Lenz DE, Cerasoli DM, Maxwell DM (2017) <br />Radiolabelled soman binding to sera from Rats, Guinea Pigs and Monkeys<br /><i>Toxicol Lett</i> <b>283</b>: 86<br /><br />McHardy SF, Bohmann JA, Corbett MR, Campos B, Tidwell MW, Thompson PM, Bemben CJ, Menchaca TA, Reeves TE, Cantrell WR, Jr., Bauta WE, Lopez A, Maxwell DM, Brecht KM, Sweeney RE, McDonough J (2014) <br />Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>24</b>: 1711<br /><br />Maxwell DM, Brecht KM, Sweeney RE (2013) <br />A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 72<br /><br />Luo C, Tong M, Maxwell DM, Saxena A (2008) <br />Comparison of oxime reactivation and aging of nerve agent-inhibited monkey and human acetylcholinesterases<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 261<br /><br />Maxwell DM, Koplovitz I, Worek F, Sweeney RE (2008) <br />A structure-activity analysis of the variation in oxime efficacy against nerve agents<br /><i>Toxicol Appl Pharmacol</i> <b>231</b>: 157<br /><br />Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, Redinbo MR (2007) <br />Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun<br /><i>Biochemistry</i> <b>46</b>: 5063<br /><br />Luo C, Tong M, Chilukuri N, Brecht K, Maxwell DM, Saxena A (2007) <br />An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes<br /><i>Biochemistry</i> <b>46</b>: 11771<br /><br />Maxwell DM, Brecht KM, Koplovitz I, Sweeney RE (2006) <br />Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?<br /><i>Archives of Toxicology</i> <b>80</b>: 756<br /><br />Maxwell DM, Brecht KM, Chang FC, Koplovitz I, Shih TM, Sweeney RE (2006) <br />Toxicodynamic modeling of highly toxic organophosphorus compounds<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 129<br /><br />Sweeney RE, Langenberg JP, Maxwell DM (2006) <br />A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes of soman in multiple species<br /><i>Archives of Toxicology</i> <b>80</b>: 719<br /><br />Lenz DE, Maxwell DM, Koplovitz I, Clark CR, Capacio BR, Cerasoli DM, Federko JM, Luo C, Saxena A, Doctor BP, Olson C (2005) <br />Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 205<br /><br />Luo C, Leader H, Radic Z, Maxwell DM, Taylor P, Doctor BP, Saxena A (2004) <br />Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Luo C, Dawson M, Maxwell DM, Doctor BP, Saxena A (2004) <br />Strategy for reactivation of organophosphate-inhibited human butyrylcholinesterase<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 251 <br /><br />Luo C, Leader H, Radic Z, Maxwell DM, Taylor P, Doctor BP, Saxena A (2003) <br />Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase<br /><i>Biochemical Pharmacology</i> <b>66</b>: 387<br /><br />Sweeney RE, Maxwell DM (2003) <br />A theoretical expression for the protection associated with stoichiometric and catalytic scavengers in a single compartment model of organophosphorus poisoning<br /><i>Math Biosci</i> <b>181</b>: 133<br /><br />Maxwell DM, Brecht KM (2001) <br />Carboxylesterase: specificity and spontaneous reactivation of an endogenous scavenger for organophosphorus compounds<br /><i>J Appl Toxicol</i> <b>21 Suppl 1</b>: S103<br /><br />Gordon RK, Feaster SR, Russell AJ, LeJeune KE, Maxwell DM, Lenz DE, Ross M, Doctor BP (1999) <br />Organophosphate skin decontamination using immobilized enzymes<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 463<br /><br />Maxwell DM, Saxena A, Gordon RK, Doctor BP (1999) <br />Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 419<br /><br />Scott DF, Chacko TL, Maxwell DM, Schlager JJ, Lanclos KD (1999) <br />Expression and Partial Purification of a Recombinant Secretory Form of Human Liver Carboxylesterase<br /><i>Protein Expr Purif</i> <b>17</b>: 16<br /><br />Sweeney RE, Maxwell DM (1999) <br />A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning<br /><i>Math Biosci</i> <b>160</b>: 175<br /><br />Luo C, Ashani Y, Saxena A, Leader H, Maxwell DM, Taylor P, Doctor BP (1998) <br />Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 215<br /><br />Maxwell DM, Brecht KM, Saxena A, Feaster SR, Doctor BP (1998) <br />Comparison of Cholinesterases and Carboxylesterase as Bioscavengers for Organophosphorus Compounds<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 387<br /><br />Saxena A, Viragh C, Frazier DS, Kovach IM, Maxwell DM, Lockridge O, Doctor BP (1998) <br />The pH Dependence of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants: Further Evidence for a Push-Pull Mechanism<br /><i>Biochemistry</i> <b>37</b>: 15086<br /><br />Baskin SI, Thomsen RH, Maxwell DM (1997) <br />Poster: The effects of AF-DX 116, a cardioselective muscarinic antagonist, on the negative inotropic action of soman, a cholinesterase inhibitor<br /><i>Life Sciences</i> <b>60</b>: 1190<br /><br />Saxena A, Maxwell DM, Quinn DM, Radic Z, Taylor P, Doctor BP (1997) <br />Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning<br /><i>Biochemical Pharmacology</i> <b>54</b>: 269<br /><br />Adler M, Maxwell DM, Sweeney RE, Deshpande SS (1995) <br />Evaluation of the Direct Actions of HI-6 in Reversing Soman-Induced Tetanic Fade<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 321<br /><br />Maxwell DM, Brecht KM, Saxena A, Taylor P, Doctor BP (1995) <br />Comparison of Acetylcholinesterase, Pyridostigmine, and HI-6 as Antidotes against Organophosphorus Compounds<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 353<br /><br />Adler M, Maxwell DM, Filbert MG, Deshpande SS (1994) <br />Contribution of direct actions of the oxime HI-6 in reversing soman-induced muscle weakness in the rat diaphragm<br /><i>European Journal of Pharmacology</i> <b>270</b>: 9<br /><br />Caranto GR, Waibel KH, Asher JM, Larrison RW, Brecht KM, Schutz MB, Raveh L, Ashani Y, Wolfe AD, Maxwell DM, Doctor BP (1994) <br />Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes<br /><i>Biochemical Pharmacology</i> <b>47</b>: 347<br /><br />Castro CA, Gresham VC, Finger AV, Maxwell DM, Solana RP, Lenz DE, Broomfield CA (1994) <br />Behavioral decrements persist in rhesus monkeys trained on a serial probe recognition task despite protection against soman lethality by butyrylcholinesterase<br /><i>Neurotoxicology & Teratology</i> <b>16</b>: 145<br /><br />Maxwell DM, Lieske CN, Brecht KM (1994) <br />Oxime-induced reactivation of carboxylesterase inhibited by organophosphorus compounds<br /><i>Chemical Research in Toxicology</i> <b>7</b>: 428<br /><br />Brimfield AA, Lenz DE, Maxwell DM, Broomfield CA (1993) <br />Catalytic antibodies hydrolysing organophosphorus esters<br /><i>Chemico-Biological Interactions</i> <b>87</b>: 95<br /><br />Doctor BP, Blick DW, Caranto G, Castro CA, Gentry MK, Larrison RW, Maxwell DM, Murphy MR, Schutz MB, Waibel KH, Wolfe AD (1993) <br />Cholinesterases as scavengers for organophosphorus compounds: protection of primate performance against soman toxicity<br /><i>Chemico-Biological Interactions</i> <b>87</b>: 285<br /><br />Maxwell DM, Brecht KM, Doctor BP, Wolfe AD (1993) <br />Comparison of antidote protection against soman by pyridostigmine, HI-6 and acetylcholinesterase<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>264</b>: 1085<br /><br />Saxena A, Doctor BP, Maxwell DM, Lenz DE, Radic Z, Taylor P (1993) <br />The role of glutamate-199 in the aging of cholinesterase<br /><i>Biochemical & Biophysical Research Communications</i> <b>197</b>: 343<br /><br />Adler M, Deshpande SS, Foster RE, Maxwell DM, Albuquerque EX (1992) <br />Effects of subacute pyridostigmine administration on mammalian skeletal muscle function<br /><i>J Appl Toxicol</i> <b>12</b>: 