Fjeld K, Gravdal A, Brekke RS, Alam J, Wilhelm SJ, El Jellas K, Pettersen HN, Lin J, Solheim MH, Steine SJ, Johansson BB, Njlstad PR, Verbeke CS, Xiao X, Lowe ME, Molven A (2022)
The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice
Pancreatology
Kahraman S, Dirice E, Basile G, Diegisser D, Alam J, Johansson BB, Gupta MK, Hu J, Huang L, Soh CL, Huangfu D, Muthuswamy SK, Raeder H, Molven A, Kulkarni RN (2022)
Abnormal exocrine-endocrine cell cross-talk promotes beta-cell dysfunction and loss in MODY8
Nat Metab 4: 76
El Jellas K, Dusatkova P, Haldorsen IS, Molnes J, Tjora E, Johansson BB, Fjeld K, Johansson S, Pruhova S, Groop L, Lohr JM, Njolstad PR, Molven A (2021)
Two new mutations in the CEL gene causing diabetes and hereditary pancreatitis: How to correctly identify MODY8 cases
J Clinical Endocrinology Metab
Gravdal A, Xiao X, Cnop M, El Jellas K, Johansson S, Njolstad PR, Lowe ME, Johansson BB, Molven A, Fjeld K (2021)
The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity
Journal of Biological Chemistry 296: 100661
Tjora E, Gravdal A, Engjom T, Cnop M, Johansson BB, Dimcevski GG, Molven A, Fjeld K (2021)
Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis
European Journal of Gastroenterology & Hepatology 33: 839
Cassidy BM, Zino S, Fjeld K, Molven A, Lowe ME, Xiao X (2020)
Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding
Hum Mutat 41: 1967
Dalva M, Lavik IK, El Jellas K, Gravdal A, Lugea A, Pandol SJ, Njolstad PR, Waldron RT, Fjeld K, Johansson BB, Molven A (2020)
Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells
Cells 9: 244
Fjeld K, Masson E, Lin JH, Michl P, Stokowy T, Gravdal A, El Jellas K, Steine SJ, Hoem D, Johansson BB, Dalva M, Ruffert C, Zou WB, Li ZS, Njolstad PR, Chen JM, Liao Z, Johansson S, Rosendahl J, Ferec C, Molven A (2020)
Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis
Pancreatology
Oracz G, Kujko AA, Fjeld K, Wertheim-Tysarowska K, Adamus-Bialek W, Steine SJ, Koziel D, Gluszek S, Molven A, Rygiel AM (2019)
The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis
Pancreatology 19: 531
Johansson BB, Fjeld K, El Jellas K, Gravdal A, Dalva M, Tjora E, Raeder H, Kulkarni RN, Johansson S, Njolstad PR, Molven A (2018)
The role of the carboxyl ester lipase (CEL) gene in pancreatic disease
Pancreatology 18: 12
Dalva M, El Jellas K, Steine SJ, Johansson BB, Ringdal M, Torsvik J, Immervoll H, Hoem D, Laemmerhirt F, Simon P, Lerch MM, Johansson S, Njolstad PR, Weiss FU, Fjeld K, Molven A (2017)
Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer
Pancreatology 17: 83
Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A (2016)
Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase
Biochemistry 55: 4636
Molven A, Fjeld K, Lowe ME (2016)
Lipase Genetic Variants in Chronic Pancreatitis: When the End Is Wrong, All's Not Well
Gastroenterology 150: 1515
Fjeld K, Weiss FU, Lasher D, Rosendahl J, Chen JM, Johansson BB, Kirsten H, Ruffert C, Masson E, Steine SJ, Bugert P, Cnop M, Grutzmann R, Mayerle J, Mossner J, Ringdal M, Schulz HU, Sendler M, Simon P, Sztromwasser P, Torsvik J, Scholz M, Tjora E, Ferec C, Witt H, Lerch MM, Njolstad PR, Johansson S, Molven A (2015)
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis
Nat Genet 47: 518
Molven A, Njolstad PR, Weiss FU (2015)
Lipase gene fusion: a new route to chronic pancreatitis
Oncotarget 6: 30443
Ragvin A, Fjeld K, Weiss FU, Torsvik J, Aghdassi A, Mayerle J, Simon P, Njolstad PR, Lerch MM, Johansson S, Molven A (2013)
The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis
Pancreatology 13: 29
Johansson BB, Torsvik J, Bjorkhaug L, Vesterhus M, Ragvin A, Tjora E, Fjeld K, Hoem D, Johansson S, Raeder H, Lindquist S, Hernell O, Cnop M, Saraste J, Flatmark T, Molven A, Njolstad PR (2011)
Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease
Journal of Biological Chemistry 286: 34593
Torsvik J, Johansson S, Johansen A, Ek J, Minton J, Raeder H, Ellard S, Hattersley A, Pedersen O, Hansen T, Molven A, Njolstad PR (2010)
Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes
Hum Genet 127: 55
Vesterhus M, Raeder H, Kurpad AJ, Kawamori D, Molven A, Kulkarni RN, Kahn CR, Njolstad PR (2010)
Pancreatic function in carboxyl-ester lipase knockout mice
Pancreatology 10: 467
Haldorsen IS, Vesterhus M, Raeder H, Jensen DK, Sovik O, Molven A, Njolstad PR (2008)
Lack of pancreatic body and tail in HNF1B mutation carriers
Diabet Med 25: 782
Vesterhus M, Raeder H, Aurlien H, Gjesdal CG, Bredrup C, Holm PI, Molven A, Bindoff L, Berstad A, Njolstad PR (2008)
Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations
Diabetes Care 31: 1738
Vesterhus M, Haldorsen IS, Raeder H, Molven A, Njolstad PR (2008)
Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young
J Clinical Endocrinology Metab 93: 3505
Vesterhus M, Raeder H, Johansson S, Molven A, Njolstad PR (2008)
Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3
Diabetes Care 31: 306
Raeder H, Haldorsen IS, Ersland L, Gruner R, Taxt T, Sovik O, Molven A, Njolstad PR (2007)
Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase
Diabetes 56: 444
Raeder H, Johansson S, Holm PI, Haldorsen IS, Mas E, Sbarra V, Nermoen I, Eide SA, Grevle L, Bjorkhaug L, Sagen JV, Aksnes L, Svik O, Lombardo D, Molven A, Njolstad PR (2006)
Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.
Nat Genet 38: 54