Villalba AM, De la Llave-Propin A, de la Fuente J, Perez C, de Chavarri EG, Diaz MT, Cabezas A, Gonzalez-Garoz R, Torrent F, Villarroel M, Bermejo-Poza R (2023)
Using underwater currents as an occupational enrichment method to improve the stress status in rainbow trout
Fish Physiol Biochem

Codony S, Entrena JM, Calvo-Tusell C, Jora B, Gonzalez-Cano R, Osuna S, Corpas R, Morisseau C, Perez B, Barniol-Xicota M, Grinan-Ferre C, Perez C, Rodriguez-Franco MI, Martinez AL, Loza MI, Pallas M, Verhelst SHL, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vazquez S (2022)
Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors
Journal of Medicinal Chemistry 65: 13660

Gonzalez-Naranjo P, Perez C, Gonzalez-Sanchez M, Gironda-Martinez A, Ulzurrun E, Bartolome F, Rubio-Fernandez M, Martin-Requero A, Campillo NE, Paez JA (2022)
Multitarget drugs as potential therapeutic agents for alzheimer's disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors
J Enzyme Inhib Med Chem 37: 2348

Codony S, Calvo-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Perez C, Rodriguez-Franco MI, Pizarro-Delgado J, Corpas R, Grinan-Ferre C, Pallas M, Sanfeliu C, Vazquez-Carrera M, Hammock BD, Feixas F, Vazquez S (2021)
From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis
Journal of Medicinal Chemistry

Jin N, Matter WF, Michael LF, Qian Y, Gheyi T, Cano L, Perez C, Lafuente C, Broughton HB, Espada A (2021)
The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage
ACS Chemical Biology

Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza MI, Brea JM, Saez E, Oyarzabal J, Pineda-Lucena A, Perez B, Perez C, Rodriguez-Franco MI, Leiva R, Osuna S, Morisseau C, Hammock BD, Vazquez-Carrera M, Vazquez S (2020)
2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis
Journal of Medicinal Chemistry 63: 9237

Nunez-Borque E, Gonzalez-Naranjo P, Bartolome F, Alquezar C, Reinares-Sebastian A, Perez C, Ceballos ML, Paez JA, Campillo NE, Martin-Requero A (2020)
Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer's Disease Lymphoblast Alterations
Molecular Neurobiology

Bermejo-Poza R, Fernandez-Muela M, de la Fuente J, Perez C, de Chavarri EG, Diaz MT, Torrent F, Villarroel M (2019)
Physio-metabolic response of rainbow trout during prolonged food deprivation before slaughter
Fish Physiol Biochem 45: 253

Estrada-Valencia M, Herrera-Arozamena C, Perez C, Vina D, Morales-Garcia JA, Perez-Castillo A, Ramos E, Romero A, Laurini E, Pricl S, Rodriguez-Franco MI (2019)
New flavonoid - N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer s disease endowed with neurogenic properties
J Enzyme Inhib Med Chem 34: 712

Gonzalez-Naranjo P, Perez-Macias N, Perez C, Roca C, Vaca G, Giron R, Sanchez-Robles E, Martin-Fontelles MI, de Ceballos ML, Martin-Requero A, Campillo NE, Paez JA (2019)
Indazolylketones as new multitarget cannabinoid drugs
Eur Journal of Medicinal Chemistry 166: 90

de Andrade P, Mantoani SP, Goncalves Nunes PS, Magadan CR, Perez C, Xavier DJ, Hojo ETS, Campillo NE, Martinez A, Carvalho I (2019)
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease
Bioorganic & Medicinal Chemistry 27: 931

Chierrito TPC, Pedersoli-Mantoani S, Roca C, Sebastian-Perez V, Martinez-Gonzalez L, Perez DI, Perez C, Canales A, Canada FJ, Campillo NE, Carvalho I, Martinez A (2018)
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Eur Journal of Medicinal Chemistry 145: 431

