Hirosawa K, Fukami T, Nakano M, Nakajima M (2023)
Evaluation of drug-drug interactions via inhibition of hydrolases by orlistat, an anti-obesity drug
Drug Metabolism & Disposition: The Biological Fate of Chemicals

Morikawa T, Fukami T, Gotoh-Saito S, Nakano M, Nakajima M (2022)
PPARalpha regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism
Biochemical Pharmacology 199: 115010

Nagaoka M, Fukami T, Kisui F, Yamada T, Sakai Y, Tashiro K, Ogiso T, Konishi K, Honda S, Hirosawa K, Nakano M, Nakajima M (2022)
Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency
Biochemical Pharmacology 195: 114842

Hirosawa K, Fukami T, Tashiro K, Sakai Y, Kisui F, Nakano M, Nakajima M (2021)
Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity
Drug Metabolism & Disposition: The Biological Fate of Chemicals

Honda S, Fukami T, Tsujiguchi T, Zhang Y, Nakano M, Nakajima M (2021)
Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC
Eur J Pharm Sci

Honda S, Fukami T, Hirosawa K, Tsujiguchi T, Zhang Y, Nakano M, Uehara S, Uno Y, Yamazaki H, Nakajima M (2021)
Differences in hydrolase activities in the liver and small intestine between marmosets and humans
Drug Metabolism & Disposition: The Biological Fate of Chemicals

Sakai Y, Fukami T, Nagaoka M, Hirosawa K, Ichida H, Sato R, Suzuki K, Nakano M, Nakajima M (2021)
Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans
Life Sciences 284: 119896

Takemoto S, Nakano M, Fukami T, Nakajima M (2021)
m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2
Biochemical Pharmacology

Yasuda K, Watanabe K, Fukami T, Nakashima S, Ikushiro SI, Nakajima M, Sakaki T (2021)
Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase
Drug Metab Pharmacokinet 39: 100397

Kisui F, Fukami T, Nakano M, Nakajima M (2019)
Strain and sex differences in drug hydrolase activities in rodent livers
Eur J Pharm Sci

Konishi K, Fukami T, Ogiso T, Nakajima M (2018)
In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury
Biochemical Pharmacology 155: 242

Miyazaki S, Tomita K, Yamane H, Kobayashi M, Asami T, Nakajima M (2018)
Characterization of a helminthosporic acid analog that is a selective agonist of gibberellin receptor
Bioorganic & Medicinal Chemistry Lett 28: 2465

Yoshida T, Fukami T, Kurokawa T, Gotoh S, Oda A, Nakajima M (2018)
Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans
Eur J Pharm Sci 111: 167

Konishi K, Fukami T, Gotoh S, Nakajima M (2017)
Identification of enzymes responsible for nitrazepam metabolism and toxicity in human
Biochemical Pharmacology 140: 150

Kurokawa T, Fukami T, Yoshida T, Nakajima M (2016)
Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog
Drug Metabolism & Disposition: The Biological Fate of Chemicals 44: 409

Fukami T, Kariya M, Kurokawa T, Iida A, Nakajima M (2015)
Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases
Eur J Pharm Sci 78: 47

Jiang K, Kurimoto T, Seo EK, Miyazaki S, Nakajima M, Nakamura H, Asami T (2015)
Development of Inhibitors of Salicylic Acid Signaling
Journal of Agricultural and Food Chemistry 63: 7124

Kurokawa T, Fukami T, Nakajima M (2015)
Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase
Drug Metabolism & Disposition: The Biological Fate of Chemicals 43: 1218

Muta K, Fukami T, Nakajima M (2015)
A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production
Biochemical Pharmacology 98: 659

Oda S, Fukami T, Yokoi T, Nakajima M (2015)
A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
Drug Metab Pharmacokinet 30: 30

Tang SC, Kort A, Cheung KL, Rosing H, Fukami T, Durmus S, Wagenaar E, Hendrikx JJ, Nakajima M, van Vlijmen BJ, Beijnen JH, Schinkel AH (2015)
P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice
Mol Pharm 12: 3714

Thumarat U, Kawabata T, Nakajima M, Nakajima H, Sugiyama A, Yazaki K, Tada T, Waku T, Tanaka N, Kawai F (2015)
Comparison of genetic structures and biochemical properties of tandem cutinase-type polyesterases from Thermobifida alba AHK119
J Biosci Bioeng 120: 491

Ito Y, Fukami T, Yokoi T, Nakajima M (2014)
An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver
Drug Metabolism & Disposition: The Biological Fate of Chemicals 42: 2109

