Mulcahy MJ, Huard SM, Paulo JA, Wang JH, McKinney S, Marks MJ, Henderson BJ, Lester HA (2021) <br />Protein profiling in the habenula after chronic (-)-menthol exposure in mice<br /><i>Journal of Neurochemistry</i> <br /><br />Subramaniam SR, Magen I, Bove N, Zhu C, Lemesre V, Dutta G, Elias CJ, Lester HA, Chesselet MF (2018) <br />Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type alpha-synuclein<br /><i>Neurobiol Dis</i> <b>117</b>: 170<br /><br />Mulcahy MJ, Lester HA (2017) <br />Granulocytes as models for human protein marker identification following nicotine exposure<br /><i>Journal of Neurochemistry</i> <b>142 Suppl 2</b>: 151<br /><br />Henderson BJ, Wall TR, Henley BM, Kim CH, Nichols WA, Moaddel R, Xiao C, Lester HA (2016) <br />Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward<br /><i>Journal of Neuroscience</i> <b>36</b>: 2957<br /><br />Nichols WA, Henderson BJ, Marotta CB, Yu CY, Richards C, Dougherty DA, Lester HA, Cohen BN (2016) <br />Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity alpha4beta2, and Increases alpha5alpha4beta2, Nicotinic Receptor Surface Expression<br /><i>PLoS ONE</i> <b>11</b>: e0158032<br /><br />Srinivasan R, Henley BM, Henderson BJ, Indersmitten T, Cohen BN, Kim CH, McKinney S, Deshpande P, Xiao C, Lester HA (2016) <br />Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons<br /><i>Journal of Neuroscience</i> <b>36</b>: 65<br /><br />Henderson BJ, Lester HA (2015) <br />Inside-out neuropharmacology of nicotinic drugs<br /><i>Neuropharmacology</i> <b>96</b>: 178<br /><br />Marotta CB, Lester HA, Dougherty DA (2015) <br />An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in alpha7 Nicotinic Acetylcholine Receptors<br /><i>Chemical Biology</i> <b>22</b>: 1063<br /><br />Post MR, Limapichat W, Lester HA, Dougherty DA (2015) <br />Heterologous expression and nonsense suppression provide insights into agonist behavior at alpha6beta2 nicotinic acetylcholine receptors<br /><i>Neuropharmacology</i> <b>97</b>: 376<br /><br />Sinkus ML, Graw S, Freedman R, Ross RG, Lester HA, Leonard S (2015) <br />The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function<br /><i>Neuropharmacology</i> <b>96</b>: 274<br /><br />Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Damaj MI, Lester HA, Patapoutian A, Mogil JS (2015) <br />The nicotinic alpha6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors<br /><i>Sci Transl Med</i> <b>7</b>: 287ra72<br /><br />Xiao C, Miwa JM, Henderson BJ, Wang Y, Deshpande P, McKinney SL, Lester HA (2015) <br />Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus<br /><i>Journal of Neuroscience</i> <b>35</b>: 3734<br /><br />Henderson BJ, Srinivasan R, Nichols WA, Dilworth CN, Gutierrez DF, Mackey ED, McKinney S, Drenan RM, Richards CI, Lester HA (2014) <br />Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors<br /><i>Journal of General Physiology</i> <b>143</b>: 51<br /><br />Kobayashi A, Parker RL, Wright AP, Brahem H, Ku P, Oliver KM, Walz A, Lester HA, Miwa JM (2014) <br />lynx1 Supports Neuronal Health in the Mouse Dorsal Striatum During Aging: an Ultrastructural Investigation<br /><i>Journal of Molecular Neuroscience</i> <b>53</b>: 525<br /><br />Marotta CB, Dilworth CN, Lester HA, Dougherty DA (2014) <br />Probing the non-canonical interface for agonist interaction with an alpha5 containing nicotinic acetylcholine receptor<br /><i>Neuropharmacology</i> <b>77</b>: 342<br /><br />Nichols WA, Henderson BJ, Yu C, Parker RL, Richards CI, Lester HA, Miwa JM (2014) <br />Lynx1 Shifts alpha4beta2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum<br /><i>Journal of Biological Chemistry</i> <b>289</b>: 31423<br /><br />Srinivasan R, Henderson BJ, Lester HA, Richards CI (2014) <br />Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease<br /><i>Pharmacol Res</i> <b>83</b>: 20<br /><br />Wang Y, Xiao C, Indersmitten T, Freedman R, Leonard S, Lester HA (2014) <br />The duplicated alpha7 subunits assemble and form functional nicotinic receptors with the full-length alpha7<br /><i>Journal of Biological Chemistry</i> <b>289</b>: 26451<br /><br />Blum AP, Van Arnam EB, German LA, Lester HA, Dougherty DA (2013) <br />Binding interactions with the complementary subunit of nicotinic receptors<br /><i>Journal of Biological Chemistry</i> <b>288</b>: 6991<br /><br />Henley BM, Williams BA, Srinivasan R, Cohen BN, Xiao C, Mackey ED, Wold BJ, Lester HA (2013) <br />Transcriptional regulation by nicotine in dopaminergic neurons<br /><i>Biochemical Pharmacology</i> <b>86</b>: 1074<br /><br />O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ (2013) <br />Mice expressing the ADNFLE valine 287 leucine mutation of the Beta2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function<br /><i>Pharmacol Biochem Behav</i> <b>103</b>: 603<br /><br />Van Arnam EB, Blythe EE, Lester HA, Dougherty DA (2013) <br />An Unusual Pattern of Ligand-Receptor Interactions for the alpha7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline<br /><i>Molecular Pharmacology</i> <b>84</b>: 201<br /><br />Cohen BN, Mackey ED, Grady SR, McKinney S, Patzlaff NE, Wageman CR, McIntosh JM, Marks MJ, Lester HA, Drenan RM (2012) <br />Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior<br /><i>Neuroscience</i> <b>200</b>: 31<br /><br />Drenan RM, Lester HA (2012) <br />Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations<br /><i>Pharmacol Rev</i> <b>64</b>: 869<br /><br />Mackey ED, Engle SE, Kim MR, O'Neill HC, Wageman CR, Patzlaff NE, Wang Y, Grady SR, McIntosh JM, Marks MJ, Lester HA, Drenan RM (2012) <br />alpha6* nicotinic acetylcholine receptor expression and function in a visual salience circuit<br /><i>Journal of Neuroscience</i> <b>32</b>: 10226<br /><br />Miwa JM, Lester HA, Walz A (2012) <br />Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction<br /><i>Physiology (Bethesda)</i> <b>27</b>: 187<br /><br />Murray TA, Bertrand D, Papke RL, George AA, Pantoja R, Srinivasan R, Liu Q, Wu J, Whiteaker P, Lester HA, Lukas RJ (2012) <br />alpha7beta2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their alpha7-alpha7 interfaces<br /><i>Molecular Pharmacology</i> <b>81</b>: 175<br /><br />Puskar NL, Lester HA, Dougherty DA (2012) <br />Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor<br /><i>ACS Chemical Biology</i> <b>7</b>: 841<br /><br />Richards CI, Luong K, Srinivasan R, Turner SW, Dougherty DA, Korlach J, Lester HA (2012) <br />Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures<br /><i>Nano Lett</i> <b>12</b>: 3690<br /><br />Srinivasan R, Richards CI, Dilworth C, Moss FJ, Dougherty DA, Lester HA (2012) <br />Forster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic alpha4beta2<br /><i>Int J Mol Sci</i> <b>13</b>: 10022<br /><br />Srinivasan R, Richards CI, Xiao C, Rhee D, Pantoja R, Dougherty DA, Miwa JM, Lester HA (2012) <br />Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response<br /><i>Molecular Pharmacology</i> <b>81</b>: 759<br /><br />Tavares Xda S, Blum AP, Nakamura DT, Puskar NL, Shanata JA, Lester HA, Dougherty DA (2012) <br />Variations in binding among several agonists at two stoichiometries of the neuronal, alpha4beta2 nicotinic receptor<br /><i>J Am Chem Soc</i> <b>134</b>: 11474<br /><br />Blum AP, Gleitsman KR, Lester HA, Dougherty DA (2011) <br />Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit<br /><i>Journal of Biological Chemistry</i> <b>286</b>: 32251<br /><br />Drenan RM, Mackey EDW, Grady SR, Patzlaff NE, Wageman CR, McIntosh JM, Marks MJ, Lester HA (2011) <br />Poster: alpha6* nAChR expression and function in brain areas influencing DA transmission probed with alpha6-GFP transgenic mice<br /><i>Biochemical Pharmacology</i> <b>82</b>: 1035<br /><br />Lummis SC, Thompson AJ, Bencherif M, Lester HA (2011) <br />Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>339</b>: 125<br /><br />Miwa JM, Freedman R, Lester HA (2011) <br />Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses<br /><i>Neuron</i> <b>70</b>: 20<br /><br />Parker RL, Rhee DS, Lester HA, Miwa JM (2011) <br />Poster: Lynx1 balances neuronal activity through nicotinic acetylcholine receptor modulation<br /><i>Biochemical Pharmacology</i> <b>82</b>: 1037<br /><br />Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC (2011) <br />A cation-pi interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists<br /><i>Molecular Pharmacology</i> <b>79</b>: 742<br /><br />Puskar NL, Xiu X, Lester HA, Dougherty DA (2011) <br />Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes<br /><i>Journal of Biological Chemistry</i> <b>286</b>: 14618<br /><br />Richards CI, Srinivasan R, Xiao C, Mackey