Lamba D, Pesaresi A (2022)
Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine
Int J Mol Sci 23:

Pesaresi A, Lamba D, Vezenkov L, Tsekova D, Lozanov V (2022)
Kinetic and structural studies on the inhibition of acetylcholinesterase and butyrylcholinesterase by a series of multitarget-directed galantamine-peptide derivatives
Chemico-Biological Interactions

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Karasova JZ, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K (2019)
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Eur Journal of Medicinal Chemistry 168: 491

Caliandro R, Pesaresi A, Cariati L, Procopio A, Oliverio M, Lamba D (2018)
Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues
J Enzyme Inhib Med Chem 33: 794

Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M (2016)
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography
Journal of Medicinal Chemistry 59: 114

Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML (2014)
Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects
Journal of Medicinal Chemistry 57: 8576

Bhonsle JB, Causey R, Oyler BL, Bartolucci C, Lamba D, Pesaresi A, Bhamare NK, Soojhawon I, Garcia GE (2013)
Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model
Chemico-Biological Interactions 203: 129

Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D (2012)
Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group
Biochemical Journal 444: 269

Bartolucci C, Haller LA, Jordis U, Fels G, Lamba D (2010)
Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives
Journal of Medicinal Chemistry 53: 745

Pesaresi A, Lamba D (2010)
Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study
Biochimie 92: 1787

Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Villetti G, Delcanale M, Lamba D (2006)
Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819)
Journal of Medicinal Chemistry 49: 5051

Krastanova I, Guarnaccia C, Zahariev S, Degrassi G, Lamba D (2005)
Heterologous expression, purification, crystallization, X-ray analysis and phasing of the acetyl xylan esterase from Bacillus pumilus
Biochimica & Biophysica Acta 1748: 222

Pesaresi A, Devescovi G, Lamba D, Venturi V, Degrassi G (2005)
Isolation, characterization, and heterologous expression of a carboxylesterase of Pseudomonas aeruginosa PAO1
Curr Microbiol 50: 102

Pesaresi A, Lamba D (2005)
Crystallization, X-ray diffraction analysis and phasing of carboxylesterase PA3859 from Pseudomonas aeruginosa
Biochimica & Biophysica Acta 1752: 197

Benini S, Degrassi G, Krastanova I, Lamba D, Venturi V (2004)
Purification, crystallization and preliminary X-ray analysis of an acetylxylan esterase from Bacillus pumilus. Erratum
Acta Crystallographica D Biol Crystallogr 60: 1346

Bartolucci C, Perola E, Pilger C, Fels G, Lamba D (2001)
Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs
Proteins 42: 182

Pilger C, Bartolucci C, Lamba D, Tropsha A, Fels G (2001)
Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking
J Mol Graph Model 19: 288

Bartolucci C, Perola E, Cellai L, Brufani M, Lamba D (1999)
Back Door Opening Implied by the Crystal Structure of a Carbamoylated Acetylcholinesterase
Biochemistry 38: 5714

Perola E, Cellai L, Lamba D, Filocamo L, Brufani M (1997)
Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase.
Biochimica & Biophysica Acta 1343: 41