Cerasoli DM, Armstrong SJ, Reeves TE, Hodgins SM, Kasten SA, Lee-Stubbs RB, Cadieux CL, Otto TC, Capacio BR, Lenz DE (2019)
Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication
Biochemical Pharmacology

Kirkpatrick MG, diTargiani RC, Sweeney RE, Otto TC (2016)
Use of V Agents and V-Analogue Compounds to Probe the Active Site of Atypical Butyrylcholinesterase from Oryzias latipes
Chemico-Biological Interactions 259: 182

Hodgins SM, Kasten SA, Harrison J, Otto TC, Oliver ZP, Rezk P, Reeves TE, Chilukuri N, Cerasoli DM (2013)
Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection
Chemico-Biological Interactions 203: 177

Otto TC, Scott JR, Kauffman MA, Hodgins SM, diTargiani RC, Hughes JH, Sarricks EP, Saturday GA, Hamilton TA, Cerasoli DM (2013)
Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents
Chemico-Biological Interactions 203: 186

Greenblatt HM, Otto TC, Kirkpatrick MG, Kovaleva E, Brown S, Buchman G, Cerasoli DM, Sussman JL (2012)
Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae
Acta Crystallographica Sect F Struct Biol Cryst Commun F68: 269

Sarkar M, Harsch CK, Matic GT, Hoffman K, Norris JR, 3rd, Otto TC, Lenz DE, Cerasoli DM, Magliery TJ (2012)
Solubilization and humanization of paraoxonase-1
J Lipids 2012: 610937

Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR (2011)
Nerve agent hydrolysis activity designed into a human drug metabolism enzyme
PLoS ONE 6: e17441

Peterson MW, Fairchild SZ, Otto TC, Mohtashemi M, Cerasoli DM, Chang WE (2011)
VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results
PLoS ONE 6: e20335

Geyer BC, Kannan L, Garnaud PE, Broomfield CA, Cadieux CL, Cherni I, Hodgins SM, Kasten SA, Kelley K, Kilbourne J, Oliver ZP, Otto TC, Puffenberger I, Reeves TE, Robbins N, 2nd, Woods RR, Soreq H, Lenz DE, Cerasoli DM, Mor TS (2010)
Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents
Proc Natl Acad Sci U S A 107: 20251

Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR (2010)
Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin
Molecular Pharmacology 77: 508

Otto TC, Kasten SA, Kovaleva E, Liu Z, Buchman G, Tolosa M, Davis D, Smith JR, Balcerzak R, Lenz DE, Cerasoli DM (2010)
Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae
Chemico-Biological Interactions 187: 388

Sanan TT, Muthukrishnan S, Beck JM, Tao P, Hayes CJ, Otto TC, Cerasoli DM, Lenz DE, Hadad CM (2010)
Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights
J Phys Org Chem 23: 357

Suzuki SM, Stevens RC, Richter RJ, Cole TB, Park S, Otto TC, Cerasoli DM, Lenz DE, Furlong CE (2010)
Engineering human PON1 in an E. coli expression system
Advances in Experimental Medicine & Biology 660: 37

Otto TC, Harsch CK, Yeung DT, Magliery TJ, Cerasoli DM, Lenz DE (2009)
Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes
Biochemistry 48: 10416