ED, Miwa JM, Lester HA (2011) <br />Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine<br /><i>Journal of Biological Chemistry</i> <b>286</b>: 31241<br /><br />Srinivasan R, Pantoja R, Moss FJ, Mackey ED, Son CD, Miwa JM, Lester HA (2011) <br />Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning<br /><i>Journal of General Physiology</i> <b>137</b>: 59<br /><br />Xiao C, Srinivasan R, Drenan RM, Mackey ED, McIntosh JM, Lester HA (2011) <br />Characterizing functional alpha6beta2 nicotinic acetylcholine receptors in vitro: mutant beta2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells<br /><i>Biochemical Pharmacology</i> <b>82</b>: 852<br /><br />Xu J, Cohen BN, Zhu Y, Dziewczapolski G, Panda S, Lester HA, Heinemann SF, Contractor A (2011) <br />Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the beta2 nicotinic receptor<br /><i>Mol Psychiatry</i> <b>16</b>: 1048<br /><br />Blum AP, Lester HA, Dougherty DA (2010) <br />Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH<br /><i>Proc Natl Acad Sci U S A</i> <b>107</b>: 13206<br /><br />Drenan RM, Grady SR, Steele AD, McKinney S, Patzlaff NE, McIntosh JM, Marks MJ, Miwa JM, Lester HA (2010) <br />Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors<br /><i>Journal of Neuroscience</i> <b>30</b>: 9877<br /><br />Grady SR, Drenan RM, Breining SR, Yohannes D, Wageman CR, Fedorov NB, McKinney S, Whiteaker P, Bencherif M, Lester HA, Marks MJ (2010) <br />Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors<br /><i>Neuropharmacology</i> <b>58</b>: 1054<br /><br />Limapichat W, Lester HA, Dougherty DA (2010) <br />Chemical scale studies of the Phe-Pro conserved motif in the cys loop of Cys loop receptors<br /><i>Journal of Biological Chemistry</i> <b>285</b>: 8976<br /><br />Zhao-Shea R, Cohen BN, Just H, McClure-Begley TD, Whiteaker P, Grady SR, Salminen O, Gardner PD, Lester HA, Tapper AR (2010) <br />Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism<br /><i>FASEB Journal</i> <b>24</b>: 49<br /><br />Breining SR, Bencherif M, Grady SR, Whiteaker P, Marks MJ, Wageman CR, Lester HA, Yohannes D (2009) <br />Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>19</b>: 4359<br /><br />Fonck C, Nashmi R, Salas R, Zhou C, Huang Q, De Biasi M, Lester RA, Lester HA (2009) <br />Demonstration of functional alpha4-containing nicotinic receptors in the medial habenula<br /><i>Neuropharmacology</i> <b>56</b>: 247<br /><br />Gleitsman KR, Lester HA, Dougherty DA (2009) <br />Probing the role of backbone hydrogen bonding in a critical beta sheet of the extracellular domain of a cys-loop receptor<br /><i>Chembiochem</i> <b>10</b>: 1385<br /><br />Gleitsman KR, Shanata JA, Frazier SJ, Lester HA, Dougherty DA (2009) <br />Long-range coupling in an allosteric receptor revealed by mutant cycle analysis<br /><i>Biophysical Journal</i> <b>96</b>: 3168<br /><br />Lester HA, Xiao C, Srinivasan R, Son CD, Miwa JM, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC (2009) <br />Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery<br /><i>AAPS J</i> <b>11</b>: 167<br /><br />Pantoja R, Rodriguez EA, Dibas MI, Dougherty DA, Lester HA (2009) <br />Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors<br /><i>Biophysical Journal</i> <b>96</b>: 226<br /><br />Pantoja R, Srinivasan R, Kadambi S, Mackey EDW, Tzlil S, Moss FJ, Lester HA (2009) <br />Poster: Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: High-resolution imaging<br /><i>Biochemical Pharmacology</i> <b>78</b>: 900<br /><br />Srinivasan R, Pantoja R, Kadambi S, Mackey EDW, Tzlil S, Moss FJ, Lester HA (2009) <br />Poster: Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: Compartments and stoichiometries<br /><i>Biochemical Pharmacology</i> <b>78</b>: 900<br /><br />Torrice MM, Bower KS, Lester HA, Dougherty DA (2009) <br />Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids<br /><i>Proc Natl Acad Sci U S A</i> <b>106</b>: 11919<br /><br />Xiao C, Nashmi R, McKinney S, Cai H, McIntosh JM, Lester HA (2009) <br />Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway<br /><i>Journal of Neuroscience</i> <b>29</b>: 12428<br /><br />Xiu X, Puskar NL, Shanata JA, Lester HA, Dougherty DA (2009) <br />Nicotine binding to brain receptors requires a strong cation-pi interaction<br /><i>Nature</i> <b>458</b>: 534<br /><br />Drenan