Baakman AC, t Hart E, Kay DG, Stevens J, Klaassen ES, Maelicke A, Groeneveld GJ (2016) <br />First in human study with a prodrug of galantamine: Improved benefit-risk ratio?<br /><i>Alzheimers Dement (N Y)</i> <b>2</b>: 13<br /><br />Bhattacharya S, Maelicke A, Montag D (2015) <br />Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice<br /><i>J Alzheimers Dis</i> <b>46</b>: 123<br /><br />Ludwig J, Hoffle-Maas A, Samochocki M, Luttmann E, Albuquerque EX, Fels G, Maelicke A (2010) <br />Localization by site-directed mutagenesis of a galantamine binding site on alpha7 nicotinic acetylcholine receptor extracellular domain<br /><i>J Recept Signal Transduct Res</i> <b>30</b>: 469<br /><br />Maelicke A, Hoeffle-Maas A, Ludwig J, Maus A, Samochocki M, Jordis U, Koepke AK (2010) <br />Memogain is a galantamine pro-drug having dramatically reduced adverse effects and enhanced efficacy<br /><i>Journal of Molecular Neuroscience</i> <b>40</b>: 135<br /><br />Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, Fujikawa Y, Maelicke A, Tomimoto H, Taniguchi T, Shimohama S (2010) <br />Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors<br /><i>Journal of Biological Chemistry</i> <b>285</b>: 40180<br /><br />Moser N, Mechawar N, Jones I, Gochberg-Sarver A, Orr-Urtreger A, Plomann M, Salas R, Molles BE, Marubio L, Roth U, Maskos U, Winzer-Serhan U, Bourgeois JP, Le Sourd AM, De Biasi M, Schroder H, Lindstrom JM, Maelicke A, Changeux JP, Wevers A (2007) <br />Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures<br /><i>Journal of Neurochemistry</i> <b>102</b>: 479<br /><br />Popa RV, Pereira EF, Lopes C, Maelicke A, Albuquerque EX (2006) <br />The N-butylcarbamate derivative of galantamine acts as an allosteric potentiating ligand on alpha7 nicotinic receptors in hippocampal neurons: clinical implications for treatment of Alzheimer's disease<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 227<br /><br />Aracava Y, Pereira EF, Maelicke A, Albuquerque EX (2005) <br />Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>312</b>: 1195<br /><br />Albuquerque EX, Pereira EF, Samochocki M, Alkondon M, Christoph U, Maelicke A (2004) <br />Nicotinic receptor modulation.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Almeida LE, Pereira EF, Camara AL, Maelicke A, Albuquerque EX (2004) <br />Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>14</b>: 1879<br /><br />Samochocki M, Hoffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, Radina M, Zerlin M, Ullmer C, Pereira EF, Lubbert H, Albuquerque EX, Maelicke A (2003) <br />Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>305</b>: 1024<br /><br />Maelicke A, Weichel C (2002) <br />[New theory! Galantamine and nicotinic-cholinergic transmission]<br /><i>Pharm Unserer Zeit</i> <b>31</b>: 390<br /><br />Pereira EF, Hilmas C, Santos MD, Alkondon M, Maelicke A, Albuquerque EX (2002) <br />Unconventional ligands and modulators of nicotinic receptors<br /><i>Journal of Neurobiology</i> <b>53</b>: 479<br /><br />Santos MD, Alkondon M, Pereira EF, Aracava Y, Eisenberg HM, Maelicke A, Albuquerque EX (2002) <br />The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system<br /><i>Molecular Pharmacology</i> <b>61</b>: 1222<br /><br />Albuquerque EX, Santos MD, Alkondon M, Pereira EF, Maelicke A (2001) <br />Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease<br /><i>Alzheimer Disease & Associated Disorders</i> <b>15 Suppl 1</b>: S19<br /><br />Maelicke A, Samochocki M, Jostock R, Fehrenbacher A, Ludwig J, Albuquerque EX, Zerlin