Del Cerro P, Alquezar C, Bartolome F, Gonzalez-Naranjo P, Perez C, Carro E, Paez JA, Campillo NE, Martin-Requero A (2018)
Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer's Disease
CNS Drugs 32: 579

Estrada Valencia M, Herrera-Arozamena C, de Andres L, Perez C, Morales-Garcia JA, Perez-Castillo A, Ramos E, Romero A, Vina D, Yanez M, Laurini E, Pricl S, Rodriguez-Franco MI (2018)
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
Eur Journal of Medicinal Chemistry 156: 534

Reis J, Cagide F, Valencia ME, Teixeira J, Bagetta D, Perez C, Uriarte E, Oliveira PJ, Ortuso F, Alcaro S, Rodriguez-Franco MI, Borges F (2018)
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors
Eur Journal of Medicinal Chemistry 158: 781

Roca C, Requena C, Sebastian-Perez V, Malhotra S, Radoux C, Perez C, Martinez A, Antonio Paez J, Blundell TL, Campillo NE (2018)
Identification of new allosteric sites and modulators of AChE through computational and experimental tools
J Enzyme Inhib Med Chem 33: 1034

Chierrito TPC, Mantoani SP, Roca C, Requena C, Sebastian-Perez V, Castillo WO, Moreira NCS, Perez C, Sakamoto-Hojo ET, Takahashi CS, Jimenez-Barbero J, Canada FJ, Campillo NE, Martinez A, Carvalho I (2017)
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease
Eur Journal of Medicinal Chemistry 139: 773

Fernandez S, Giglio J, Reyes AL, Damian A, Perez C, Perez DI, Gonzalez M, Oliver P, Rey A, Engler H, Cerecetto H (2017)
3-(Benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain
Future Med Chem 9: 983

Monjas L, Arce MP, Leon R, Egea J, Perez C, Villarroya M, Lopez MG, Gil C, Conde S, Rodriguez-Franco MI (2017)
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia
Eur Journal of Medicinal Chemistry 130: 60

Chlebek J, De Simone A, Hostalkova A, Opletal L, Perez C, Perez DI, Havlikova L, Cahlikova L, Andrisano V (2016)
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets
Fitoterapia 109: 241

Estrada M, Herrera-Arozamena C, Perez C, Vina D, Romero A, Morales-Garcia JA, Perez-Castillo A, Rodriguez-Franco MI (2016)
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties
Eur Journal of Medicinal Chemistry 121: 376

Estrada M, Perez C, Soriano E, Laurini E, Romano M, Pricl S, Morales-Garcia JA, Perez-Castillo A, Rodriguez-Franco MI (2016)
New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with sigma-1 agonism and beta-secretase inhibition
Future Med Chem 8: 1191

Gonzalez-Naranjo P, Perez-Macias N, Campillo NE, Perez C, Aran VJ, Giron R, Sanchez-Robles E, Martin MI, Gomez-Canas M, Garcia-Arencibia M, Fernandez-Ruiz J, Paez JA (2014)
Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease
Eur Journal of Medicinal Chemistry 73: 56

Lopez-Iglesias B, Perez C, Morales-Garcia JA, Alonso-Gil S, Perez-Castillo A, Romero A, Lopez MG, Villarroya M, Conde S, Rodriguez-Franco MI (2014)
New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease
Journal of Medicinal Chemistry 57: 3773

Bolea I, Gella A, Monjas L, Perez C, Rodriguez-Franco MI, Marco-Contelles J, Samadi A, Unzeta M (2013)
Multipotent, permeable drug ASS234 inhibits Abeta aggregation, possesses antioxidant properties and protects from Abeta-induced apoptosis in vitro
Curr Alzheimer Res 10: 797

Gonzalez-Naranjo P, Campillo NE, Perez C, Paez JA (2013)
Multitarget cannabinoids as novel strategy for Alzheimer disease
Curr Alzheimer Res 10: 229