RM, Grady SR, Whiteaker P, McClure-Begley TD, McKinney S, Miwa JM, Bupp S, Heintz N, McIntosh JM, Bencherif M, Marks MJ, Lester HA (2008) <br />In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors<br /><i>Neuron</i> <b>60</b>: 123<br /><br />Drenan RM, Nashmi R, Imoukhuede P, Just H, McKinney S, Lester HA (2008) <br />Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits<br /><i>Molecular Pharmacology</i> <b>73</b>: 27<br /><br />Gleitsman KR, Kedrowski SM, Lester HA, Dougherty DA (2008) <br />An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating<br /><i>Journal of Biological Chemistry</i> <b>283</b>: 35638<br /><br />Hanek AP, Lester HA, Dougherty DA (2008) <br />A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor<br /><i>J Am Chem Soc</i> <b>130</b>: 13216<br /><br />Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL (2008) <br />Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm<br /><i>Journal of Neuroscience</i> <b>28</b>: 519<br /><br />Cashin AL, Torrice MM, McMenimen KA, Lester HA, Dougherty DA (2007) <br />Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor<br /><i>Biochemistry</i> <b>46</b>: 630<br /><br />Damaj MI, Fonck C, Marks MJ, Deshpande P, Labarca C, Lester HA, Collins AC, Martin BR (2007) <br />Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>321</b>: 1161<br /><br />Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, Whiteaker P, Huang Q, McClure-Begley TD, Lindstrom JM, Labarca C, Collins AC, Marks MJ, Lester HA (2007) <br />Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path<br /><i>Journal of Neuroscience</i> <b>27</b>: 8202<br /><br />Nashmi R, Lester HA (2007) <br />Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation<br /><i>Biochemical Pharmacology</i> <b>74</b>: 1145<br /><br />Tapper AR, McKinney SL, Marks MJ, Lester HA (2007) <br />Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice<br /><i>Physiol Genomics</i> <b>31</b>: 422<br /><br />Teper Y, Whyte D, Cahir E, Lester HA, Grady SR, Marks MJ, Cohen BN, Fonck C, McClure-Begley TD, McIntosh JM, Labarca C, Lawrence A, Chen F, Gantois I, Davies PJ, Petrou S, Murphy M, Waddington J, Horne MK, Berkovic SF, Drago J (2007) <br />Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation<br /><i>Journal of Neuroscience</i> <b>27</b>: 10128<br /><br />Miwa JM, Stevens TR, King SL, Caldarone BJ, Ibanez-Tallon I, Xiao C, Fitzsimonds RM, Pavlides C, Lester HA, Picciotto MR, Heintz N (2006) <br />The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo<br /><i>Neuron</i> <b>51</b>: 587<br /><br />Nashmi R, Lester HA (2006) <br />CNS localization of neuronal nicotinic receptors<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 181<br /><br />Schwarz J, Schwarz SC, Dorigo O, Stutzer A, Wegner F, Labarca C, Deshpande P, Gil JS, Berk AJ, Lester HA (2006) <br />Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons<br /><i>FASEB Journal</i> <b>20</b>: 935<br /><br />Cashin AL, Petersson EJ, Lester HA, Dougherty DA (2005) <br />Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor<br /><i>J Am Chem Soc</i> <b>127</b>: 350<br /><br />Fonck C, Cohen BN, Nashmi R, Whiteaker P, Wagenaar DA, Rodrigues-Pinguet N, Deshpande P, McKinney S, Kwoh S, Munoz J, Labarca C, Collins AC, Marks MJ, Lester HA (2005) <br />Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors<br /><i>Journal of Neuroscience</i> <b>25</b>: 11396<br /><br />Lummis SC, D LB, Harrison NJ, Lester HA, Dougherty DA (2005) <br />A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor<br /><i>Chemical Biology</i> <b>12</b>: 993<br /><br />Rodrigues-Pinguet NO, Pinguet TJ, Figl A, Lester HA, Cohen BN (2005) <br />Mutations linked to autosomal dominant nocturnal frontal lobe epilepsy affect allosteric Ca2+ activation of the alpha 4 beta 2 nicotinic acetylcholine receptor<br /><i>Molecular Pharmacology</i> <b>68</b>: 487<br /><br />Xiu X, Hanek AP, Wang J, Lester HA, Dougherty DA (2005) <br />A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors<br /><i>Journal of Biological Chemistry</i> <b>280</b>: 41655<br /><br />Bhattacharya A, Dang H, Zhu QM, Schnegelsberg B, Rozengurt N, Cain G, Prantil R, Vorp DA, Guy N, Julius D, Ford AP, Lester HA, Cockayne DA (2004) <br />Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit<br /><i>Journal of Neuroscience</i> <b>24</b>: 