M (2001) <br />Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease<br /><i>Biological Psychiatry</i> <b>49</b>: 279<br /><br />Maelicke A (2001) <br />Pharmacokinetic rationale for switching from donepezil to galantamine<br /><i>Clin Ther</i> <b>23 Suppl A</b>: A8<br /><br />Maelicke A (2001) <br />The pharmacological rationale for treating vascular dementia with galantamine (Reminyl)<br /><i>Int J Clin Pract Suppl</i> <br /><br />Albuquerque EX, Pereira EF, Alkondon M, Eisenberg HM, Maelicke A (2000) <br />Neuronal Nicotinic Receptors and Synaptic Transmission in the Mammalian Central Nervous System<br /><i>Handbook of Experimental Pharmacology</i> <b>144</b>: 337<br /><br />Albuquerque EX, Pereira EF, Mike A, Eisenberg HM, Maelicke A, Alkondon M (2000) <br />Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance<br /><i>Behavioural Brain Research</i> <b>113</b>: 131<br /><br />Alkondon M, Braga MF, Pereira EF, Maelicke A, Albuquerque EX (2000) <br />alpha7 nicotinic acetylcholine receptors and modulation of gabaergic synaptic transmission in the hippocampus<br /><i>European Journal of Pharmacology</i> <b>393</b>: 59<br /><br />Maelicke A, Albuquerque EX (2000) <br />Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease<br /><i>European Journal of Pharmacology</i> <b>393</b>: 165<br /><br />Maelicke A, Schrattenholz A, Samochocki M, Radina M, Albuquerque EX (2000) <br />Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease<br /><i>Behavioural Brain Research</i> <b>113</b>: 199<br /><br />Maelicke A, Schrattenholz A, Albuquerque EX (2000) <br />Neuronal Nicotinic Acetylcholine Receptors in Non-neuronal Cells, Expression and Renaturation of Ligand Binding Domain, and Modulatory Control by Allosterically Acting Ligands<br /><i>Handbook of Experimental Pharmacology</i> <b>144</b>: 477<br /><br />Samochocki M, Zerlin M, Jostock R, Groot Kormelink PJ, Luyten WH, Albuquerque EX, Maelicke A (2000) <br />Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR<br /><i>Acta Neurologica Scandinavica Supplementum</i> <b>176</b>: 68<br /><br />Fischer U, Reinhardt S, Albuquerque EX, Maelicke A (1999) <br />Expression of functional alpha7 nicotinic acetylcholine receptor during mammalian muscle development and denervation<br /><i>European Journal of Neuroscience</i> <b>11</b>: 2856<br /><br />Wevers A, Monteggia L, Nowacki S, Bloch W, Schutz U, Lindstrom JM, Pereira EF, Eisenberg H, Giacobini E, de Vos RA, Steur EN, Maelicke A, Albuquerque EX, Schroder H (1999) <br />Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein<br /><i>European Journal of Neuroscience</i> <b>11</b>: 2551<br /><br />Hermsen B, Stetzer E, Thees R, Heiermann R, Schrattenholz A, Ebbinghaus U, Kretschmer A, Methfessel C, Reinhardt S, Maelicke A (1998) <br />Neuronal nicotinic receptors in the locust Locusta migratoria. Cloning and expression<br /><i>Journal of Biological Chemistry</i> <b>273</b>: 18394<br /><br />Schmidt EK, Liebermann T, Kreiter M, Jonczyk A, Naumann R, Offenhausser A, Neumann E, Kukol A, Maelicke A, Knoll W (1998) <br />Incorporation of the acetylcholine receptor dimer from Torpedo californica in a peptide supported lipid membrane investigated by surface plasmon and fluorescence spectroscopy<br /><i>Biosensors & Bioelectronics</i> <b>13</b>: 585<br /><br />Schrattenholz A, Pfeiffer S, Pejovic V, Rudolph R, Godovac-Zimmermann J, Maelicke A (1998) <br />Expression and renaturation of the N-terminal extracellular domain of torpedo nicotinic acetylcholine receptor alpha-subunit<br /><i>Journal of