25<br /><br />Lieske CN, Gepp RT, Maxwell DM, Clark JH, Broomfield CA, Blumbergs P, Tseng CC (1992) <br />Cholinesterase studies with (R) (+)- and (S)(-)-5-(1,3,3-trimethylindolinyl)-N-(1-phenylethyl)carbamate<br /><i>J Enzyme Inhib</i> <b>6</b>: 283<br /><br />Lieske CN, Clark JH, Maxwell DM, Zoeffel LD, Sultan WE (1992) <br />Studies of the amplification of carbaryl toxicity by various oximes<br /><i>Toxicology Letters</i> <b>62</b>: 127<br /><br />Maxwell DM, Castro CA, De La Hoz DM, Gentry MK, Gold MB, Solana RP, Wolfe AD, Doctor BP (1992) <br />Protection of rhesus monkeys against soman and prevention of performance decrement by pretreatment with acetylcholinesterase<br /><i>Toxicology & Applied Pharmacology</i> <b>115</b>: 44<br /><br />Maxwell DM (1992) <br />The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds<br /><i>Toxicol Appl Pharmacol</i> <b>114</b>: 306<br /><br />Broomfield CA, Maxwell DM, Solana RP, Castro CA, Finger AV, Lenz DE (1991) <br />Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>259</b>: 633<br /><br />Doctor BP, Raveh L, Wolfe AD, Maxwell DM, Ashani Y (1991) <br />Enzymes as pretreatment drugs for organophosphate toxicity<br /><i>Neurosci Biobehav Rev</i> <b>15</b>: 123<br /><br />Maxwell DM, Thomsen RH, Baskin SI (1991) <br />Species differences in the negative inotropic effect of acetylcholine and soman in rat, guinea pig, and rabbit hearts<br /><i>Comparative Biochemistry & Physiology C Pharmacol Toxicol</i> <b>100</b>: 591<br /><br />Maxwell DM, Wolfe AD, Ashani Y, Doctor BP (1991) <br />Cholinesterase and Carboxyl esterase as Scavengers for Organophosphorus Agents<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 206<br /><br />Maxwell DM, Brecht KM (1991) <br />The role of carboxylesterase in species variation of oxime protection against soman<br /><i>Neurosci Biobehav Rev</i> <b>15</b>: 135<br /><br />Wolfe AD, Ashani Y, Doctor BP, Maxwell DM (1991) <br />Poster: Esterases as organophosphate scavengers<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 306<br /><br />Little JS, Maxwell DM, Fox-Talbot MK, Brecht K, Lenz DE (1990) <br />Hepatic subcellular localization of cresylbenzodioxaphosphorin oxide (CBDP)-sensitive soman binding sites<br /><i>Biochemical Pharmacology</i> <b>40</b>: 1733<br /><br />Maxwell DM, Koplovitz I (1990) <br />Effect of endogenous carboxylesterase on HI-6 protection against soman toxicity<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>254</b>: 440<br /><br />Jimmerson VR, Shih TM, Maxwell DM, Kaminskis A, Mailman RB (1989) <br />The effect of 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide on tissue cholinesterase and carboxylesterase activities of the rat<br /><i>Fundamental & Applied Toxicology</i> <b>13</b>: 568<br /><br />Jimmerson VR, Shih TM, Maxwell DM, Mailman RB (1989) <br />Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat<br /><i>Toxicol Lett</i> <b>48</b>: 93<br /><br />Maxwell DM, Brecht KM, Lenz DE, O'Neill BL (1988) <br />Effect of carboxylesterase inhibition on carbamate protection against soman toxicity<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>246</b>: 986<br /><br />Maxwell DM, Brecht KM, O'Neill BL (1987) <br />The effect of carboxylesterase inhibition on interspecies differences in soman toxicity<br /><i>Toxicol Lett</i> <b>39</b>: 35<br /><br />Adler M, Chang FC, Maxwell DM, Mark G, Glenn JF, Foster RE (1986) <br />Effect of Diisopropylfluorophosphate on Synaptic Transmission and Acetylcholine Sensitivity in Neuroblastoma-Myotube Co-Culture<br /><i>Advances in Behavioral Biology</i> <b>30</b>: 607<br /><br />Lenz DE, Maxwell DM (1981) <br />Inhibition of rat cerebrum acetylcholinesterase isoenzymes after acute administration of soman<br /><i>Biochemical Pharmacology</i> <b>30</b>: 1369<br /><br />