5537<br /><br />Dahan DS, Dibas MI, Petersson EJ, Auyeung VC, Chanda B, Bezanilla F, Dougherty DA, Lester HA (2004) <br />A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site<br /><i>Proc Natl Acad Sci U S A</i> <b>101</b>: 10195<br /><br />Orb S, Wieacker J, Labarca C, Fonck C, Lester HA, Schwarz J (2004) <br />Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally<br /><i>Physiol Genomics</i> <b>18</b>: 299<br /><br />Tapper AR, McKinney SL, Nashmi R, Schwarz J, Deshpande P, Labarca C, Whiteaker P, Marks MJ, Collins AC, Lester HA (2004) <br />Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization<br /><i>Science</i> <b>306</b>: 1029<br /><br />Fonck C, Nashmi R, Deshpande P, Damaj MI, Marks MJ, Riedel A, Schwarz J, Collins AC, Labarca C, Lester HA (2003) <br />Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors<br /><i>Journal of Neuroscience</i> <b>23</b>: 2582<br /><br />Leite JF, Blanton MP, Shahgholi M, Dougherty DA, Lester HA (2003) <br />Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry<br /><i>Proc Natl Acad Sci U S A</i> <b>100</b>: 13054<br /><br />Leite JF, Dougherty DA, Lester HA, Shahgholi M (2003) <br />Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide<br /><i>Rapid Commun Mass Spectrom</i> <b>17</b>: 1677<br /><br />Lester HA, Fonck C, Tapper AR, McKinney S, Damaj MI, Balogh S, Owens J, Wehner JM, Collins AC, Labarca C (2003) <br />Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action<br /><i>Curr Opin Drug Discov Devel</i> <b>6</b>: 633<br /><br />Monahan SL, Lester HA, Dougherty DA (2003) <br />Site-specific incorporation of unnatural amino acids into receptors expressed in Mammalian cells<br /><i>Chemical Biology</i> <b>10</b>: 573<br /><br />Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA (2003) <br />Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons<br /><i>Journal of Neuroscience</i> <b>23</b>: 11554<br /><br />Owens JC, Balogh SA, McClure-Begley TD, Butt CM, Labarca C, Lester HA, Picciotto MR, Wehner JM, Collins AC (2003) <br />Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response<br /><i>Alcohol Clin Exp Res</i> <b>27</b>: 1867<br /><br />Rodrigues-Pinguet N, Jia L, Li M, Figl A, Klaassen A, Truong A, Lester HA, Cohen BN (2003) <br />Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response<br /><i>The Journal of Physiology</i> <b>550</b>: 11<br /><br />Beene DL, Brandt GS, Zhong W, Zacharias NM, Lester HA, Dougherty DA (2002) <br />Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine<br /><i>Biochemistry</i> <b>41</b>: 10262<br /><br />Li P, Slimko EM, Lester HA (2002) <br />Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel<br /><i>FEBS Letters</i> <b>528</b>: 77<br /><br />Petersson EJ, Choi A, Dahan DS, Lester HA, Dougherty DA (2002) <br />A perturbed pK(a) at the binding site of the nicotinic acetylcholine receptor: implications for nicotine binding<br /><i>J Am Chem Soc</i> <b>124</b>: 12662<br /><br />Dougherty DA, Lester HA (2001) <br />Neurobiology. Snails, synapses and smokers<br /><i>Nature</i> <b>411</b>: 252<br /><br />Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Nashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, Wehner JM, Lester HA (2001) <br />Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety<br /><i>Proc Natl Acad Sci U S A</i> <b>98</b>: 2786<br /><br />Li L, Zhong W, Zacharias N, Gibbs C, Lester HA, Dougherty DA (2001) <br />The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor<br /><i>Chemical Biology</i> <b>8</b>: 47<br /><br />Khakh BS, Zhou X, Sydes J, Galligan JJ, Lester HA (2000) <br />State-dependent cross-inhibition between transmitter-gated cation channels<br /><i>Nature</i> <b>406</b>: 405<br /><br />Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA (2000) <br />Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins<br /><i>Journal of Biological Chemistry</i> <b>275</b>: 3397<br /><br />England PM, Lester HA, Dougherty DA (1999) <br />Mapping disulfide connectivity using backbone ester hydrolysis<br /><i>Biochemistry</i> <b>38</b>: 14409<br /><br />England PM, Zhang Y, Dougherty DA, Lester HA (1999) <br />Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating<br /><i>Cell</i> <b>96</b>: 89<br /><br />Miller JC, Silverman SK, England PM, Dougherty DA, Lester HA (1998) <br />Flash decaging of