Biological Chemistry</i> <b>273</b>: 32393<br /><br />Albuquerque EX, Alkondon M, Pereira EF, Castro NG, Schrattenholz A, Barbosa CT, Bonfante-Cabarcas R, Aracava Y, Eisenberg HM, Maelicke A (1997) <br />Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>280</b>: 1117<br /><br />Albuquerque EX, Pereira EF, Alkondon M, Schrattenholz A, Maelicke A (1997) <br />Nicotinic acetylcholine receptors on hippocampal neurons: distribution on the neuronal surface and modulation of receptor activity<br /><i>J Recept Signal Transduct Res</i> <b>17</b>: 243<br /><br />Alkondon M, Pereira EF, Cortes WS, Maelicke A, Albuquerque EX (1997) <br />Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons<br /><i>European Journal of Neuroscience</i> <b>9</b>: 2734<br /><br />Camara AL, Braga MF, Rocha ES, Santos MD, Cortes WS, Cintra WM, Aracava Y, Maelicke A, Albuquerque EX (1997) <br />Methamidophos: an anticholinesterase without significant effects on postsynaptic receptors or transmitter release<br /><i>Neurotoxicology</i> <b>18</b>: 589<br /><br />Maelicke A, Coban T, Storch A, Schrattenholz A, Pereira EF, Albuquerque EX (1997) <br />Allosteric modulation of Torpedo nicotinic acetylcholine receptor ion channel activity by noncompetitive agonists<br /><i>J Recept Signal Transduct Res</i> <b>17</b>: 11<br /><br />Schrattenholz A, Roth U, Godovac-Zimmermann J, Maelicke A (1997) <br />Mapping of a binding site for ATP within the extracellular region of the Torpedo nicotinic acetylcholine receptor beta-subunit<br /><i>Biochemistry</i> <b>36</b>: 13333<br /><br />Albuquerque EX, Pereira EF, Bonfante-Cabarcas R, Marchioro M, Matsubayashi H, Alkondon M, Maelicke A (1996) <br />Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity<br /><i>Prog Brain Res</i> <b>109</b>: 111<br /><br />Alkondon M, Rocha ES, Maelicke A, Albuquerque EX (1996) <br />Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>278</b>: 1460<br /><br />Barbosa CT, Alkondon M, Aracava Y, Maelicke A, Albuquerque EX (1996) <br />Ligand-gated ion channels in acutely dissociated rat hippocampal neurons with long dendrites<br /><i>Neuroscience Letters</i> <b>210</b>: 177<br /><br />Maelicke A (1996) <br />Nicotinic receptors of the vertebrate CNS: introductory remarks<br /><i>Prog Brain Res</i> <b>109</b>: 107<br /><br />Rocha ES, Swanson KL, Aracava Y, Goolsby JE, Maelicke A, Albuquerque EX (1996) <br />Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>278</b>: 1175<br /><br />Schrattenholz A, Pereira EF, Roth U, Weber KH, Albuquerque EX, Maelicke A (1996) <br />Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands<br /><i>Molecular Pharmacology</i> <b>49</b>: 1<br /><br />Stetzer E, Ebbinghaus U, Storch A, Poteur L, Schrattenholz A, Kramer G, Methfessel C, Maelicke A (1996) <br />Stable expression in HEK-293 cells of the rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor<br /><i>FEBS Letters</i> <b>397</b>: 39<br /><br />Albuquerque EX, Pereira EF, Castro NG, Alkondon M, Reinhardt S, Schroder H, Maelicke A (1995) <br />Nicotinic receptor function in the mammalian central nervous system<br /><i>Annals of the New York Academy of Sciences</i> <b>757</b>: 48<br /><br />Lobron C, Wevers A, Damgen K, Jeske A, Rontal D, Birtsch C, Heinemann S, Reinhardt S, Maelicke A, Schroder H (1995) <br />Cellular distribution in the rat telencephalon of mRNAs encoding for the alpha 3 and alpha 4 subunits of the nicotinic acetylcholine receptor<br /><i>Brain Research Mol Brain Res</i> <b>30</b>: 70<br /><br />Maelicke A, Schrattenholz A, Storch