM, Ferreira LT, Marion S, Fontes S, Gomez M, Ferguson SS, Prado MAM, Prado VF (2007)
SEC14-like protein 1 interacts with cholinergic transporters
Neurochem Int 50: 356

Ribeiro FM, Pinthong M, Black SA, Gordon AC, Prado VF, Prado MAM, Rylett RJ, Ferguson SS (2007)
Regulated recycling and plasma membrane recruitment of the high-affinity choline transporter
European Journal of Neuroscience 26: 3437

Prado VF, Martins-Silva C, de Castro BM, Lima RF, Barros DM, Amaral E, Ramsey AJ, Sotnikova TD, Ramirez MR, Kim HG, Rossato JI, Koenen J, Quan H, Cota VR, Moraes MF, Gomez MV, Guatimosim C, Wetsel WC, Kushmerick C, Pereira GS, Gainetdinov RR, Izquierdo I, Caron MG, Prado MAM (2006)
Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition
Neuron 51: 601

Ribeiro FM, Black SA, Prado VF, Rylett RJ, Ferguson SS, Prado MAM (2006)
The ins and outs of the high-affinity choline transporter CHT1
Journal of Neurochemistry 97: 1

Ferreira LT, Santos MS, Kolmakova NG, Koenen J, Barbosa J, Jr., Gomez MV, Guatimosim C, Zhang X, Parsons SM, Prado VF, Prado MAM (2005)
Structural requirements for steady-state localization of the vesicular acetylcholine transporter
Journal of Neurochemistry 94: 957

Ribeiro FM, Black SA, Cregan SP, Prado VF, Prado MAM, Rylett RJ, Ferguson SS (2005)
Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif
Journal of Neurochemistry 94: 86

Ribeiro FM, Alves-Silva J, Volknandt W, Martins-Silva C, Mahmud H, Wilhelm A, Gomez MV, Rylett RJ, Ferguson SS, Prado VF, Prado MAM (2003)
The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles
Journal of Neurochemistry 87: 136

Barbosa J, Jr., Ferreira LT, Martins-Silva C, Santos MS, Torres GE, Caron MG, Gomez MV, Ferguson SS, Prado MAM, Prado VF (2002)
Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex
Journal of Neurochemistry 82: 1221

Prado MAM, Reis RA, Prado VF, de Mello MC, Gomez MV, de Mello FG (2002)
Regulation of acetylcholine synthesis and storage
Neurochem Int 41: 291

Prado VF, Prado MAM (2002)
Signals involved in targeting membrane proteins to synaptic vesicles
Cellular Molecular Neurobiology 22: 565

Santos MS, Barbosa J, Jr., Veloso GS, Ribeiro F, Kushmerick C, Gomez MV, Ferguson SS, Prado VF, Prado MAM (2001)
Trafficking of green fluorescent protein tagged-vesicular acetylcholine transporter to varicosities in a cholinergic cell line
Journal of Neurochemistry 78: 1104

Santos MS, Barbosa J, Jr., Kushmerick C, Gomez MV, Prado VF, Prado MAM (2000)
Visualization and trafficking of the vesicular acetylcholine transporter in living cholinergic cells
Journal of Neurochemistry 74: 2425

Barbosa J, Jr., Massensini AR, Santos MS, Meireles SI, Gomez RS, Gomez MV, Romano-Silva MA, Prado VF, Prado MAM (1999)
Expression of the vesicular acetylcholine transporter, proteins involved in exocytosis, and functional calcium signaling in varicosities and soma of a murine septal cell line
Journal of Neurochemistry 73: 1881

Clarizia AD, Gomez MV, Romano-Silva MA, Parsons SM, Prado VF, Prado MAM (1999)
Control of the binding of a vesamicol analog to the vesicular acetylcholine transporter
Neuroreport 10: 2783

Clarizia AD, Romano-Silva MA, Prado VF, Gomez MV, Prado MAM (1998)
Role of protein kinase C in the release of [3H]acetylcholine from myenteric plexus treated with vesamicol
Neuroscience Letters 244: 115

Barbosa J, Jr., Clarizia AD, Gomez MV, Romano-Silva MA, Prado VF, Prado MAM (1997)
Effect of protein kinase C activation on the release of [3H]acetylcholine in the presence of vesamicol
Journal of Neurochemistry 69: 2608