tyrosine sidechains in an ion channel<br /><i>Neuron</i> <b>20</b>: 619<br /><br />Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA (1998) <br />From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor<br /><i>Proc Natl Acad Sci U S A</i> <b>95</b>: 12088<br /><br />Doupnik CA, Davidson N, Lester HA, Kofuji P (1997) <br />RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels<br /><i>Proc Natl Acad Sci U S A</i> <b>94</b>: 10461<br /><br />England PM, Lester HA, Davidson N, Dougherty DA (1997) <br />Site-specific, photochemical proteolysis applied to ion channels in vivo<br /><i>Proc Natl Acad Sci U S A</i> <b>94</b>: 11025<br /><br />Gallivan JP, Lester HA, Dougherty DA (1997) <br />Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins<br /><i>Chemical Biology</i> <b>4</b>: 739<br /><br />West AP, Jr., Bjorkman PJ, Dougherty DA, Lester HA (1997) <br />Expression and circular dichroism studies of the extracellular domain of the alpha subunit of the nicotinic acetylcholine receptor<br /><i>Journal of Biological Chemistry</i> <b>272</b>: 25468<br /><br />Figl A, Labarca C, Davidson N, Lester HA, Cohen BN (1996) <br />Voltage-jump relaxation kinetics for wild-type and chimeric beta subunits of neuronal nicotinic receptors<br /><i>Journal of General Physiology</i> <b>107</b>: 369<br /><br />Kearney PC, Nowak MW, Zhong W, Silverman SK, Lester HA, Dougherty DA (1996) <br />Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists<br /><i>Molecular Pharmacology</i> <b>50</b>: 1401<br /><br />Kearney PC, Zhang H, Zhong W, Dougherty DA, Lester HA (1996) <br />Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position<br /><i>Neuron</i> <b>17</b>: 1221<br /><br />Saks ME, Sampson JR, Nowak MW, Kearney PC, Du F, Abelson JN, Lester HA, Dougherty DA (1996) <br />An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression<br /><i>Journal of Biological Chemistry</i> <b>271</b>: 23169<br /><br />Schreibmayer W, Dessauer CW, Vorobiov D, Gilman AG, Lester HA, Davidson N, Dascal N (1996) <br />Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits<br /><i>Nature</i> <b>380</b>: 624<br /><br />Silverman SK, Kofuji P, Dougherty DA, Davidson N, Lester HA (1996) <br />A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation<br /><i>Proc Natl Acad Sci U S A</i> <b>93</b>: 15429<br /><br />Cohen BN, Figl A, Quick MW, Labarca C, Davidson N, Lester HA (1995) <br />Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors<br /><i>Journal of General Physiology</i> <b>105</b>: 745<br /><br />Kofuji P, Davidson N, Lester HA (1995) <br />Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers<br /><i>Proc Natl Acad Sci U S A</i> <b>92</b>: 6542<br /><br />Labarca C, Nowak MW, Zhang H, Tang L, Deshpande P, Lester HA (1995) <br />Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors<br /><i>Nature</i> <b>376</b>: 514<br /><br />Lester HA (1995) <br />Activation of ion channels by acetylcholine: two contrasting transduction pathways<br /><i>Harvey Lect</i> <b>91</b>: 79<br /><br />Karschin A, Wischmeyer E, Davidson N, Lester HA (1994) <br />Fast inhibition of inwardly rectifying K+ channels by multiple neurotransmitter receptors in oligodendroglia<br /><i>European Journal of Neuroscience</i> <b>6</b>: 1756<br /><br />Dascal N, Lim NF, Schreibmayer W, Wang W, Davidson N, Lester HA (1993) <br />Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes<br /><i>Proc Natl Acad Sci U S A</i> <b>90</b>: 6596<br /><br />Lester HA, Dascal N (1993) <br />Potassium channels. The response to vagusstoff<br /><i>Nature</i> <b>364</b>: 758<br /><br />Charnet P, Labarca C, Cohen BN, Davidson N, Lester HA, Pilar G (1992) <br />Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes<br /><i>The Journal of Physiology</i> <b>450</b>: 375<br /><br />Charnet P, Labarca C, Lester HA (1992) <br />Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission<br /><i>Molecular Pharmacology</i> <b>41</b>: 708<br /><br />Cohen BN, Labarca C, Czyzyk L, Davidson N, Lester HA (1992) <br />Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region<br /><i>Journal of General Physiology</i> <b>99</b>: 545<br /><br />Cohen BN, Labarca C, Davidson N, Lester HA (1992) <br />Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations<br /><i>Journal of General Physiology</i> <b>100</b>: 373<br /><br />Figl A, Cohen BN, Quick MW, Davidson N, Lester HA (1992) <br />Regions of beta 4.beta 2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors<br /><i>FEBS Letters</i> <b>308</b>: 245<br /><br />Karschin A, Ho BY, Labarca C, Elroy-Stein O, Moss B, Davidson N, Lester HA (1991) <br />Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart<br /><i>Proc Natl Acad Sci U S A</i> <b>88</b>: 5694<br /><br />Leonard RJ, Charnet P, Labarca C, Vogelaar NJ, Czyzyk L, Gouin A, Davidson N, Lester HA (1991) <br />Mutations affecting local anesthetic block of the nicotinic acetylcholine receptor ion channel<br /><i>NIDA Res Monogr</i> <b>111</b>: 28<br /><br />Leonard RJ, Charnet P, Labarca C, Vogelaar NJ, Czyzyk L, Gouin A, Davidson N, Lester HA (1991) <br />Reverse pharmacology of the nicotinic acetylcholine receptor. Mapping the local anesthetic binding site<br /><i>Annals of the New York Academy of Sciences</i> <b>625</b>: 588<br /><br />Walter AE, Hoger JH, Labarca C, Yu L, Davidson N, Lester HA (1991) <br />Low molecular weight mRNA encodes a protein that controls serotonin 5-HT1c and acetylcholine M1 receptor sensitivity in Xenopus oocytes<br /><i>Journal of General Physiology</i> <b>98</b>: 399<br /><br />Yang XC, Karschin A, Labarca C, Elroy-Stein O, Moss B, Davidson N, Lester HA (1991) <br />Expression of ion channels and receptors in Xenopus oocytes using vaccinia virus<br /><i>FASEB Journal</i> <b>5</b>: 2209<br /><br />Yu L, Leonard RJ, Davidson N, Lester HA (1991) <br />Single-channel properties of mouse-Torpedo acetylcholine receptor hybrids expressed in Xenopus oocytes<br /><i>Brain Research Mol Brain Res</i> <b>10</b>: 203<br /><br />Charnet P, Labarca C, Leonard RJ, Vogelaar NJ, Czyzyk L, Gouin A, Davidson N, Lester HA (1990) <br />An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor<br /><i>Neuron</i> <b>4</b>: 87<br /><br />Yu L, Blumer KJ, Davidson N, Lester HA, Thorner J (1989) <br />Functional expression of the yeast alpha-factor receptor in Xenopus oocytes<br /><i>Journal of Biological Chemistry</i> <b>264</b>: 20847<br /><br />Leonard RJ, Labarca CG, Charnet P, Davidson N, Lester HA (1988) <br />Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor<br /><i>Science</i> <b>242</b>: 1578<br /><br />Gurney AM, Lester HA (1987) <br />Light-flash physiology with synthetic photosensitive compounds<br /><i>Physiol Rev</i> <b>67</b>: 583<br /><br />Mayne KM, Yoshii K, Yu L, Lester HA, Davidson N (1987) <br />Expression of mouse-Torpedo acetylcholine receptor subunit chimeras and hybrids in Xenopus oocytes<br /><i>Brain Research</i> <b>388</b>: 191<br /><br />Yoshii K, Yu L, Mayne KM, Davidson N, Lester HA (1987) <br />Equilibrium properties of mouse-Torpedo acetylcholine receptor hybrids expressed in Xenopus oocytes<br /><i>Journal of General Physiology</i> <b>90</b>: 553<br /><br />Chabala LD, Gurney AM, Lester HA (1986) <br />Dose-response of acetylcholine receptor channels opened by a flash-activated agonist in voltage-clamped rat myoballs<br /><i>The Journal of Physiology</i> <b>371</b>: 407<br /><br />Chabala LD, Lester HA (1986) <br />Activation of acetylcholine receptor channels by covalently bound agonists in cultured rat myoballs<br /><i>The Journal of Physiology</i> <b>379</b>: 83<br /><br />Dascal N, Ifune C, Hopkins R, Snutch TP, Lubbert H, Davidson N, Simon MI, Lester HA (1986) <br />Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA<br /><i>Brain Research</i> <b>387</b>: 201<br /><br />Dascal N, Snutch TP, Lubbert H, Davidson N, Lester HA (1986) <br />Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes<br /><i>Science</i> <b>231</b>: 1147<br /><br />Lester HA, Chabala LD, Gurney AM, Sheridan RE (1986) <br />Experiments with photoisomerizable molecules at nicotinic acetylcholine receptors in cells and membrane patches from rat muscle<br /><i>Soc Gen Physiol Ser</i> <b>40</b>: 447<br /><br />Chabala LD, Gurney AM, Lester HA (1985) <br />Photoactivation and dissociation of agonist molecules at the nicotinic acetylcholine receptor in voltage-clamped rat myoballs<br /><i>Biophysical Journal</i> <b>48</b>: 241<br /><br />Dascal N, Lotan I, Gillo B, Lester HA, Lass Y (1985) <br />Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes<br /><i>Proc Natl Acad Sci U S A</i> <b>82</b>: 6001<br /><br />Krouse ME, Lester HA, Wassermann