A, Schroder B, Gutbrod O, Methfessel C, Weber KH, Pereira EE, Alkondon M, Albuquerque EX (1995) <br />Noncompetitive agonism at nicotinic acetylcholine receptors; functional significance for CNS signal transduction<br /><i>J Recept Signal Transduct Res</i> <b>15</b>: 333<br /><br />Storch A, Schrattenholz A, Cooper JC, Abdel Ghani EM, Gutbrod O, Weber KH, Reinhardt S, Lobron C, Hermsen B, Soskic V, Pereira EF, Albuquerque EX, Methfessel C, Maelicke A (1995) <br />Physostigmine, galanthamine and codeine act as 'noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma cells<br /><i>European Journal of Pharmacology</i> <b>290</b>: 207<br /><br />Alkondon M, Reinhardt S, Lobron C, Hermsen B, Maelicke A, Albuquerque EX (1994) <br />Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>271</b>: 494<br /><br />Pereira EF, Alkondon M, Reinhardt S, Maelicke A, Peng X, Lindstrom JM, Whiting P, Albuquerque EX (1994) <br />Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>270</b>: 768<br /><br />Schrattenholz A, Roth U, Schuhen A, Schafer HJ, Godovac-Zimmermann J, Albuquerque EX, Maelicke A (1994) <br />Identification of purine binding sites on Torpedo acetylcholine receptor<br /><i>J Recept Res</i> <b>14</b>: 197<br /><br />Schroder B, Reinhardt-Maelicke S, Schrattenholz A, McLane KE, Kretschmer A, Conti-Tronconi BM, Maelicke A (1994) <br />Monoclonal antibodies FK1 and WF6 define two neighboring ligand binding sites on Torpedo acetylcholine receptor alpha-polypeptide<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 10407<br /><br />Maelicke A, Coban T, Schrattenholz A, Schroder B, Reinhardt-Maelicke S, Storch A, Godovac-Zimmermann J, Methfessel C, Pereira EF, Albuquerque EX (1993) <br />Physostigmine and neuromuscular transmission<br /><i>Annals of the New York Academy of Sciences</i> <b>681</b>: 140<br /><br />Pereira EF, Alkondon M, Tano T, Castro NG, Froes-Ferrao MM, Rozental R, Aronstam RS, Schrattenholz A, Maelicke A, Albuquerque EX (1993) <br />A novel agonist binding site on nicotinic acetylcholine receptors<br /><i>J Recept Res</i> <b>13</b>: 413<br /><br />Pereira EF, Reinhardt-Maelicke S, Schrattenholz A, Maelicke A, Albuquerque EX (1993) <br />Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>265</b>: 1474<br /><br />Schrattenholz A, Coban T, Schroder B, Okonjo KO, Kuhlmann J, Pereira EF, Albuquerque EX, Maelicke A (1993) <br />Biochemical characterization of a novel channel-activating site on nicotinic acetylcholine receptors<br /><i>J Recept Res</i> <b>13</b>: 393<br /><br />Schrattenholz A, Godovac-Zimmermann J, Schafer HJ, Albuquerque EX, Maelicke A (1993) <br />Photoaffinity labeling of Torpedo acetylcholine receptor by physostigmine<br /><i>European Journal of Biochemistry</i> <b>216</b>: 671<br /><br />Hosli L, Hosli E, Maelicke A, Schroder H (1992) <br />Peptidergic and cholinergic receptors on cultured astrocytes of different regions of the rat CNS<br /><i>Prog Brain Res</i> <b>94</b>: 317<br /><br />Kuhlmann J, Okonjo KO, Maelicke A (1991) <br />Desensitization is a property of the cholinergic binding region of the nicotinic acetylcholine receptor, not of the receptor-integral ion channel<br /><i>FEBS Letters</i> <b>279</b>: 216<br /><br />Maelicke A (1991) <br />Acetylcholine esterase: the structure<br /><i>Trends in Biochemical Sciences</i> <b>16</b>: 355<br /><br />Okonjo KO, Kuhlmann J, Maelicke A (1991) <br />A second pathway of activation of the Torpedo acetylcholine receptor channel<br /><i>European Journal of Biochemistry</i> <b>200</b>: 671<br /><br />Schroder