Muta K, Fukami T, Nakajima M, Yokoi T (2014)
N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity
Biochemical Pharmacology 87: 352

Shimizu M, Fukami T, Nakajima M, Yokoi T (2014)
Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase
Drug Metabolism & Disposition: The Biological Fate of Chemicals 42: 1103

Higuchi R, Fukami T, Nakajima M, Yokoi T (2013)
Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation
Drug Metabolism & Disposition: The Biological Fate of Chemicals 41: 1220

Yoon JM, Nakajima M, Mashiguchi K, Park SH, Otani M, Asami T (2013)
Chemical screening of an inhibitor for gibberellin receptors based on a yeast two-hybrid system
Bioorganic & Medicinal Chemistry Lett 23: 1096

Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T (2012)
Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver
Journal of Biological Chemistry 287: 9240

Kobayashi Y, Fukami T, Nakajima A, Watanabe A, Nakajima M, Yokoi T (2012)
Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse
Drug Metabolism & Disposition: The Biological Fate of Chemicals 40: 671

Kobayashi Y, Fukami T, Shimizu M, Nakajima M, Yokoi T (2012)
Contributions of arylacetamide deacetylase and carboxylesterase 2 to flutamide hydrolysis in human liver
Drug Metabolism & Disposition: The Biological Fate of Chemicals 40: 1080

Sawada Y, Umetsu A, Komatsu Y, Kitamura J, Suzuki H, Asami T, Fukuda M, Honda I, Mitsuhashi W, Nakajima M, Toyomasu T (2012)
An unusual spliced variant of DELLA protein, a negative regulator of gibberellin signaling, in lettuce
Biosci Biotechnol Biochem 76: 544

Shimizu M, Fukami T, Kobayashi Y, Takamiya M, Aoki Y, Nakajima M, Yokoi T (2012)
A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity
Drug Metabolism & Disposition: The Biological Fate of Chemicals 40: 1183

Nakajima A, Fukami T, Kobayashi Y, Watanabe A, Nakajima M, Yokoi T (2011)
Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine
Biochemical Pharmacology 82: 1747

Fukami T, Takahashi S, Nakagawa N, Maruichi T, Nakajima M, Yokoi T (2010)
In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities
Drug Metabolism & Disposition: The Biological Fate of Chemicals 38: 2173

Maruichi T, Fukami T, Nakajima M, Yokoi T (2010)
Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2)
Biochemical Pharmacology 79: 288

Watanabe A, Fukami T, Takahashi S, Kobayashi Y, Nakagawa N, Nakajima M, Yokoi T (2010)
Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen
Drug Metabolism & Disposition: The Biological Fate of Chemicals 38: 1532

Suzuki H, Park SH, Okubo K, Kitamura J, Ueguchi-Tanaka M, Iuchi S, Katoh E, Kobayashi M, Yamaguchi I, Matsuoka M, Asami T, Nakajima M (2009)
Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants
Plant J 60: 48

Takahashi S, Katoh M, Saitoh T, Nakajima M, Yokoi T (2009)
Different inhibitory effects in rat and human carboxylesterases
Drug Metabolism & Disposition: The Biological Fate of Chemicals 37: 956

Watanabe A, Fukami T, Nakajima M, Takamiya M, Aoki Y, Yokoi T (2009)
Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis
Drug Metabolism & Disposition: The Biological Fate of Chemicals 37: 1513

Fukami T, Nakajima M, Maruichi T, Takahashi S, Takamiya M, Aoki Y, McLeod HL, Yokoi T (2008)
Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes
Pharmacogenet Genomics 18: 911

Minami K, Nakajima M, Fujiki Y, Katoh M, Gonzalez FJ, Yokoi T (2008)
Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor
Journal of Toxicological Sciences 33: 405

Shimada A, Ueguchi-Tanaka M, Nakatsu T, Nakajima M, Naoe Y, Ohmiya H, Kato H, Matsuoka M (2008)
Structural basis for gibberellin recognition by its receptor GID1
Nature 456: 520

Takahashi S, Katoh M, Saitoh T, Nakajima M, Yokoi T (2008)
Allosteric kinetics of human carboxylesterase 1: species differences and interindividual variability
J Pharm Sci 97: 5434

Iuchi S, Suzuki H, Kim YC, Iuchi A, Kuromori T, Ueguchi-Tanaka M, Asami T, Yamaguchi I, Matsuoka M, Kobayashi M, Nakajima M (2007)
Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal
Plant J 50: 958