NH, Erlanger BF (1985) <br />Rates and equilibria for a photoisomerizable antagonist at the acetylcholine receptor of Electrophorus electroplaques<br /><i>Journal of General Physiology</i> <b>86</b>: 235<br /><br />White MM, Mayne KM, Lester HA, Davidson N (1985) <br />Mouse-Torpedo hybrid acetylcholine receptors: functional homology does not equal sequence homology<br /><i>Proc Natl Acad Sci U S A</i> <b>82</b>: 4852<br /><br />Nerbonne JM, Sheridan RE, Chabala LD, Lester HA (1983) <br />cis-3,3'-Bis-[alpha-(trimethylammonium)methyl]azobenzene (cis-Bis-Q). Purification and properties at acetylcholine receptors of Electrophorus electroplaques<br /><i>Molecular Pharmacology</i> <b>23</b>: 344<br /><br />Lester HA, Nerbonne JM (1982) <br />Physiological and pharmacological manipulations with light flashes<br /><i>Annu Rev Biophys Bioeng</i> <b>11</b>: 151<br /><br />Lester HA, Steer ML, Michaelson DM (1982) <br />ADP-ribosylation of membrane proteins in cholinergic nerve terminals<br /><i>Journal of Neurochemistry</i> <b>38</b>: 1080<br /><br />Nargeot J, Lester HA, Birdsall NJ, Stockton J, Wassermann NH, Erlanger BF (1982) <br />A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart<br /><i>Journal of General Physiology</i> <b>79</b>: 657<br /><br />Sheridan RE, Lester HA (1982) <br />Functional stoichiometry at the nicotinic receptor. The photon cross section for phase 1 corresponds to two bis-Q molecules per channel<br /><i>Journal of General Physiology</i> <b>80</b>: 499<br /><br />Lester HA, Krouse ME, Nass MM, Wassermann NH, Erlanger BF (1980) <br />A covalently bound photoisomerizable agonist: comparison with reversibly bound agonists at Electrophorus electroplaques<br /><i>Journal of General Physiology</i> <b>75</b>: 207<br /><br />Lester HA, Nass MM, Krouse ME, Nerbonne JM, Wassermann NH, Erlanger BF (1980) <br />Electrophysiological experiments with photoisomerizable cholinergic compounds: review and progress report<br /><i>Annals of the New York Academy of Sciences</i> <b>346</b>: 475<br /><br />Armstrong DL, Lester HA (1979) <br />The kinetics of tubocurarine action and restricted diffusion within the synaptic cleft<br /><i>The Journal of Physiology</i> <b>294</b>: 365<br /><br />Koblin DD, Lester HA (1979) <br />Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques<br /><i>Molecular Pharmacology</i> <b>15</b>: 559<br /><br />Wathey JC, Nass MM, Lester HA (1979) <br />Numerical reconstruction of the quantal event at nicotinic synapses<br /><i>Biophysical Journal</i> <b>27</b>: 145<br /><br />Lester HA (1978) <br />Analysis of sodium and potassium redistribution during sustained permeability increases at the innervated face of Electrophorus electroplaques<br /><i>Journal of General Physiology</i> <b>72</b>: 847<br /><br />Lester HA, Koblin DD, Sheridan RE (1978) <br />Role of voltage-sensitive receptors in nicotinic transmission<br /><i>Biophysical Journal</i> <b>21</b>: 181<br /><br />Nass MM, Lester HA, Krouse ME (1978) <br />Response of acetylcholine receptors to photoisomerizations of bound agonist molecules<br /><i>Biophysical Journal</i> <b>24</b>: 135<br /><br />Lester HA (1977) <br />The response to acetylcholine<br /><i>Sci Am</i> <b>236</b>: 106<br /><br />Lester HA, Chang HW (1977) <br />Response of acetylcholine receptors to rapid photochemically produced increases in agonist concentration<br /><i>Nature</i> <b>266</b>: 373<br /><br />Sheridan RE, Lester HA (1977) <br />Rates and equilibria at the acetylcholine receptor of Electrophorus electroplaques: a study of neurally evoked postsynaptic currents and of voltage-jump relaxations<br /><i>Journal of General Physiology</i> <b>70</b>: 187<br /><br />Sheridan RE, Lester HA (1975) <br />Relaxation measurements on the acetylcholine receptor<br /><i>Proc Natl Acad Sci U S A</i> <b>72</b>: 3496<br /><br />Lester HA (1972) <br />Blockade of acetylcholine receptors by cobra toxin: electrophysiological studies<br /><i>Molecular Pharmacology</i> <b>8</b>: 623<br /><br />Lester HA (1972) <br />Vulnerability of desensitized or curare-treated acetylcholine receptors to irreversible blockade by cobra toxin<br /><i>Molecular Pharmacology</i> <b>8</b>: 632<br /><br />Lester HA (1970) <br />Postsynaptic action of cobra toxin at the myoneural junction<br /><i>Nature</i> <b>227</b>: 727<br /><br />