H, Giacobini E, Struble RG, Zilles K, Maelicke A (1991) <br />Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease<br /><i>Neurobiology of Aging</i> <b>12</b>: 259<br /><br />Schroder H, Giacobini E, Struble RG, Zilles K, Maelicke A, Luiten PG, Strosberg AD (1991) <br />Cellular distribution and expression of cortical acetylcholine receptors in aging and Alzheimer's disease<br /><i>Annals of the New York Academy of Sciences</i> <b>640</b>: 189<br /><br />Kyriatsoulis A, Manns M, Gerken G, Lohse AW, Maelicke A, Wessler I, Reske K, Meyer zum Buschenfelde KH (1988) <br />Immunochemical characterization of anti-acetylcholine receptor antibodies in primary biliary cirrhosis<br /><i>Journal of Hepatology</i> <b>6</b>: 283<br /><br />Maelicke A (1988) <br />Structure and Function of the Nicotinic Acetylcholine Receptor<br /><i>Handbook of Experimental Pharmacology</i> <b>86</b>: 267<br /><br />Covarrubias M, Prinz H, Meyers HW, Maelicke A (1986) <br />Equilibrium binding of cholinergic ligands to the membrane-bound acetylcholine receptor<br /><i>Journal of Biological Chemistry</i> <b>261</b>: 14955<br /><br />Covarrubias M, Prinz H, Maelicke A (1984) <br />Ligand-specific state transitions of the membrane-bound acetylcholine receptor<br /><i>FEBS Letters</i> <b>169</b>: 229<br /><br />Jurss R, Maelicke A (1983) <br />Appendix. Synthesis of NBD-5-acylcholine<br /><i>Journal of Biological Chemistry</i> <b>258</b>: 10272<br /><br />Meyers HW, Jurss R, Brenner HR, Fels G, Prinz H, Watzke H, Maelicke A (1983) <br />Synthesis and properties of NBD-n-acylcholines, fluorescent analogs of acetylcholine<br /><i>European Journal of Biochemistry</i> <b>137</b>: 399<br /><br />Prinz H, Maelicke A (1983) <br />Interaction of cholinergic ligands with the purified acetylcholine receptor protein. I. Equilibrium binding studies<br /><i>Journal of Biological Chemistry</i> <b>258</b>: 10263<br /><br />Prinz H, Maelicke A (1983) <br />Interaction of cholinergic ligands with the purified acetylcholine receptor protein. II. Kinetic studies<br /><i>Journal of Biological Chemistry</i> <b>258</b>: 10273<br /><br />Boheim G, Hanke W, Barrantes FJ, Eibl H, Sakmann B, Fels G, Maelicke A (1981) <br />Agonist-activated ionic channels in acetylcholine receptor reconstituted into planar lipid bilayers<br /><i>Proc Natl Acad Sci U S A</i> <b>78</b>: 3586<br /><br />Jurss R, Maelicke A (1981) <br />Interaction of acetylcholine esterase with fluorescent analogs of acetylcholine<br /><i>Journal of Biological Chemistry</i> <b>256</b>: 2887<br /><br />Jurss R, Prinz H, Maelicke A (1979) <br />NBD-5-acylcholine: fluorescent analog of acetylcholine and agonist at the neuromuscular junction<br /><i>Proc Natl Acad Sci U S A</i> <b>76</b>: 1064<br /><br />Miskin R, Easton TG, Maelicke A, Reich E (1978) <br />Metabolism of acetylcholine receptor in chick embryo muscle cells: effects of RSV and PMA<br /><i>Cell</i> <b>15</b>: 1287<br /><br />Maelicke A, Fulpius BW, Klett RP, Reich E (1977) <br />Acetylcholine receptor. Responses to drug binding<br /><i>Journal of Biological Chemistry</i> <b>252</b>: 4811<br /><br />Maelicke A, Reich E (1976) <br />On the interaction between cobra alpha-neurotoxin and the acetylcholine receptor<br /><i>Cold Spring Harbor Symposium on Quantitative Biology</i> <b>40</b>: 231<br /><br />Fulpius BW, Maelicke A, Klett RP, Reich E (1975) <br />The acetylcholine receptor: studies of the interaction with Alpha-Neurotoxin from Naja naja Siamensis<br /><i>Cholinergic.Mechanisms, Raven Press</i> <br /><br />