Ueguchi-Tanaka M, Nakajima M, Katoh E, Ohmiya H, Asano K, Saji S, Hongyu X, Ashikari M, Kitano H, Yamaguchi I, Matsuoka M (2007)
Molecular interactions of a soluble gibberellin receptor, GID1, with a rice DELLA protein, SLR1, and gibberellin
Plant Cell 19: 2140

Nakajima M, Shimada A, Takashi Y, Kim YC, Park SH, Ueguchi-Tanaka M, Suzuki H, Katoh E, Iuchi S, Kobayashi M, Maeda T, Matsuoka M, Yamaguchi I (2006)
Identification and characterization of Arabidopsis gibberellin receptors
Plant J 46: 880

Ueguchi-Tanaka M, Ashikari M, Nakajima M, Itoh H, Katoh E, Kobayashi M, Chow TY, Hsing YI, Kitano H, Yamaguchi I, Matsuoka M (2005)
GIBBERELLIN INSENSITIVE DWARF1 encodes a soluble receptor for gibberellin
Nature 437: 693

Yamada K, Lim J, Dale JM, Chen H, Shinn P, Palm CJ, Southwick AM, Wu HC, Kim C, Nguyen M, Pham P, Cheuk R, Karlin-Newmann G, Liu SX, Lam B, Sakano H, Wu T, Yu G, Miranda M, Quach HL, Tripp M, Chang CH, Lee JM, Toriumi M, Chan MM, Tang CC, Onodera CS, Deng JM, Akiyama K, Ansari Y, Arakawa T, Banh J, Banno F, Bowser L, Brooks S, Carninci P, Chao Q, Choy N, Enju A, Goldsmith AD, Gurjal M, Hansen NF, Hayashizaki Y, Johnson-Hopson C, Hsuan VW, Iida K, Karnes M, Khan S, Koesema E, Ishida J, Jiang PX, Jones T, Kawai J, Kamiya A, Meyers C, Nakajima M, Narusaka M, Seki M, Sakurai T, Satou M, Tamse R, Vaysberg M, Wallender EK, Wong C, Yamamura Y, Yuan S, Shinozaki K, Davis RW, Theologis A, Ecker JR (2003)
Empirical analysis of transcriptional activity in the Arabidopsis genome
Science 302: 842

Hori Y, Nakajima M, Fujisawa M, Shimada K, Hirota T, Yoshioka T (2002)
[Simultaneous determination of propanil, carbaryl and 3,4-dichloroaniline in human serum by HPLC with UV detector following solid phase extraction]
Yakugaku Zasshi 122: 247

Seki M, Narusaka M, Kamiya A, Ishida J, Satou M, Sakurai T, Nakajima M, Enju A, Akiyama K, Oono Y, Muramatsu M, Hayashizaki Y, Kawai J, Carninci P, Itoh M, Ishii Y, Arakawa T, Shibata K, Shinagawa A, Shinozaki K (2002)
Functional annotation of a full-length Arabidopsis cDNA collection
Science 296: 141

Kinoshita H, Hirose Y, Tanaka T, Hori Y, Nakajima M, Fujisawa M, Oseki M (2001)
[A case of carbamate poisoning in which GCMS was useful to identify causal substance and to decide the appropriate treatment]
Chudoku Kenkyu 14: 343

Maruyama T, Nakajima M, Seki M (2001)
Effect of hydrocarbon-water interfaces on synthetic and hydrolytic activities of lipases
J Biosci Bioeng 92: 242

Maruyama T, Nakajima M, Ichikawa S, Sano Y, Nabetani H, Furusaki S, Seki M (2001)
Small-angle X-ray scattering analysis of stearic acid modified lipase
Biosci Biotechnol Biochem 65: 1003

Niijima H, Nagao M, Nakajima M, Takatori T, Matsuda Y, Iwase H, Kobayashi M (1999)
Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains
Toxicol Appl Pharmacol 156: 64

Matsuda Y, Nagao M, Takatori T, Niijima H, Nakajima M, Iwase H, Kobayashi M, Iwadate K (1998)
Detection of the sarin hydrolysis product in formalin-fixed brain tissues of victims of the Tokyo subway terrorist attack
Toxicol Appl Pharmacol 150: 310

Nagao M, Takatori T, Matsuda Y, Nakajima M, Iwase H, Iwadate K (1997)
Definitive evidence for the acute sarin poisoning diagnosis in the Tokyo subway
Toxicol Appl Pharmacol 144: 198

Nagao M, Takatori T, Matsuda Y, Nakajima M, Niijima H, Iwase H, Iwadate K, Amano T (1997)
Detection of sarin hydrolysis products from sarin-like organophosphorus agent-exposed human erythrocytes
Journal of Chromatography B Biomed Sci Appl 701: 9