Samadi A, de la Fuente Revenga M, Perez C, Iriepa I, Moraleda I, Rodriguez-Franco MI, Marco-Contelles J (2013)
Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 67: 64

Silva D, Chioua M, Samadi A, Agostinho P, Garcao P, Lajarin-Cuesta R, de los Rios C, Iriepa I, Moraleda I, Gonzalez-Lafuente L, Mendes E, Perez C, Rodriguez-Franco MI, Marco-Contelles J, Carmo Carreiras M (2013)
Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity
ACS Chem Neurosci 4: 547

Fernandez-Bachiller MI, Perez C, Monjas L, Rademann J, Rodriguez-Franco MI (2012)
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and beta-amyloid-reducing properties
Journal of Medicinal Chemistry 55: 1303

Samadi A, Estrada M, Perez C, Rodriguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Marco-Contelles J (2012)
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
Eur Journal of Medicinal Chemistry 57C: 296

Gonzalez-Munoz GC, Arce MP, Lopez B, Perez C, Romero A, Del Barrio L, Martin-de-Saavedra MD, Egea J, Leon R, Villarroya M, Lopez MG, Garcia AG, Conde S, Rodriguez-Franco MI (2011)
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 46: 2224

Fernandez-Bachiller MI, Perez C, Gonzalez-Munoz GC, Conde S, Lopez MG, Villarroya M, Garcia AG, Rodriguez-Franco MI (2010)
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties
Journal of Medicinal Chemistry 53: 4927

Gonzalez-Munoz GC, Arce MP, Lopez B, Perez C, Villarroya M, Lopez MG, Garcia AG, Conde S, Rodriguez-Franco MI (2010)
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases
Eur Journal of Medicinal Chemistry 45: 6152

Arce MP, Rodriguez-Franco MI, Gonzalez-Munoz GC, Perez C, Lopez B, Villarroya M, Lopez MG, Garcia AG, Conde S (2009)
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease
Journal of Medicinal Chemistry 52: 7249

Fernandez-Bachiller MI, Perez C, Campillo NE, Paez JA, Gonzalez-Munoz GC, Usan P, Garcia-Palomero E, Lopez MG, Villarroya M, Garcia AG, Martinez A, Rodriguez-Franco MI (2009)
Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties
ChemMedChem 4: 828

Rodriguez-Franco MI, Fernandez-Bachiller MI, Perez C, Hernandez-Ledesma B, Bartolome B (2006)
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties
Journal of Medicinal Chemistry 49: 459

Rodriguez-Franco MI, Fernandez-Bachiller MI, Perez C, Castro A, Martinez A (2005)
Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase
Bioorganic & Medicinal Chemistry 13: 6795

Martinez A, Lanot C, Perez C, Castro A, Lopez-Serrano P, Conde S (2000)
Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives
Bioorganic & Medicinal Chemistry 8: 731

Rodriguez-Franco MI, Dorronsoro I, Martinez A, Perez C, Badia A, Banos JE (2000)
Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties
Arch Pharm (Weinheim) 333: 118

Servin-Gonzalez L, Castro C, Perez C, Rubio M, Valdez F (1997)
bldA-dependent expression of the Streptomyces exfoliatus M11 lipase gene (lipA) is mediated by the product of a contiguous gene, lipR, encoding a putative transcriptional activator
Journal of Bacteriology 179: 7816

Cruz H, Perez C, Wellington E, Castro C, Servin-Gonzalez L (1994)
Sequence of the Streptomyces albus G lipase-encoding gene reveals the presence of a prokaryotic lipase family
Gene 144: 141

Perez C, Juarez K, Garcia-Castells E, Soberon G, Servin-Gonzalez L (1993)
Cloning, characterization, and expression in Streptomyces lividans 66 of an extracellular lipase-encoding gene from Streptomyces sp. M11
Gene 123: 109